DRAIC

Summary

DRAIC (downregulated RNA in cancer, inhibitor of cell invasion and migration, HGNC:27082) is a long non-coding RNA gene on chromosome 15q23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27082
Approved symbol	DRAIC
Name	downregulated RNA in cancer, inhibitor of cell invasion and migration
Location	15q23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245750
Ensembl biotype	lncRNA
OMIM	616387
Entrez	145837
RNAcentral	URS000075EB40 — lncRNA, 1705 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 105 — 103 lncRNA, 2 retained_intron

ENST00000498938, ENST00000558309, ENST00000558385, ENST00000558411, ENST00000558633, ENST00000558781, ENST00000558941, ENST00000559025, ENST00000559029, ENST00000559212, ENST00000559477, ENST00000560655, ENST00000560853, ENST00000560882, ENST00000642210, ENST00000643306, ENST00000644274, ENST00000645479, ENST00000646247, ENST00000647319, ENST00000653225, ENST00000653427, ENST00000653477, ENST00000653708, ENST00000653825, ENST00000654004, ENST00000654249, ENST00000654529, ENST00000654883, ENST00000655251, ENST00000656433, ENST00000657438, ENST00000658420, ENST00000659150, ENST00000660367, ENST00000660495, ENST00000660521, ENST00000660592, ENST00000660880, ENST00000661448, ENST00000661515, ENST00000661726, ENST00000662698, ENST00000662925, ENST00000663039, ENST00000663838, ENST00000665425, ENST00000665434, ENST00000667053, ENST00000668587, ENST00000668790, ENST00000668982, ENST00000669215, ENST00000669701, ENST00000671448, ENST00000674201, ENST00000674230, ENST00000674248, ENST00000674275, ENST00000674283, ENST00000674319, ENST00000674321, ENST00000674348, ENST00000674364, ENST00000674366, ENST00000674396, ENST00000674402, ENST00000674404, ENST00000674409, ENST00000674454, ENST00000674476, ENST00000674486, ENST00000674502, ENST00000702034, ENST00000754044, ENST00000754045, ENST00000754046, ENST00000754047, ENST00000754048, ENST00000754049, ENST00000798860, ENST00000798861, ENST00000798862, ENST00000798863, ENST00000798864, ENST00000798865, ENST00000798866, ENST00000798867, ENST00000798868, ENST00000798869, ENST00000798870, ENST00000798871, ENST00000798872, ENST00000798873, ENST00000798874, ENST00000798875, ENST00000798876, ENST00000798877, ENST00000798878, ENST00000798879, ENST00000798880, ENST00000798881, ENST00000798882, ENST00000798883, ENST00000798884

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000498938 — 5 exons

Exon	Start	End
ENSE00001978552	69563590	69563804
ENSE00002552807	69565194	69565527
ENSE00003861127	69570740	69570924
ENSE00003885925	69563066	69563302
ENSE00003886771	69561752	69562017

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 87.70.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4219 / max 164.4010, expressed in 112 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147471	0.1013	57
147456	0.0558	21
147461	0.0516	14
147464	0.0497	7
147463	0.0459	4
147462	0.0390	10
147458	0.0319	4
147460	0.0163	3
147466	0.0156	8
147465	0.0054	5

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	87.70	gold quality
right lobe of liver	UBERON:0001114	86.19	gold quality
secondary oocyte	CL:0000655	84.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.06	gold quality
liver	UBERON:0002107	78.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.73	gold quality
adult mammalian kidney	UBERON:0000082	76.86	gold quality
right uterine tube	UBERON:0001302	76.60	gold quality
sural nerve	UBERON:0015488	76.43	gold quality
mucosa of transverse colon	UBERON:0004991	76.29	gold quality
rectum	UBERON:0001052	75.44	gold quality
oocyte	CL:0000023	75.15	gold quality
kidney	UBERON:0002113	74.33	gold quality
sperm	CL:0000019	73.96	silver quality
colonic epithelium	UBERON:0000397	73.79	gold quality
prostate gland	UBERON:0002367	73.08	gold quality
cortex of kidney	UBERON:0001225	72.30	gold quality
upper arm skin	UBERON:0004263	71.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.66	gold quality
bone marrow cell	CL:0002092	71.18	gold quality
left testis	UBERON:0004533	69.65	gold quality
blood	UBERON:0000178	69.06	gold quality
right testis	UBERON:0004534	68.82	gold quality
testis	UBERON:0000473	68.53	gold quality
body of stomach	UBERON:0001161	68.17	gold quality
vermiform appendix	UBERON:0001154	68.08	gold quality
lymph node	UBERON:0000029	67.58	gold quality
stomach	UBERON:0000945	67.58	gold quality
monocyte	CL:0000576	67.46	gold quality
leukocyte	CL:0000738	67.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• A novel role for lncRNA DRAIC in the regulation of autophagic flux. Interestingly, DRAIC’s pro-proliferative effects is autophagy-independent. (PMID:30872794)
• Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-kappaB Activation. (PMID:31900260)
• LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5. (PMID:32351584)
• Regulatory effect of LncRNA DRAIC/miR-149-5p/NFIB molecular network on autophagy of esophageal cancer cells and its biological behavior. (PMID:32659236)
• SET7/9 promotes H3K4me3 at lncRNA DRAIC promoter to modulate growth and metastasis of glioma. (PMID:33336743)
• DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP. (PMID:34645975)
• Comprehensive analysis of DRAIC and TP53TG1 in breast cancer luminal subtypes through the construction of lncRNAs regulatory model. (PMID:35871431)
• Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers. (PMID:35997635)
• [LncRNA DRAIC regulates the proliferation, apoptosis, migration and invasion of lung adenocarcinoma cells by targeting let-7i-5p]. (PMID:37355465)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.