DRC11L

Summary

DRC11L (dynein regulatory complex subunit 11 like, HGNC:22831) is a protein-coding gene on chromosome 7q36.1, encoding Dynein regulatory complex subunit like-11 (A6NCM1).

Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in microtubule cytoskeleton organization.

Source: NCBI Gene 392843 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001304419

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22831
Approved symbol	DRC11L
Name	dynein regulatory complex subunit 11 like
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Aliases	TCAG_9762
Ensembl gene	ENSG00000278685
Ensembl biotype	protein_coding
Entrez	392843

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 nonsense_mediated_decay, 1 protein_coding

ENST00000611102, ENST00000613681, ENST00000615129

RefSeq mRNA: 1 — MANE Select: NM_001304419 NM_001304419

CCDS: CCDS78288

Canonical transcript exons

ENST00000615129 — 19 exons

Exon	Start	End
ENSE00001602946	151205444	151205496
ENSE00001775321	151204509	151204836
ENSE00003227856	151203395	151203514
ENSE00003715064	151193291	151193490
ENSE00003715120	151200383	151200454
ENSE00003715891	151195575	151195658
ENSE00003720034	151202911	151203096
ENSE00003720841	151192743	151192829
ENSE00003722459	151190873	151191087
ENSE00003723255	151192276	151192453
ENSE00003724583	151196448	151196554
ENSE00003727457	151195430	151195485
ENSE00003728912	151196977	151197052
ENSE00003730627	151194256	151194363
ENSE00003731810	151198798	151199003
ENSE00003734945	151197205	151197327
ENSE00003739402	151194516	151194598
ENSE00003740583	151191638	151191876
ENSE00003749559	151197822	151197906

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 82.58.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.58	silver quality
left testis	UBERON:0004533	76.90	gold quality
right testis	UBERON:0004534	76.37	gold quality
testis	UBERON:0000473	76.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.80	gold quality
sural nerve	UBERON:0015488	55.91	gold quality
skeletal muscle tissue	UBERON:0001134	52.64	gold quality
muscle of leg	UBERON:0001383	50.30	gold quality
gastrocnemius	UBERON:0001388	49.62	gold quality
muscle tissue	UBERON:0002385	47.44	gold quality
hindlimb stylopod muscle	UBERON:0004252	45.45	gold quality
right coronary artery	UBERON:0001625	43.76	gold quality
bone marrow cell	CL:0002092	41.72	gold quality
ganglionic eminence	UBERON:0004023	40.59	gold quality
popliteal artery	UBERON:0002250	38.89	silver quality
tibial artery	UBERON:0007610	38.86	silver quality
ascending aorta	UBERON:0001496	38.42	gold quality
thoracic aorta	UBERON:0001515	38.22	silver quality
left uterine tube	UBERON:0001303	38.19	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
omental fat pad	UBERON:0010414	36.89	gold quality
mucosa of stomach	UBERON:0001199	36.74	silver quality
adipose tissue	UBERON:0001013	36.58	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	36.31	silver quality
granulocyte	CL:0000094	36.11	gold quality
right ovary	UBERON:0002118	35.81	silver quality
prefrontal cortex	UBERON:0000451	35.78	gold quality
tibial nerve	UBERON:0001323	35.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.11

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

5 targeting DRC11L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3187-5P	98.36	65.74	1776
HSA-MIR-1285-3P	97.72	67.02	1932
HSA-MIR-5189-5P	97.72	66.96	1814
HSA-MIR-612	97.26	65.95	1597
HSA-MIR-6860	97.21	66.31	1656

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Iqca1l	ENSMUSG00000038199
rattus_norvegicus	Iqca1l	ENSRNOG00000011092
drosophila_melanogaster	CG14183	FBGN0036931
drosophila_melanogaster	CG16789	FBGN0037712

Paralogs (1): IQCA1 (ENSG00000132321)

Protein

Protein identifiers

Dynein regulatory complex subunit like-11 — A6NCM1 (reviewed: A6NCM1)

Alternative names: IQ and AAA domain-containing protein 1 pseudogene 1, IQ and AAA domain-containing protein 1-like

All UniProt accessions (3): A6NCM1, A0A087WVA7, A0A087X1I9

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the AAA ATPase family.

RefSeq proteins (1): NP_001291348* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000048	IQ_motif_EF-hand-BS	Binding_site
IPR003959	ATPase_AAA_core	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR052267	N-DRC_Component	Family

Pfam: PF00004, PF00612

UniProt features (8 total): region of interest 3, compositionally biased region 2, chain 1, domain 1, binding site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NCM1-F1	81.58	0.41

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 567–574

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 16 (showing top): GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES, GOMF_MICROTUBULE_SEVERING_ATPASE_ACTIVITY, GOMF_ATP_HYDROLYSIS_ACTIVITY, GOMF_ADENYL_NUCLEOTIDE_BINDING, GOMF_ISOMERASE_ACTIVITY, MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED, GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION, GOBP_MICROTUBULE_SEVERING, GOMF_ATP_DEPENDENT_ACTIVITY, GOMF_PROTEIN_CONTAINING_COMPLEX_DESTABILIZING_ACTIVITY, GOBP_MICROTUBULE_BASED_PROCESS, GOMF_MACROMOLECULAR_CONFORMATION_ISOMERASE_ACTIVITY, GOMF_POLYPEPTIDE_CONFORMATION_OR_ASSEMBLY_ISOMERASE_ACTIVITY, GOMF_PURINE_NUCLEOTIDE_BINDING, GOBP_CYTOSKELETON_ORGANIZATION

GO Biological Process (1): microtubule severing (GO:0051013)

GO Molecular Function (5): ATP binding (GO:0005524), microtubule severing ATPase activity (GO:0008568), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
microtubule cytoskeleton organization	2
ATP-dependent activity	2
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
polypeptide conformation or assembly isomerase activity	1
catalytic activity, acting on a protein	1
microtubule destabilizing activity	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1323 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DRC11L	ENTREP2	O60320	606
DRC11L	C7orf33	Q8WU49	570
DRC11L	GBX1	Q14549	543
DRC11L	A0A087WTJ2	A0A087WTJ2	511
DRC11L	RNF212	Q495C1	508
DRC11L	ZNF425	Q6IV72	481
DRC11L	ZBED10P	Q96FA7	480
DRC11L	ASB10	Q8WXI3	480
DRC11L	ZNF786	Q8N393	479
DRC11L	LRRC61	Q9BV99	476
DRC11L	LRRC14B	A6NHZ5	475
DRC11L	ZNF783	Q6ZMS7	475
DRC11L	WDR86	Q86TI4	469
DRC11L	KRABD3	A5PL33	448
DRC11L	ZNF775	Q96BV0	445

IntAct

3 interactions, top by confidence:

A	B	Type	Score
IQCA1L	RPL4	psi-mi:“MI:0915”(physical association)	0.400
IQCA1L	H1-5	psi-mi:“MI:0915”(physical association)	0.400

ESM2 similar proteins: A0AVI2, A0FGR9, A3KGK3, A6NCM1, A6QQP7, B0DOB4, B3DLH6, B7FF09, B7ZC32, D3ZGS3, F1S5L4, O00329, O35904, O70145, O75923, P0DM40, P32019, P58069, P97564, Q0VA04, Q15283, Q17I16, Q1LXZ7, Q2WGJ9, Q32PH0, Q5DTI8, Q5GJ77, Q5RE88, Q5T0N1, Q5XIZ9, Q61586, Q62240, Q63713, Q69ZN7, Q6DCF6, Q6P5U7, Q6PA97, Q86VS3, Q86YR7, Q8BWR4

Diamond homologs: A2VDN5, A6H690, A6NCM1, A8IHT2, A8QFF6, A8XV40, B2RYN7, B3M301, B3P8A3, B4G437, B4HGG6, B4JII0, B4K799, B4M0H8, B4NBP4, B4PL32, B4QSF0, B7PXE3, O60058, P40328, Q298L4, Q5HY92, Q5ZK92, Q6AXQ7, Q6AZT2, Q719N1, Q7QBW0, Q86XH1, Q8I0P1, Q9CUL5, Q9ERZ6, Q9QYY8, Q9UBP0, Q6NW58, Q05AS3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3981 predictions. Top by Δscore:

Variant	Effect	Δscore
7:151191632:CCTCA:C	donor_loss	1.0000
7:151191633:CTCAC:C	donor_loss	1.0000
7:151191636:ACCT:A	donor_loss	1.0000
7:151191637:CCTTC:C	donor_loss	1.0000
7:151191658:C:A	donor_gain	1.0000
7:151191875:CA:C	acceptor_gain	1.0000
7:151191885:A:C	acceptor_gain	1.0000
7:151192454:C:CC	acceptor_gain	1.0000
7:151192460:C:CT	acceptor_gain	1.0000
7:151192461:A:T	acceptor_gain	1.0000
7:151192736:C:CA	donor_gain	1.0000
7:151192737:CCTCA:C	donor_loss	1.0000
7:151192738:CTCAC:C	donor_loss	1.0000
7:151192740:CA:C	donor_loss	1.0000
7:151192741:ACCT:A	donor_gain	1.0000
7:151192742:CCT:C	donor_gain	1.0000
7:151192742:CCTC:C	donor_gain	1.0000
7:151192744:T:TA	donor_gain	1.0000
7:151192826:CTAC:C	acceptor_gain	1.0000
7:151192827:TAC:T	acceptor_gain	1.0000
7:151192830:C:CC	acceptor_gain	1.0000
7:151192830:CTGG:C	acceptor_loss	1.0000
7:151192831:T:C	acceptor_loss	1.0000
7:151192834:A:AC	acceptor_gain	1.0000
7:151192834:A:C	acceptor_gain	1.0000
7:151192840:C:CT	acceptor_gain	1.0000
7:151192841:A:T	acceptor_gain	1.0000
7:151193326:T:TA	donor_gain	1.0000
7:151195569:T:C	donor_gain	1.0000
7:151195600:T:TA	donor_gain	1.0000

AlphaMissense

5332 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:151191871:A:G	W706R	0.990
7:151191871:A:T	W706R	0.990
7:151192375:C:A	G671W	0.988
7:151193445:A:G	L564P	0.987
7:151192374:C:T	G671E	0.983
7:151192825:G:T	A617D	0.982
7:151192804:A:T	V624E	0.980
7:151196455:C:G	R436P	0.980
7:151191084:A:G	W785R	0.978
7:151191084:A:T	W785R	0.978
7:151195633:A:G	L447P	0.978
7:151204588:A:G	L87P	0.978
7:151193406:A:T	V577D	0.977
7:151191799:A:G	S730P	0.976
7:151192281:C:G	R702P	0.974
7:151192773:G:C	F634L	0.974
7:151192773:G:T	F634L	0.974
7:151192775:A:G	F634L	0.974
7:151193380:C:G	A586P	0.974
7:151193401:C:G	A579P	0.974
7:151198819:C:G	R301P	0.974
7:151197888:G:C	F314L	0.973
7:151197888:G:T	F314L	0.973
7:151197890:A:G	F314L	0.973
7:151198814:A:G	W303R	0.973
7:151198814:A:T	W303R	0.973
7:151204600:C:G	R83P	0.973
7:151192425:A:G	L654P	0.972
7:151192826:C:G	A617P	0.972
7:151192801:A:T	I625N	0.971

dbSNP variants (sampled 300 via entrez): RS1000368595 (7:151205940 G>C), RS1000468077 (7:151193666 C>G,T), RS1000615188 (7:151202653 A>G), RS1000641011 (7:151200113 T>C), RS1000682003 (7:151203929 G>A), RS1000692874 (7:151195528 G>A,C), RS1000753923 (7:151190411 A>G), RS1001166174 (7:151199295 C>G,T), RS1001243785 (7:151194261 C>T), RS1001245913 (7:151199117 C>T), RS1001344508 (7:151204924 C>T), RS1001375598 (7:151204685 G>A,C), RS1001523384 (7:151197203 AC>A), RS1001694827 (7:151194776 G>C), RS1001694848 (7:151194465 C>A,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST012256_5	SAPHO syndrome	4.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.