DOT1L-AS1

Summary

DOT1L-AS1 (DOT1L antisense RNA 1, HGNC:58317) is a long non-coding RNA gene on chromosome 19p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58317
Approved symbol	DOT1L-AS1
Name	DOT1L antisense RNA 1
Location	19p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267122
Ensembl biotype	lncRNA
Entrez	124904611
RNAcentral	URS00000B91F5 — lncRNA, 2738 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000585593

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585593 — 2 exons

Exon	Start	End
ENSE00002743847	2215494	2215565
ENSE00002796165	2212029	2214694

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 83.62.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.62	gold quality
bone marrow cell	CL:0002092	69.06	silver quality
ganglionic eminence	UBERON:0004023	55.42	silver quality
bone marrow	UBERON:0002371	54.54	silver quality
myometrium	UBERON:0001296	54.05	silver quality
blood	UBERON:0000178	52.07	gold quality
uterine cervix	UBERON:0000002	51.97	gold quality
primary visual cortex	UBERON:0002436	50.64	gold quality
lymph node	UBERON:0000029	50.24	gold quality
skin of leg	UBERON:0001511	50.19	gold quality
zone of skin	UBERON:0000014	50.18	gold quality
skin of abdomen	UBERON:0001416	50.03	gold quality
prefrontal cortex	UBERON:0000451	49.76	silver quality
ectocervix	UBERON:0012249	48.81	gold quality
tonsil	UBERON:0002372	48.19	gold quality
lower esophagus mucosa	UBERON:0035834	47.33	silver quality
superior frontal gyrus	UBERON:0002661	46.62	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	46.53	silver quality
duodenum	UBERON:0002114	46.49	silver quality
pancreas	UBERON:0001264	46.43	silver quality
vermiform appendix	UBERON:0001154	46.39	gold quality
frontal cortex	UBERON:0001870	46.21	silver quality
muscle of leg	UBERON:0001383	45.74	silver quality
vagina	UBERON:0000996	45.50	gold quality
thoracic mammary gland	UBERON:0005200	45.37	gold quality
islet of Langerhans	UBERON:0000006	45.27	silver quality
gastrocnemius	UBERON:0001388	44.98	silver quality
subcutaneous adipose tissue	UBERON:0002190	44.75	gold quality
adipose tissue	UBERON:0001013	44.72	gold quality
endometrium	UBERON:0001295	44.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.