DTX3

Summary

DTX3 (deltex E3 ubiquitin ligase 3, HGNC:24457) is a protein-coding gene on chromosome 12q13.3, encoding E3 ubiquitin-protein ligase DTX3 (Q8N9I9). Functions as an ubiquitin ligase protein, and regulates Notch signaling.

DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).

Source: NCBI Gene 196403 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 39 total
• MANE Select transcript: NM_178502

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24457
Approved symbol	DTX3
Name	deltex E3 ubiquitin ligase 3
Location	12q13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ34766, RNF154
Ensembl gene	ENSG00000178498
Ensembl biotype	protein_coding
OMIM	613142
Entrez	196403

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 31 protein_coding

ENST00000337737, ENST00000548198, ENST00000548478, ENST00000548804, ENST00000549583, ENST00000550300, ENST00000550596, ENST00000551632, ENST00000551835, ENST00000884287, ENST00000884288, ENST00000884289, ENST00000884290, ENST00000884291, ENST00000884292, ENST00000884293, ENST00000884294, ENST00000884295, ENST00000884296, ENST00000884297, ENST00000939591, ENST00000939592, ENST00000939593, ENST00000939594, ENST00000939595, ENST00000939596, ENST00000939597, ENST00000939598, ENST00000946644, ENST00000946645, ENST00000946646

RefSeq mRNA: 3 — MANE Select: NM_178502 NM_001286245, NM_001286246, NM_178502

CCDS: CCDS41800, CCDS66410

Canonical transcript exons

ENST00000337737 — 7 exons

Exon	Start	End
ENSE00001261570	57608520	57608737
ENSE00001354875	57606865	57607613
ENSE00001388355	57605571	57605731
ENSE00001531534	57606190	57606252
ENSE00001531538	57604824	57604858
ENSE00003536365	57606443	57606518
ENSE00003846520	57609077	57609802

Expression profiles

Bgee: expression breadth ubiquitous, 241 present calls, max score 98.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.5535 / max 172.2434, expressed in 1494 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126286	12.6630	1488
126284	0.8414	497
126283	0.5246	293
126285	0.4460	267
126287	0.0784	29

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	98.75	gold quality
cerebellar hemisphere	UBERON:0002245	98.63	gold quality
cerebellar cortex	UBERON:0002129	98.58	gold quality
adenohypophysis	UBERON:0002196	97.99	gold quality
right frontal lobe	UBERON:0002810	97.89	gold quality
cerebellum	UBERON:0002037	97.86	gold quality
pituitary gland	UBERON:0000007	97.80	gold quality
cortical plate	UBERON:0005343	97.55	gold quality
right uterine tube	UBERON:0001302	97.49	gold quality
endothelial cell	CL:0000115	97.39	gold quality
left ovary	UBERON:0002119	97.30	gold quality
body of uterus	UBERON:0009853	97.26	gold quality
right ovary	UBERON:0002118	97.19	gold quality
anterior cingulate cortex	UBERON:0009835	97.09	gold quality
cingulate cortex	UBERON:0003027	97.05	gold quality
nucleus accumbens	UBERON:0001882	96.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.85	gold quality
lower esophagus	UBERON:0013473	96.83	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.78	gold quality
caudate nucleus	UBERON:0001873	96.75	gold quality
ganglionic eminence	UBERON:0004023	96.65	gold quality
endocervix	UBERON:0000458	96.61	gold quality
apex of heart	UBERON:0002098	96.61	gold quality
amygdala	UBERON:0001876	96.40	gold quality
left uterine tube	UBERON:0001303	96.32	gold quality
mucosa of stomach	UBERON:0001199	96.29	gold quality
primary visual cortex	UBERON:0002436	95.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.89	gold quality
right coronary artery	UBERON:0001625	95.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

41 targeting DTX3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-328-5P	99.08	64.65	1000
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-6885-5P	98.71	64.33	902
HSA-MIR-6878-5P	98.49	67.91	2142
HSA-MIR-6511A-5P	98.13	67.47	1770
HSA-MIR-4665-5P	97.91	67.69	1536
HSA-MIR-4329	97.68	66.26	1003
HSA-MIR-6892-5P	97.27	68.60	847
HSA-MIR-602	97.09	61.68	156
HSA-MIR-4690-3P	97.02	64.72	981

Literature-anchored findings (GeneRIF, showing 5)

• It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. (PMID:12670957)
• We show here that both molecules (Deltex (DTX) and AIP4) interact and partially colocalize to endocytic vesicles, and that AIP4 targets DTX for lysosomal degradation. (PMID:17028573)
• DTX3, a novel E3 ligase for NOTCH2 was identified, and promoted its ubiquitination and degradation. DTX3 overexpression suppressed the proliferation and tumorigenicity of human oesophageal carcinoma cells. The analysis of tissue samples from patients revealed that the expression of DTX3 was low in esophageal cancer cells. (PMID:31854042)
• DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis. (PMID:33616774)
• Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway. (PMID:36614304)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dtx3	ENSDARG00000025766
mus_musculus	Dtx3	ENSMUSG00000040415
rattus_norvegicus	Dtx3	ENSRNOG00000005129

Paralogs (4): DTX2 (ENSG00000091073), DTX4 (ENSG00000110042), DTX1 (ENSG00000135144), DTX3L (ENSG00000163840)

Protein

Protein identifiers

E3 ubiquitin-protein ligase DTX3 — Q8N9I9 (reviewed: Q8N9I9)

Alternative names: Protein deltex-3, RING finger protein 154, RING-type E3 ubiquitin transferase DTX3

All UniProt accessions (6): A0A0C4DGI8, A0A1Y8EH36, Q8N9I9, F8VUZ4, F8VV96, H0YHF9

UniProt curated annotations — full annotation on UniProt →

Function. Functions as an ubiquitin ligase protein, and regulates Notch signaling. By promoting the ubiquitination and subsequent degradation of target proteins, it can block activation of the Notch signaling pathway, potentially acting as a tumor suppressor in human cancers. Involved in the angiogenic EPHB4 kinase degradation in cancer cell.

Subunit / interactions. Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1.

Subcellular location. Cytoplasm. Nucleus.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the Deltex family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8N9I9-1	1, DTX3A	yes
Q8N9I9-2	2, DTX3B
Q8N9I9-3	3, DTX3C

RefSeq proteins (3): NP_001273174, NP_001273175, NP_848597* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR039396	Deltex_C	Domain
IPR039398	Deltex_fam	Family
IPR039399	Deltex_C_sf	Homologous_superfamily

Pfam: PF13923, PF18102

UniProt features (6 total): splice variant 2, chain 1, zinc finger region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N9I9-F1	83.28	0.55

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 95 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, CAGCTG_AP4_Q5, MARTINEZ_RB1_TARGETS_DN, DOANE_RESPONSE_TO_ANDROGEN_DN, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY, AFP1_Q6, RYTTCCTG_ETS2_B, CCCNNGGGAR_OLF1_01, MARTINEZ_RB1_AND_TP53_TARGETS_UP, AP2GAMMA_01, TGGAAA_NFAT_Q4_01, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY

GO Biological Process (3): Notch signaling pathway (GO:0007219), regulation of Notch signaling pathway (GO:0008593), protein ubiquitination (GO:0016567)

GO Molecular Function (5): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell surface receptor signaling pathway	1
Notch signaling pathway	1
regulation of signal transduction	1
protein modification by small protein conjugation	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

496 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DTX3	PARP9	Q8IXQ6	837
DTX3	ANK2	Q01484	652
DTX3	ANK3	Q12955	639
DTX3	ANK1	P16157	636
DTX3	DVL3	Q92997	559
DTX3	UBE2D1	P51668	547
DTX3	AMBRA1	Q9C0C7	406
DTX3	CIRSR	Q86X95	400
DTX3	METTL6	Q8TCB7	396
DTX3	DCAF13	Q9NV06	378
DTX3	MRPS23	Q9Y3D9	377
DTX3	LFNG	Q8NES3	376
DTX3	C22orf15	Q8WYQ4	369
DTX3	NOTCH4	Q99466	358
DTX3	SYAP1	Q96A49	355

IntAct

121 interactions, top by confidence:

A	B	Type	Score
UBE2K	DTX3	psi-mi:“MI:0915”(physical association)	0.720
DTX3	UBE2K	psi-mi:“MI:0915”(physical association)	0.720
DTX3	UBE2D1	psi-mi:“MI:0915”(physical association)	0.670
UBE2D3	DTX3	psi-mi:“MI:0915”(physical association)	0.670
DTX3	UBE2L6	psi-mi:“MI:0915”(physical association)	0.670
UBE2D4	DTX3	psi-mi:“MI:0915”(physical association)	0.670
UBE2D1	DTX3	psi-mi:“MI:0915”(physical association)	0.670
DTX3	TRAF4	psi-mi:“MI:0915”(physical association)	0.670
UBE2L6	DTX3	psi-mi:“MI:0915”(physical association)	0.670
DTX3	UBE2D4	psi-mi:“MI:0915”(physical association)	0.670
TRAF4	DTX3	psi-mi:“MI:0915”(physical association)	0.670
FYN	DTX3	psi-mi:“MI:0915”(physical association)	0.600
DTX3	FYN	psi-mi:“MI:0915”(physical association)	0.600
UBASH3B	DTX3	psi-mi:“MI:0915”(physical association)	0.560
TRIP10	DTX3	psi-mi:“MI:0915”(physical association)	0.560
DTX3	ZMYND19	psi-mi:“MI:0915”(physical association)	0.560
DTX3	PARP11	psi-mi:“MI:0915”(physical association)	0.560
PTK6	DTX3	psi-mi:“MI:0915”(physical association)	0.560
UBASH3A	DTX3	psi-mi:“MI:0915”(physical association)	0.560
DTX3	NFKBID	psi-mi:“MI:0915”(physical association)	0.560
BAG3	DTX3	psi-mi:“MI:0915”(physical association)	0.560
EPM2AIP1	DTX3	psi-mi:“MI:0915”(physical association)	0.560
FAM90A1	DTX3	psi-mi:“MI:0915”(physical association)	0.560
YES1	DTX3	psi-mi:“MI:0915”(physical association)	0.560
	DTX3	psi-mi:“MI:0915”(physical association)	0.560
NCK2	DTX3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (151): DTX3 (Two-hybrid), DTX3 (Two-hybrid), FARSB (Affinity Capture-MS), NARFL (Affinity Capture-MS), NDUFAF5 (Affinity Capture-MS), CHFR (Affinity Capture-MS), ITSN1 (Affinity Capture-MS), MAPK9 (Affinity Capture-MS), NMD3 (Affinity Capture-MS), NDUFS6 (Affinity Capture-MS), RNF114 (Affinity Capture-MS), CHFR (Affinity Capture-MS), NARFL (Affinity Capture-MS), NMD3 (Affinity Capture-MS), ITSN1 (Affinity Capture-MS)

ESM2 similar proteins: A1L1K1, A2ARM1, A2AVJ5, A4IFC9, A7E305, G5EGQ2, O08653, O36006, O43435, O46080, O95343, P13481, P28702, P28704, P56423, P56424, P56645, P61260, P97499, Q02556, Q07820, Q2NL16, Q32N92, Q5E9R0, Q5REG4, Q5SQI0, Q5TJF7, Q5U2W6, Q5U2Y1, Q61010, Q62233, Q6MZQ0, Q80V91, Q86Y01, Q86YD1, Q8AW93, Q8BIG4, Q8HYS5, Q8N9I9, Q91VU8

Diamond homologs: Q23985, Q3UIR3, Q5REG4, Q61010, Q80V91, Q86UW9, Q86Y01, Q8N9I9, Q8R3P2, Q8TDB6, Q6PDK8, Q8AW93, Q9Y2E6, Q07G17, Q2KJ29, Q3KNV8, Q80Z37, Q8BTQ0, Q9NS56, B4F6W9, F1LP64, G5E870, Q13670, F4KGU4, Q2EMV9, Q9NS91, Q9QXK2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	DTX3	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 49 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	8	86.7×	6e-12
Negative regulators of DDX58/IFIH1 signaling	5	48.0×	4e-06
Regulation of TNFR1 signaling	6	39.5×	8e-07
E3 ubiquitin ligases ubiquitinate target proteins	5	28.5×	4e-05
Antigen processing: Ubiquitination & Proteasome degradation	13	14.2×	3e-10

GO biological processes:

GO term	Partners	Fold	FDR
protein K11-linked ubiquitination	7	61.0×	2e-09
protein monoubiquitination	5	38.2×	1e-05
protein K48-linked ubiquitination	9	33.7×	8e-10
protein K63-linked ubiquitination	5	29.7×	3e-05
protein modification process	5	27.1×	5e-05
protein polyubiquitination	10	25.6×	8e-10
ubiquitin-dependent protein catabolic process	9	14.8×	6e-07
protein ubiquitination	7	6.4×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1305 predictions. Top by Δscore:

Variant	Effect	Δscore
12:57604856:GAG:G	donor_gain	1.0000
12:57604858:GGTA:G	donor_loss	1.0000
12:57606519:G:GG	donor_gain	1.0000
12:57607586:G:GG	donor_gain	1.0000
12:57607610:GGGG:G	donor_gain	1.0000
12:57607611:GGG:G	donor_gain	1.0000
12:57607611:GGGG:G	donor_gain	1.0000
12:57607612:GGG:G	donor_gain	1.0000
12:57608671:G:GT	donor_gain	1.0000
12:57608717:C:G	donor_gain	1.0000
12:57608725:G:GT	donor_gain	1.0000
12:57608735:GCT:G	donor_gain	1.0000
12:57608736:C:G	donor_gain	1.0000
12:57608738:G:GG	donor_gain	1.0000
12:57604854:GAGAG:G	donor_gain	0.9900
12:57604859:G:GG	donor_gain	0.9900
12:57606107:G:GT	donor_gain	0.9900
12:57606112:G:GT	donor_gain	0.9900
12:57606112:G:T	donor_gain	0.9900
12:57606188:A:AG	acceptor_gain	0.9900
12:57606189:G:GA	acceptor_gain	0.9900
12:57606189:GTCCT:G	acceptor_gain	0.9900
12:57606432:C:A	acceptor_gain	0.9900
12:57606441:A:AG	acceptor_gain	0.9900
12:57606441:A:G	acceptor_loss	0.9900
12:57606442:G:GG	acceptor_gain	0.9900
12:57606515:CAAAG:C	donor_loss	0.9900
12:57606517:AA:A	donor_gain	0.9900
12:57606517:AAGT:A	donor_loss	0.9900
12:57606518:AGTAA:A	donor_loss	0.9900

AlphaMissense

2212 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:57607353:T:C	C164R	1.000
12:57607355:C:G	C164W	1.000
12:57607362:T:A	C167S	1.000
12:57607362:T:C	C167R	1.000
12:57607363:G:C	C167S	1.000
12:57607401:T:A	C180S	1.000
12:57607401:T:C	C180R	1.000
12:57607402:G:C	C180S	1.000
12:57607413:T:C	F184L	1.000
12:57607414:T:C	F184S	1.000
12:57607415:C:A	F184L	1.000
12:57607415:C:G	F184L	1.000
12:57607416:T:C	C185R	1.000
12:57607425:T:A	C188S	1.000
12:57607425:T:C	C188R	1.000
12:57607426:G:C	C188S	1.000
12:57607458:T:A	C199S	1.000
12:57607458:T:C	C199R	1.000
12:57607459:G:A	C199Y	1.000
12:57607459:G:C	C199S	1.000
12:57607467:T:A	C202S	1.000
12:57607467:T:C	C202R	1.000
12:57607468:G:C	C202S	1.000
12:57607495:G:T	G211V	1.000
12:57607582:T:A	I240N	1.000
12:57607587:T:C	Y242H	1.000
12:57607610:G:C	Q249H	1.000
12:57607610:G:T	Q249H	1.000
12:57608547:T:G	Y260D	1.000
12:57608563:G:C	R265P	1.000

dbSNP variants (sampled 300 via entrez): RS1000700275 (12:57607160 G>C,T), RS1001378807 (12:57610282 G>A), RS1001638897 (12:57603538 A>C), RS1001900918 (12:57605200 A>C,G), RS1002192094 (12:57606510 A>G), RS1002931301 (12:57603463 T>C), RS1003193296 (12:57605082 C>T), RS1003268092 (12:57604892 G>A), RS1003970140 (12:57606687 A>G), RS1004226437 (12:57606155 G>A), RS1004503996 (12:57607750 T>G), RS1004802818 (12:57609660 T>C,G), RS1004979544 (12:57604104 ACAC>A,ACACCAC), RS1006708007 (12:57604233 G>C), RS1007170108 (12:57604533 G>C)

Disease associations

OMIM: gene MIM:613142 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	4
sodium arsenite	decreases expression, increases expression	2
(+)-JQ1 compound	decreases expression	2
nickel sulfate	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	increases reaction, affects binding	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
enzalutamide	affects expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Zoledronic Acid	increases expression	1
Glyphosate	increases expression	1
Acrolein	affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	affects expression	1
Estradiol	decreases expression	1
Hydrogen Peroxide	affects expression	1
Nickel	decreases expression	1
Ozone	affects cotreatment, decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	decreases methylation	1
Gold Compounds	increases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	increases expression	1

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1QG	Abcam HeLa DTX3 KO	Cancer cell line	Female
CVCL_D7NW	Ubigene A-549 DTX3 KO	Cancer cell line	Male
CVCL_D9DN	Ubigene HEK293 DTX3 KO	Transformed cell line	Female
CVCL_E0BW	Ubigene HeLa DTX3 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.