DPEP2NB

Summary

DPEP2NB (DPEP2 neighbor, HGNC:52385) is a protein-coding gene on chromosome 16q22.1, encoding DPEP2 neighbor protein (A0A0U1RQF7).

At a glance

• MANE Select transcript: NM_001282442

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52385
Approved symbol	DPEP2NB
Name	DPEP2 neighbor
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000263201
Ensembl biotype	protein_coding
Entrez	100131303

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000574912

RefSeq mRNA: 1 — MANE Select: NM_001282442 NM_001282442

CCDS: CCDS82001

Canonical transcript exons

ENST00000574912 — 2 exons

Exon	Start	End
ENSE00002643910	68015704	68015911
ENSE00002651964	68013436	68014412

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 85.64.

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	85.64	silver quality
pancreatic ductal cell	CL:0002079	85.60	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.97	silver quality
sperm	CL:0000019	80.92	silver quality
ileal mucosa	UBERON:0000331	77.96	silver quality
deltoid	UBERON:0001476	74.07	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	71.87	gold quality
upper arm skin	UBERON:0004263	71.66	gold quality
quadriceps femoris	UBERON:0001377	71.33	gold quality
cardiac muscle of right atrium	UBERON:0003379	71.13	gold quality
left ventricle myocardium	UBERON:0006566	70.99	gold quality
epithelial cell of pancreas	CL:0000083	70.28	gold quality
vastus lateralis	UBERON:0001379	69.77	gold quality
myocardium	UBERON:0002349	69.64	gold quality
kidney epithelium	UBERON:0004819	69.56	gold quality
placenta	UBERON:0001987	68.12	gold quality
superficial temporal artery	UBERON:0001614	66.58	gold quality
amniotic fluid	UBERON:0000173	62.62	gold quality
epithelium of nasopharynx	UBERON:0001951	61.82	gold quality
left testis	UBERON:0004533	61.28	gold quality
right testis	UBERON:0004534	60.96	gold quality
mucosa of paranasal sinus	UBERON:0005030	60.22	gold quality
testis	UBERON:0000473	59.74	gold quality
buccal mucosa cell	CL:0002336	59.65	gold quality
vena cava	UBERON:0004087	59.58	gold quality
layer of synovial tissue	UBERON:0007616	58.74	gold quality
trabecular bone tissue	UBERON:0002483	58.50	gold quality
epithelium of mammary gland	UBERON:0003244	58.21	gold quality
mammary duct	UBERON:0001765	58.05	gold quality
biceps brachii	UBERON:0001507	57.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

59 targeting DPEP2NB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4677-5P	99.70	70.09	1940

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Dpep2nb	ENSMUSG00000115768
rattus_norvegicus		ENSRNOG00000067161
rattus_norvegicus	Dpep2nb	ENSRNOG00000080114

Protein

Protein identifiers

DPEP2 neighbor protein — A0A0U1RQF7 (reviewed: A0A0U1RQF7)

All UniProt accessions (1): A0A0U1RQF7

RefSeq proteins (1): NP_001269371* (*=MANE)

Domains & families (InterPro)

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A0U1RQF7-F1	47.90	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 7 (showing top): chr16q22, MIR4306, MIR3688_3P, MIR6721_5P, MIR6800_3P, DESCARTES_MAIN_FETAL_CSH1_CSH2_POSITIVE_CELLS, GSE43863_NAIVE_VS_LY6C_INT_CXCR5POS_CD4_EFF_TCELL_D6_LCMV_DN

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

2 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DPEP2NB	TRAF4	Q9BUZ4	0

IntAct

25 interactions, top by confidence:

A	B	Type	Score
DPEP2NB	KANK2	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	NBL1	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	ZNF410	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	ARMC7	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	FRS3	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	COL8A1	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	TRAF4	psi-mi:“MI:0915”(physical association)	0.560
DPEP2NB	CABP2	psi-mi:“MI:0915”(physical association)	0.560
NBL1	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
ZNF410	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
ARMC7	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
FRS3	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
COL8A1	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
CABP2	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
KANK2	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000
TRAF4	DPEP2NB	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A0A0U1RQF7, A6YQT5, O54842, O60356, O82286, P03131, P03238, P04602, P04605, P05909, P06937, P09267, P0C765, P17759, P18098, P19847, P23057, P24103, P24820, P27224, P27261, P27445, P35959, P50445, P54092, P54093, P69484, P69485, Q00039, Q06658, Q0VCV7, Q1X709, Q1X711, Q32LJ5, Q4JQX3, Q5R5R7, Q67684, Q8B912, Q8BG31, Q8C3M9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

279 predictions. Top by Δscore:

Variant	Effect	Δscore
16:68014410:CAG:C	acceptor_gain	0.9900
16:68014413:C:CC	acceptor_gain	0.9900
16:68015804:A:AC	donor_gain	0.9900
16:68015805:C:CC	donor_gain	0.9900
16:68014408:TGCAG:T	acceptor_gain	0.9800
16:68014409:GCAG:G	acceptor_gain	0.9800
16:68014410:CAGC:C	acceptor_gain	0.9800
16:68014411:AG:A	acceptor_gain	0.9800
16:68014411:A:T	acceptor_gain	0.9600
16:68015540:G:A	donor_gain	0.8900
16:68015826:T:TA	donor_gain	0.8800
16:68015521:G:A	donor_gain	0.8500
16:68015698:GCCTA:G	donor_loss	0.8400
16:68015699:CCTA:C	donor_loss	0.8400
16:68015700:CTAC:C	donor_loss	0.8400
16:68015701:TA:T	donor_loss	0.8400
16:68015702:ACC:A	donor_loss	0.8400
16:68015703:C:CA	donor_loss	0.8400
16:68015704:C:A	donor_loss	0.8400
16:68015847:G:C	donor_gain	0.8400
16:68015800:T:C	donor_gain	0.8100
16:68015703:CCTG:C	donor_gain	0.7800
16:68015695:TATGC:T	donor_loss	0.7700
16:68015889:C:CT	donor_gain	0.7700
16:68015890:T:TT	donor_gain	0.7700
16:68015587:A:AC	donor_gain	0.7600
16:68015247:G:C	donor_gain	0.7400
16:68014488:T:TA	donor_gain	0.7200
16:68015266:G:A	donor_gain	0.7000
16:68015705:T:A	donor_loss	0.6800

AlphaMissense

775 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:68015763:T:A	D3V	0.854
16:68014330:C:A	W50C	0.838
16:68014330:C:G	W50C	0.838
16:68014322:T:A	E53V	0.828
16:68014312:G:C	C56W	0.821
16:68014325:C:A	G52V	0.821
16:68014326:C:A	G52W	0.816
16:68015757:A:G	I5T	0.813
16:68014367:A:T	V38D	0.805
16:68014317:A:C	Y55D	0.804
16:68014287:C:A	G65W	0.795
16:68014332:A:G	W50R	0.775
16:68014332:A:T	W50R	0.775
16:68015757:A:C	I5S	0.769
16:68014282:A:C	D66E	0.767
16:68014282:A:T	D66E	0.767
16:68015752:A:C	Y7D	0.767
16:68014314:A:G	C56R	0.761
16:68014286:C:T	G65E	0.756
16:68015764:C:G	D3H	0.754
16:68014283:T:A	D66V	0.750
16:68014284:C:G	D66H	0.742
16:68014374:A:C	Y36D	0.736
16:68014286:C:A	G65V	0.732
16:68014283:T:C	D66G	0.716
16:68014304:C:A	G59V	0.708
16:68014295:C:G	R62P	0.706
16:68014369:A:C	H37Q	0.706
16:68014369:A:T	H37Q	0.706
16:68014331:C:A	W50L	0.698

dbSNP variants (sampled 300 via entrez): RS1001118495 (16:68016261 G>A), RS1001337848 (16:68015433 C>A,T), RS1001551539 (16:68016523 G>T), RS1002187220 (16:68017318 C>G,T), RS1003010780 (16:68017494 A>T), RS1003069995 (16:68017209 C>T), RS1003118128 (16:68013083 G>A), RS1003810140 (16:68015662 G>A), RS1004279101 (16:68016380 G>T), RS1004613815 (16:68016157 G>A,C), RS1005907510 (16:68013451 ATTTT>A,ATTT,ATTTTT), RS1005971792 (16:68017037 T>G), RS1005987875 (16:68015162 T>A,C), RS1006634200 (16:68012995 A>G), RS1007086909 (16:68014615 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.