DNMT3L-AS1

Summary

DNMT3L-AS1 (DNMT3L antisense RNA 1, HGNC:40189) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40189
Approved symbol	DNMT3L-AS1
Name	DNMT3L antisense RNA 1
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232010
Ensembl biotype	lncRNA
Entrez	105372833
RNAcentral	URS0000A769FF — lncRNA, 524 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000442785

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442785 — 2 exons

Exon	Start	End
ENSE00001605285	44251127	44251520
ENSE00001615938	44250813	44250941

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 71.30.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	71.30	gold quality
right lobe of liver	UBERON:0001114	67.80	gold quality
kidney	UBERON:0002113	67.33	gold quality
adult mammalian kidney	UBERON:0000082	66.62	gold quality
cortex of kidney	UBERON:0001225	64.87	gold quality
lower esophagus mucosa	UBERON:0035834	64.15	gold quality
bone marrow cell	CL:0002092	62.75	silver quality
metanephros cortex	UBERON:0010533	61.45	gold quality
lymph node	UBERON:0000029	61.18	gold quality
bone marrow	UBERON:0002371	59.36	gold quality
blood	UBERON:0000178	56.78	gold quality
prefrontal cortex	UBERON:0000451	55.48	gold quality
tonsil	UBERON:0002372	54.99	gold quality
spleen	UBERON:0002106	53.78	gold quality
small intestine	UBERON:0002108	53.49	gold quality
vermiform appendix	UBERON:0001154	53.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	53.03	gold quality
islet of Langerhans	UBERON:0000006	52.63	gold quality
placenta	UBERON:0001987	51.28	gold quality
muscle of leg	UBERON:0001383	51.25	gold quality
pancreas	UBERON:0001264	51.12	gold quality
granulocyte	CL:0000094	50.99	silver quality
gastrocnemius	UBERON:0001388	50.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	50.78	gold quality
endocervix	UBERON:0000458	50.25	gold quality
mucosa of transverse colon	UBERON:0004991	49.99	gold quality
frontal cortex	UBERON:0001870	49.83	gold quality
intestine	UBERON:0000160	49.26	gold quality
right uterine tube	UBERON:0001302	48.92	gold quality
esophagus mucosa	UBERON:0002469	48.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.