DNAH17-AS1

Summary

DNAH17-AS1 (DNAH17 antisense RNA 1, HGNC:48594) is a long non-coding RNA gene on chromosome 17q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48594
Approved symbol	DNAH17-AS1
Name	DNAH17 antisense RNA 1
Location	17q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267432
Ensembl biotype	lncRNA
Entrez	100996295
RNAcentral	URS000075C866 — lncRNA, 5163 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 lncRNA, 1 retained_intron

ENST00000588565, ENST00000591373, ENST00000598378, ENST00000663269

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000588565 — 3 exons

Exon	Start	End
ENSE00002767070	78489375	78489574
ENSE00002825024	78490002	78490105
ENSE00002915594	78484882	78485090

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 89.54.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6875 / max 224.4635, expressed in 184 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163113	0.3464	116
163114	0.1925	42
163112	0.1317	71
163119	0.0170	9

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	89.54	gold quality
spinal cord	UBERON:0002240	85.12	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.85	gold quality
substantia nigra	UBERON:0002038	65.36	gold quality
midbrain	UBERON:0001891	62.28	gold quality
prefrontal cortex	UBERON:0000451	60.08	gold quality
colonic epithelium	UBERON:0000397	59.79	silver quality
hypothalamus	UBERON:0001898	59.04	gold quality
corpus callosum	UBERON:0002336	56.11	gold quality
monocyte	CL:0000576	54.98	gold quality
amygdala	UBERON:0001876	54.63	gold quality
Ammon’s horn	UBERON:0001954	54.52	gold quality
Brodmann (1909) area 9	UBERON:0013540	54.24	gold quality
frontal cortex	UBERON:0001870	52.54	gold quality
putamen	UBERON:0001874	52.11	gold quality
neocortex	UBERON:0001950	51.75	gold quality
left adrenal gland cortex	UBERON:0035825	51.32	gold quality
right adrenal gland cortex	UBERON:0035827	51.27	gold quality
brain	UBERON:0000955	50.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.59	gold quality
cerebral cortex	UBERON:0000956	50.51	gold quality
forebrain	UBERON:0001890	50.30	gold quality
anterior cingulate cortex	UBERON:0009835	50.03	gold quality
right frontal lobe	UBERON:0002810	49.96	gold quality
spleen	UBERON:0002106	49.83	gold quality
nucleus accumbens	UBERON:0001882	49.34	gold quality
cerebellar hemisphere	UBERON:0002245	49.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	49.22	gold quality
vermiform appendix	UBERON:0001154	49.20	gold quality
cerebellar cortex	UBERON:0002129	49.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p. (PMID:32351291)
• Long noncoding RNA DNAH17-AS1 promotes tumorigenesis and metastasis of non-small cell lung cancer via regulating miR-877-5p/CCNA2 pathway. (PMID:32981678)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.