DSCR9

Summary

DSCR9 (Down syndrome critical region 9, HGNC:16301) is a long non-coding RNA gene on chromosome 21q22.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16301
Approved symbol	DSCR9
Name	Down syndrome critical region 9
Location	21q22.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00038
Ensembl gene	ENSG00000230366
Ensembl biotype	lncRNA
Entrez	257203
RNAcentral	URS000075A2ED — lncRNA, 1681 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000454482, ENST00000578829, ENST00000581640, ENST00000584840, ENST00000585273, ENST00000715704, ENST00000715705, ENST00000787292, ENST00000787293, ENST00000812251, ENST00000812252

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000454482 — 3 exons

Exon	Start	End
ENSE00001775785	37208654	37208756
ENSE00001786499	37220238	37221736
ENSE00004027640	37208503	37208544

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 86.29.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1006 / max 8.1033, expressed in 44 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189030	0.1006	44

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.29	gold quality
right testis	UBERON:0004534	75.93	gold quality
left testis	UBERON:0004533	75.76	gold quality
testis	UBERON:0000473	75.10	gold quality
skeletal muscle tissue	UBERON:0001134	62.83	gold quality
ventricular zone	UBERON:0003053	60.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.05	gold quality
ganglionic eminence	UBERON:0004023	59.78	gold quality
cortical plate	UBERON:0005343	59.49	gold quality
superior frontal gyrus	UBERON:0002661	55.71	gold quality
prefrontal cortex	UBERON:0000451	55.40	gold quality
islet of Langerhans	UBERON:0000006	55.30	gold quality
granulocyte	CL:0000094	55.16	gold quality
stromal cell of endometrium	CL:0002255	53.54	silver quality
blood	UBERON:0000178	52.61	gold quality
monocyte	CL:0000576	52.57	gold quality
adenohypophysis	UBERON:0002196	52.37	gold quality
pituitary gland	UBERON:0000007	52.25	gold quality
frontal cortex	UBERON:0001870	52.09	gold quality
cerebellum	UBERON:0002037	51.87	gold quality
cerebellar cortex	UBERON:0002129	51.73	gold quality
cerebellar hemisphere	UBERON:0002245	51.66	gold quality
bone marrow	UBERON:0002371	51.61	gold quality
muscle of leg	UBERON:0001383	51.45	gold quality
primary visual cortex	UBERON:0002436	51.34	gold quality
nucleus accumbens	UBERON:0001882	51.10	gold quality
vermiform appendix	UBERON:0001154	50.96	gold quality
gastrocnemius	UBERON:0001388	50.66	gold quality
lymph node	UBERON:0000029	50.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	50.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.72

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• DSCR9 was highly correlated with genes that were known as important factors in the developments and functions of nervous system, indicating that DSCR9 may regulate neurological proteins regarding Down syndrome and other neurological-related diseases (PMID:29351810)
• DSCR9/miR-21-5p axis inhibits pancreatic cancer proliferation and resistance to gemcitabine via BTG2 signaling. (PMID:36789695)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.