DNM3OS

Summary

DNM3OS (DNM3 opposite strand/antisense RNA, HGNC:41228) is a long non-coding RNA gene on chromosome 1q24.3.

Enables miRNA inhibitor activity via base-pairing. Involved in cellular response to transforming growth factor beta stimulus and regulation of macromolecule metabolic process. Predicted to be part of RISC complex.

Source: NCBI Gene 100628315 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41228
Approved symbol	DNM3OS
Name	DNM3 opposite strand/antisense RNA
Location	1q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MIR199A2HG
Ensembl gene	ENSG00000230630
Ensembl biotype	lncRNA
Entrez	100628315
RNAcentral	URS000075EFF6 — lncRNA, 7957 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000417354, ENST00000648228, ENST00000648909, ENST00000650013, ENST00000650189, ENST00000650416, ENST00000718875

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417354 — 4 exons

Exon	Start	End
ENSE00001694922	172138397	172140596
ENSE00001732658	172144365	172144437
ENSE00001742497	172144654	172144840
ENSE00001776854	172142136	172142213

Expression profiles

Bgee: expression breadth ubiquitous, 190 present calls, max score 99.20.

FANTOM5 (CAGE): breadth broad, TPM avg 5.1092 / max 456.6105, expressed in 730 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15910	2.5472	639
15909	1.4224	438
15908	0.6936	300
15906	0.1562	81
15911	0.1097	41
15907	0.0960	28
201818	0.0841	18

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	99.20	gold quality
left ovary	UBERON:0002119	94.94	gold quality
tendon	UBERON:0000043	94.76	gold quality
smooth muscle tissue	UBERON:0001135	94.60	gold quality
right ovary	UBERON:0002118	93.80	gold quality
right coronary artery	UBERON:0001625	93.36	gold quality
tibia	UBERON:0000979	92.69	gold quality
descending thoracic aorta	UBERON:0002345	92.33	gold quality
left uterine tube	UBERON:0001303	91.72	gold quality
body of uterus	UBERON:0009853	91.20	gold quality
gall bladder	UBERON:0002110	91.00	gold quality
adrenal tissue	UBERON:0018303	90.96	gold quality
spleen	UBERON:0002106	90.56	gold quality
ovary	UBERON:0000992	90.55	gold quality
stromal cell of endometrium	CL:0002255	90.38	gold quality
thoracic aorta	UBERON:0001515	89.49	gold quality
left coronary artery	UBERON:0001626	89.25	gold quality
ascending aorta	UBERON:0001496	89.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.16	gold quality
skin of hip	UBERON:0001554	87.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.80	gold quality
endometrium	UBERON:0001295	87.17	gold quality
coronary artery	UBERON:0001621	86.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.94	gold quality
uterus	UBERON:0000995	86.87	gold quality
lower esophagus	UBERON:0013473	86.87	gold quality
myometrium	UBERON:0001296	86.76	gold quality
aorta	UBERON:0000947	86.08	gold quality
mucosa of stomach	UBERON:0001199	85.98	gold quality
vermiform appendix	UBERON:0001154	85.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.88

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• DNM3OS was found to have a much higher expression level in esophageal cancer cells and in tumor tissues of esophageal squamous cell carcinoma patient. FOXO1, a transcription factor downstream of PDGFbeta/PDGFRbeta signaling pathway, initiated the transcription of DNM3OS by binding to DNM3OS promoter. DNM3OS conferred significant radioresistance in vitro and in vivo by regulating DNA damage response. (PMID:30463848)
• DNM3OS knockdown inhibited the proliferation of Gastric Cancer cells, and reduced DNM3OS suppressed tumor growth in vivo. (PMID:30770102)
• Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGFbeta1 axes. (PMID:31694982)
• Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis. (PMID:33472090)
• DNM3OS Facilitates Ovarian Cancer Progression by Regulating miR-193a-3p/MAP3K3 Axis. (PMID:34027641)
• [The potential role of long non-coding RNA Dnm3os in the activation of cardiac fibroblasts]. (PMID:34180204)
• DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression. (PMID:38152068)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.