DNAJC3-DT

Summary

DNAJC3-DT (DNAJC3 divergent transcript, HGNC:39808) is a long non-coding RNA gene on chromosome 13q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39808
Approved symbol	DNAJC3-DT
Name	DNAJC3 divergent transcript
Location	13q32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000247400
Ensembl biotype	lncRNA
Entrez	100289274
RNAcentral	URS00003A0E13 — lncRNA, 2908 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000499499, ENST00000606011, ENST00000662244, ENST00000671463, ENST00000685997, ENST00000691965, ENST00000692031, ENST00000700803, ENST00000701077, ENST00000743092, ENST00000743093, ENST00000743094, ENST00000743095, ENST00000743096, ENST00000743097, ENST00000743098, ENST00000743099, ENST00000743100, ENST00000743101

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499499 — 2 exons

Exon	Start	End
ENSE00003980911	95672632	95674668
ENSE00004081220	95675852	95677014

Expression profiles

Bgee: expression breadth ubiquitous, 177 present calls, max score 86.03.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.1100 / max 114.2033, expressed in 1072 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137895	3.1100	1072

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.03	gold quality
sural nerve	UBERON:0015488	79.52	gold quality
islet of Langerhans	UBERON:0000006	77.83	gold quality
secondary oocyte	CL:0000655	77.78	gold quality
endothelial cell	CL:0000115	77.04	silver quality
adenohypophysis	UBERON:0002196	76.83	gold quality
pituitary gland	UBERON:0000007	76.67	gold quality
right uterine tube	UBERON:0001302	74.69	gold quality
bone marrow cell	CL:0002092	73.75	silver quality
pancreas	UBERON:0001264	72.59	gold quality
right lobe of thyroid gland	UBERON:0001119	72.52	gold quality
left lobe of thyroid gland	UBERON:0001120	72.24	gold quality
thyroid gland	UBERON:0002046	71.84	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.68	gold quality
body of pancreas	UBERON:0001150	71.45	gold quality
cortical plate	UBERON:0005343	71.37	gold quality
anterior cingulate cortex	UBERON:0009835	70.08	gold quality
ventricular zone	UBERON:0003053	70.01	gold quality
cerebellar hemisphere	UBERON:0002245	69.63	gold quality
cerebellar cortex	UBERON:0002129	69.54	gold quality
ganglionic eminence	UBERON:0004023	69.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.40	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.18	gold quality
right lobe of liver	UBERON:0001114	69.04	gold quality
prefrontal cortex	UBERON:0000451	68.64	gold quality
nucleus accumbens	UBERON:0001882	68.64	gold quality
pigmented layer of retina	UBERON:0001782	68.60	gold quality
hypothalamus	UBERON:0001898	68.55	gold quality
metanephros cortex	UBERON:0010533	68.45	gold quality
cerebellum	UBERON:0002037	68.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.73

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis. (PMID:33629299)
• miRNA-144 targeting DNAJC3-AS1 reverses the resistance of the breast cancer cell line Michigan Cancer Foundation-7 to doxorubicin. (PMID:34895046)
• LncRNA DNAJC3-AS1 promotes the biological functions of papillary thyroid carcinoma via regulating the microRNA-27a-3p/CCBE1 axis. (PMID:36583660)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.