DNAH8-AS1

Summary

DNAH8-AS1 (DNAH8 antisense RNA 1, HGNC:40188) is a long non-coding RNA gene on chromosome 6p21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40188
Approved symbol	DNAH8-AS1
Name	DNAH8 antisense RNA 1
Location	6p21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-SAYSD1-1
Ensembl gene	ENSG00000231150
Ensembl biotype	lncRNA
Entrez	100131047
RNAcentral	URS000075C5A8 — lncRNA, 2146 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000416948, ENST00000418399, ENST00000453417, ENST00000828392

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416948 — 4 exons

Exon	Start	End
ENSE00001628508	38936293	38936392
ENSE00001633994	38923029	38923567
ENSE00001691093	38924913	38925051
ENSE00001762482	38953048	38953099

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 81.78.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0159 / max 14.4347, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73465	0.0159	4

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.78	gold quality
left testis	UBERON:0004533	71.56	gold quality
testis	UBERON:0000473	71.21	gold quality
right testis	UBERON:0004534	69.80	gold quality
bone marrow cell	CL:0002092	64.13	silver quality
prostate gland	UBERON:0002367	61.82	gold quality
liver	UBERON:0002107	61.31	silver quality
urinary bladder	UBERON:0001255	61.10	gold quality
prefrontal cortex	UBERON:0000451	57.30	gold quality
amygdala	UBERON:0001876	57.29	gold quality
duodenum	UBERON:0002114	56.72	gold quality
monocyte	CL:0000576	56.23	gold quality
multicellular organism	UBERON:0000468	56.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.46	gold quality
vermiform appendix	UBERON:0001154	55.28	gold quality
lymph node	UBERON:0000029	55.26	gold quality
islet of Langerhans	UBERON:0000006	54.20	gold quality
gall bladder	UBERON:0002110	53.66	gold quality
blood	UBERON:0000178	53.23	gold quality
muscle of leg	UBERON:0001383	52.62	gold quality
placenta	UBERON:0001987	51.54	gold quality
gastrocnemius	UBERON:0001388	51.25	gold quality
tibial artery	UBERON:0007610	50.96	gold quality
tibial nerve	UBERON:0001323	48.16	gold quality
left adrenal gland	UBERON:0001234	47.66	gold quality
heart	UBERON:0000948	46.96	gold quality
right adrenal gland	UBERON:0001233	46.92	gold quality
intestine	UBERON:0000160	46.57	gold quality
small intestine	UBERON:0002108	46.51	gold quality
hypothalamus	UBERON:0001898	46.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.74

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.