DRC10

Summary

DRC10 (dynein regulatory complex subunit 10, HGNC:25168) is a protein-coding gene on chromosome 12q24.13, encoding Dynein regulatory complex subunit 10 (Q96DY2). Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.

Located in ciliary basal body.

Source: NCBI Gene 115811 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 33 total
• MANE Select transcript: NM_001330452

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25168
Approved symbol	DRC10
Name	dynein regulatory complex subunit 10
Location	12q24.13
Locus type	gene with protein product
Status	Approved
Aliases	DRC10, CFAP84
Ensembl gene	ENSG00000166578
Ensembl biotype	protein_coding
Entrez	115811

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 protein_coding

ENST00000299732, ENST00000416617, ENST00000546692, ENST00000900797, ENST00000900798, ENST00000900799, ENST00000900800, ENST00000900801, ENST00000900802, ENST00000900803, ENST00000900804, ENST00000900805, ENST00000930474, ENST00000930475, ENST00000930476, ENST00000965256

RefSeq mRNA: 2 — MANE Select: NM_001330452 NM_001330452, NM_138451

CCDS: CCDS81743, CCDS9167

Canonical transcript exons

ENST00000416617 — 5 exons

Exon	Start	End
ENSE00001104362	113195446	113195889
ENSE00001104365	113207438	113208259
ENSE00001512407	113220997	113221094
ENSE00001619192	113197541	113197612
ENSE00001721499	113200580	113200813

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 91.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.9545 / max 159.8600, expressed in 1059 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133356	1.8873	755
133355	0.9913	506
133354	0.0758	40

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	91.93	gold quality
right testis	UBERON:0004534	91.24	gold quality
right uterine tube	UBERON:0001302	90.83	gold quality
testis	UBERON:0000473	89.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.77	gold quality
oocyte	CL:0000023	87.14	gold quality
bronchial epithelial cell	CL:0002328	86.46	gold quality
secondary oocyte	CL:0000655	86.43	gold quality
bronchus	UBERON:0002185	84.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.19	silver quality
oviduct epithelium	UBERON:0004804	77.58	gold quality
fallopian tube	UBERON:0003889	76.23	gold quality
epithelium of nasopharynx	UBERON:0001951	73.72	silver quality
sperm	CL:0000019	72.88	gold quality
ventricular zone	UBERON:0003053	72.82	gold quality
islet of Langerhans	UBERON:0000006	72.00	gold quality
tendon of biceps brachii	UBERON:0008188	71.60	silver quality
buccal mucosa cell	CL:0002336	71.17	silver quality
adenohypophysis	UBERON:0002196	69.44	gold quality
ganglionic eminence	UBERON:0004023	68.90	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.60	gold quality
right lung	UBERON:0002167	68.52	gold quality
pituitary gland	UBERON:0000007	68.15	gold quality
medial globus pallidus	UBERON:0002477	68.02	gold quality
metanephros cortex	UBERON:0010533	67.49	gold quality
mucosa of paranasal sinus	UBERON:0005030	67.25	silver quality
hypothalamus	UBERON:0001898	66.58	gold quality
caudate nucleus	UBERON:0001873	66.55	gold quality
nasal cavity mucosa	UBERON:0001826	66.38	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.80
E-MTAB-9388	yes	6.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting DRC10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-330-5P	98.73	67.63	1788
HSA-MIR-326	98.25	66.44	1565
HSA-MIR-204-3P	97.80	66.84	1656
HSA-MIR-4314	97.50	67.30	1369
HSA-MIR-4474-3P	96.97	65.87	870

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	iqcd	ENSDARG00000035551
mus_musculus	Iqcd	ENSMUSG00000029601
rattus_norvegicus	Iqcd	ENSRNOG00000087772

Protein

Protein identifiers

Dynein regulatory complex subunit 10 — Q96DY2 (reviewed: Q96DY2)

Alternative names: IQ domain-containing protein D

All UniProt accessions (2): F8VZV9, Q96DY2

UniProt curated annotations — full annotation on UniProt →

Function. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.

Subunit / interactions. Component of the nexin-dynein regulatory complex (N-DRC). Interacts with CFAP52.

Subcellular location. Cytoplasm. Cytoskeleton. Flagellum axoneme.

Similarity. Belongs to the DRC10 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96DY2-1	1	yes
Q96DY2-2	2
Q96DY2-3	3

RefSeq proteins (2): NP_001317381, NP_612460 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000048	IQ_motif_EF-hand-BS	Binding_site
IPR042815	DRC10	Family

Pfam: PF00612

UniProt features (9 total): splice variant 3, chain 1, domain 1, region of interest 1, coiled-coil region 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8J07	ELECTRON MICROSCOPY	4.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96DY2-F1	82.03	0.51

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): ciliary basal body (GO:0036064), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), cilium (GO:0005929), motile cilium (GO:0031514), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cilium	2
cellular anatomical structure	2
binding	1
microtubule organizing center	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

362 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DRC10	DRC5	Q5JU00	671
DRC10	METTL27	Q8N6F8	597
DRC10	DRC8	Q5VUJ9	591
DRC10	MYCBPAP	Q8TBZ2	571
DRC10	IQUB	Q8NA54	556
DRC10	CFAP144	A6NL82	540
DRC10	VWA3A	A6NCI4	539
DRC10	DRC7	Q8IY82	531
DRC10	FBXL13	Q8NEE6	515
DRC10	TPCN1	Q9ULQ1	488
DRC10	CFAP73	A6NFT4	484
DRC10	ARMC3	Q5W041	483
DRC10	BPIFC	Q8NFQ6	478
DRC10	DRC11	Q86XH1	473
DRC10	RSPH3	Q86UC2	472

IntAct

3 interactions, top by confidence:

A	B	Type	Score
IQCD	H3-4	psi-mi:“MI:0915”(physical association)	0.400
TNNC1	MYO1B	psi-mi:“MI:0914”(association)	0.350

BioGRID (5): IQCD (Affinity Capture-MS), IQCD (Affinity Capture-MS), IQCD (Two-hybrid), IQCD (Proximity Label-MS), IQCD (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IFG5, A0A480NP79, A0A974E306, A0AUT1, A0JLY1, A4IJ21, A5A6J4, A8I9E8, A8IRJ7, A8IUG5, E1BJL9, F1N7G5, M0R3K6, M1V4Y8, O95990, Q0VC09, Q0VFZ6, Q17QH9, Q1RM03, Q2KI00, Q2KIQ2, Q32LH1, Q3TGF2, Q3TVW5, Q4R698, Q4R7T8, Q4R8Y5, Q5NVP3, Q5RE49, Q5U4F3, Q5XIN9, Q61884, Q6AXN9, Q6AXQ8, Q6AYL4, Q6PBA8, Q6ZN84, Q78TU8, Q8BRC6, Q8N443

Diamond homologs: F1RKB1, Q17QH9, Q4R8Y5, Q5XIR6, Q96DY2, Q9D3V1, Q2T9V2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
IQCD	“form complex”	“Nexin-dynein regulatory complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

33 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2987 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:113195694:A:G	W411R	0.994
12:113195694:A:T	W411R	0.994
12:113195688:C:G	G413R	0.992
12:113195715:C:G	A404P	0.991
12:113195714:G:T	A404D	0.990
12:113195700:C:G	A409P	0.989
12:113197601:T:A	K325N	0.989
12:113197601:T:G	K325N	0.989
12:113195687:C:T	G413D	0.988
12:113195676:G:T	R417S	0.984
12:113195718:C:G	A403P	0.984
12:113200587:A:G	L319P	0.983
12:113197567:A:C	Y337D	0.982
12:113200583:C:A	R320S	0.982
12:113200583:C:G	R320S	0.982
12:113195701:C:A	Q408H	0.981
12:113195701:C:G	Q408H	0.981
12:113195675:C:G	R417P	0.980
12:113195693:C:G	W411S	0.980
12:113195831:A:G	L365P	0.980
12:113200717:C:G	A276P	0.980
12:113200782:A:G	L254P	0.980
12:113197563:T:G	D338A	0.977
12:113197566:T:G	Y337S	0.977
12:113197579:A:G	W333R	0.977
12:113197579:A:T	W333R	0.977
12:113207598:A:G	L190P	0.974
12:113195705:A:T	I407N	0.972
12:113195692:C:A	W411C	0.970
12:113195692:C:G	W411C	0.970

dbSNP variants (sampled 300 via entrez): RS1000193900 (12:113198582 C>T), RS1000344568 (12:113209892 G>A), RS1000452027 (12:113205238 A>G), RS1000476379 (12:113222841 C>T), RS1000717240 (12:113218915 G>T), RS1000862209 (12:113209586 A>C,G), RS1000943407 (12:113196315 A>T), RS1001320091 (12:113197681 G>A), RS1001423443 (12:113215757 A>G), RS1001573137 (12:113222493 C>G,T), RS1001698823 (12:113208550 G>A), RS1001738870 (12:113216567 A>G), RS1001892688 (12:113196724 C>G,T), RS1001907619 (12:113208855 G>C), RS1001919066 (12:113209140 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Smoke	decreases expression, increases abundance, increases expression	2
Tobacco Smoke Pollution	decreases expression, decreases methylation	2
Okadaic Acid	increases expression	2
aristolochic acid I	increases expression	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	decreases expression	1
aflatoxin B2	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
dinophysistoxin 1	increases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
jinfukang	increases expression, affects cotreatment	1
Zoledronic Acid	increases expression	1
Leflunomide	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	increases methylation	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, increases expression	1
Iron	increases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression, affects cotreatment	1
Tretinoin	decreases expression	1
Valproic Acid	increases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases expression	1
Copper Sulfate	increases expression	1
Acrylamide	decreases expression	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.