DNAJC15

Summary

DNAJC15 (DnaJ heat shock protein family (Hsp40) member C15, HGNC:20325) is a protein-coding gene on chromosome 13q14.11, encoding DnaJ homolog subfamily C member 15 (Q9Y5T4). Negative regulator of the mitochondrial respiratory chain.

Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Located in mitochondrion.

Source: NCBI Gene 29103 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_013238

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20325
Approved symbol	DNAJC15
Name	DnaJ heat shock protein family (Hsp40) member C15
Location	13q14.11
Locus type	gene with protein product
Status	Approved
Aliases	MCJ
Ensembl gene	ENSG00000120675
Ensembl biotype	protein_coding
OMIM	615339
Entrez	29103

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000379221, ENST00000474320, ENST00000885099, ENST00000885100

RefSeq mRNA: 1 — MANE Select: NM_013238 NM_013238

CCDS: CCDS9388

Canonical transcript exons

ENST00000379221 — 6 exons

Exon	Start	End
ENSE00000817254	43078612	43078688
ENSE00000817255	43085768	43085838
ENSE00001001657	43107178	43114213
ENSE00003519888	43023586	43023734
ENSE00003546263	43068930	43069003
ENSE00003558761	43065686	43065737

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 97.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 66.1746 / max 434.1932, expressed in 1675 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134897	62.1819	1675
134895	2.8009	786
134896	0.8060	393
134894	0.3857	149

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	97.37	gold quality
seminal vesicle	UBERON:0000998	96.36	gold quality
heart right ventricle	UBERON:0002080	95.77	gold quality
corpus epididymis	UBERON:0004359	94.66	gold quality
oocyte	CL:0000023	94.48	gold quality
left ventricle myocardium	UBERON:0006566	94.48	gold quality
myocardium	UBERON:0002349	94.41	gold quality
tendon of biceps brachii	UBERON:0008188	93.88	gold quality
adult organism	UBERON:0007023	93.67	gold quality
nephron tubule	UBERON:0001231	93.57	gold quality
medial globus pallidus	UBERON:0002477	93.55	gold quality
colonic mucosa	UBERON:0000317	93.26	gold quality
duodenum	UBERON:0002114	92.93	gold quality
jejunum	UBERON:0002115	92.87	gold quality
palpebral conjunctiva	UBERON:0001812	92.67	gold quality
mucosa of sigmoid colon	UBERON:0004993	92.43	gold quality
cardiac muscle of right atrium	UBERON:0003379	92.27	gold quality
parotid gland	UBERON:0001831	91.80	gold quality
periodontal ligament	UBERON:0008266	91.65	gold quality
ileal mucosa	UBERON:0000331	91.44	gold quality
endothelial cell	CL:0000115	91.34	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.95	gold quality
lower lobe of lung	UBERON:0008949	90.91	gold quality
caput epididymis	UBERON:0004358	90.73	gold quality
cauda epididymis	UBERON:0004360	90.63	gold quality
biceps brachii	UBERON:0001507	90.59	gold quality
saphenous vein	UBERON:0007318	90.57	gold quality
cranial nerve II	UBERON:0000941	90.56	gold quality
pigmented layer of retina	UBERON:0001782	90.49	gold quality
endometrium	UBERON:0001295	90.48	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-8559	yes	321.54
E-MTAB-8271	yes	7.28
E-MTAB-6819	no	1464.94
E-MTAB-10018	no	1051.78
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

82 targeting DNAJC15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-12136	99.98	72.81	5713
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-205-5P	99.81	70.05	1557
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-4428	99.73	66.41	1733
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-1296-3P	99.72	64.04	636

Literature-anchored findings (GeneRIF, showing 16)

• loss of expression of MCJ by DNA methylation is associated with drug-resistance in ovarian cancer (PMID:14729589)
• evidence of MCJ hypermethylation in intracranial primitive neuroectodermal tumours (PNETs) (medulloblastomas, supratentorial PNETs & ependymomas); data indicate epigenetic inactivation of MCJ may play a role in development of pediatric brain tumours (PMID:16049974)
• MCJ is required in these cells to prevent c-Jun-mediated expression of ABCB1 and maintain drug response. (PMID:17283040)
• Following transient expression of MDR-1 and MCJ, changes in the sensitivity of Sk-Ov-3 cells to paclitaxel were detected whereas expression of Src, Bcl-2 and Bcl-X(L) decreased the sensitivity of Sk-Ov-3 cells to carboplatin. (PMID:18324624)
• MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. (PMID:23263864)
• Report functional connection between mitochondrial inner membrane protein translocation machinery-associated J-protein DnaJC15 and regulation of cell death pathways. (PMID:24603329)
• Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys. (PMID:26040030)
• These results identify the MCJ gene as a transcriptional target of IFNgamma and provide evidence of the dynamic adaptation of normal tissues to changes in the environment as a way to adapt metabolically to new conditions (PMID:26419808)
• this study shows that memory CD8+ T cells lacking MCJ provide superior protection against influenza virus infection (PMID:27234056)
• Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. (PMID:27330077)
• Acetaminophen interferes with the formation of mitochondrial respiratory supercomplexes via the mitochondrial negative regulator MCJ. Study also show higher levels of MCJ in livers from patients with acetaminophen-induced liver injury. (PMID:29233977)
• Notably, the top signal of differentiated ASE between inter-continental populations was observed in DNAJC15, of which the derived allele of rs12015, a single nucleotide polymorphism (SNP), showed significantly higher expression than did the ancestral allele specifically in European individuals. (PMID:29346564)
• DNAJC15 as a new target gene responsible for ETV7-mediated Doxorubicin-resistance. (PMID:30025229)
• The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis. (PMID:31953445)
• Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation. (PMID:32620763)
• MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension. (PMID:38241373)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	dnajc15	ENSDARG00000038309
mus_musculus	Dnajc15	ENSMUSG00000022013
rattus_norvegicus	Dnajc15	ENSRNOG00000009063
drosophila_melanogaster	CG7394	FBGN0036173
caenorhabditis_elegans	dnj-21	WBGENE00001039

Paralogs (1): DNAJC19 (ENSG00000205981)

Protein

Protein identifiers

DnaJ homolog subfamily C member 15 — Q9Y5T4 (reviewed: Q9Y5T4)

Alternative names: Cell growth-inhibiting gene 22 protein, Methylation-controlled J protein

All UniProt accessions (1): Q9Y5T4

UniProt curated annotations — full annotation on UniProt →

Function. Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

Subunit / interactions. Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Expressed at highest levels in heart, followed by liver and kidney.

Disease relevance. Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

RefSeq proteins (1): NP_037370* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001623	DnaJ_domain	Domain
IPR036869	J_dom_sf	Homologous_superfamily

UniProt features (9 total): topological domain 2, sequence conflict 2, chain 1, transmembrane region 1, domain 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5T4-F1	78.66	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 104

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 209 (showing top): GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_UP, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, WALLACE_PROSTATE_CANCER_RACE_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOZGIT_ESR1_TARGETS_DN, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, GOBP_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION, GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_OXIDATIVE_PHOSPHORYLATION, GOBP_ELECTRON_TRANSPORT_CHAIN

GO Biological Process (9): mitochondrial electron transport, NADH to ubiquinone (GO:0006120), intracellular protein transport (GO:0006886), cellular response to starvation (GO:0009267), regulation of lipid metabolic process (GO:0019216), protein import into mitochondrial matrix (GO:0030150), negative regulation of protein-containing complex assembly (GO:0031333), protein-containing complex assembly (GO:0065003), negative regulation of mitochondrial electron transport, NADH to ubiquinone (GO:1902957), protein transport (GO:0015031)

GO Molecular Function (2): ATPase activator activity (GO:0001671), protein binding (GO:0005515)

GO Cellular Component (5): PAM complex, Tim23 associated import motor (GO:0001405), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), TIM23 mitochondrial import inner membrane translocase complex (GO:0005744), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular protein localization	2
inner mitochondrial membrane protein complex	2
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
protein transport	1
intracellular transport	1
cellular response to nutrient levels	1
cellular response to stress	1
response to starvation	1
lipid metabolic process	1
regulation of primary metabolic process	1
protein transmembrane import into intracellular organelle	1
protein localization to mitochondrion	1
import into the mitochondrion	1
mitochondrial protein import pathway	1
regulation of protein-containing complex assembly	1
negative regulation of cellular component organization	1
protein-containing complex assembly	1
cellular component assembly	1
protein-containing complex organization	1
mitochondrial electron transport, NADH to ubiquinone	1
regulation of mitochondrial electron transport, NADH to ubiquinone	1
negative regulation of mitochondrial ATP synthesis coupled electron transport	1
transport	1
establishment of protein localization	1
ATP-dependent activity	1
molecular function activator activity	1
binding	1
TIM23 mitochondrial import inner membrane translocase complex	1
mitochondrial matrix	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1234 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DNAJC15	TIMM44	O43615	817
DNAJC15	PAM16	Q9Y3D7	810
DNAJC15	HSPA9	P30036	726
DNAJC15	PPIF	P30405	712
DNAJC15	GRPEL1	Q9HAV7	659
DNAJC15	DNAJC19	Q96DA6	559
DNAJC15	TIMM21	Q9BVV7	532
DNAJC15	DNAJC1	Q96KC8	512
DNAJC15	DNAJC9	Q8WXX5	501
DNAJC15	TIMM17B	O60830	500
DNAJC15	TIMM50	Q3ZCQ8	499
DNAJC15	TIMM17A	Q99595	498
DNAJC15	DNAJC25	Q9H1X3	497
DNAJC15	FAM216B	Q8N7L0	478
DNAJC15	DNAJC12	Q9UKB3	476
DNAJC15	PSMA6	P34062	476

IntAct

19 interactions, top by confidence:

A	B	Type	Score
DNAJC15	PAM16	psi-mi:“MI:0915”(physical association)	0.710
TIMM17B	TIMM23	psi-mi:“MI:0914”(association)	0.670
SIAH1	DNAJC15	psi-mi:“MI:0915”(physical association)	0.560
DNAJC15	FAM9B	psi-mi:“MI:0915”(physical association)	0.560
DNAJC15	SIAH1	psi-mi:“MI:0915”(physical association)	0.560
SLC39A4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
	HSPA9	psi-mi:“MI:0882”(atpase reaction)	0.440
DNAJC15	TIMM17B	psi-mi:“MI:0914”(association)	0.350
DNAJC15	GAPDHS	psi-mi:“MI:0914”(association)	0.350
SAAL1	TMEM223	psi-mi:“MI:0914”(association)	0.350
ATF5	IGF2BP3	psi-mi:“MI:0914”(association)	0.350

BioGRID (173): DNAJC15 (Two-hybrid), FAM9B (Two-hybrid), DNAJC15 (Affinity Capture-Western), DNAJC15 (Affinity Capture-Western), PAM16 (Affinity Capture-Western), DNAJC15 (Affinity Capture-Western), TIMM17A (Affinity Capture-Western), TIMM17B (Affinity Capture-Western), DNAJC15 (Affinity Capture-MS), DNAJC15 (Affinity Capture-MS), HAX1 (Affinity Capture-MS), ANP32B (Affinity Capture-MS), YME1L1 (Affinity Capture-MS), DHX9 (Affinity Capture-MS), DNMT1 (Affinity Capture-MS)

ESM2 similar proteins: F3YDF1, F4JIN3, O13633, O36966, O59824, P14906, P32795, P34454, P40341, P42834, P43613, P54813, Q07914, Q0IIE8, Q0WT48, Q149L6, Q17433, Q17438, Q20748, Q28I38, Q2QUP1, Q4WI88, Q54QN1, Q58E03, Q58E76, Q59SI2, Q5B4H1, Q5HZT9, Q5R6H3, Q5RCP4, Q6BH37, Q6CEU0, Q6CNW2, Q6DDA1, Q6FPU1, Q6NVR9, Q6PAX2, Q6PBT7, Q759D2, Q78YY6

Diamond homologs: P42834, P91454, Q07914, Q3ZBN8, Q4I7T5, Q4WI88, Q54QN1, Q59SI2, Q5B4H1, Q5RCP4, Q5RF34, Q617M0, Q6BH37, Q6CEU0, Q6CNW2, Q6DDA1, Q6FPU1, Q6PBT7, Q759D2, Q78YY6, Q7RX75, Q8RV04, Q96DA6, Q9CQV7, Q9LYY2, Q9SF33, Q9UT37, Q9VTJ8, Q9Y5T4, A0A0D1E2P6, P42824, P42825, P43644, Q0JB88, Q94AW8, A4IR30, A9MXI3, B4T6D7, B4TIB5, B4TVZ6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
DNAJC15	“form complex”	“TIM23 complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1085 predictions. Top by Δscore:

Variant	Effect	Δscore
13:43023730:GACTG:G	donor_gain	1.0000
13:43023735:G:GG	donor_gain	1.0000
13:43068921:A:AG	acceptor_gain	1.0000
13:43068922:C:G	acceptor_gain	1.0000
13:43068927:TAGG:T	acceptor_loss	1.0000
13:43068928:A:AG	acceptor_gain	1.0000
13:43068929:G:GG	acceptor_gain	1.0000
13:43068929:GGTC:G	acceptor_gain	1.0000
13:43068999:CTCCT:C	donor_gain	1.0000
13:43069000:TCCT:T	donor_gain	1.0000
13:43069000:TCCTG:T	donor_loss	1.0000
13:43069001:CCT:C	donor_gain	1.0000
13:43069001:CCTGT:C	donor_loss	1.0000
13:43069002:CT:C	donor_gain	1.0000
13:43069002:CTG:C	donor_loss	1.0000
13:43069003:TGTA:T	donor_loss	1.0000
13:43069004:G:GG	donor_gain	1.0000
13:43069005:T:TC	donor_loss	1.0000
13:43069006:AA:A	donor_loss	1.0000
13:43069007:AGTTA:A	donor_loss	1.0000
13:43069008:G:C	donor_loss	1.0000
13:43069009:T:G	donor_gain	1.0000
13:43085766:A:AG	acceptor_gain	1.0000
13:43085767:G:GG	acceptor_gain	1.0000
13:43023731:ACTG:A	donor_gain	0.9900
13:43023732:CTG:C	donor_gain	0.9900
13:43023733:TG:T	donor_gain	0.9900
13:43023733:TGGT:T	donor_loss	0.9900
13:43023734:GG:G	donor_gain	0.9900
13:43023735:G:GA	donor_loss	0.9900

AlphaMissense

957 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:43078639:T:C	F88L	0.995
13:43078641:T:A	F88L	0.995
13:43078641:T:G	F88L	0.995
13:43107218:A:C	K141N	0.994
13:43107218:A:T	K141N	0.994
13:43085828:C:A	H124Q	0.992
13:43085828:C:G	H124Q	0.992
13:43107203:A:C	K136N	0.992
13:43107203:A:T	K136N	0.992
13:43107213:G:C	A140P	0.990
13:43078640:T:G	F88C	0.987
13:43085802:C:G	H116D	0.987
13:43085825:T:A	N123K	0.987
13:43085825:T:G	N123K	0.987
13:43085826:C:G	H124D	0.987
13:43107205:T:A	I137K	0.987
13:43078679:T:C	L101S	0.986
13:43107217:A:T	K141I	0.986
13:43085799:G:C	A115P	0.985
13:43078666:G:C	A97P	0.983
13:43078667:C:A	A97D	0.983
13:43078676:T:A	I100N	0.983
13:43078640:T:C	F88S	0.982
13:43078665:A:C	E96D	0.981
13:43078665:A:T	E96D	0.981
13:43078673:T:C	L99P	0.980
13:43085827:A:G	H124R	0.980
13:43078652:T:C	M92T	0.979
13:43107205:T:G	I137R	0.979
13:43107181:G:A	G129E	0.977

dbSNP variants (sampled 300 via entrez): RS1000001561 (13:43051898 C>T), RS1000017042 (13:43024740 T>C), RS1000027301 (13:43103108 C>G), RS1000061408 (13:43102831 A>G), RS1000093772 (13:43060160 G>A), RS1000122674 (13:43048995 G>A), RS1000137970 (13:43058989 A>G), RS1000236134 (13:43095683 A>G), RS1000277473 (13:43054723 T>C), RS1000288023 (13:43080620 T>A,G), RS1000295504 (13:43041334 C>A,T), RS1000352736 (13:43043531 C>G,T), RS1000387499 (13:43053090 A>G), RS1000395982 (13:43047785 T>C), RS1000397169 (13:43054374 T>C)

Disease associations

OMIM: gene MIM:615339 | disease phenotypes: MIM:192350

GenCC curated gene-disease

Mondo (1): VACTERL/vater association (MONDO:0008642)

Orphanet (1): VACTERL/VATER association (Orphanet:887)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000477_45	Cognitive performance	9.000000e-06
GCST008358_2	Response to cognitive-behavioural therapy in anxiety and major depressive disorders	5.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0003926	neuropsychological test
EFO:0007820	cognitive behavioural therapy

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
Benzo(a)pyrene	affects methylation, decreases expression	3
Air Pollutants	decreases expression, increases abundance	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
potassium chromate(VI)	decreases expression	1
deguelin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
pyrachlostrobin	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Atrazine	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Carbamazepine	affects expression	1
DDT	increases expression	1
Diclofenac	affects expression	1
Diuron	decreases expression	1
Estradiol	affects cotreatment, increases expression	1
Hydrogen Peroxide	increases expression, affects cotreatment	1
Phenobarbital	decreases expression	1
Progesterone	affects cotreatment, increases expression	1
Rotenone	increases expression	1
Smoke	decreases expression, increases abundance	1
Tetrachlorodibenzodioxin	decreases expression	1
Theophylline	affects cotreatment, increases expression	1
Isotretinoin	decreases expression	1

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03799705	Not specified	COMPLETED	Genetic Variants in Nicotinamide Adenine Dinucleotide (NAD) Synthesis Pathway