DUBR

Summary

DUBR (DPPA2 upstream binding RNA, HGNC:48569) is a long non-coding RNA gene on chromosome 3q13.12.

Predicted to act upstream of or within several processes, including generation of neurons; negative regulation of macromolecule biosynthetic process; and protein stabilization. Predicted to be active in cytoplasm and nucleus.

Source: NCBI Gene 344595 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48569
Approved symbol	DUBR
Name	DPPA2 upstream binding RNA
Location	3q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000243701
Ensembl biotype	lncRNA
OMIM	616619
Entrez	344595
RNAcentral	URS000075AD4F — lncRNA, 3278 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000463143, ENST00000466734, ENST00000473550, ENST00000490441, ENST00000495228, ENST00000651804, ENST00000653298, ENST00000653509, ENST00000654269, ENST00000655772, ENST00000657097, ENST00000657581, ENST00000658510, ENST00000659830, ENST00000659955, ENST00000660575, ENST00000660597, ENST00000662418, ENST00000663366, ENST00000663370, ENST00000665694, ENST00000666345, ENST00000667411, ENST00000667442, ENST00000667603, ENST00000667620, ENST00000667634, ENST00000667710, ENST00000667856, ENST00000669523, ENST00000669723, ENST00000670833, ENST00000671419, ENST00000715947, ENST00000715948

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000463143 — 3 exons

Exon	Start	End
ENSE00001812589	107240692	107241087
ENSE00001860553	107326466	107326701
ENSE00001883191	107291762	107291930

Expression profiles

Bgee: expression breadth ubiquitous, 229 present calls, max score 98.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.9473 / max 179.4404, expressed in 1488 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
37778	3.8398	1191
37777	2.9272	1230
37779	2.0348	686
37776	0.1287	49
37775	0.0168	6

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	98.95	gold quality
tendon of biceps brachii	UBERON:0008188	91.54	gold quality
left ovary	UBERON:0002119	90.81	gold quality
right ovary	UBERON:0002118	90.25	gold quality
right uterine tube	UBERON:0001302	89.32	gold quality
adrenal tissue	UBERON:0018303	87.35	gold quality
ovary	UBERON:0000992	87.30	gold quality
corpus callosum	UBERON:0002336	87.26	gold quality
ganglionic eminence	UBERON:0004023	87.22	gold quality
bronchial epithelial cell	CL:0002328	86.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.76	gold quality
medial globus pallidus	UBERON:0002477	85.69	gold quality
caput epididymis	UBERON:0004358	85.61	gold quality
bronchus	UBERON:0002185	85.55	gold quality
corpus epididymis	UBERON:0004359	84.94	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.03	gold quality
tendon	UBERON:0000043	83.82	gold quality
tibial nerve	UBERON:0001323	83.67	gold quality
cauda epididymis	UBERON:0004360	83.59	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.29	gold quality
right coronary artery	UBERON:0001625	83.09	gold quality
popliteal artery	UBERON:0002250	82.75	gold quality
tibial artery	UBERON:0007610	82.74	gold quality
globus pallidus	UBERON:0001875	82.64	gold quality
spinal cord	UBERON:0002240	82.52	gold quality
colonic epithelium	UBERON:0000397	82.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.27	gold quality
aorta	UBERON:0000947	82.19	gold quality
apex of heart	UBERON:0002098	82.09	gold quality
left coronary artery	UBERON:0001626	81.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation. (PMID:33758355)
• Linc00883 affects colorectal cancer through miR-577/FKBP14 axis: a novel mechanism for regulating colorectal cancer cell proliferation, invasion, and migration. (PMID:35833665)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.