DUSP11

Summary

DUSP11 (dual specificity phosphatase 11, HGNC:3066) is a protein-coding gene on chromosome 2p13.1, encoding RNA/RNP complex-1-interacting phosphatase (O75319). Possesses RNA 5’-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.

Source: NCBI Gene 8446 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_003584

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:3066
Approved symbol	DUSP11
Name	dual specificity phosphatase 11
Location	2p13.1
Locus type	gene with protein product
Status	Approved
Aliases	PIR1
Ensembl gene	ENSG00000144048
Ensembl biotype	protein_coding
OMIM	603092
Entrez	8446

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 13 protein_coding, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000272444, ENST00000443070, ENST00000452812, ENST00000477458, ENST00000480948, ENST00000696050, ENST00000696051, ENST00000696052, ENST00000696053, ENST00000696054, ENST00000696055, ENST00000696056, ENST00000696057, ENST00000717658, ENST00000909492, ENST00000909493, ENST00000972157

RefSeq mRNA: 2 — MANE Select: NM_003584 NM_001424649, NM_003584

CCDS: CCDS1928

Canonical transcript exons

ENST00000272444 — 9 exons

Exon	Start	End
ENSE00001792898	73779874	73780103
ENSE00003483768	73774913	73775044
ENSE00003493881	73778301	73778376
ENSE00003505998	73769265	73769325
ENSE00003537651	73773800	73773923
ENSE00003579562	73767161	73767207
ENSE00004033068	73766418	73766594
ENSE00004033069	73766828	73766903
ENSE00004033181	73762213	73762859

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 95.11.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.4608 / max 271.5399, expressed in 1822 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29149	41.3833	1821
29148	2.0775	1193

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagus squamous epithelium	UBERON:0006920	95.11	gold quality
epithelium of esophagus	UBERON:0001976	93.29	gold quality
penis	UBERON:0000989	92.86	gold quality
secondary oocyte	CL:0000655	92.61	gold quality
calcaneal tendon	UBERON:0003701	91.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.13	gold quality
upper leg skin	UBERON:0004262	91.02	gold quality
esophagus mucosa	UBERON:0002469	90.96	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.95	gold quality
mammalian vulva	UBERON:0000997	90.84	gold quality
oral cavity	UBERON:0000167	90.73	gold quality
gingiva	UBERON:0001828	90.72	gold quality
endometrium epithelium	UBERON:0004811	90.62	gold quality
gingival epithelium	UBERON:0001949	90.52	gold quality
caput epididymis	UBERON:0004358	90.48	gold quality
epithelium of nasopharynx	UBERON:0001951	90.40	gold quality
lower esophagus mucosa	UBERON:0035834	90.39	gold quality
nasopharynx	UBERON:0001728	90.38	gold quality
right uterine tube	UBERON:0001302	90.26	gold quality
oocyte	CL:0000023	89.83	gold quality
squamous epithelium	UBERON:0006914	89.08	gold quality
bone marrow	UBERON:0002371	88.96	gold quality
pharyngeal mucosa	UBERON:0000355	88.76	gold quality
skin of abdomen	UBERON:0001416	88.76	gold quality
skin of hip	UBERON:0001554	88.64	gold quality
tonsil	UBERON:0002372	88.49	gold quality
zone of skin	UBERON:0000014	88.46	gold quality
vagina	UBERON:0000996	88.32	gold quality
palpebral conjunctiva	UBERON:0001812	88.28	gold quality
lymph node	UBERON:0000029	88.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.40

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

Literature-anchored findings (GeneRIF, showing 8)

• results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68 (PMID:19120688)
• the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution. (PMID:24447265)
• DUSP11 converts the 5’ triphosphate of miRNA precursors to a 5’ monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5’ monophosphate-dependent strand selection mechanism. (PMID:27798849)
• DUSP11 regulates host and viral non-coding RNAs in mammalian cells. (PMID:28296624)
• PIR gene expression is highly dependent on the expression of HR-HPV E6 and E7 oncoproteins HPV-positive cell lines. (PMID:29118270)
• DUSP11 limits both miR-122-dependent and miR-122-independent Hepatitis C RNA accumulation. (PMID:29672716)
• Results implicate DUSP11 as an important component of XRN-mediated restriction of hepatitis C virus replication. (PMID:30038017)
• Atypical phosphatase DUSP11 inhibition promotes nc886 expression and potentiates gemcitabine-mediated cell death through NF-kB modulation. (PMID:39048662)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dusp11	ENSDARG00000038156
mus_musculus	Dusp11	ENSMUSG00000030002
rattus_norvegicus	Dusp11	ENSRNOG00000045539

Paralogs (1): RNGTT (ENSG00000111880)

Protein

Protein identifiers

RNA/RNP complex-1-interacting phosphatase — O75319 (reviewed: O75319)

Alternative names: Dual specificity protein phosphatase 11, Phosphatase that interacts with RNA/RNP complex 1

All UniProt accessions (9): O75319, A0A8Q3SI82, A0A8Q3SI85, A0A8Q3SIB0, A0A8Q3SIC9, A0A8Q3SIE6, A0A8Q3SIF8, A0A8Q3WM77, H7C0E6

UniProt curated annotations — full annotation on UniProt →

Function. Possesses RNA 5’-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

Subunit / interactions. Monomer. May interact with SFRS7 and SFRS9/SRP30C.

Subcellular location. Nucleus. Nucleus speckle.

Miscellaneous. Produced by alternative initiation. Based on proteomic data. Major isoform.

Similarity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
O75319-3	3	yes
O75319-1	1
O75319-2	2

RefSeq proteins (2): NP_001411578, NP_003575* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000340	Dual-sp_phosphatase_cat-dom	Domain
IPR000387	Tyr_Pase_dom	Domain
IPR016130	Tyr_Pase_AS	Active_site
IPR020422	TYR_PHOSPHATASE_DUAL_dom	Domain
IPR029021	Prot-tyrosine_phosphatase-like	Homologous_superfamily
IPR051029

Pfam: PF00782

UniProt features (33 total): helix 9, strand 6, mutagenesis site 5, sequence conflict 3, splice variant 3, active site 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, binding site 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
4NYH	X-RAY DIFFRACTION	1.2
4MBB	X-RAY DIFFRACTION	1.85
4JMJ	X-RAY DIFFRACTION	2.38

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75319-F1	69.34	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 152 (phosphocysteine intermediate); 158 (proton donor/acceptor)

Ligand- & substrate-binding residues (1): 153–158

Mutagenesis-validated functional residues (5):

Position	Phenotype
119	no effect on phosphatase activity with atp and adp.
152	loss of activity. no effect in rna-binding.
154	strongly decreases phosphatase activity with atp and adp.
157	strongly decreases phosphatase activity with atp and adp.
192	slightly decreases phosphatase activity with atp. strongly decreases phosphatase activity with adp.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 131 (showing top): RNGTGGGC_UNKNOWN, MORF_RAB5A, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, MORF_PSMC2, PUJANA_CHEK2_PCC_NETWORK, ZIC1_01, GENTILE_UV_HIGH_DOSE_DN, GENTILE_UV_RESPONSE_CLUSTER_D5, SCHLOSSER_SERUM_RESPONSE_DN, GOBP_DEPHOSPHORYLATION, GOBP_PROTEIN_DEPHOSPHORYLATION, ZHANG_BREAST_CANCER_PROGENITORS_UP, GOCC_NUCLEAR_SPECK

GO Biological Process (3): RNA processing (GO:0006396), protein dephosphorylation (GO:0006470), dephosphorylation (GO:0016311)

GO Molecular Function (7): RNA binding (GO:0003723), polynucleotide 5’-phosphatase activity (GO:0004651), protein tyrosine phosphatase activity (GO:0004725), phosphatase activity (GO:0016791), catalytic activity (GO:0003824), phosphoprotein phosphatase activity (GO:0004721), hydrolase activity (GO:0016787)

GO Cellular Component (6): fibrillar center (GO:0001650), nucleus (GO:0005634), nucleoplasm (GO:0005654), mitochondrion (GO:0005739), nuclear speck (GO:0016607), intercellular bridge (GO:0045171)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
phosphatase activity	2
intracellular membrane-bounded organelle	2
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
dephosphorylation	1
protein modification process	1
phosphate-containing compound metabolic process	1
nucleic acid binding	1
phosphoprotein phosphatase activity	1
phosphoric ester hydrolase activity	1
molecular_function	1
catalytic activity, acting on a protein	1
catalytic activity	1
nucleolus	1
nuclear lumen	1
cytoplasm	1
nuclear ribonucleoprotein granule	1

Protein interactions and networks

STRING

1084 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DUSP11	DUSP5	Q16690	894
DUSP11	RNF144B	Q7Z419	729
DUSP11	DXO	O77932	692
DUSP11	PIWIL1	Q96J94	612
DUSP11	XRN1	Q8IZH2	590
DUSP11	XRN2	Q9H0D6	589
DUSP11	ERI1	Q8IV48	501
DUSP11	DICER1	Q9UPY3	501
DUSP11	ADARB1	P78555	496
DUSP11	DUSP21	Q9H596	487
DUSP11	DCP2	Q8IU60	474
DUSP11	DUSP3	P51452	460
DUSP11	SACK1H	Q6ZRV2	460
DUSP11	DUSP12	Q9UNI6	442
DUSP11	DUSP22	Q9NRW4	438

IntAct

69 interactions, top by confidence:

A	B	Type	Score
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
APBA3	DUSP11	psi-mi:“MI:0914”(association)	0.530
KLHL40	CBX4	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
PRKCA	DUSP11	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
HNRNPA1	PTCD1	psi-mi:“MI:0914”(association)	0.530
ZNRD2	MYO9A	psi-mi:“MI:0914”(association)	0.530
ZNRD2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
THOC1	TARS3	psi-mi:“MI:0914”(association)	0.350
HNRNPA1	MATR3	psi-mi:“MI:0914”(association)	0.350
Csde1	TXNDC9	psi-mi:“MI:0914”(association)	0.350
KIF11	MAP4	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
PLOD1	COL25A1	psi-mi:“MI:0914”(association)	0.350
APOBEC3D	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
SYNCRIP	HNRNPR	psi-mi:“MI:0914”(association)	0.350
HNRNPA1	HNRNPR	psi-mi:“MI:0914”(association)	0.350
AHCYL2	AHCYL1	psi-mi:“MI:0914”(association)	0.350
CIAO1	SOX1	psi-mi:“MI:0914”(association)	0.350
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (100): DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), NIPAL4 (Affinity Capture-MS), DUSP11 (Affinity Capture-MS), RPS15 (Affinity Capture-MS), MRPS35 (Affinity Capture-MS)

ESM2 similar proteins: A2AD83, A3KMI0, A4Q9F0, A8WRV1, D4A280, O18017, O75319, O95835, P23293, P34442, P81299, Q04859, Q0IJ08, Q2M1K5, Q3MK94, Q4CQJ5, Q4DTX9, Q4KM79, Q5E999, Q5HYM0, Q5HZJ0, Q5U243, Q62726, Q6DJS0, Q6DTM3, Q6NXK5, Q6P158, Q6P5D3, Q6ZT98, Q6ZUT3, Q7PNM6, Q7ZXG4, Q8BGX1, Q8BMD7, Q8BY02, Q8BYR2, Q8C015, Q8K3Y6, Q8R151, Q8TE76

Diamond homologs: O10274, O55236, O60942, O75319, P24656, P34442, Q17607, Q22707, Q4KM79, Q5E999, Q6NXK5, Q6NY98, Q6NT99, Q9BVJ7, Q9P7H1, Q6PFY9, Q6CWR0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 83 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	7	17.8×	8e-06
Viral mRNA Translation	7	17.8×	8e-06
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	7	17.6×	8e-06
Selenocysteine synthesis	7	16.8×	8e-06
Eukaryotic Translation Termination	7	16.8×	8e-06
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7	16.5×	8e-06
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	7	16.5×	8e-06
Formation of a pool of free 40S subunits	7	15.7×	9e-06

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	6	18.2×	2e-04
cytoplasmic translation	7	17.3×	7e-05
negative regulation of translation	5	13.1×	3e-03
translation	7	9.6×	1e-03
mRNA splicing, via spliceosome	7	8.6×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	6
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

885 predictions. Top by Δscore:

Variant	Effect	Δscore
2:73762856:TTTT:T	acceptor_gain	1.0000
2:73762860:C:CC	acceptor_gain	1.0000
2:73762861:T:C	acceptor_gain	1.0000
2:73762861:T:TC	acceptor_gain	1.0000
2:73762867:C:CT	acceptor_gain	1.0000
2:73766821:GACTT:G	donor_loss	1.0000
2:73766822:ACTT:A	donor_loss	1.0000
2:73766823:CTTAC:C	donor_loss	1.0000
2:73766824:TTA:T	donor_loss	1.0000
2:73766825:TACT:T	donor_loss	1.0000
2:73766826:A:AC	donor_gain	1.0000
2:73766826:A:C	donor_loss	1.0000
2:73766826:ACTTT:A	donor_gain	1.0000
2:73766827:C:CT	donor_gain	1.0000
2:73766827:CT:C	donor_gain	1.0000
2:73766827:CTT:C	donor_gain	1.0000
2:73766827:CTTT:C	donor_gain	1.0000
2:73766827:CTTTC:C	donor_gain	1.0000
2:73766899:GAATA:G	acceptor_gain	1.0000
2:73766900:AATA:A	acceptor_gain	1.0000
2:73766901:ATA:A	acceptor_gain	1.0000
2:73766902:TA:T	acceptor_gain	1.0000
2:73766904:C:CC	acceptor_gain	1.0000
2:73767159:A:AC	donor_gain	1.0000
2:73767160:C:CC	donor_gain	1.0000
2:73767160:CA:C	donor_gain	1.0000
2:73767160:CATT:C	donor_gain	1.0000
2:73769260:CTTA:C	donor_loss	1.0000
2:73769261:TTACC:T	donor_loss	1.0000
2:73769262:TAC:T	donor_loss	1.0000

AlphaMissense

2479 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:73769274:A:G	L209P	0.996
2:73769285:C:A	R205S	0.996
2:73769285:C:G	R205S	0.996
2:73769286:C:A	R205M	0.996
2:73773832:A:T	V181D	0.996
2:73778329:A:G	F97S	0.996
2:73769267:G:C	C211W	0.995
2:73769286:C:G	R205T	0.995
2:73769295:C:T	G202D	0.995
2:73769310:A:T	V197D	0.995
2:73773844:A:G	F177S	0.995
2:73778316:T:A	K101N	0.995
2:73778316:T:G	K101N	0.995
2:73769280:C:T	G207D	0.994
2:73769288:G:C	N204K	0.994
2:73769288:G:T	N204K	0.994
2:73769295:C:A	G202V	0.994
2:73778373:C:A	W82C	0.994
2:73778373:C:G	W82C	0.994
2:73778375:A:G	W82R	0.994
2:73778375:A:T	W82R	0.994
2:73766899:G:C	F229L	0.993
2:73766899:G:T	F229L	0.993
2:73766901:A:G	F229L	0.993
2:73769268:C:T	C211Y	0.993
2:73769278:A:C	Y208D	0.993
2:73773843:G:C	F177L	0.993
2:73773843:G:T	F177L	0.993
2:73773845:A:G	F177L	0.993
2:73769269:A:G	C211R	0.992

dbSNP variants (sampled 300 via entrez): RS1000366231 (2:73767723 T>C), RS1000529318 (2:73779275 T>C), RS1000530558 (2:73778545 C>T), RS1000782872 (2:73765849 T>C,G), RS1000801749 (2:73772605 G>A), RS1000957102 (2:73766081 G>A), RS1001081248 (2:73778884 C>A,T), RS1001136964 (2:73772898 C>G,T), RS1001353406 (2:73765768 T>C), RS1001382929 (2:73772717 A>G), RS1001475640 (2:73777408 C>G,T), RS1001505350 (2:73778087 T>C), RS1001528143 (2:73777822 A>C,T), RS1001838875 (2:73779473 A>G), RS1001867502 (2:73772786 A>G)

Disease associations

OMIM: gene MIM:603092 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000651_1	Creatinine levels	1.000000e-15
GCST001220_3	Metabolite levels	1.000000e-11
GCST006249_13	Serum metabolite levels	1.000000e-77
GCST006249_37	Serum metabolite levels	9.000000e-13
GCST006249_52	Serum metabolite levels	5.000000e-11
GCST006249_62	Serum metabolite levels	7.000000e-24
GCST006249_77	Serum metabolite levels	7.000000e-33
GCST008153_48	Lean body mass	9.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004725	metabolite measurement
EFO:0004995	lean body mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	affects expression, increases expression	3
sodium arsenite	affects expression, decreases expression	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Benzo(a)pyrene	increases mutagenesis, increases expression	2
Cisplatin	increases expression	2
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
4-oxoretinoic acid	decreases expression	1
triphenyl phosphate	affects expression	1
cobaltous chloride	decreases expression	1
tanshinone	increases expression	1
zinc chromate	increases abundance, increases expression	1
beta-methylcholine	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
azoxystrobin	increases expression	1
K 7174	increases expression	1
abrine	increases expression	1
picoxystrobin	increases expression	1
Alitretinoin	decreases expression	1
Glyphosate	increases expression	1
Atrazine	decreases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Gold	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.