DSCR4

Summary

DSCR4 (Down syndrome critical region 4, HGNC:3045) is a long non-coding RNA gene on chromosome 21q22.13.

The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus.

Source: NCBI Gene 10281 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:3045
Approved symbol	DSCR4
Name	Down syndrome critical region 4
Location	21q22.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	DCRB
Ensembl gene	ENSG00000184029
Ensembl biotype	lncRNA
OMIM	604829
Entrez	10281
RNAcentral	URS0000BC43FE — lncRNA, 1114 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000328264, ENST00000398948, ENST00000482032

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000328264 — 3 exons

Exon	Start	End
ENSE00001302780	38120307	38120408
ENSE00001329903	38054011	38054773
ENSE00001535700	38121128	38121360

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 90.95.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0710 / max 13.4987, expressed in 45 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190423	1.6143	111
190422	0.0710	45

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	90.95	gold quality
vastus lateralis	UBERON:0001379	87.18	gold quality
quadriceps femoris	UBERON:0001377	86.97	gold quality
metanephric glomerulus	UBERON:0004736	85.37	gold quality
saliva-secreting gland	UBERON:0001044	83.18	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.06	gold quality
layer of synovial tissue	UBERON:0007616	81.34	gold quality
endometrium epithelium	UBERON:0004811	80.57	gold quality
cerebellum	UBERON:0002037	79.85	gold quality
anterior cingulate cortex	UBERON:0009835	78.83	gold quality
dorsal plus ventral thalamus	UBERON:0001897	78.27	gold quality
trachea	UBERON:0003126	78.20	gold quality
pituitary gland	UBERON:0000007	77.96	gold quality
corpus callosum	UBERON:0002336	77.03	gold quality
dorsal root ganglion	UBERON:0000044	75.97	gold quality
caudate nucleus	UBERON:0001873	75.26	gold quality
liver	UBERON:0002107	74.79	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.73	gold quality
kidney	UBERON:0002113	74.10	gold quality
primary visual cortex	UBERON:0002436	74.00	gold quality
Brodmann (1909) area 10	UBERON:0013541	73.98	gold quality
superior frontal gyrus	UBERON:0002661	72.88	gold quality
cerebellar vermis	UBERON:0004720	72.69	gold quality
sigmoid colon	UBERON:0001159	72.53	gold quality
lung	UBERON:0002048	71.09	gold quality
frontal pole	UBERON:0002795	70.31	gold quality
paraflocculus	UBERON:0005351	69.99	gold quality
middle frontal gyrus	UBERON:0002702	69.73	gold quality
epithelium of bronchus	UBERON:0002031	69.16	gold quality
thymus	UBERON:0002370	69.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TCF3

Literature-anchored findings (GeneRIF, showing 1)

• transcription of DSCR4 gene is regulated positively by binding of OLF-1-like transcription factor and negatively by binding of E47-like transcription factor (PMID:18086574)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.