DNTTIP2

Summary

DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2, HGNC:24013) is a protein-coding gene on chromosome 1p22.1, encoding Deoxynucleotidyltransferase terminal-interacting protein 2 (Q5QJE6). Regulates the transcriptional activity of DNTT and ESR1. It is a selective cancer dependency (DepMap: 73.4% of cell lines).

This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease.

Source: NCBI Gene 30836 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 112 total
• Cancer dependency (DepMap): dependent in 73.4% of screened cell lines
• MANE Select transcript: NM_014597

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24013
Approved symbol	DNTTIP2
Name	deoxynucleotidyltransferase terminal interacting protein 2
Location	1p22.1
Locus type	gene with protein product
Status	Approved
Aliases	HSU15552, ERBP, TdIF2
Ensembl gene	ENSG00000067334
Ensembl biotype	protein_coding
OMIM	611199
Entrez	30836

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 3 protein_coding_CDS_not_defined, 2 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000359208, ENST00000436063, ENST00000460191, ENST00000462746, ENST00000496535, ENST00000496672, ENST00000528680

RefSeq mRNA: 1 — MANE Select: NM_014597 NM_014597

CCDS: CCDS44174

Canonical transcript exons

ENST00000436063 — 7 exons

Exon	Start	End
ENSE00000777089	93875645	93875783
ENSE00001774432	93866284	93869944
ENSE00002201976	93879077	93879206
ENSE00003464563	93876268	93877862
ENSE00003551497	93873119	93873214
ENSE00003641262	93870683	93870792
ENSE00003655393	93872072	93872236

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 96.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.2469 / max 531.0837, expressed in 1787 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13346	21.9365	1774
13347	3.2626	1393
13338	0.0478	25

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.82	gold quality
gingival epithelium	UBERON:0001949	95.66	gold quality
cervix squamous epithelium	UBERON:0006922	95.40	gold quality
gingiva	UBERON:0001828	95.39	gold quality
islet of Langerhans	UBERON:0000006	95.36	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.03	gold quality
ventricular zone	UBERON:0003053	95.01	gold quality
gluteal muscle	UBERON:0002000	94.89	gold quality
tongue squamous epithelium	UBERON:0006919	94.89	gold quality
biceps brachii	UBERON:0001507	94.88	gold quality
tendon	UBERON:0000043	94.84	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.67	gold quality
heart right ventricle	UBERON:0002080	94.56	gold quality
cranial nerve II	UBERON:0000941	94.47	gold quality
gastrocnemius	UBERON:0001388	94.11	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.07	gold quality
deltoid	UBERON:0001476	93.93	gold quality
ganglionic eminence	UBERON:0004023	93.89	gold quality
endothelial cell	CL:0000115	93.83	gold quality
skin of hip	UBERON:0001554	93.81	gold quality
cervix epithelium	UBERON:0004801	93.79	gold quality
cortical plate	UBERON:0005343	93.73	gold quality
bronchial epithelial cell	CL:0002328	93.69	gold quality
tibialis anterior	UBERON:0001385	93.65	gold quality
nasal cavity epithelium	UBERON:0005384	93.56	gold quality
muscle of leg	UBERON:0001383	93.41	gold quality
bone marrow cell	CL:0002092	93.40	gold quality
colonic epithelium	UBERON:0000397	93.40	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-53	no	672.50
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): KAT5

miRNA regulators (miRDB)

21 targeting DNTTIP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-200A-5P	99.76	69.10	949
HSA-MIR-200B-5P	99.76	69.05	948
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-409-3P	99.50	66.33	1192
HSA-MIR-302B-5P	99.50	69.49	1857
HSA-MIR-302D-5P	99.50	69.34	1863
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-5007-5P	97.95	64.71	614
HSA-MIR-193A-5P	95.70	65.33	613
HSA-MIR-4694-5P	94.62	65.39	532
HSA-MIR-758-5P	93.99	64.46	534

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 73.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• The TdIF2 might promote hrDNAP activity by suppressing Tip60’s HAT activity and promoting UBF acetylation. (PMID:21668587)
• Depletion of DNTTIP2 Induces Cell Cycle Arrest in Pancreatic Cancer Cells. (PMID:38151292)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	dnttip2	ENSDARG00000057648
mus_musculus	Dnttip2	ENSMUSG00000039756
rattus_norvegicus	Dnttip2	ENSRNOG00000025025
drosophila_melanogaster	CG1142	FBGN0037504
caenorhabditis_elegans		WBGENE00021715

Protein

Protein identifiers

Deoxynucleotidyltransferase terminal-interacting protein 2 — Q5QJE6 (reviewed: Q5QJE6)

Alternative names: Estrogen receptor-binding protein, LPTS-interacting protein 2, Terminal deoxynucleotidyltransferase-interacting factor 2

All UniProt accessions (3): Q5QJE6, E9PRB3, J3KP30

UniProt curated annotations — full annotation on UniProt →

Function. Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Subunit / interactions. Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Widely expressed with higher levels in testis.

RefSeq proteins (1): NP_055412* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR014810	Fcf2_C	Domain
IPR039883	Fcf2/DNTTIP2	Family

Pfam: PF08698

UniProt features (53 total): modified residue 19, cross-link 15, compositionally biased region 5, sequence variant 5, region of interest 4, sequence conflict 3, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7MQA	ELECTRON MICROSCOPY	2.7
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5QJE6-F1	54.47	0.16

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (34): 21, 117, 129, 141, 145, 148, 184, 194, 232, 239, 251, 253, 324, 330, 381, 434, 512, 569, 610, 217 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 135 (showing top): SHEPARD_BMYB_MORPHOLINO_UP, GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_MATURATION_OF_SSU_RRNA, PUJANA_CHEK2_PCC_NETWORK, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, GARY_CD5_TARGETS_DN, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, chr1p22, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GCM_DDX5, VANTVEER_BREAST_CANCER_BRCA1_UP

GO Biological Process (2): RNA processing (GO:0006396), ribosomal small subunit biogenesis (GO:0042274)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (5): nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), small-subunit processome (GO:0032040), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear lumen	2
intracellular membraneless organelle	2
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
ribonucleoprotein complex biogenesis	1
ribosome biogenesis	1
nucleic acid binding	1
binding	1
cellular anatomical structure	1
nucleolus	1
preribosome	1
t-UTP complex	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2001 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DNTTIP2	FCF1	Q9Y324	965
DNTTIP2	FAF1	Q9UNN5	834
DNTTIP2	UTP3	Q9NQZ2	770
DNTTIP2	DNTT	P04053	767
DNTTIP2	WDR46	O15213	724
DNTTIP2	UTP11	Q9Y3A2	692
DNTTIP2	FBL	P22087	520
DNTTIP2	ESR2	Q92731	515
DNTTIP2	DNTTIP1	Q9H147	503
DNTTIP2	UTP15	Q8TED0	477
DNTTIP2	KRR1	Q13601	457
DNTTIP2	UTP20	O75691	453
DNTTIP2	UTP23	Q9BRU9	447
DNTTIP2	ESR1	P03372	438
DNTTIP2	HEATR1	Q9H583	426

IntAct

105 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
DNTTIP2	CAVIN1	psi-mi:“MI:0915”(physical association)	0.680
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
DNTTIP2	CEP70	psi-mi:“MI:0915”(physical association)	0.560
DNTTIP2	PICK1	psi-mi:“MI:0915”(physical association)	0.560
RNF8	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.560
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
EXOSC4	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
NPM1	WDR46	psi-mi:“MI:0914”(association)	0.480
RBM6	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.400
RPF2	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.400
IFIT2	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.400
FAM50A	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.400
NELL1	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.400
	DNTTIP2	psi-mi:“MI:0915”(physical association)	0.370
DNTTIP2		psi-mi:“MI:0915”(physical association)	0.370
PHF8	MACROH2A1	psi-mi:“MI:0914”(association)	0.350
Kif20b	SHTN1	psi-mi:“MI:0914”(association)	0.350
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
DGCR8	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
RBM4	NOP56	psi-mi:“MI:0914”(association)	0.350
NIFK	RRP8	psi-mi:“MI:0914”(association)	0.350
HNRNPA1	HNRNPR	psi-mi:“MI:0914”(association)	0.350

BioGRID (174): DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Affinity Capture-MS), DNTTIP2 (Positive Genetic)

ESM2 similar proteins: A0A3Q2UEI8, A0JNH9, A2BIL8, A8PUI7, B1H1S4, B2GUZ2, E7FAP1, E9Q309, F1R983, O60284, P49452, P51960, P86345, Q0P5H2, Q3T0A6, Q3T8J9, Q4KLP8, Q4QY64, Q4R731, Q535K8, Q563C3, Q58EL7, Q5FBB7, Q5QJE6, Q5VT06, Q5XG21, Q65Z40, Q6KAQ7, Q6NWJ0, Q6P0N0, Q6P6I6, Q76FK4, Q7YQM1, Q7YQM2, Q80WQ8, Q8C263, Q8C551, Q8IYH5, Q8NA57, Q8R2M2

Diamond homologs: O42877, Q0P5H2, Q12035, Q5QJE6, Q8R2M2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 128 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Major pathway of rRNA processing in the nucleolus and cytosol	16	10.8×	5e-10
rRNA modification in the nucleus and cytosol	5	10.3×	4e-03
Formation of a pool of free 40S subunits	8	9.8×	3e-04
Peptide chain elongation	7	9.8×	5e-04
Viral mRNA Translation	7	9.8×	5e-04
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	7	9.7×	5e-04
SARS-CoV-1-host interactions	5	9.7×	5e-03
Selenocysteine synthesis	7	9.2×	5e-04

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	7	13.6×	2e-04
RNA processing	7	13.1×	2e-04
cytoplasmic translation	8	12.7×	2e-04
regulation of alternative mRNA splicing, via spliceosome	6	12.5×	8e-04
heterochromatin formation	5	10.9×	7e-03
rRNA processing	8	9.7×	2e-04
RNA splicing	10	7.5×	2e-04
mRNA processing	10	6.7×	3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

774 predictions. Top by Δscore:

Variant	Effect	Δscore
1:93869853:A:AC	donor_gain	1.0000
1:93869854:A:C	donor_gain	1.0000
1:93869868:T:TA	donor_gain	1.0000
1:93869940:TGTAT:T	acceptor_gain	1.0000
1:93869941:GTAT:G	acceptor_gain	1.0000
1:93869942:TAT:T	acceptor_gain	1.0000
1:93869943:ATCTG:A	acceptor_loss	1.0000
1:93869944:TC:T	acceptor_loss	1.0000
1:93869945:C:CC	acceptor_gain	1.0000
1:93869945:C:CG	acceptor_loss	1.0000
1:93869946:T:C	acceptor_loss	1.0000
1:93870675:T:TA	donor_gain	1.0000
1:93870680:TACC:T	donor_loss	1.0000
1:93870681:A:AC	donor_gain	1.0000
1:93870682:C:CC	donor_gain	1.0000
1:93870682:C:CG	donor_loss	1.0000
1:93870682:CCTT:C	donor_gain	1.0000
1:93870788:CCAAT:C	acceptor_gain	1.0000
1:93870789:CAAT:C	acceptor_gain	1.0000
1:93870789:CAATC:C	acceptor_gain	1.0000
1:93870792:TC:T	acceptor_loss	1.0000
1:93870793:C:CC	acceptor_gain	1.0000
1:93870793:CTGT:C	acceptor_loss	1.0000
1:93870800:C:CT	acceptor_gain	1.0000
1:93872067:CATAC:C	donor_loss	1.0000
1:93872068:ATACC:A	donor_loss	1.0000
1:93872069:TACCT:T	donor_loss	1.0000
1:93872070:A:C	donor_loss	1.0000
1:93872071:C:CT	donor_loss	1.0000
1:93872233:CTTT:C	acceptor_gain	1.0000

AlphaMissense

5044 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:93870707:A:G	L718P	1.000
1:93870760:G:C	F700L	0.999
1:93870760:G:T	F700L	0.999
1:93870762:A:G	F700L	0.999
1:93872108:C:A	K677N	0.999
1:93872108:C:G	K677N	0.999
1:93872114:A:C	F675L	0.999
1:93872114:A:T	F675L	0.999
1:93872116:A:G	F675L	0.999
1:93872138:T:A	R667S	0.999
1:93872138:T:G	R667S	0.999
1:93872148:A:G	L664P	0.999
1:93872157:A:G	L661P	0.999
1:93872206:A:G	W645R	0.999
1:93872206:A:T	W645R	0.999
1:93869913:C:G	A737P	0.998
1:93870704:A:G	L719P	0.998
1:93870730:C:A	R710S	0.998
1:93870730:C:G	R710S	0.998
1:93870788:C:T	G691E	0.998
1:93870789:C:G	G691R	0.998
1:93870789:C:T	G691R	0.998
1:93872110:T:C	K677E	0.998
1:93872139:C:G	R667T	0.998
1:93872169:A:G	L657P	0.998
1:93872204:C:A	W645C	0.998
1:93872204:C:G	W645C	0.998
1:93869928:A:C	Y732D	0.997
1:93870688:G:C	F724L	0.997
1:93870688:G:T	F724L	0.997

dbSNP variants (sampled 300 via entrez): RS1000148046 (1:93871982 C>T), RS1000148458 (1:93866941 C>G), RS1000285851 (1:93878789 CAGTA>C), RS1000287791 (1:93871812 A>T), RS1000642110 (1:93877206 T>C,G), RS1000830720 (1:93867838 AACAG>A), RS1000975096 (1:93865919 G>C), RS1001075127 (1:93867464 G>A), RS1001491318 (1:93878346 C>T), RS1001791780 (1:93871546 G>T), RS1002536006 (1:93880147 A>C,G), RS1002980585 (1:93868309 G>A), RS1003007550 (1:93880375 A>T), RS1003193162 (1:93874926 G>A), RS1003315973 (1:93869567 A>G)

Disease associations

OMIM: gene MIM:611199 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST010313_2	Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome	1.000000e-08
GCST010313_3	Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome	1.000000e-07
GCST010313_5	Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome	1.000000e-07
GCST010818_3	Gut microbiota alpha diversity (PD_whole_tree index)	5.000000e-06

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0008343	sex interaction measurement
EFO:0010733	polyunsaturated fatty acid measurement
EFO:0006807	linoleic acid measurement
EFO:0005680	omega-6 polyunsaturated fatty acid measurement
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	5
bisphenol A	affects expression, decreases expression	3
deoxynivalenol	increases expression	2
sodium arsenite	decreases expression	2
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	decreases methylation	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
sodium arsenate	decreases expression	1
kojic acid	decreases expression	1
sulforaphane	increases expression	1
cobaltous chloride	increases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
coumarin	affects phosphorylation	1
nivalenol	increases expression	1
epigallocatechin gallate	increases expression, affects cotreatment	1
azoxystrobin	decreases expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
fenpyroximate	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
pyrachlostrobin	decreases expression	1
jinfukang	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
MT19c compound	increases expression	1
Air Pollutants	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.