DNAJC18

Summary

DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18, HGNC:28429) is a protein-coding gene on chromosome 5q31.2, encoding DnaJ homolog subfamily C member 18 (Q9H819). (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection.

Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum membrane.

Source: NCBI Gene 202052 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 58 total — 1 pathogenic
• MANE Select transcript: NM_152686

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28429
Approved symbol	DNAJC18
Name	DnaJ heat shock protein family (Hsp40) member C18
Location	5q31.2
Locus type	gene with protein product
Status	Approved
Aliases	MGC29463
Ensembl gene	ENSG00000170464
Ensembl biotype	protein_coding
OMIM	621108
Entrez	202052

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 8 protein_coding, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000302060, ENST00000505268, ENST00000505568, ENST00000506870, ENST00000507405, ENST00000508445, ENST00000510770, ENST00000512473, ENST00000514052, ENST00000515277, ENST00000515559, ENST00000515581, ENST00000886188, ENST00000928618

RefSeq mRNA: 1 — MANE Select: NM_152686 NM_152686

CCDS: CCDS4214

Canonical transcript exons

ENST00000302060 — 8 exons

Exon	Start	End
ENSE00001128111	139420053	139420225
ENSE00001128116	139422708	139422817
ENSE00001128150	139410203	139414272
ENSE00001302993	139437372	139437558
ENSE00002042422	139439406	139439525
ENSE00003459963	139428538	139428683
ENSE00003484363	139425005	139425114
ENSE00003686540	139426172	139426357

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 98.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.8373 / max 272.7187, expressed in 1525 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
63755	3.5504	1385
63754	3.1528	983
63756	0.0802	4
63758	0.0431	3
63757	0.0107	3

Top tissues by expression

143 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	98.24	gold quality
right testis	UBERON:0004534	97.98	gold quality
testis	UBERON:0000473	96.89	gold quality
cortical plate	UBERON:0005343	94.37	gold quality
embryo	UBERON:0000922	92.66	gold quality
ganglionic eminence	UBERON:0004023	92.66	gold quality
ventricular zone	UBERON:0003053	91.66	gold quality
corpus callosum	UBERON:0002336	90.59	gold quality
sural nerve	UBERON:0015488	89.83	gold quality
calcaneal tendon	UBERON:0003701	89.68	gold quality
prefrontal cortex	UBERON:0000451	88.48	gold quality
superior frontal gyrus	UBERON:0002661	88.18	gold quality
frontal cortex	UBERON:0001870	87.29	gold quality
frontal lobe	UBERON:0016525	87.29	gold quality
primary visual cortex	UBERON:0002436	87.18	gold quality
apex of heart	UBERON:0002098	86.94	gold quality
cerebral cortex	UBERON:0000956	86.15	gold quality
adrenal tissue	UBERON:0018303	86.06	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.61	gold quality
mucosa of stomach	UBERON:0001199	85.49	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.38	gold quality
right frontal lobe	UBERON:0002810	85.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	85.23	gold quality
anterior cingulate cortex	UBERON:0009835	85.07	gold quality
cerebellum	UBERON:0002037	85.02	gold quality
cerebellar cortex	UBERON:0002129	84.99	gold quality
cerebellar hemisphere	UBERON:0002245	84.97	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.94	gold quality
brain	UBERON:0000955	84.88	gold quality
spinal cord	UBERON:0002240	84.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

133 targeting DNAJC18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-3681-5P	99.82	66.88	387
HSA-MIR-181B-2-3P	99.81	70.06	1646

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
danio_rerio	dnajc3a	ENSDARG00000041110
mus_musculus	Dnajc18	ENSMUSG00000024350
rattus_norvegicus	Dnajc18	ENSRNOG00000019995
drosophila_melanogaster	Csp	FBGN0004179
drosophila_melanogaster	CG10565	FBGN0037051
drosophila_melanogaster	P58IPK	FBGN0037718
drosophila_melanogaster	l(3)80Fg	FBGN0287183
caenorhabditis_elegans		WBGENE00001020
caenorhabditis_elegans		WBGENE00001025
caenorhabditis_elegans		WBGENE00001026
caenorhabditis_elegans		WBGENE00001029
caenorhabditis_elegans		WBGENE00001032
caenorhabditis_elegans	dnj-28	WBGENE00001046
caenorhabditis_elegans		WBGENE00008122

Paralogs (20): DNAJC11 (ENSG00000007923), DNAJC25 (ENSG00000059769), DNAJC10 (ENSG00000077232), DNAJC5 (ENSG00000101152), DNAJC3 (ENSG00000102580), DNAJC17 (ENSG00000104129), DNAJC2 (ENSG00000105821), DNAJC12 (ENSG00000108176), DNAJC4 (ENSG00000110011), DNAJC16 (ENSG00000116138), DNAJC14 (ENSG00000135392), DNAJC1 (ENSG00000136770), DNAJC13 (ENSG00000138246), DNAJC5B (ENSG00000147570), DNAJC5G (ENSG00000163793), DNAJC7 (ENSG00000168259), DNAJC21 (ENSG00000168724), DNAJC24 (ENSG00000170946), DNAJC30 (ENSG00000176410), DNAJC9 (ENSG00000213551)

Protein

Protein identifiers

DnaJ homolog subfamily C member 18 — Q9H819 (reviewed: Q9H819)

All UniProt accessions (9): Q9H819, A0A096LP15, D6RB03, D6RB44, D6RCS7, D6REJ9, D6RHF6, H0Y9V6, H0YA78

UniProt curated annotations — full annotation on UniProt →

Function. (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection. Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane. The foci represent the site from which SV40 penetrates into the cytosol.

Subcellular location. Endoplasmic reticulum membrane.

RefSeq proteins (1): NP_689899* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001623	DnaJ_domain	Domain
IPR015399	DUF1977_DnaJ-like	Domain
IPR018253	DnaJ_domain_CS	Conserved_site
IPR036869	J_dom_sf	Homologous_superfamily
IPR051100	DnaJ_subfamily_B/C	Family

Pfam: PF00226, PF09320

UniProt features (4 total): chain 1, transmembrane region 1, domain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H819-F1	71.31	0.28

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
110	loss of colocalization with sv40-induced foci upon sv40 invection.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 92 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN, GOBP_PROTEIN_MATURATION, TGCTGAY_UNKNOWN, GOBP_PROTEIN_FOLDING, GOBP_RESPONSE_TO_MISFOLDED_PROTEIN, GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN, chr5q31, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, GOMF_HEAT_SHOCK_PROTEIN_BINDING, GOMF_PROTEIN_FOLDING_CHAPERONE_BINDING

GO Biological Process (1): cellular response to misfolded protein (GO:0071218)

GO Molecular Function (1): Hsp70 protein binding (GO:0030544)

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular response to topologically incorrect protein	1
response to misfolded protein	1
heat shock protein binding	1
protein-folding chaperone binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1969 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DNAJC18	SPATA24	Q86W54	673
DNAJC18	DNAJC8	O75937	667
DNAJC18	SGTA	O43765	647
DNAJC18	HSPH1	Q92598	636
DNAJC18	SMIM33	A0A1B0GW64	623
DNAJC18	EMC1	Q8N766	572
DNAJC18	DNAJC22	Q8N4W6	559
DNAJC18	DNAJC28	Q9NX36	538
DNAJC18	DNAJC24	Q6P3W2	529
DNAJC18	HSPB9	Q9BQS6	527
DNAJC18	SIRAL2	Q9NWS6	506
DNAJC18	DNAJC2	Q99543	494
DNAJC18	HSPA8	P11142	487
DNAJC18	ECSCR	Q19T08	479
DNAJC18	ERP29	P30040	462

IntAct

71 interactions, top by confidence:

A	B	Type	Score
ADCY9	NEMP1	psi-mi:“MI:0914”(association)	0.640
KCNA5	TMEM223	psi-mi:“MI:0914”(association)	0.530
ADGRG5	KLRG2	psi-mi:“MI:0914”(association)	0.530
FSHR	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ZNRF4	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
KCNS3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
GABRD	ATF6	psi-mi:“MI:0914”(association)	0.530
CHST6	CANX	psi-mi:“MI:0914”(association)	0.530
TCIRG1	AP3D1	psi-mi:“MI:0914”(association)	0.530
CHRNA9	CHEK1	psi-mi:“MI:0914”(association)	0.530
IL27RA	B4GALT5	psi-mi:“MI:0914”(association)	0.530
GABRG2	GPAA1	psi-mi:“MI:0914”(association)	0.530
CHRND	TPST2	psi-mi:“MI:0914”(association)	0.530
PTGIR	TMEM63A	psi-mi:“MI:0914”(association)	0.530
ANO4	ANO6	psi-mi:“MI:0914”(association)	0.530
DGCR2	HOXD13	psi-mi:“MI:0914”(association)	0.530
UNC93B1	GPR89A	psi-mi:“MI:0914”(association)	0.530
DNAJC18	dacD	psi-mi:“MI:0915”(physical association)	0.370
CHRNA9	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TMPRSS3	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
PCDHAC1	C2CD2L	psi-mi:“MI:0914”(association)	0.350
IL27RA	NRP1	psi-mi:“MI:0914”(association)	0.350
GABRG2	B4GALT5	psi-mi:“MI:0914”(association)	0.350
PTGIR	GPAA1	psi-mi:“MI:0914”(association)	0.350

BioGRID (104): DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS)

ESM2 similar proteins: A1YVX4, A2ALW5, A3KMI0, A5DTG8, F4JIN3, O13633, O88379, P09758, P34454, P41229, P43613, P70302, P83093, P84903, P92029, Q0WT48, Q13586, Q149L6, Q17433, Q19293, Q28056, Q28I38, Q2QUP1, Q38JA7, Q3UZP0, Q58CP9, Q58E03, Q5BJW9, Q5EA26, Q5HZT9, Q61712, Q6PGC1, Q7XVN7, Q7Z478, Q7ZXQ8, Q8GUN6, Q8IMZ9, Q90830, Q91WT4, Q95KD5

Diamond homologs: A0AIS3, A0Q1R3, A1W0P5, A4IR30, A5ITA7, A5N6M3, A5UYW4, A5VJE8, A6LJ63, A6Q486, A6QBG7, A6QHC2, A6U251, A7H2C0, A7NS65, A7X2Y0, A8Z4B8, B1HUD0, B1XQF6, B2G6W4, B2TLZ8, B2V2I6, B5ENA2, B5YAR4, B7J7X8, B8DE39, B9DNJ9, C1KVB9, C5D4U0, G2K045, O13633, O69269, O75953, O89114, P0CW06, P0CW07, P0DJM1, P25491, P30725, P48353

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 90 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
G alpha (s) signalling events	6	7.0×	7e-03
Neuronal System	8	5.6×	3e-03
Transport of small molecules	10	4.0×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
acetylcholine receptor signaling pathway	5	37.6×	3e-05
membrane depolarization	6	36.9×	4e-06
monoatomic ion transmembrane transport	9	22.6×	2e-07
chloride transmembrane transport	7	20.0×	1e-05
regulation of membrane potential	5	13.9×	2e-03
sodium ion transmembrane transport	5	12.2×	3e-03
potassium ion transmembrane transport	7	11.5×	4e-04
monoatomic ion transport	6	11.3×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	51
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
58117	GRCh38/hg38 5q31.2(chr5:139151411-139493628)x3	Pathogenic

SpliceAI

1467 predictions. Top by Δscore:

Variant	Effect	Δscore
5:139420051:A:AC	donor_gain	1.0000
5:139420052:C:CC	donor_gain	1.0000
5:139420098:AAT:A	donor_gain	1.0000
5:139422706:A:AC	donor_gain	1.0000
5:139422707:C:CC	donor_gain	1.0000
5:139425000:GGTAC:G	donor_loss	1.0000
5:139425001:GTAC:G	donor_loss	1.0000
5:139425002:TACC:T	donor_loss	1.0000
5:139425003:AC:A	donor_loss	1.0000
5:139425004:C:CA	donor_loss	1.0000
5:139425021:T:TA	donor_gain	1.0000
5:139425111:TTTC:T	acceptor_gain	1.0000
5:139426167:CTAA:C	donor_loss	1.0000
5:139426168:TAA:T	donor_loss	1.0000
5:139426169:AAC:A	donor_loss	1.0000
5:139426170:A:C	donor_loss	1.0000
5:139426171:C:CA	donor_loss	1.0000
5:139439408:T:A	donor_gain	1.0000
5:139414123:AGC:A	donor_gain	0.9900
5:139414132:TAGG:T	donor_gain	0.9900
5:139414133:AGGA:A	donor_gain	0.9900
5:139414142:AT:A	donor_gain	0.9900
5:139414148:TCAGC:T	donor_gain	0.9900
5:139414149:CAGCC:C	donor_gain	0.9900
5:139414150:AGCCA:A	donor_gain	0.9900
5:139414152:C:CT	donor_gain	0.9900
5:139420047:T:C	donor_gain	0.9900
5:139420052:CT:C	donor_gain	0.9900
5:139420100:T:TA	donor_gain	0.9900
5:139420104:T:TA	donor_gain	0.9900

AlphaMissense

2344 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:139428542:G:C	F123L	1.000
5:139428542:G:T	F123L	1.000
5:139428543:A:G	F123S	1.000
5:139428544:A:G	F123L	1.000
5:139428572:C:A	K113N	1.000
5:139428572:C:G	K113N	1.000
5:139428581:G:C	H110Q	1.000
5:139428581:G:T	H110Q	1.000
5:139428583:G:C	H110D	1.000
5:139428583:G:T	H110N	1.000
5:139428594:G:T	A106D	1.000
5:139428602:T:A	R103S	1.000
5:139428602:T:G	R103S	1.000
5:139428607:A:C	Y102D	1.000
5:139414191:C:G	C345S	0.999
5:139414192:A:T	C345S	0.999
5:139414263:A:G	L321P	0.999
5:139420072:A:C	C311W	0.999
5:139420073:C:G	C311S	0.999
5:139420073:C:T	C311Y	0.999
5:139420074:A:G	C311R	0.999
5:139420074:A:T	C311S	0.999
5:139420176:A:C	Y277D	0.999
5:139422783:A:T	V235D	0.999
5:139426191:A:C	F180L	0.999
5:139426191:A:T	F180L	0.999
5:139426193:A:G	F180L	0.999
5:139426203:G:C	F176L	0.999
5:139426203:G:T	F176L	0.999
5:139426205:A:G	F176L	0.999

dbSNP variants (sampled 300 via entrez): RS1000092606 (5:139437068 G>T), RS1000154802 (5:139413980 A>T), RS1000226115 (5:139430048 T>C), RS1000235682 (5:139434704 T>A), RS1000443009 (5:139437318 A>G), RS1000522360 (5:139436446 A>G), RS1000573349 (5:139436098 T>C), RS1000694080 (5:139414423 G>A), RS1000932902 (5:139421754 G>A), RS1001503892 (5:139429041 T>C,G), RS1001581667 (5:139441010 C>T), RS1001722211 (5:139429967 C>A), RS1001741265 (5:139413102 T>C), RS1001777759 (5:139429646 T>C), RS1001955366 (5:139436992 A>G)

Disease associations

OMIM: gene MIM:621108 | disease phenotypes: MIM:615934

GenCC curated gene-disease

Mondo (1): STING-associated vasculopathy with onset in infancy (MONDO:0014405)

Orphanet (1): STING-associated vasculopathy with onset in infancy (Orphanet:425120)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST005951_151	Body mass index	6.000000e-07
GCST006138_29	Resting-state electroencephalogram vigilance	9.000000e-06
GCST008758_52	Pre-treatment viral load in HIV-1 infection	2.000000e-16
GCST010725_68	Malaria	4.000000e-07
GCST010725_7	Malaria	2.000000e-06
GCST011205_13	Hypertrophic cardiomyopathy (MTAG)	3.000000e-09
GCST011211_8	Hypertrophic cardiomyopathy	5.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004357	electroencephalogram measurement
EFO:0010125	viral load

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	5
sodium arsenite	decreases expression, increases abundance, increases expression	3
entinostat	decreases expression, affects cotreatment	2
Chenodeoxycholic Acid	affects cotreatment, increases expression, decreases expression	2
Deoxycholic Acid	affects cotreatment, increases expression, decreases expression	2
Glycochenodeoxycholic Acid	affects cotreatment, increases expression, decreases expression	2
Glycocholic Acid	affects cotreatment, increases expression, decreases expression	2
Glycodeoxycholic Acid	affects cotreatment, increases expression, decreases expression	2
Nickel	decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt	affects cotreatment, decreases expression	1
bisphenol A	increases expression	1
trichostatin A	decreases expression	1
nefazodone	affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	increases methylation	1
Resveratrol	affects cotreatment, increases expression	1
Vorinostat	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Carbamazepine	affects expression	1
Cisplatin	increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diclofenac	affects expression	1
Plant Extracts	affects cotreatment, increases expression	1
Tartrazine	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04517253	PHASE2/PHASE3	TERMINATED	A Study of Baricitinib (LY3009104) in Adult and Pediatric Japanese Participants With NNS/CANDLE, SAVI, and AGS
NCT02974595	Not specified	RECRUITING	Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still’S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)