DRC11

Summary

DRC11 (dynein regulatory complex subunit 11, HGNC:26195) is a protein-coding gene on chromosome 2q37.2-q37.3, encoding Dynein regulatory complex subunit 11 (Q86XH1). Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.

The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Source: NCBI Gene 79781 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 89 total
• MANE Select transcript: NM_024726

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26195
Approved symbol	DRC11
Name	dynein regulatory complex subunit 11
Location	2q37.2-q37.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ22527
Ensembl gene	ENSG00000132321
Ensembl biotype	protein_coding
Entrez	79781

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 7 protein_coding, 3 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000254653, ENST00000309507, ENST00000409100, ENST00000409907, ENST00000418802, ENST00000431676, ENST00000465621, ENST00000467572, ENST00000479471, ENST00000479783, ENST00000857593, ENST00000857594, ENST00000919534

RefSeq mRNA: 3 — MANE Select: NM_024726 NM_001270584, NM_001270585, NM_024726

CCDS: CCDS46549, CCDS59441, CCDS74677

Canonical transcript exons

ENST00000409907 — 19 exons

Exon	Start	End
ENSE00001036378	236377103	236377185
ENSE00001036384	236368194	236368301
ENSE00001036387	236363780	236363979
ENSE00001073615	236488000	236488191
ENSE00001073625	236465505	236465710
ENSE00001270370	236486829	236486900
ENSE00001270387	236493768	236493887
ENSE00001584437	236380569	236380633
ENSE00001905180	236507257	236507476
ENSE00003470651	236338205	236338382
ENSE00003516048	236399413	236399488
ENSE00003554235	236331359	236331597
ENSE00003560106	236419149	236419271
ENSE00003621529	236344557	236344643
ENSE00003630372	236391976	236392071
ENSE00003637010	236392244	236392350
ENSE00003675637	236441040	236441124
ENSE00003681200	236324151	236324783
ENSE00003727278	236497163	236497487

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 98.77.

FANTOM5 (CAGE): breadth broad, TPM avg 3.3670 / max 162.0869, expressed in 568 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
34661	2.6449	546
34663	0.4746	169
34662	0.1276	75
34660	0.1199	52

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.77	gold quality
male germ cell	CL:0000015	95.93	gold quality
bronchial epithelial cell	CL:0002328	94.67	gold quality
oocyte	CL:0000023	93.62	gold quality
secondary oocyte	CL:0000655	92.94	gold quality
epithelium of bronchus	UBERON:0002031	91.57	gold quality
right uterine tube	UBERON:0001302	91.45	gold quality
caudate nucleus	UBERON:0001873	90.85	gold quality
bronchus	UBERON:0002185	90.67	gold quality
medial globus pallidus	UBERON:0002477	90.62	gold quality
left lobe of thyroid gland	UBERON:0001120	90.58	gold quality
right lobe of thyroid gland	UBERON:0001119	90.39	gold quality
thyroid gland	UBERON:0002046	90.20	gold quality
mucosa of paranasal sinus	UBERON:0005030	90.05	gold quality
Brodmann (1909) area 23	UBERON:0013554	89.63	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.44	gold quality
putamen	UBERON:0001874	89.04	gold quality
globus pallidus	UBERON:0001875	88.79	gold quality
germinal epithelium of ovary	UBERON:0001304	88.71	gold quality
nucleus accumbens	UBERON:0001882	88.50	gold quality
lateral globus pallidus	UBERON:0002476	86.60	gold quality
amygdala	UBERON:0001876	86.10	gold quality
middle temporal gyrus	UBERON:0002771	85.97	gold quality
primary visual cortex	UBERON:0002436	85.53	gold quality
pituitary gland	UBERON:0000007	85.40	gold quality
adenohypophysis	UBERON:0002196	85.08	gold quality
anterior cingulate cortex	UBERON:0009835	83.87	gold quality
cingulate cortex	UBERON:0003027	83.80	gold quality
hypothalamus	UBERON:0001898	83.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.10

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting DRC11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-549A-3P	99.54	68.17	825
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-7114-5P	98.51	67.87	1349
HSA-MIR-6773-3P	98.17	65.51	1213
HSA-MIR-1278	97.75	67.55	628
HSA-MIR-708-3P	97.50	68.67	1082
HSA-MIR-890	97.47	68.67	982
HSA-MIR-490-5P	96.75	65.81	661

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	iqca1	ENSDARG00000057276
mus_musculus	Iqca1	ENSMUSG00000026301
rattus_norvegicus	Iqca1	ENSRNOG00000019592
drosophila_melanogaster	CG14183	FBGN0036931
drosophila_melanogaster	CG16789	FBGN0037712

Paralogs (1): IQCA1L (ENSG00000278685)

Protein

Protein identifiers

Dynein regulatory complex subunit 11 — Q86XH1 (reviewed: Q86XH1)

Alternative names: IQ and AAA domain-containing protein 1

All UniProt accessions (3): A0A0A0MSY6, H7BZR5, Q86XH1

UniProt curated annotations — full annotation on UniProt →

Function. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.

Subunit / interactions. Component of the nexin-dynein regulatory complex (N-DRC).

Subcellular location. Cytoplasm. Cytoskeleton. Flagellum axoneme.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the AAA ATPase family. DRC11 subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q86XH1-1	1	yes
Q86XH1-2	2
Q86XH1-5	3

RefSeq proteins (3): NP_001257513, NP_001257514, NP_079002* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003959	ATPase_AAA_core	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR052267	N-DRC_Component	Family

Pfam: PF00004

UniProt features (19 total): splice variant 4, sequence conflict 4, sequence variant 3, compositionally biased region 3, region of interest 2, chain 1, domain 1, binding site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8J07	ELECTRON MICROSCOPY	4.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86XH1-F1	79.87	0.35

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 575–582

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (1): microtubule severing (GO:0051013)

GO Molecular Function (4): ATP binding (GO:0005524), microtubule severing ATPase activity (GO:0008568), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166)

GO Cellular Component (6): nucleus (GO:0005634), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), cilium (GO:0005929), motile cilium (GO:0031514), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
microtubule cytoskeleton organization	2
ATP-dependent activity	2
cellular anatomical structure	2
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
polypeptide conformation or assembly isomerase activity	1
catalytic activity, acting on a protein	1
microtubule destabilizing activity	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cilium	1

Protein interactions and networks

STRING

1760 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DRC11	DRC5	Q5JU00	668
DRC11	DRC7	Q8IY82	622
DRC11	DRC8	Q5VUJ9	578
DRC11	CCDC149	Q6ZUS6	531
DRC11	DRC4	O95995	523
DRC11	LRCOL1	A6NCL2	520
DRC11	DAW1	Q8N136	518
DRC11	CALM1	P02593	507
DRC11	ULK4	Q96C45	502
DRC11	CALML6	Q8TD86	488
DRC11	CALML3	P27482	488
DRC11	CALML5	Q9NZT1	488
DRC11	CALML4	Q96GE6	488
DRC11	DRC2	Q8IXS2	486
DRC11	ADGB	Q8N7X0	480

IntAct

4 interactions, top by confidence:

A	B	Type	Score
KLHL22	TRAV18	psi-mi:“MI:0914”(association)	0.350
FTL		psi-mi:“MI:0914”(association)	0.350
ZCCHC10	ARHGAP10	psi-mi:“MI:0914”(association)	0.350

BioGRID (5): IQCA1 (Affinity Capture-MS), IQCA1 (Cross-Linking-MS (XL-MS)), ATP5A1 (Cross-Linking-MS (XL-MS)), IQCA1 (Affinity Capture-MS), NEFM (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A1A5P5, A6H690, A6NCM1, A7SK48, B2RY04, E7EXT2, O70481, P97393, P97564, Q12874, Q13017, Q14185, Q14738, Q1LXZ7, Q24087, Q2KI89, Q2TAA8, Q3SYG4, Q3U0M1, Q45GW3, Q4R8Y5, Q5GJ77, Q5R629, Q5ZL77, Q68F70, Q6AX60, Q6AXQ7, Q6NU25, Q7ZYV9, Q811G0, Q86XH1, Q8BUR4, Q8BWR8, Q8C3J5, Q8CDK3, Q8CIM8, Q8IUC4, Q8IWV7, Q8T773, Q92608

Diamond homologs: A2VDN5, A6H690, A6NCM1, A8IHT2, A8QFF6, A8XV40, B2RYN7, B3M301, B3P8A3, B4G437, B4HGG6, B4JII0, B4K799, B4M0H8, B4NBP4, B4PL32, B4QSF0, B7PXE3, O60058, P40328, Q298L4, Q5HY92, Q5ZK92, Q6AXQ7, Q6AZT2, Q719N1, Q7QBW0, Q86XH1, Q8I0P1, Q9CUL5, Q9ERZ6, Q9QYY8, Q9UBP0, Q6NW58, Q05AS3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
IQCA1	“form complex”	“Nexin-dynein regulatory complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	66
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

5450 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:236331592:A:G	W714R	0.996
2:236331592:A:T	W714R	0.996
2:236363925:C:T	G575E	0.994
2:236363926:C:A	G575W	0.993
2:236363926:C:G	G575R	0.993
2:236363926:C:T	G575R	0.993
2:236392046:A:G	L448P	0.992
2:236497254:C:G	R82P	0.991
2:236488124:C:G	R175P	0.990
2:236497242:A:G	L86P	0.990
2:236363869:C:G	A594P	0.989
2:236363890:C:G	A587P	0.989
2:236338304:C:A	G679W	0.988
2:236344639:G:T	A625D	0.987
2:236324780:A:G	W793R	0.986
2:236324780:A:T	W793R	0.986
2:236363934:A:G	L572P	0.986
2:236344640:C:G	A625P	0.985
2:236363895:A:T	V585D	0.984
2:236338303:C:T	G679E	0.983
2:236465526:C:G	R302P	0.983
2:236344618:A:T	V632E	0.982
2:236344587:G:C	F642L	0.981
2:236344587:G:T	F642L	0.981
2:236344589:A:G	F642L	0.981
2:236338288:G:T	P684H	0.980
2:236363925:C:A	G575V	0.980
2:236338312:A:G	L676P	0.979
2:236338225:G:C	P705R	0.978
2:236338304:C:G	G679R	0.978

dbSNP variants (sampled 300 via entrez): RS1000000758 (2:236401732 G>A), RS1000004888 (2:236506175 A>C,G,T), RS1000015202 (2:236312926 C>A), RS1000017138 (2:236453442 C>G), RS1000030593 (2:236402003 A>G), RS1000030912 (2:236375373 C>T), RS1000062105 (2:236352344 G>A), RS1000101127 (2:236498333 C>T), RS1000101711 (2:236442998 C>G,T), RS1000122088 (2:236409617 T>C), RS1000133788 (2:236348021 A>G), RS1000150009 (2:236367660 C>T), RS1000160343 (2:236490807 G>A), RS1000195973 (2:236462603 G>A), RS1000212399 (2:236395693 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST000635_22	Response to statin therapy	2.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	7
methylmercuric chloride	decreases expression	2
methacrylaldehyde	increases abundance, affects cotreatment, decreases expression	2
Panobinostat	affects cotreatment, increases expression	2
Acrolein	affects cotreatment, decreases expression, increases abundance	2
Ozone	decreases expression, increases abundance, affects cotreatment	2
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	increases expression	1
trichostatin A	increases expression	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	decreases methylation, increases methylation	1
aflatoxin B2	decreases methylation	1
CGP 52608	affects binding, increases reaction	1
entinostat	increases expression, affects cotreatment	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	affects methylation	1
Sunitinib	decreases expression	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	affects cotreatment, increases expression	1
Methapyrilene	decreases methylation, increases methylation	1
Rifampin	decreases expression	1
Testosterone	affects cotreatment, increases expression, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Vanadates	decreases expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Lithium Chloride	increases expression	1
Volatile Organic Compounds	decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.