DNAJA4

Summary

DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4, HGNC:14885) is a protein-coding gene on chromosome 15q25.1, encoding DnaJ homolog subfamily A member 4 (Q8WW22).

Enables protein-folding chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane.

Source: NCBI Gene 55466 — RefSeq curated summary.

At a glance

• GWAS associations: 23
• Clinical variants (ClinVar): 77 total
• MANE Select transcript: NM_001130182

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14885
Approved symbol	DNAJA4
Name	DnaJ heat shock protein family (Hsp40) member A4
Location	15q25.1
Locus type	gene with protein product
Status	Approved
Aliases	PRO1472
Ensembl gene	ENSG00000140403
Ensembl biotype	protein_coding
Entrez	55466

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 12 protein_coding, 4 nonsense_mediated_decay, 3 retained_intron

ENST00000343789, ENST00000394852, ENST00000394855, ENST00000423642, ENST00000440911, ENST00000446172, ENST00000480425, ENST00000483802, ENST00000485075, ENST00000489435, ENST00000493321, ENST00000542636, ENST00000852615, ENST00000852616, ENST00000959631, ENST00000959632, ENST00000959633, ENST00000959634, ENST00000959635

RefSeq mRNA: 8 — MANE Select: NM_001130182 NM_001130182, NM_001130183, NM_001387384, NM_001387385, NM_001387386, NM_001387387, NM_001387388, NM_018602

CCDS: CCDS10299, CCDS45316, CCDS45317

Canonical transcript exons

ENST00000394852 — 7 exons

Exon	Start	End
ENSE00001519799	78280245	78282191
ENSE00001519801	78264562	78264895
ENSE00003505477	78274197	78274424
ENSE00003543339	78273095	78273199
ENSE00003572749	78280045	78280145
ENSE00003573978	78270497	78270677
ENSE00003639640	78275498	78275728

Expression profiles

Bgee: expression breadth ubiquitous, 265 present calls, max score 99.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.2109 / max 3694.4783, expressed in 1163 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147893	19.3595	1116
147890	1.2392	175
147894	0.8526	306
147892	0.3208	61
147897	0.2216	11
147891	0.1473	41
147896	0.0699	38

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	99.41	gold quality
right testis	UBERON:0004534	98.36	gold quality
left testis	UBERON:0004533	98.34	gold quality
sperm	CL:0000019	97.85	gold quality
heart right ventricle	UBERON:0002080	97.69	gold quality
right atrium auricular region	UBERON:0006631	97.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.14	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.01	gold quality
biceps brachii	UBERON:0001507	96.92	gold quality
body of tongue	UBERON:0011876	96.82	gold quality
anterior cingulate cortex	UBERON:0009835	96.73	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	96.68	gold quality
right uterine tube	UBERON:0001302	96.66	gold quality
cingulate cortex	UBERON:0003027	96.66	gold quality
superior vestibular nucleus	UBERON:0007227	96.64	gold quality
cerebellar hemisphere	UBERON:0002245	96.63	gold quality
cerebellar cortex	UBERON:0002129	96.60	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.58	gold quality
nucleus accumbens	UBERON:0001882	96.48	gold quality
lateral nuclear group of thalamus	UBERON:0002736	96.48	gold quality
substantia nigra pars compacta	UBERON:0001965	96.44	gold quality
heart left ventricle	UBERON:0002084	96.27	gold quality
male germ cell	CL:0000015	96.25	gold quality
cardiac ventricle	UBERON:0002082	96.22	gold quality
testis	UBERON:0000473	96.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.99	gold quality
right frontal lobe	UBERON:0002810	95.96	gold quality
substantia nigra pars reticulata	UBERON:0001966	95.88	gold quality
amygdala	UBERON:0001876	95.80	gold quality
pons	UBERON:0000988	95.75	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-109979	no	87.54
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
APOE	Activation

miRNA regulators (miRDB)

67 targeting DNAJA4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-6755-5P	99.95	65.59	464
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-4470	99.66	69.35	1767

Literature-anchored findings (GeneRIF, showing 5)

• Hyperthermia reduced HaCaT cell proliferation and promoted cytokine expressions responsible for anti-viral activity, mainly through a NF-kB dependent pathway. DNAJA4-deficiency enhanced the activation of NF-kB by hyperthermia in HaCaT cells. (PMID:29807809)
• DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells. (PMID:32925288)
• DNA methylation status of DNAJA4 is essential for human erythropoiesis. (PMID:36420716)
• DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus. (PMID:36672799)
• DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation. (PMID:37875476)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dnaja	ENSDARG00000051762
mus_musculus	Dnaja4	ENSMUSG00000032285
rattus_norvegicus	Dnaja4	ENSRNOG00000012106

Paralogs (3): DNAJA2 (ENSG00000069345), DNAJA1 (ENSG00000086061), DNAJA3 (ENSG00000103423)

Protein

Protein identifiers

DnaJ homolog subfamily A member 4 — Q8WW22 (reviewed: Q8WW22)

All UniProt accessions (6): Q8WW22, C9JDE6, F5GWV1, F5H170, F5H300, F8WF76

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8WW22-1	1	yes
Q8WW22-2	2
Q8WW22-3	3

RefSeq proteins (8): NP_001123654, NP_001123655, NP_001374313, NP_001374314, NP_001374315, NP_001374316, NP_001374317, NP_061072 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001305	HSP_DnaJ_Cys-rich_dom	Domain
IPR001623	DnaJ_domain	Domain
IPR002939	DnaJ_C	Domain
IPR008971	HSP40/DnaJ_pept-bd	Homologous_superfamily
IPR012724	DnaJ	Family
IPR018253	DnaJ_domain_CS	Conserved_site
IPR036410	HSP_DnaJ_Cys-rich_dom_sf	Homologous_superfamily
IPR036869	J_dom_sf	Homologous_superfamily
IPR044713	DNJA1/2-like	Family

Pfam: PF00226, PF00684, PF01556

UniProt features (24 total): binding site 8, repeat 4, modified residue 2, splice variant 2, sequence conflict 2, chain 1, propeptide 1, lipid moiety-binding region 1, domain 1, sequence variant 1, zinc finger region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WW22-F1	84.76	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 151; 154; 178; 181; 194; 197; 135; 138

Post-translational modifications (3): 18, 394, 394

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

MSigDB gene sets: 211 (showing top): PEREZ_TP63_TARGETS, GOZGIT_ESR1_TARGETS_DN, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_PROTEIN_MATURATION, CADWELL_ATG16L1_TARGETS_DN, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, LIAO_METASTASIS, GOBP_REGULATION_OF_INCLUSION_BODY_ASSEMBLY, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, GOBP_PROTEIN_FOLDING, GOBP_CELLULAR_RESPONSE_TO_HEAT

GO Biological Process (6): response to heat (GO:0009408), negative regulation of endothelial cell migration (GO:0010596), positive regulation of gene expression (GO:0010628), protein refolding (GO:0042026), negative regulation of inclusion body assembly (GO:0090084), protein folding (GO:0006457)

GO Molecular Function (8): ATP binding (GO:0005524), zinc ion binding (GO:0008270), Hsp70 protein binding (GO:0030544), obsolete unfolded protein binding (GO:0051082), protein-folding chaperone binding (GO:0051087), protein binding (GO:0005515), heat shock protein binding (GO:0031072), metal ion binding (GO:0046872)

GO Cellular Component (3): cytoplasm (GO:0005737), cytosol (GO:0005829), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Cellular responses to stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
protein binding	2
response to stress	1
response to temperature stimulus	1
regulation of endothelial cell migration	1
negative regulation of cell migration	1
endothelial cell migration	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
protein folding	1
negative regulation of cellular component organization	1
inclusion body assembly	1
regulation of inclusion body assembly	1
cellular process	1
protein maturation	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
transition metal ion binding	1
heat shock protein binding	1
protein-folding chaperone binding	1
binding	1
cation binding	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

3007 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DNAJA4	DNAJC6	O75061	638
DNAJA4	HSPA4	P34932	513
DNAJA4	LRP8	Q14114	512
DNAJA4	HSPA6	P17066	502
DNAJA4	HSPA5	P11021	496
DNAJA4	HSPA4L	O95757	495
DNAJA4	HSPH1	Q92598	495
DNAJA4	HSPA1A	P08107	487
DNAJA4	DNAJB4	Q9UDY4	478
DNAJA4	HSPA8	P11142	477
DNAJA4	HSP90B1	P14625	460
DNAJA4	INHBA	P08476	450
DNAJA4	HSP90AA1	P07900	442
DNAJA4	KIF20A	O95235	439
DNAJA4	BAG3	O95817	434

IntAct

44 interactions, top by confidence:

A	B	Type	Score
DNAJA4	DNAJA2	psi-mi:“MI:0915”(physical association)	0.710
DNAJA4	DNAJA2	psi-mi:“MI:0914”(association)	0.710
TSPYL6	USP12	psi-mi:“MI:0914”(association)	0.640
L3MBTL1	DNAJB6	psi-mi:“MI:0914”(association)	0.530
MYORG	HSPA5	psi-mi:“MI:0914”(association)	0.530
HPSE	OS9	psi-mi:“MI:0914”(association)	0.530
DNAJA1	DNAJA2	psi-mi:“MI:0914”(association)	0.530
DNAJA4	ENDOG	psi-mi:“MI:0915”(physical association)	0.500
Tubb5		psi-mi:“MI:0915”(physical association)	0.400
ACOX3	DNAJA4	psi-mi:“MI:0915”(physical association)	0.400
AICDA	DNAJA4	psi-mi:“MI:0915”(physical association)	0.400
DNAJA4	CALU	psi-mi:“MI:0915”(physical association)	0.400
DNAJA4	DNAJA4	psi-mi:“MI:0915”(physical association)	0.400
AARSD1	DNAJA4	psi-mi:“MI:0915”(physical association)	0.400
SGTB	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
SYNCRIP	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
BAG6	CNOT1	psi-mi:“MI:0914”(association)	0.350
SORT1	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
RIPK4	VWA8	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TCTN2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PSCA	METTL15	psi-mi:“MI:0914”(association)	0.350
GPR45	VWA8	psi-mi:“MI:0914”(association)	0.350
TUBB		psi-mi:“MI:0914”(association)	0.350
DNAJA2	QSOX1	psi-mi:“MI:0914”(association)	0.350
AFG2A	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (110): DNAJA4 (Two-hybrid), DNAJA4 (Affinity Capture-Western), DNAJA4 (Affinity Capture-Western), DNAJA4 (Affinity Capture-MS), CCT2 (Co-fractionation), CCT3 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation), DNAJA4 (Co-fractionation)

ESM2 similar proteins: A6QBG7, B9FHF3, O35824, O60884, O74752, O75953, O89114, O94625, O94657, P25294, P25303, P25491, P25685, P42824, P42825, P43644, P59910, P78004, P81999, Q03363, Q04960, Q09912, Q0JB88, Q24133, Q2HJ94, Q2KIT4, Q3AQP5, Q3MI00, Q3ZBA6, Q54ED3, Q5BIP8, Q5R8J8, Q5RAJ6, Q626I7, Q6MNG0, Q6TUG0, Q8A8C3, Q8GWW8, Q8MPX3, Q8TA83

Diamond homologs: A0LJ41, A1KR91, A3DF24, A4XKA5, A5EYE5, A5ITA7, A6LRN5, A6Q486, A6QHC2, A6U251, A6UEY1, A7X2Y0, A8Z4B8, A9IGC5, A9KG87, A9LZV9, A9N8H1, B0SHT0, B0SRF0, B2IBR5, B2TLZ8, B2V2I6, B3CP03, B6IZJ1, B6J7U6, B8I304, B9FHF3, B9JZ89, B9MJZ0, C0R562, C3MC05, O27352, O35824, O60884, O66921, O74752, O75953, O89114, P25491, P31689

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	61
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1279 predictions. Top by Δscore:

Variant	Effect	Δscore
15:78264881:GA:G	donor_gain	1.0000
15:78264887:G:GT	donor_gain	1.0000
15:78264892:GAAG:G	donor_gain	1.0000
15:78264894:AGGT:A	donor_loss	1.0000
15:78264897:T:A	donor_loss	1.0000
15:78265536:TGAC:T	donor_gain	1.0000
15:78265559:A:AG	donor_gain	1.0000
15:78270494:A:G	acceptor_gain	1.0000
15:78270495:A:G	acceptor_gain	1.0000
15:78270496:GTTTA:G	acceptor_gain	1.0000
15:78273093:A:G	acceptor_gain	1.0000
15:78273197:AAG:A	donor_gain	1.0000
15:78274196:GGT:G	acceptor_gain	1.0000
15:78280044:GGT:G	acceptor_gain	1.0000
15:78280141:TTTTA:T	donor_gain	1.0000
15:78280142:TTTA:T	donor_gain	1.0000
15:78280146:G:GG	donor_gain	1.0000
15:78280235:C:G	acceptor_gain	1.0000
15:78280243:A:AC	acceptor_loss	1.0000
15:78280244:G:GC	acceptor_loss	1.0000
15:78264844:G:GT	donor_gain	0.9900
15:78264859:G:GG	donor_gain	0.9900
15:78264882:A:G	donor_gain	0.9900
15:78264889:C:T	donor_gain	0.9900
15:78265537:GACA:G	donor_gain	0.9900
15:78265538:ACAA:A	donor_gain	0.9900
15:78265555:GATCA:G	donor_gain	0.9900
15:78265559:A:G	donor_gain	0.9900
15:78270493:A:AG	acceptor_gain	0.9900
15:78270493:AAAGT:A	acceptor_loss	0.9900

AlphaMissense

2638 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:78264843:G:C	R27P	1.000
15:78264863:C:A	H34N	1.000
15:78264863:C:G	H34D	1.000
15:78264865:C:A	H34Q	1.000
15:78264865:C:G	H34Q	1.000
15:78270497:T:C	F45L	1.000
15:78270499:T:A	F45L	1.000
15:78270499:T:G	F45L	1.000
15:78264839:T:G	Y26D	0.999
15:78264852:C:A	A30E	0.999
15:78264864:A:G	H34R	0.999
15:78270498:T:C	F45S	0.999
15:78270498:T:G	F45C	0.999
15:78270507:T:A	I48K	0.999
15:78270509:T:C	S49P	0.999
15:78270515:G:C	A51P	0.999
15:78270528:T:A	L55H	0.999
15:78270528:T:C	L55P	0.999
15:78274229:T:C	C151R	0.999
15:78274238:T:A	C154S	0.999
15:78274238:T:C	C154R	0.999
15:78274239:G:C	C154S	0.999
15:78274310:T:C	C178R	0.999
15:78274312:C:G	C178W	0.999
15:78274319:T:A	C181S	0.999
15:78274320:G:C	C181S	0.999
15:78264832:G:C	K23N	0.998
15:78264832:G:T	K23N	0.998
15:78264855:T:C	L31P	0.998
15:78264866:C:T	P35S	0.998

dbSNP variants (sampled 300 via entrez): RS1000192761 (15:78267104 G>C), RS1000267205 (15:78277312 C>T), RS1000306479 (15:78263291 A>T), RS1000394290 (15:78277843 C>T), RS1000642448 (15:78264378 C>T), RS1000684440 (15:78265881 G>A), RS1000909588 (15:78271998 A>G,T), RS1000996282 (15:78274110 G>T), RS1001593403 (15:78264194 C>G,T), RS1001785513 (15:78281942 T>C), RS1001816916 (15:78276815 G>T), RS1001947651 (15:78277072 T>A,C), RS1001972965 (15:78264960 T>C,G), RS1002009049 (15:78264942 G>A,T), RS1002042009 (15:78265198 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

23 associations (top):

Study	Trait	p-value
GCST003476_6	Eyebrow thickness	1.000000e-06
GCST004619_145	Reticulocyte fraction of red cells	3.000000e-15
GCST004621_79	Red cell distribution width	9.000000e-54
GCST004622_133	Reticulocyte count	9.000000e-20
GCST005576_24	Intracranial aneurysm	5.000000e-06
GCST006804_49	Red cell distribution width	3.000000e-13
GCST006804_77	Red cell distribution width	6.000000e-38
GCST010083_49	Hemoglobin levels	1.000000e-14
GCST012020_458	Serum metabolite levels	8.000000e-28
GCST012020_459	Serum metabolite levels	2.000000e-16
GCST90002383_235	Hematocrit	4.000000e-10
GCST90002385_60	High light scatter reticulocyte count	6.000000e-20
GCST90002386_600	High light scatter reticulocyte percentage of red cells	1.000000e-22
GCST90002392_435	Mean corpuscular volume	2.000000e-12
GCST90002397_265	Mean spheric corpuscular volume	3.000000e-26
GCST90002400_163	Plateletcrit	5.000000e-15
GCST90002402_168	Platelet count	3.000000e-12
GCST90002404_370	Red cell distribution width	9.000000e-57
GCST90002404_371	Red cell distribution width	2.000000e-37
GCST90002405_342	Reticulocyte count	4.000000e-20
GCST90002405_343	Reticulocyte count	1.000000e-20
GCST90002406_391	Reticulocyte fraction of red cells	5.000000e-24
GCST90002406_392	Reticulocyte fraction of red cells	6.000000e-17

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0009188	Red cell distribution width
EFO:0004509	hemoglobin measurement
EFO:0004348	hematocrit
EFO:0007985	platelet crit
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

55 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium	increases abundance, increases expression	4
Copper	decreases expression, increases expression, affects binding	3
Tobacco Smoke Pollution	affects expression, increases expression	3
Cadmium Chloride	decreases expression, increases abundance, increases expression	3
bisphenol A	increases expression, affects cotreatment	2
Benzo(a)pyrene	affects methylation, decreases methylation	2
Silicon Dioxide	increases expression	2
Valproic Acid	affects expression, increases expression, increases methylation	2
Particulate Matter	increases expression, affects expression, increases reaction, increases abundance	2
bisphenol F	affects cotreatment, increases expression	1
methylmercuric chloride	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	decreases expression	1
nickel sulfate	decreases expression	1
cupric oxide	increases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	increases expression	1
2-palmitoylglycerol	increases expression	1
oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	affects expression, increases reaction	1
dimethylarsinous acid	increases expression	1
ICG 001	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
licochalcone B	increases expression	1
NSC 689534	affects binding, increases expression	1
Decitabine	increases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.