DSCAM-AS1

Summary

DSCAM-AS1 (DSCAM antisense RNA 1, HGNC:40197) is a long non-coding RNA gene on chromosome 21q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40197
Approved symbol	DSCAM-AS1
Name	DSCAM antisense RNA 1
Location	21q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	M41
Ensembl gene	ENSG00000235123
Ensembl biotype	lncRNA
Entrez	100506492
RNAcentral	URS000054C6DF — lncRNA, 1640 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000422749, ENST00000427451, ENST00000444046, ENST00000455354, ENST00000763137, ENST00000763138, ENST00000763139, ENST00000763140, ENST00000763141, ENST00000763142, ENST00000763143, ENST00000763144, ENST00000763145

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422749 — 3 exons

Exon	Start	End
ENSE00001602383	40383506	40383584
ENSE00004118941	40384579	40385439
ENSE00004118948	40383029	40383408

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 59.36.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8559 / max 70.6980, expressed in 97 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189199	0.2636	92
189200	0.2062	87
189197	0.1767	90
189198	0.1107	67
189201	0.0986	63

Top tissues by expression

162 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	59.36	gold quality
calcaneal tendon	UBERON:0003701	57.20	gold quality
prostate gland	UBERON:0002367	57.15	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.33	silver quality
skin of hip	UBERON:0001554	54.06	silver quality
monocyte	CL:0000576	52.05	silver quality
tibial nerve	UBERON:0001323	51.41	gold quality
minor salivary gland	UBERON:0001830	50.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	50.53	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.98	gold quality
upper leg skin	UBERON:0004262	49.34	gold quality
muscle of leg	UBERON:0001383	48.16	silver quality
islet of Langerhans	UBERON:0000006	46.32	silver quality
prefrontal cortex	UBERON:0000451	46.08	silver quality
vermiform appendix	UBERON:0001154	46.00	silver quality
gastrocnemius	UBERON:0001388	45.33	silver quality
ectocervix	UBERON:0012249	45.02	gold quality
mouth mucosa	UBERON:0003729	44.90	gold quality
nasal cavity mucosa	UBERON:0001826	44.71	gold quality
saliva-secreting gland	UBERON:0001044	44.56	gold quality
skin of leg	UBERON:0001511	44.47	silver quality
endocervix	UBERON:0000458	44.23	silver quality
tibial artery	UBERON:0007610	43.41	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
blood	UBERON:0000178	43.29	gold quality
lymph node	UBERON:0000029	43.22	silver quality
adrenal gland	UBERON:0002369	43.00	gold quality
putamen	UBERON:0001874	42.73	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
ascending aorta	UBERON:0001496	42.39	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• DSCAM-AS1 is an Unliganded Estrogen Receptor alpha target gene reported to be involved in MCF-7 cell line survival and proliferation. (PMID:26621851)
• By highlighting the role of DSCAM-AS1 in breast cancer biology and treatment resistance, this study provides insight into the potential clinical implications of lncRNAs in breast cancer. (PMID:27666543)
• LncRNA DSCAM-AS1 acts as a competing endogenous RNA of miR-137 and regulates EPS8 to promote cell reproduction and suppresses cell apoptosis in Tamoxifen-resistant breast cancer (PMID:30203615)
• Luminal breast cancer patients with high DSCAM-AS1 expression level are inclined to be resistant to endocrine therapy. High expression of DSCAM-AS1 is a poor prognostic factor. Hence, DSCAM-AS1 is a promising clinical therapeutic target that may prolong survival in luminal breast cancer patients treated with endocrine therapy. (PMID:30430768)
• High DSCAM-AS1 expression is associated with breast cancer. (PMID:30457164)
• The significant up-regulation of DSCAM-AS1 in tumoral tissues compared with adjacent non-cancerous tissues provides further evidences for participation of this lncRNA in the pathogenesis of breast cancer. (PMID:30594914)
• We observed that DSCAM-AS1 could enhance non-small cell lung cancer cell migration and invasion via upregulating BCL11A. (PMID:30779076)
• Long noncoding RNA DSCAM-AS1 is associated with poor clinical prognosis and contributes to melanoma development by sponging miR-136. (PMID:31002140)
• Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression. (PMID:32379981)
• LncRNA DSCAM-AS1 promotes non-small cell lung cancer progression via regulating miR-577/HMGB1 axis. (PMID:32386483)
• Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT. (PMID:32716908)
• LncRNA DSCAM-AS1 promoted cell proliferation and invasion in osteosarcoma by sponging miR-101. (PMID:32744697)
• DSCAM-AS1 accelerates cell proliferation and migration in osteosarcoma through miR-186-5p/GPRC5A signaling. (PMID:32865178)
• LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. (PMID:32929382)
• Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma. (PMID:33012018)
• The clinical significance of circulating DSCAM-AS1 in patients with ER-positive breast cancer and construction of its competitive endogenous RNA network. (PMID:33040318)
• Long non-coding RNA (lncRNA) DSCAM-AS1 is upregulated in breast cancer. (PMID:33554879)
• Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis. (PMID:35142595)
• DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p. (PMID:35378649)
• LncRNA DSCAM-AS1 Negatively Interacts with miR-124 to Promote Hepatocellular Carcinoma Proliferation. (PMID:35695605)
• LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer. (PMID:35996247)
• METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis. (PMID:38833042)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.