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DRGX

gene
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Also known as DRG11

Summary

DRGX (dorsal root ganglia homeobox, HGNC:21536) is a protein-coding gene on chromosome 10q11.23, encoding Dorsal root ganglia homeobox protein (A6NNA5). Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in chromatin.

Source: NCBI Gene 644168 — RefSeq curated summary.

At a glance

  • GWAS associations: 1
  • Clinical variants (ClinVar): 4 total
  • MANE Select transcript: NM_001276451

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:21536
Approved symbolDRGX
Namedorsal root ganglia homeobox
Location10q11.23
Locus typegene with protein product
StatusApproved
AliasesDRG11
Ensembl geneENSG00000165606
Ensembl biotypeprotein_coding
OMIM606701
Entrez644168

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000374139, ENST00000891545, ENST00000967011

RefSeq mRNA: 1 — MANE Select: NM_001276451 NM_001276451

CCDS: CCDS44388

Canonical transcript exons

ENST00000374139 — 7 exons

ExonStartEnd
ENSE000010945864938668049386858
ENSE000010945874938647849386590
ENSE000010945894939013349390234
ENSE000011896924939116449391261
ENSE000014625694936406649366381
ENSE000037534914939540749395521
ENSE000037538944939593549396089

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 77.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3583 / max 428.4960, expressed in 48 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter IDTPM avgSamples expressed
1093310.358348

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047377.34silver quality
superior frontal gyrusUBERON:000266160.94gold quality
prefrontal cortexUBERON:000045159.30gold quality
Brodmann (1909) area 9UBERON:001354059.09gold quality
dorsolateral prefrontal cortexUBERON:000983458.76gold quality
frontal cortexUBERON:000187058.68gold quality
right frontal lobeUBERON:000281057.57gold quality
cerebral cortexUBERON:000095653.00gold quality
rectumUBERON:000105248.38gold quality
vermiform appendixUBERON:000115448.24gold quality
C1 segment of cervical spinal cordUBERON:000646948.17gold quality
anterior cingulate cortexUBERON:000983547.37gold quality
right adrenal glandUBERON:000123346.23gold quality
endometriumUBERON:000129546.17gold quality
bone marrowUBERON:000237144.79gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099144.73silver quality
primary visual cortexUBERON:000243643.03silver quality
skin of legUBERON:000151142.83gold quality
adrenal glandUBERON:000236942.66gold quality
bone marrow cellCL:000209241.99gold quality
left adrenal gland cortexUBERON:003582541.43gold quality
brainUBERON:000095541.15gold quality
colonic epitheliumUBERON:000039741.14gold quality
zone of skinUBERON:000001440.65gold quality
lower esophagus mucosaUBERON:003583440.20silver quality
left adrenal glandUBERON:000123440.08gold quality
gall bladderUBERON:000211039.49silver quality
pituitary glandUBERON:000000739.36gold quality
mucosa of transverse colonUBERON:000499139.24silver quality
right hemisphere of cerebellumUBERON:001489038.62gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no2.12

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

TargetRegulation
DRGX
RGMBUnknown

JASPAR motifs

MotifNameFamily
MA1481.1DRGXPaired-related HD factors
MA1481.2DRGXPaired-related HD factors
MA1940.1ETV2::DRGXEts-related::Paired-related HD factors
MA1940.2ETV2::DRGXEts-related::Paired-related HD factors
MA1944.1ETV5::DRGXEts-related::Paired-related HD factors
MA1944.2ETV5::DRGXEts-related::Paired-related HD factors
MA1949.1FLI1::DRGXPaired-related HD factors::Ets-related
MA1949.2FLI1::DRGXPaired-related HD factors::Ets-related

JASPAR matrix evidence (PMIDs): PMID:25131932, PMID:24218641

Upstream regulators (CollecTRI, top): DRGX

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriodrgxENSDARG00000069329
mus_musculusDrgxENSMUSG00000041730
rattus_norvegicusDrgxENSRNOG00000020045

Paralogs (50): ARX (ENSG00000004848), PAX6 (ENSG00000007372), PAX7 (ENSG00000009709), ALX4 (ENSG00000052850), GSC2 (ENSG00000063515), PITX1 (ENSG00000069011), PAX2 (ENSG00000075891), RHOXF1 (ENSG00000101883), CRX (ENSG00000105392), EVX1 (ENSG00000106038), PAX4 (ENSG00000106331), NOBOX (ENSG00000106410), PITX3 (ENSG00000107859), PHOX2B (ENSG00000109132), OTX1 (ENSG00000115507), PRRX1 (ENSG00000116132), VSX2 (ENSG00000119614), ESX1 (ENSG00000123576), PAX8 (ENSG00000125618), PAX1 (ENSG00000125813), RHOXF2 (ENSG00000131721), GSC (ENSG00000133937), RAX (ENSG00000134438), PAX3 (ENSG00000135903), ALX3 (ENSG00000156150), HESX1 (ENSG00000163666), PITX2 (ENSG00000164093), UNCX (ENSG00000164853), PHOX2A (ENSG00000165462), OTX2 (ENSG00000165588), PRRX2 (ENSG00000167157), SHOX2 (ENSG00000168779), OTP (ENSG00000171540), RAX2 (ENSG00000173976), EVX2 (ENSG00000174279), PROP1 (ENSG00000175325), ISX (ENSG00000175329), ALX1 (ENSG00000180318), MIXL1 (ENSG00000185155), SHOX (ENSG00000185960)

Protein

Protein identifiers

Dorsal root ganglia homeobox protein — A6NNA5 (reviewed: A6NNA5)

Alternative names: Paired-related homeobox protein-like 1

All UniProt accessions (1): A6NNA5

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

Subunit / interactions. Interacts with RGMB.

Subcellular location. Nucleus.

Similarity. Belongs to the paired homeobox family.

RefSeq proteins (1): NP_001263380* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001356HDDomain
IPR003654OAR_domDomain
IPR009057Homeodomain-like_sfHomologous_superfamily
IPR017970Homeobox_CSConserved_site
IPR050649Paired_Homeobox_TFsFamily

Pfam: PF00046, PF03826

UniProt features (9 total): compositionally biased region 4, region of interest 2, chain 1, DNA-binding region 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-A6NNA5-F167.750.24

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 60 (showing top): GOBP_SPINAL_CORD_DEVELOPMENT, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GOBP_NEUROGENESIS, GOBP_CRANIAL_NERVE_DEVELOPMENT, GOBP_DETECTION_OF_TEMPERATURE_STIMULUS, GOBP_NERVE_DEVELOPMENT, GOBP_NEURON_MIGRATION, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_DETECTION_OF_ABIOTIC_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOBP_CELL_PROJECTION_ORGANIZATION, GOBP_DORSAL_SPINAL_CORD_DEVELOPMENT, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED

GO Biological Process (13): neuron migration (GO:0001764), regulation of transcription by RNA polymerase II (GO:0006357), axon guidance (GO:0007411), detection of chemical stimulus (GO:0009593), detection of temperature stimulus (GO:0016048), dorsal spinal cord development (GO:0021516), trigeminal nerve development (GO:0021559), neuron development (GO:0048666), sensory perception of mechanical stimulus (GO:0050954), regulation of DNA-templated transcription (GO:0006355), nervous system development (GO:0007399), axonogenesis (GO:0007409), neuron differentiation (GO:0030182)

GO Molecular Function (4): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
generation of neurons2
cell migration1
regulation of DNA-templated transcription1
transcription by RNA polymerase II1
axonogenesis1
neuron projection guidance1
response to chemical1
detection of stimulus1
response to temperature stimulus1
detection of external stimulus1
detection of abiotic stimulus1
spinal cord development1
anatomical structure development1
cranial nerve development1
neuron differentiation1
cell development1
sensory perception1
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
system development1
cell morphogenesis involved in neuron differentiation1
neuron projection morphogenesis1
axon development1
cell differentiation1
transcription cis-regulatory region binding1
chromatin1
RNA polymerase II transcription regulatory region sequence-specific DNA binding1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
double-stranded DNA binding1
sequence-specific DNA binding1
nucleic acid binding1
chromosome1
cellular anatomical structure1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

566 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
DRGXRGMBQ6NW40878
DRGXRGMAQ96B86861
DRGXHJVQ6ZVN8651
DRGXERCC6Q03468583
DRGXPRDM12Q9H4Q4575
DRGXPOU4F1Q01851491
DRGXNGFP01138426
DRGXNOGQ13253425
DRGXBMP4P12644421
DRGXBMP2P12643409
DRGXTPRX1Q8N7U7403
DRGXE2F3O00716390
DRGXLRRC18Q8N456383
DRGXZMAT1Q5H9K5379
DRGXSKOR2Q2VWA4379

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1W2PPF3, A1A546, A1YGA4, A2T779, A2T7T2, A5YC49, A6NFQ7, A6NMT0, A6NNA5, F1Q4R9, O08686, O42173, O42358, P17278, P17482, P20615, P31272, P43688, P52950, P70368, P70436, P97436, P97458, Q01703, Q28ET4, Q2M1V0, Q3LU38, Q3LU39, Q3LU40, Q5NSW5, Q5TIS6, Q5TM83, Q61658, Q62798, Q80Z64, Q8BYH0, Q8JJ26, Q8MJI9, Q91926, Q92988

Diamond homologs: A0A1W2PPF3, A1YEY5, A1YFI3, A1YG57, A2T733, A2T7P4, A6NLW8, A6NNA5, F1NEA7, G5EBU4, G5EDS1, O18381, O35137, O35160, O42250, O43186, O43316, O43812, O54751, O70137, O73917, O75360, O75364, O95076, P09088, P0CJ85, P0CJ86, P0CJ87, P0CJ88, P0CJ89, P0CJ90, P21711, P22810, P26367, P26630, P29454, P32242, P32243, P34764, P34765

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance2
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1165 predictions. Top by Δscore:

VariantEffectΔscore
10:49386586:CCAGG:Cacceptor_gain1.0000
10:49386587:CAGGC:Cacceptor_gain1.0000
10:49386676:TCA:Tdonor_loss1.0000
10:49386679:C:CTdonor_loss1.0000
10:49386679:CCT:Cdonor_gain1.0000
10:49388959:AC:Adonor_gain1.0000
10:49388960:CC:Cdonor_gain1.0000
10:49390127:GTTTA:Gdonor_loss1.0000
10:49390128:TTTAC:Tdonor_loss1.0000
10:49390129:TTAC:Tdonor_loss1.0000
10:49390130:TACCT:Tdonor_loss1.0000
10:49390131:A:ATdonor_loss1.0000
10:49390231:CCAG:Cacceptor_gain1.0000
10:49390232:CAG:Cacceptor_gain1.0000
10:49390232:CAGC:Cacceptor_gain1.0000
10:49390235:C:CCacceptor_gain1.0000
10:49390238:G:Cacceptor_gain1.0000
10:49390238:G:GCacceptor_gain1.0000
10:49366378:CCCC:Cacceptor_gain0.9900
10:49366379:CCC:Cacceptor_gain0.9900
10:49366379:CCCC:Cacceptor_gain0.9900
10:49366380:CC:Cacceptor_gain0.9900
10:49366380:CCC:Cacceptor_gain0.9900
10:49366381:CC:Cacceptor_gain0.9900
10:49386587:CAGG:Cacceptor_gain0.9900
10:49386589:GG:Gacceptor_gain0.9900
10:49386591:C:CCacceptor_gain0.9900
10:49386701:T:TAdonor_gain0.9900
10:49386709:A:ACdonor_gain0.9900
10:49386710:C:CCdonor_gain0.9900

AlphaMissense

1707 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
10:49366282:A:GL209P1.000
10:49386826:C:AR89S1.000
10:49386826:C:GR89S1.000
10:49386827:C:AR89M1.000
10:49386827:C:GR89T1.000
10:49386832:T:AK87N1.000
10:49386832:T:GK87N1.000
10:49386833:T:AK87I1.000
10:49386834:T:CK87E1.000
10:49386836:G:TA86D1.000
10:49386837:C:GA86P1.000
10:49386838:C:AR85S1.000
10:49386838:C:GR85S1.000
10:49386839:C:AR85M1.000
10:49386839:C:GR85T1.000
10:49386840:T:CR85G1.000
10:49386841:T:AR84S1.000
10:49386841:T:GR84S1.000
10:49386842:C:AR84I1.000
10:49386842:C:GR84T1.000
10:49386843:T:CR84G1.000
10:49386844:G:CN83K1.000
10:49386844:G:TN83K1.000
10:49386845:T:AN83I1.000
10:49386845:T:CN83S1.000
10:49386845:T:GN83T1.000
10:49386846:T:CN83D1.000
10:49386846:T:GN83H1.000
10:49386847:C:AQ82H1.000
10:49386847:C:GQ82H1.000

dbSNP variants (sampled 300 via entrez): RS1000092203 (10:49394607 C>T), RS1000113564 (10:49394888 G>A,T), RS1000136808 (10:49379116 CA>C,CAA), RS1000184475 (10:49368280 G>A), RS1000223513 (10:49388503 A>C), RS1000281866 (10:49383187 C>T), RS1000486017 (10:49378845 G>A), RS1000509674 (10:49378537 C>T), RS1000635172 (10:49372690 C>A), RS1000728317 (10:49372953 G>A), RS1000887736 (10:49383573 T>C), RS1000909349 (10:49389336 A>G), RS1000943126 (10:49378785 A>G), RS1001134511 (10:49393444 T>C), RS1001183153 (10:49369210 T>G)

Disease associations

OMIM: gene MIM:606701 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

StudyTraitp-value
GCST001371_12Inflammatory biomarkers1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyrenedecreases expression, increases methylation2
methyleugenoldecreases expression1
propionaldehydedecreases expression1
aflatoxin B2increases methylation1
tebuconazoledecreases expression1
Fulvestrantincreases methylation1
Arsenicaffects methylation1
Rotenonedecreases expression1
Smokeincreases expression1
1-Methyl-4-phenylpyridiniumdecreases expression1
Okadaic Aciddecreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot