DSN1

Summary

DSN1 (DSN1 component of MIS12 kinetochore complex, HGNC:16165) is a protein-coding gene on chromosome 20q11.23, encoding Kinetochore-associated protein DSN1 homolog (Q9H410). Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. It is a selective cancer dependency (DepMap: 89.5% of cell lines).

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 79980 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 57 total
• Cancer dependency (DepMap): dependent in 89.5% of screened cell lines
• MANE Select transcript: NM_001145315

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16165
Approved symbol	DSN1
Name	DSN1 component of MIS12 kinetochore complex
Location	20q11.23
Locus type	gene with protein product
Status	Approved
Aliases	dJ469A13.2, MIS13, KNL3, hKNL-3
Ensembl gene	ENSG00000149636
Ensembl biotype	protein_coding
OMIM	609175
Entrez	79980

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 27 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000373734, ENST00000373740, ENST00000373750, ENST00000426836, ENST00000438549, ENST00000447406, ENST00000448110, ENST00000473615, ENST00000480153, ENST00000492703, ENST00000863304, ENST00000863305, ENST00000863306, ENST00000863307, ENST00000863308, ENST00000863309, ENST00000925982, ENST00000925983, ENST00000925984, ENST00000925985, ENST00000925986, ENST00000925987, ENST00000925988, ENST00000925989, ENST00000925990, ENST00000925991, ENST00000925992, ENST00000925993, ENST00000963378, ENST00000963379

RefSeq mRNA: 5 — MANE Select: NM_001145315 NM_001145315, NM_001145316, NM_001145317, NM_001145318, NM_024918

CCDS: CCDS13286, CCDS46596, CCDS46597

Canonical transcript exons

ENST00000373750 — 11 exons

Exon	Start	End
ENSE00001889455	36773662	36773763
ENSE00003460215	36767969	36768042
ENSE00003500393	36766769	36766841
ENSE00003508637	36762461	36762548
ENSE00003525551	36755682	36755829
ENSE00003526723	36754763	36754850
ENSE00003558030	36771425	36771473
ENSE00003575420	36770873	36771193
ENSE00003612406	36758558	36758617
ENSE00003686269	36751795	36752897
ENSE00003784063	36758087	36758161

Expression profiles

Bgee: expression breadth ubiquitous, 209 present calls, max score 93.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.0521 / max 110.7990, expressed in 1752 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
187141	12.0521	1752

Top tissues by expression

267 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.90	gold quality
ventricular zone	UBERON:0003053	91.44	gold quality
right testis	UBERON:0004534	88.77	gold quality
secondary oocyte	CL:0000655	88.34	gold quality
left testis	UBERON:0004533	88.28	gold quality
ganglionic eminence	UBERON:0004023	87.00	gold quality
testis	UBERON:0000473	86.53	gold quality
oocyte	CL:0000023	86.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.39	gold quality
rectum	UBERON:0001052	84.27	gold quality
right adrenal gland cortex	UBERON:0035827	83.94	gold quality
adrenal tissue	UBERON:0018303	82.87	gold quality
right adrenal gland	UBERON:0001233	82.63	gold quality
mucosa of transverse colon	UBERON:0004991	82.42	gold quality
left adrenal gland cortex	UBERON:0035825	82.17	gold quality
granulocyte	CL:0000094	81.35	gold quality
left adrenal gland	UBERON:0001234	81.31	gold quality
adrenal cortex	UBERON:0001235	80.72	gold quality
stromal cell of endometrium	CL:0002255	80.65	gold quality
adrenal gland	UBERON:0002369	80.36	gold quality
calcaneal tendon	UBERON:0003701	80.24	gold quality
lymph node	UBERON:0000029	79.76	gold quality
spleen	UBERON:0002106	79.74	gold quality
embryo	UBERON:0000922	79.42	gold quality
descending thoracic aorta	UBERON:0002345	78.89	gold quality
esophagus mucosa	UBERON:0002469	78.81	gold quality
right lung	UBERON:0002167	78.50	gold quality
skin of leg	UBERON:0001511	78.46	gold quality
bone marrow cell	CL:0002092	78.42	gold quality
skin of abdomen	UBERON:0001416	78.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

50 targeting DSN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-1284	99.67	73.56	1353
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-6727-3P	99.49	65.92	1333
HSA-MIR-3123	99.47	67.15	2693

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 89.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• HsMis13 phosphorylation by Aurora B is required for organizing a stable bi-oriented microtubule kinetochore attachment that is essential for faithful chromosome segregation in mitosis. (PMID:18640974)
• this report provides clear evidence that overexpression of the AURKA, SKA3, and DSN1 genes strongly correlates with the progression of colorectal adenomas to colorectal cancer (PMID:27329586)
• DSN1 is overexpressed in hepatocellular carcinoma tissues and strongly associated with poor prognosis. (PMID:30136646)
• Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology. (PMID:33153400)
• DSN1 is a prognostic biomarker and correlated with clinical characterize in breast cancer. (PMID:34238686)
• SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner. (PMID:35509101)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dsn1	ENSDARG00000089922
mus_musculus	Dsn1	ENSMUSG00000027635
rattus_norvegicus	Dsn1	ENSRNOG00000006236

Protein

Protein identifiers

Kinetochore-associated protein DSN1 homolog — Q9H410 (reviewed: Q9H410)

All UniProt accessions (4): Q9H410, Q5JW53, Q5JW54, Q5JW57

UniProt curated annotations — full annotation on UniProt →

Function. Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Subunit / interactions. Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN.

Subcellular location. Nucleus. Chromosome. Centromere. Kinetochore.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9H410-1	1	yes
Q9H410-2	2
Q9H410-4	4
Q9H410-3	3

RefSeq proteins (5): NP_001138787, NP_001138788, NP_001138789, NP_001138790, NP_079194 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013218	Dsn1/Mis13	Family

Pfam: PF08202

UniProt features (31 total): helix 11, modified residue 8, splice variant 3, region of interest 2, compositionally biased region 2, chain 1, cross-link 1, sequence conflict 1, strand 1, turn 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
5LSI	X-RAY DIFFRACTION	2
8PPR	ELECTRON MICROSCOPY	3
5LSJ	X-RAY DIFFRACTION	3.25
5LSK	X-RAY DIFFRACTION	3.5
8Q5H	ELECTRON MICROSCOPY	4.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H410-F1	68.28	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 109, 125, 331, 253, 28, 30, 58, 77, 81

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813	Separation of Sister Chromatids
R-HSA-2500257	Resolution of Sister Chromatid Cohesion
R-HSA-5663220	RHO GTPases Activate Formins
R-HSA-6798695	Neutrophil degranulation
R-HSA-68877	Mitotic Prometaphase
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation

MSigDB gene sets: 151 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE, REACTOME_INNATE_IMMUNE_SYSTEM, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOCC_SECRETORY_GRANULE, GOBP_CHROMOSOME_LOCALIZATION, GOBP_MUSCLE_CELL_PROLIFERATION, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOBP_STRIATED_MUSCLE_CELL_PROLIFERATION, FISCHER_DREAM_TARGETS, chr20q11, ACEVEDO_LIVER_CANCER_UP, GOBP_ORGANELLE_LOCALIZATION, KOBAYASHI_EGFR_SIGNALING_24HR_DN, REACTOME_CELL_CYCLE_CHECKPOINTS

GO Biological Process (4): attachment of spindle microtubules to kinetochore (GO:0008608), skeletal muscle satellite cell proliferation (GO:0014841), cell division (GO:0051301), chromosome segregation (GO:0007059)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (14): MIS12/MIND type complex (GO:0000444), kinetochore (GO:0000776), spindle pole (GO:0000922), outer kinetochore (GO:0000940), fibrillar center (GO:0001650), extracellular region (GO:0005576), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), nuclear body (GO:0016604), azurophil granule lumen (GO:0035578), chromosome, centromeric region (GO:0000775), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Mitotic Prometaphase	2
Amplification of signal from the kinetochores	1
Mitotic Anaphase	1
RHO GTPase Effectors	1
Innate Immune System	1
M Phase	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
intracellular membraneless organelle	4
cell cycle process	2
nuclear lumen	2
microtubule binding	1
metaphase chromosome alignment	1
skeletal muscle cell proliferation	1
cellular process	1
binding	1
outer kinetochore	1
condensed chromosome, centromeric region	1
supramolecular complex	1
spindle	1
kinetochore	1
protein-containing complex	1
nucleolus	1
intracellular membrane-bounded organelle	1
cytoplasm	1
nucleoplasm	1
vacuolar lumen	1
secretory granule lumen	1
azurophil granule	1
chromosomal region	1

Protein interactions and networks

STRING

1801 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DSN1	PMF1	Q6P1K2	998
DSN1	A0A087WT04	A0A087WT04	998
DSN1	NSL1	Q96IY1	987
DSN1	MIS12	Q9H081	984
DSN1	ZWINT	O95229	949
DSN1	KNL1	Q8NG31	948
DSN1	CENPA	P49450	899
DSN1	SPC24	Q8NBT2	899
DSN1	CENPC	Q03188	890
DSN1	CBX5	P45973	888
DSN1	CENPT	Q96BT3	816
DSN1	INCENP	Q9NQS7	807
DSN1	NUF2	Q9BZD4	806
DSN1	CENPI	Q92674	798
DSN1	AURKB	Q96GD4	797

IntAct

132 interactions, top by confidence:

A	B	Type	Score
ZWINT	NDC80	psi-mi:“MI:0914”(association)	0.940
SPC25	NDC80	psi-mi:“MI:0914”(association)	0.940
DSN1	MIS12	psi-mi:“MI:2364”(proximity)	0.930
MIS12	DSN1	psi-mi:“MI:2364”(proximity)	0.930
MIS12	DSN1	psi-mi:“MI:0915”(physical association)	0.930
DSN1	MIS12	psi-mi:“MI:0915”(physical association)	0.930
SPC24	NDC80	psi-mi:“MI:0914”(association)	0.920
DSN1	NSL1	psi-mi:“MI:2364”(proximity)	0.920
NSL1	DSN1	psi-mi:“MI:2364”(proximity)	0.920
NSL1	DSN1	psi-mi:“MI:0915”(physical association)	0.920
DSN1	NSL1	psi-mi:“MI:0915”(physical association)	0.920

BioGRID (233): DSN1 (Affinity Capture-RNA), DSN1 (Affinity Capture-RNA), DSN1 (Affinity Capture-MS), DSN1 (Affinity Capture-MS), DSN1 (Affinity Capture-MS), DSN1 (Affinity Capture-MS), DSN1 (Affinity Capture-MS), RNF20 (Affinity Capture-MS), RNF40 (Affinity Capture-MS), CASC5 (Affinity Capture-MS), SPC25 (Affinity Capture-MS), EXOC7 (Affinity Capture-MS), BRCA2 (Affinity Capture-MS), SPC24 (Affinity Capture-MS), NDC80 (Affinity Capture-MS)

ESM2 similar proteins: A0A0M3U1B0, A0A1L8EYB2, A0JMF7, A1L2Y1, A2ALV5, A9JRX0, B2GUZ2, D3ZSP7, F1QB81, O35892, O70608, O75113, P23497, P70347, Q0P5X5, Q13129, Q16533, Q2T9I9, Q3U1D0, Q5CZC0, Q5H9M0, Q5REF4, Q5RHB5, Q5SW75, Q5T4T6, Q5T5J6, Q5XG69, Q5ZLE9, Q60664, Q63HN8, Q7M6U3, Q7Z4H7, Q80VH0, Q8BVK9, Q8C263, Q8CCC3, Q8NA03, Q90WN7, Q92844, Q96QP1

Diamond homologs: Q9CYC5, Q9H410

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
AURKB	down-regulates	DSN1	phosphorylation
UBR2	“down-regulates quantity”	DSN1	ubiquitination
DSN1	“form complex”	“MIS12 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 84 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Amplification of signal from the kinetochores	9	30.6×	7e-10
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	14	28.1×	2e-14
Mitotic Spindle Checkpoint	9	24.6×	4e-09
EML4 and NUDC in mitotic spindle formation	14	22.4×	1e-13
Resolution of Sister Chromatid Cohesion	14	20.9×	3e-13
RHO GTPases Activate Formins	15	20.1×	9e-14
Cell Cycle Checkpoints	11	16.8×	2e-09
Mitotic Prometaphase	14	16.7×	6e-12

GO biological processes:

GO term	Partners	Fold	FDR
attachment of spindle microtubules to kinetochore	8	101.2×	2e-12
mitotic spindle assembly checkpoint signaling	7	53.1×	9e-09
mitotic sister chromatid segregation	6	39.0×	1e-06
chromosome segregation	8	18.8×	1e-06
cell division	15	9.4×	9e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1526 predictions. Top by Δscore:

Variant	Effect	Δscore
20:36752893:CTTTC:C	acceptor_gain	1.0000
20:36752894:TTTC:T	acceptor_gain	1.0000
20:36752895:TTC:T	acceptor_gain	1.0000
20:36752896:TC:T	acceptor_gain	1.0000
20:36752896:TCCT:T	acceptor_loss	1.0000
20:36752897:CC:C	acceptor_gain	1.0000
20:36752897:CCTGC:C	acceptor_loss	1.0000
20:36752898:C:CA	acceptor_loss	1.0000
20:36752898:C:CC	acceptor_gain	1.0000
20:36754757:GCTTA:G	donor_loss	1.0000
20:36754758:CTTAC:C	donor_loss	1.0000
20:36754759:TTA:T	donor_loss	1.0000
20:36754760:T:TG	donor_loss	1.0000
20:36754761:A:AC	donor_gain	1.0000
20:36754761:ACCGA:A	donor_loss	1.0000
20:36754762:C:CC	donor_gain	1.0000
20:36754762:C:T	donor_loss	1.0000
20:36754762:CCGAG:C	donor_gain	1.0000
20:36754766:G:C	donor_gain	1.0000
20:36754792:TGGG:T	donor_gain	1.0000
20:36754801:T:A	donor_gain	1.0000
20:36754846:TCCAT:T	acceptor_gain	1.0000
20:36754847:CCAT:C	acceptor_gain	1.0000
20:36754847:CCATC:C	acceptor_gain	1.0000
20:36754848:CAT:C	acceptor_gain	1.0000
20:36754848:CATC:C	acceptor_gain	1.0000
20:36754848:CATCT:C	acceptor_loss	1.0000
20:36754849:AT:A	acceptor_gain	1.0000
20:36754849:ATCTG:A	acceptor_loss	1.0000
20:36754850:TC:T	acceptor_loss	1.0000

AlphaMissense

2338 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:36767975:A:C	S141R	0.993
20:36767975:A:T	S141R	0.993
20:36767977:T:G	S141R	0.993
20:36758139:A:G	W225R	0.989
20:36758139:A:T	W225R	0.989
20:36767988:A:G	L137P	0.981
20:36758137:C:A	W225C	0.980
20:36758137:C:G	W225C	0.980
20:36768000:C:G	R133P	0.977
20:36754840:A:G	L295P	0.975
20:36754819:A:G	L302P	0.973
20:36766825:A:G	L149P	0.971
20:36766839:G:C	F144L	0.970
20:36766839:G:T	F144L	0.970
20:36766841:A:G	F144L	0.970
20:36755742:T:A	K271N	0.964
20:36755742:T:G	K271N	0.964
20:36758129:A:G	L228P	0.963
20:36767985:A:G	L138P	0.962
20:36754797:A:C	S309R	0.957
20:36754797:A:T	S309R	0.957
20:36754799:T:G	S309R	0.957
20:36770928:A:C	S100R	0.957
20:36770928:A:T	S100R	0.957
20:36770930:T:G	S100R	0.957
20:36766794:G:C	F159L	0.956
20:36766794:G:T	F159L	0.956
20:36766796:A:G	F159L	0.956
20:36767973:A:G	F142S	0.949
20:36766780:A:G	F164S	0.946

dbSNP variants (sampled 300 via entrez): RS1000191120 (20:36763905 A>AAG), RS1000251492 (20:36762224 A>C), RS1000312909 (20:36768630 G>T), RS1000363646 (20:36760946 G>A,C), RS1000376783 (20:36769003 C>T), RS1000396277 (20:36760765 G>A), RS1000485227 (20:36761904 G>C), RS1000723548 (20:36774556 C>T), RS1000755230 (20:36774276 A>G), RS1000910599 (20:36756547 T>A,C), RS1000982305 (20:36757173 T>A,G), RS1001427832 (20:36753217 G>A,T), RS1001594663 (20:36752510 G>A), RS1001626759 (20:36768519 G>T), RS1001743870 (20:36766963 C>A,G)

Disease associations

OMIM: gene MIM:609175 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007401_21	Factor VII activity	7.000000e-07
GCST009847_9	Hallux valgus	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004619	factor VII measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

52 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
Tetrachlorodibenzodioxin	affects expression, decreases expression	3
Cyclosporine	decreases expression	3
bisphenol A	affects expression, decreases expression	2
Resveratrol	affects cotreatment, increases expression	2
Air Pollutants	affects cotreatment, affects expression, increases abundance, decreases expression	2
Arsenic	increases expression, affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	increases expression, increases mutagenesis	2
Cisplatin	affects cotreatment, increases expression	2
Estradiol	decreases reaction, increases expression, decreases expression	2
Valproic Acid	affects expression, decreases expression	2
FR900359	affects phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
testosterone enanthate	affects expression	1
alpha-pinene	affects cotreatment, affects expression, increases abundance	1
propionaldehyde	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	affects cotreatment, affects expression, increases abundance	1
chromium hexavalent ion	decreases expression, increases abundance	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
incobotulinumtoxinA	decreases expression	1
Dasatinib	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.