DNAJC11

Summary

DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11, HGNC:25570) is a protein-coding gene on chromosome 1p36.31, encoding DnaJ homolog subfamily C member 11 (Q9NVH1). Required for mitochondrial inner membrane organization. It is a selective cancer dependency (DepMap: 61.4% of cell lines).

Involved in cristae formation. Located in MICOS complex; SAM complex; and nuclear speck. Part of MIB complex.

Source: NCBI Gene 55735 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 84 total
• Cancer dependency (DepMap): dependent in 61.4% of screened cell lines
• MANE Select transcript: NM_018198

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25570
Approved symbol	DNAJC11
Name	DnaJ heat shock protein family (Hsp40) member C11
Location	1p36.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10737
Ensembl gene	ENSG00000007923
Ensembl biotype	protein_coding
OMIM	614827
Entrez	55735

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 15 protein_coding, 12 retained_intron, 6 protein_coding_CDS_not_defined, 3 nonsense_mediated_decay

ENST00000294401, ENST00000377577, ENST00000426784, ENST00000451196, ENST00000460594, ENST00000465508, ENST00000465911, ENST00000469318, ENST00000472414, ENST00000473993, ENST00000485073, ENST00000685129, ENST00000685360, ENST00000685485, ENST00000686243, ENST00000688162, ENST00000688524, ENST00000689025, ENST00000689169, ENST00000689474, ENST00000690062, ENST00000690452, ENST00000691444, ENST00000691481, ENST00000693337, ENST00000885067, ENST00000885068, ENST00000885069, ENST00000885070, ENST00000885071, ENST00000885072, ENST00000939001, ENST00000939002, ENST00000939003, ENST00000954225, ENST00000954226

RefSeq mRNA: 1 — MANE Select: NM_018198 NM_018198

CCDS: CCDS87

Canonical transcript exons

ENST00000377577 — 16 exons

Exon	Start	End
ENSE00001787167	6645041	6645126
ENSE00001805559	6638295	6638364
ENSE00002155401	6645789	6645978
ENSE00003458382	6637447	6637504
ENSE00003464933	6678394	6678467
ENSE00003469839	6651529	6651602
ENSE00003515843	6644558	6644674
ENSE00003550242	6652829	6652951
ENSE00003551429	6667709	6667810
ENSE00003568465	6636117	6636246
ENSE00003629167	6639902	6640057
ENSE00003653255	6653911	6654039
ENSE00003670393	6634170	6635700
ENSE00003679343	6680908	6681037
ENSE00003692941	6637198	6637340
ENSE00003849078	6701729	6701816

Expression profiles

Bgee: expression breadth ubiquitous, 276 present calls, max score 95.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.2419 / max 459.3157, expressed in 1812 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
10066	25.4603	1812
10065	0.7816	518

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	95.58	gold quality
apex of heart	UBERON:0002098	94.23	gold quality
rectum	UBERON:0001052	94.21	gold quality
mucosa of transverse colon	UBERON:0004991	93.93	gold quality
sural nerve	UBERON:0015488	93.72	gold quality
renal medulla	UBERON:0000362	93.38	gold quality
islet of Langerhans	UBERON:0000006	93.29	gold quality
heart left ventricle	UBERON:0002084	92.86	gold quality
transverse colon	UBERON:0001157	92.56	gold quality
cardiac ventricle	UBERON:0002082	92.55	gold quality
right adrenal gland	UBERON:0001233	92.48	gold quality
right adrenal gland cortex	UBERON:0035827	92.33	gold quality
muscle of leg	UBERON:0001383	92.31	gold quality
left adrenal gland	UBERON:0001234	92.26	gold quality
gastrocnemius	UBERON:0001388	92.26	gold quality
adult mammalian kidney	UBERON:0000082	92.19	gold quality
left adrenal gland cortex	UBERON:0035825	92.10	gold quality
adrenal gland	UBERON:0002369	91.98	gold quality
right atrium auricular region	UBERON:0006631	91.87	gold quality
stromal cell of endometrium	CL:0002255	91.85	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.80	gold quality
adrenal cortex	UBERON:0001235	91.62	gold quality
adrenal tissue	UBERON:0018303	91.51	gold quality
heart	UBERON:0000948	91.19	gold quality
Brodmann (1909) area 10	UBERON:0013541	91.11	gold quality
endometrium epithelium	UBERON:0004811	91.09	silver quality
cardiac atrium	UBERON:0002081	90.94	gold quality
body of stomach	UBERON:0001161	90.46	gold quality
frontal pole	UBERON:0002795	90.46	gold quality
colon	UBERON:0001155	90.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

58 targeting DNAJC11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-7156-5P	99.64	68.81	1369
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451
HSA-MIR-4273	99.45	67.93	1206
HSA-MIR-20A-3P	99.44	69.10	1575
HSA-MIR-6839-3P	99.39	68.86	1301
HSA-MIR-128-1-5P	99.33	60.46	332

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 61.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate tumor suppressor genes of neuroblastoma (PMID:12964007)
• FLJ10737 protein consists of the DnaJ domain, bipartite NLS, FADH domain, and FEMCA domain. Mouse E030019A03, zebrafish MGC55845, Drosophila CG8531 and Arabidopsis At2g35720 were homologs of human FLJ10737. (PMID:12964007)
• no evidence for somatic mutations in CAMTA1 in neuroblastoma (PMID:17222547)
• mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3) have been implicated in protein import; DnaJC11 is a chaperone-like protein that may have a similar role (PMID:17624330)
• a link between DNAJC11 and neuromuscular diseases (PMID:25111180)
• CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway. (PMID:36895010)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	dnajc11a	ENSDARG00000011196
danio_rerio	dnajc11b	ENSDARG00000102696
mus_musculus	Dnajc11	ENSMUSG00000039768
rattus_norvegicus	Dnajc11	ENSRNOG00000008802
drosophila_melanogaster	CG8531	FBGN0033918
caenorhabditis_elegans		WBGENE00001020
caenorhabditis_elegans		WBGENE00001025
caenorhabditis_elegans	dnj-28	WBGENE00001046
caenorhabditis_elegans		WBGENE00008122

Paralogs (20): DNAJC25 (ENSG00000059769), DNAJC10 (ENSG00000077232), DNAJC5 (ENSG00000101152), DNAJC3 (ENSG00000102580), DNAJC17 (ENSG00000104129), DNAJC2 (ENSG00000105821), DNAJC12 (ENSG00000108176), DNAJC4 (ENSG00000110011), DNAJC16 (ENSG00000116138), DNAJC14 (ENSG00000135392), DNAJC1 (ENSG00000136770), DNAJC13 (ENSG00000138246), DNAJC5B (ENSG00000147570), DNAJC5G (ENSG00000163793), DNAJC7 (ENSG00000168259), DNAJC21 (ENSG00000168724), DNAJC18 (ENSG00000170464), DNAJC24 (ENSG00000170946), DNAJC30 (ENSG00000176410), DNAJC9 (ENSG00000213551)

Protein

Protein identifiers

DnaJ homolog subfamily C member 11 — Q9NVH1 (reviewed: Q9NVH1)

All UniProt accessions (6): Q9NVH1, A0A8I5KRM1, A0A8I5KXQ7, A0A8I5QJB4, B1AK20, Q5TH61

UniProt curated annotations — full annotation on UniProt →

Function. Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.

Subunit / interactions. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both mitochondrial membranes termed the mitochondrial intermembrane space bridging (MIB) complex.

Subcellular location. Mitochondrion Mitochondrion outer membrane.

Similarity. Belongs to the DNAJC11 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NVH1-1	1	yes
Q9NVH1-2	2
Q9NVH1-3	3

RefSeq proteins (1): NP_060668* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001623	DnaJ_domain	Domain
IPR018253	DnaJ_domain_CS	Conserved_site
IPR024586	DnaJ-like_C11_C	Domain
IPR036869	J_dom_sf	Homologous_superfamily
IPR052243	Mito_inner_membrane_organizer	Family
IPR055225	DNAJC11-like_beta-barrel	Domain

Pfam: PF00226, PF11875, PF22774

UniProt features (12 total): sequence variant 3, modified residue 2, splice variant 2, initiator methionine 1, chain 1, sequence conflict 1, domain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVH1-F1	84.57	0.39

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 204

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8949613	Cristae formation

MSigDB gene sets: 170 (showing top): E2F_Q4, MORF_DNMT1, E2F_Q4_01, PAX4_01, WHITE_NEUROBLASTOMA_WITH_1P36.3_DELETION, TGACCTY_ERR1_Q2, MORF_HDAC2, GOBP_CRISTAE_FORMATION, E2F_Q3, GOBP_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION, TGCTGAY_UNKNOWN, MORF_BUB3, MORF_RFC4, MORF_PRKDC, GOCC_MITOCHONDRIAL_ENVELOPE

GO Biological Process (2): inner mitochondrial membrane organization (GO:0007007), cristae formation (GO:0042407)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): SAM complex (GO:0001401), nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), nuclear speck (GO:0016607), MIB complex (GO:0140275), membrane (GO:0016020), MICOS complex (GO:0061617)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Mitochondrial biogenesis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
inner mitochondrial membrane protein complex	2
mitochondrial membrane organization	1
inner mitochondrial membrane organization	1
binding	1
mitochondrial outer membrane translocase complex	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrial membrane	1
organelle outer membrane	1
nuclear ribonucleoprotein granule	1

Protein interactions and networks

STRING

2761 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DNAJC11	SAMM50	Q9Y512	871
DNAJC11	IMMT	Q16891	835
DNAJC11	APOOL	Q6UXV4	792
DNAJC11	CHCHD3	Q9NX63	782
DNAJC11	APOO	Q9BUR5	772
DNAJC11	MTX1	Q13505	757
DNAJC11	CHCHD6	Q9BRQ6	705
DNAJC11	MTX2	O75431	699
DNAJC11	DNAJC4	Q9NNZ3	686
DNAJC11	MICOS10	Q5TGZ0	629
DNAJC11	THAP3	Q8WTV1	625
DNAJC11	MICOS13	Q5XKP0	621
DNAJC11	HSPA9	P30036	610
DNAJC11	DNAJC30	Q96LL9	573
DNAJC11	CHCHD10	Q8WYQ3	541

IntAct

151 interactions, top by confidence:

A	B	Type	Score
IMMT	MTX2	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
ARMC1	DNAJC11	psi-mi:“MI:0915”(physical association)	0.670
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
PM20D2	DNAJC11	psi-mi:“MI:0915”(physical association)	0.560
LXN	DNAJC11	psi-mi:“MI:0915”(physical association)	0.560
VPS52	DNAJC11	psi-mi:“MI:0915”(physical association)	0.560
APOOL	MTX2	psi-mi:“MI:0914”(association)	0.530
rep	IDE	psi-mi:“MI:0914”(association)	0.530
FAM174A	BLTP3B	psi-mi:“MI:0914”(association)	0.530
MCOLN3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
TRABD	FCN1	psi-mi:“MI:0914”(association)	0.530
RIC3	ATP9A	psi-mi:“MI:0914”(association)	0.530
SUOX	CES3	psi-mi:“MI:0914”(association)	0.530
EMILIN1	METTL15	psi-mi:“MI:0914”(association)	0.530
ZNRD2	MYO9A	psi-mi:“MI:0914”(association)	0.530
APLNR	SLC33A1	psi-mi:“MI:0914”(association)	0.530
TMEM184A	SLC33A1	psi-mi:“MI:0914”(association)	0.530
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
HSPA8	ARHGEF10	psi-mi:“MI:2364”(proximity)	0.480
AIFM1	HAX1	psi-mi:“MI:0914”(association)	0.420
AIFM1	HAX1	psi-mi:“MI:2364”(proximity)	0.420
AIFM1	SEC16A	psi-mi:“MI:2364”(proximity)	0.420
HTRA2	HAX1	psi-mi:“MI:2364”(proximity)	0.420

BioGRID (302): DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Affinity Capture-MS), DNAJC11 (Proximity Label-MS), DNAJC11 (Proximity Label-MS), DNAJC11 (Affinity Capture-MS), ANXA7 (Affinity Capture-MS), CAPG (Affinity Capture-MS), H3F3A (Affinity Capture-MS)

ESM2 similar proteins: A1Z6L1, A4QTI8, A5DCL4, A7F1G7, A8NWS6, B0DK33, B6K463, B8P366, C4XVQ6, C5DG70, O13498, O13656, O13814, O96008, P04840, P23644, P24391, P40478, Q0JJV1, Q0TWV0, Q10S27, Q18090, Q1LZB5, Q21752, Q2H740, Q2NL21, Q39079, Q5RC70, Q5U458, Q61Z83, Q6CAG4, Q6L5I5, Q6P825, Q758T7, Q75Q40, Q7SBE0, Q7ZTM6, Q84P97, Q8J0L4, Q9FHQ9

Diamond homologs: A1JJD6, A1KR91, A1TLH8, A2SIR5, A4G8D1, A4XKA5, A5IIT4, A5UF67, A6LJ63, A6T225, A6T4F5, A7MWW1, A7ZHA5, A7ZVV8, A9LZV9, B1IRF9, B1LCI2, B1LFU5, B1Y787, B2U233, B4F2V6, B5Y241, B5YYA8, B6HZ11, B7L4D9, B7LVP7, B7M0B1, B7MAD6, B7MNM2, B7N7N9, B7NHB7, B7UI60, B9KAB9, O06431, O87778, P25685, P31689, P32527, P34454, P39102

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
DNAJC11	up-regulates	Mitochondrial_biogenesis

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 188 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
cristae formation	5	32.9×	3e-04
inner mitochondrial membrane organization	5	26.3×	5e-04
mitochondrion organization	8	7.6×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

84 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	1
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2735 predictions. Top by Δscore:

Variant	Effect	Δscore
1:6635701:C:CC	acceptor_gain	1.0000
1:6636112:CTCA:C	donor_loss	1.0000
1:6636114:CA:C	donor_loss	1.0000
1:6636115:A:AC	donor_gain	1.0000
1:6636115:AC:A	donor_loss	1.0000
1:6636116:C:CA	donor_gain	1.0000
1:6636116:CA:C	donor_gain	1.0000
1:6636116:CACT:C	donor_gain	1.0000
1:6636116:CACTG:C	donor_gain	1.0000
1:6636242:CCAGC:C	acceptor_gain	1.0000
1:6636243:CAGC:C	acceptor_gain	1.0000
1:6636243:CAGCC:C	acceptor_gain	1.0000
1:6636244:AGC:A	acceptor_gain	1.0000
1:6636244:AGCCT:A	acceptor_loss	1.0000
1:6636245:GC:G	acceptor_gain	1.0000
1:6636246:CC:C	acceptor_gain	1.0000
1:6636246:CCTG:C	acceptor_loss	1.0000
1:6636247:C:CC	acceptor_gain	1.0000
1:6637193:TGTA:T	donor_loss	1.0000
1:6637194:GTACC:G	donor_loss	1.0000
1:6637195:TACCT:T	donor_loss	1.0000
1:6637197:CCTT:C	donor_loss	1.0000
1:6637445:A:AC	donor_gain	1.0000
1:6637446:C:CC	donor_gain	1.0000
1:6637503:ACC:A	acceptor_loss	1.0000
1:6637505:CTGC:C	acceptor_loss	1.0000
1:6637506:T:A	acceptor_loss	1.0000
1:6637509:C:CT	acceptor_gain	1.0000
1:6637510:A:T	acceptor_gain	1.0000
1:6638293:A:AC	donor_gain	1.0000

AlphaMissense

3645 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:6636178:G:C	F531L	1.000
1:6636178:G:T	F531L	1.000
1:6636180:A:G	F531L	1.000
1:6636197:A:G	L525P	1.000
1:6636233:C:T	G513D	1.000
1:6637220:A:G	L501P	1.000
1:6637313:C:T	G470E	1.000
1:6653919:A:G	S167P	1.000
1:6680933:A:C	F59L	1.000
1:6680933:A:T	F59L	1.000
1:6680935:A:G	F59L	1.000
1:6680982:G:T	P43Q	1.000
1:6680984:A:C	H42Q	1.000
1:6680984:A:T	H42Q	1.000
1:6680986:G:C	H42D	1.000
1:6680986:G:T	H42N	1.000
1:6636125:G:T	P549Q	0.999
1:6636126:G:A	P549S	0.999
1:6636128:A:T	I548K	0.999
1:6636165:G:C	H536D	0.999
1:6636186:A:C	Y529D	0.999
1:6636230:A:G	F514S	0.999
1:6636234:C:G	G513R	0.999
1:6637220:A:C	L501R	0.999
1:6637220:A:T	L501H	0.999
1:6637247:A:G	L492P	0.999
1:6637313:C:A	G470V	0.999
1:6637314:C:A	G470W	0.999
1:6637314:C:G	G470R	0.999
1:6637314:C:T	G470R	0.999

dbSNP variants (sampled 300 via entrez): RS1000031894 (1:6666638 G>A), RS1000045664 (1:6636929 G>A), RS1000160269 (1:6634153 G>A,C), RS1000195623 (1:6661033 C>T), RS1000222362 (1:6645694 G>A,C), RS1000281283 (1:6661131 C>T), RS1000344463 (1:6695832 A>G,T), RS1000366221 (1:6683877 T>C), RS1000367351 (1:6639247 C>G,T), RS1000378377 (1:6654830 T>A), RS1000430334 (1:6689801 G>T), RS1000432814 (1:6648704 A>G), RS1000457275 (1:6686719 C>T), RS1000467838 (1:6638162 C>T), RS1000469925 (1:6644496 A>C)

Disease associations

OMIM: gene MIM:614827 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005790_74	Rosacea symptom severity	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009180	rosacea severity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, decreases methylation	2
sodium arsenite	decreases expression, increases expression	2
Acetaminophen	decreases expression	2
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	increases expression	1
cylindrospermopsin	increases expression	1
CGP 52608	increases reaction, affects binding	1
bisphenol S	increases expression	1
Air Pollutants, Occupational	affects expression	1
Benzo(a)pyrene	increases methylation	1
Carbamazepine	affects expression	1
Diclofenac	affects expression	1
Estradiol	increases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1
Magnetite Nanoparticles	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.