DUSP12

Summary

DUSP12 (dual specificity phosphatase 12, HGNC:3067) is a protein-coding gene on chromosome 1q23.3, encoding Dual specificity protein phosphatase 12 (Q9UNI6). Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Source: NCBI Gene 11266 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_007240

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:3067
Approved symbol	DUSP12
Name	dual specificity phosphatase 12
Location	1q23.3
Locus type	gene with protein product
Status	Approved
Aliases	YVH1, DUSP1
Ensembl gene	ENSG00000081721
Ensembl biotype	protein_coding
OMIM	604835
Entrez	11266

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 3 nonsense_mediated_decay, 1 retained_intron

ENST00000367943, ENST00000463365, ENST00000464004, ENST00000484291, ENST00000490591, ENST00000881382, ENST00000931531, ENST00000954827, ENST00000954828

RefSeq mRNA: 1 — MANE Select: NM_007240 NM_007240

CCDS: CCDS1234

Canonical transcript exons

ENST00000367943 — 6 exons

Exon	Start	End
ENSE00000899911	161751668	161751781
ENSE00001445976	161756786	161757238
ENSE00001834189	161749786	161750145
ENSE00003515472	161753075	161753261
ENSE00003550275	161751866	161751984
ENSE00003649014	161752368	161752464

Expression profiles

Bgee: expression breadth ubiquitous, 272 present calls, max score 91.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.0834 / max 150.4954, expressed in 1819 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
6278	23.0111	1819
6279	0.0722	24

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	91.45	gold quality
cerebellar hemisphere	UBERON:0002245	90.97	gold quality
cerebellar cortex	UBERON:0002129	90.92	gold quality
cortical plate	UBERON:0005343	90.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.60	gold quality
cerebellum	UBERON:0002037	90.55	gold quality
granulocyte	CL:0000094	90.41	gold quality
embryo	UBERON:0000922	90.10	gold quality
cerebellar vermis	UBERON:0004720	89.27	gold quality
ganglionic eminence	UBERON:0004023	89.12	gold quality
body of uterus	UBERON:0009853	88.80	gold quality
left ovary	UBERON:0002119	88.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.17	gold quality
lymph node	UBERON:0000029	88.01	gold quality
monocyte	CL:0000576	87.95	gold quality
left coronary artery	UBERON:0001626	87.91	gold quality
superficial temporal artery	UBERON:0001614	87.90	gold quality
mononuclear cell	CL:0000842	87.88	gold quality
leukocyte	CL:0000738	87.83	gold quality
thoracic aorta	UBERON:0001515	87.83	gold quality
right coronary artery	UBERON:0001625	87.83	gold quality
body of pancreas	UBERON:0001150	87.82	gold quality
descending thoracic aorta	UBERON:0002345	87.80	gold quality
ascending aorta	UBERON:0001496	87.76	gold quality
hair follicle	UBERON:0002073	87.64	silver quality
ventricular zone	UBERON:0003053	87.53	gold quality
left lobe of thyroid gland	UBERON:0001120	87.51	gold quality
coronary artery	UBERON:0001621	87.43	gold quality
right ovary	UBERON:0002118	87.43	gold quality
aorta	UBERON:0000947	87.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting DUSP12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-2116-3P	99.74	64.32	889
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-105-5P	99.54	69.24	2060
HSA-MIR-7853-5P	99.54	69.30	2055
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-889-3P	99.40	69.76	2103
HSA-MIR-4727-5P	99.23	67.55	1154
HSA-MIR-5590-5P	98.81	68.78	969
HSA-MIR-2276-3P	98.76	67.75	1384
HSA-MIR-3161	98.71	67.14	816
HSA-MIR-4659B-5P	98.03	66.84	979
HSA-MIR-4659A-5P	98.03	66.42	819
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026

Literature-anchored findings (GeneRIF, showing 11)

• Our data suggest that sequences in or upstream of DUSP12 may contribute to type 2 diabetes susceptibility, but the lack of replication suggests a small effect size. (PMID:16936214)
• hYVH1 is a novel cell survival phosphatase that co-operates with Hsp70 to positively affect cell viability in response to cellular insults. (PMID:18973475)
• Data determined that hYVH1 forms intramolecular disulfide bonds at the catalytic cleft as well as within the zinc binding domain to avoid irreversible inactivation during severe oxidative stress. (PMID:19567874)
• tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. (PMID:20103624)
• these data suggests common SNPs within DUSP12-ATF6 locus may not play a major role in glucose metabolism in the Chinese. (PMID:21211013)
• hYVH1 is a novel modulator of cell cycle progression mediated by a phosphorylation site located at the C-terminal end of the zinc-binding domain (PMID:21521943)
• propose that the BRC repeats in BRCA2 cooperate in a partially redundant but reinforcing manner to ensure a high probability of RAD51 filament formation (PMID:21556130)
• Results from a study on gene variability markers in early-stage human embryos shows that DUSP12 is a putative variability marker for the 3-day, 8-cell embryo stage. (PMID:26288249)
• A significant decrease in DUSP12 expression in hypertrophic hearts and cardiomyocytes. (PMID:27702885)
• These results propagate a role for dual specificity phosphatases at RNP particles and suggest that hYVH1 may affect a variety of fundamental cellular processes by regulating messenger ribonucleoprotein (mRNP) dynamics. (PMID:27856639)
• Network analysis of DUSP12 partners in the nucleus under genotoxic stress. (PMID:30779967)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dusp12	ENSDARG00000076330
mus_musculus	Dusp12	ENSMUSG00000026659
rattus_norvegicus	Dusp12	ENSRNOG00000003100

Paralogs (31): DUSP13B (ENSG00000079393), SSH1 (ENSG00000084112), DUSP3 (ENSG00000108861), PTPMT1 (ENSG00000110536), DUSP16 (ENSG00000111266), EPM2A (ENSG00000112425), DUSP22 (ENSG00000112679), DUSP1 (ENSG00000120129), DUSP4 (ENSG00000120875), STYXL1 (ENSG00000127952), DUSP9 (ENSG00000130829), DUSP26 (ENSG00000133878), DUSP5 (ENSG00000138166), DUSP6 (ENSG00000139318), SSH2 (ENSG00000141298), DUSP10 (ENSG00000143507), DUSP15 (ENSG00000149599), DUSP2 (ENSG00000158050), KASH5 (ENSG00000161609), DUSP19 (ENSG00000162999), DUSP7 (ENSG00000164086), DUSP18 (ENSG00000167065), SSH3 (ENSG00000172830), DUSP8 (ENSG00000184545), DUSP28 (ENSG00000188542), DUSP29 (ENSG00000188716), DUSP21 (ENSG00000189037), STYX (ENSG00000198252), STYXL2 (ENSG00000198842), DUSP14 (ENSG00000276023), DUSP13A (ENSG00000293543)

Protein

Protein identifiers

Dual specificity protein phosphatase 12 — Q9UNI6 (reviewed: Q9UNI6)

Alternative names: Dual specificity tyrosine phosphatase YVH1

All UniProt accessions (3): Q9UNI6, V9GY92, V9GYV5

UniProt curated annotations — full annotation on UniProt →

Function. Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.

Subunit / interactions. Monomer.

Subcellular location. Nucleus. Cytoplasm. Cytosol.

Tissue specificity. Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.

Cofactor. Binds 2 Zn(2+) ions per subunit.

Similarity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

RefSeq proteins (1): NP_009171* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000340	Dual-sp_phosphatase_cat-dom	Domain
IPR000387	Tyr_Pase_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR016278	DUSP12	Family
IPR020422	TYR_PHOSPHATASE_DUAL_dom	Domain
IPR029021	Prot-tyrosine_phosphatase-like	Homologous_superfamily

Pfam: PF00782

Catalyzed reactions (Rhea), 3 shown:

• O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (RHEA:10684)
• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (21 total): helix 8, strand 6, modified residue 2, chain 1, domain 1, active site 1, binding site 1, sequence variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
4KI9	X-RAY DIFFRACTION	2
4JNB	X-RAY DIFFRACTION	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UNI6-F1	86.21	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 115 (phosphocysteine intermediate)

Ligand- & substrate-binding residues (1): 116–121

Post-translational modifications (2): 1, 335

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 850 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8_TCELL_DN, GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, GSE45365_NK_CELL_VS_CD11B_DC_DN, GSE45365_NK_CELL_VS_BCELL_UP, ATF_B, BIOCARTA_TNFR2_PATHWAY, GGGACCA_MIR133A_MIR133B, GOBP_CHROMOSOME_ORGANIZATION, GOBP_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE, GOBP_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_REGULATION_OF_CELL_CYCLE_CHECKPOINT, FREAC2_01

GO Biological Process (3): dephosphorylation (GO:0016311), protein modification process (GO:0036211), protein dephosphorylation (GO:0006470)

GO Molecular Function (10): protein serine/threonine phosphatase activity (GO:0004722), protein tyrosine phosphatase activity (GO:0004725), protein tyrosine/serine/threonine phosphatase activity (GO:0008138), zinc ion binding (GO:0008270), phosphatase activity (GO:0016791), kinase binding (GO:0019900), phosphoprotein phosphatase activity (GO:0004721), protein binding (GO:0005515), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
phosphoprotein phosphatase activity	3
cellular anatomical structure	3
phosphate-containing compound metabolic process	1
protein metabolic process	1
macromolecule modification	1
dephosphorylation	1
protein modification process	1
transition metal ion binding	1
phosphoric ester hydrolase activity	1
enzyme binding	1
phosphatase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

3180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DUSP12	FOS	P01100	769
DUSP12	JUN	P05412	746
DUSP12	MAPK1	P28482	734
DUSP12	ATF3	P18847	733
DUSP12	MRTO4	Q9UKD2	731
DUSP12	MAPK8	P45983	726
DUSP12	MAPK14	Q16539	719
DUSP12	FOSB	P53539	708
DUSP12	NR4A1	P22736	692
DUSP12	HSD17B12	Q53GQ0	675
DUSP12	MAPK3	P27361	632
DUSP12	BTG2	P78543	627
DUSP12	EGFR	P00533	623
DUSP12	IL6	P05231	607
DUSP12	DUSP2	Q05923	606

IntAct

48 interactions, top by confidence:

A	B	Type	Score
CCNH	DUSP12	psi-mi:“MI:0915”(physical association)	0.780
RABAC1	DUSP12	psi-mi:“MI:0915”(physical association)	0.780
DUSP12	CCNH	psi-mi:“MI:0915”(physical association)	0.780
DUSP12	RABAC1	psi-mi:“MI:0915”(physical association)	0.780
CALCOCO2	DUSP12	psi-mi:“MI:0915”(physical association)	0.740
DUSP12	CALCOCO2	psi-mi:“MI:0915”(physical association)	0.740
DUSP12	EIF5	psi-mi:“MI:0915”(physical association)	0.720
EIF5	DUSP12	psi-mi:“MI:0915”(physical association)	0.720
DUSP12	PPP2R3B	psi-mi:“MI:0915”(physical association)	0.670
PPP2R3B	DUSP12	psi-mi:“MI:0915”(physical association)	0.670
DUSP12	USO1	psi-mi:“MI:0915”(physical association)	0.560
HSPB8	DUSP12	psi-mi:“MI:0915”(physical association)	0.560
USO1	DUSP12	psi-mi:“MI:0915”(physical association)	0.560
DUSP12	HSPB8	psi-mi:“MI:0915”(physical association)	0.560
M6PR	DUSP12	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (74): DUSP12 (Two-hybrid), DUSP12 (Two-hybrid), DUSP12 (Two-hybrid), DUSP12 (Two-hybrid), DUSP12 (Two-hybrid), HSPB8 (Two-hybrid), PPP2R3B (Two-hybrid), DUSP12 (Two-hybrid), C21orf59 (Co-fractionation), DUSP12 (Co-fractionation), DUSP12 (Two-hybrid), PPP2R3B (Two-hybrid), DUSP12 (Affinity Capture-MS), DUSP13 (Affinity Capture-MS), PPM1A (Affinity Capture-MS)

ESM2 similar proteins: A2TF48, A5HNF6, A8QMS7, B3SRQ2, B3Y678, B3Y679, B3Y680, B3Y681, B3Y682, B3Y683, B6CJX2, C8BKC7, F1QWA8, I3L5V6, O02697, O88879, P0CI65, P22366, P42338, P48736, P52735, Q13158, Q28DJ2, Q3UR70, Q3V3E1, Q4LBC6, Q599T9, Q5FWM2, Q5XJ85, Q60992, Q61160, Q645M6, Q6AZT7, Q6Y1S1, Q7TNH6, Q7Z494, Q7ZYP6, Q803A6, Q8BGG7, Q8BTI9

Diamond homologs: A0A7H0DN78, P07239, P0C597, P0C598, P0C5A0, P0C5A1, P0DOQ5, P0DOQ6, P20495, P28191, P28562, P28563, P29074, P51452, P80994, Q05923, Q13115, Q16690, Q16828, Q2KJ36, Q4RQD3, Q54R42, Q54T76, Q5RD73, Q62767, Q64346, Q64623, Q6B8I0, Q6B8I1, Q84JU4, Q85297, Q8BFV3, Q90W58, Q91790, Q99956, Q9D0T2, Q9DBB1, Q9J592, Q9M8K7, Q9PW71

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
DUSP12	“down-regulates activity”	MAP3K5	dephosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

892 predictions. Top by Δscore:

Variant	Effect	Δscore
1:161751774:GAGGC:G	donor_gain	1.0000
1:161751776:GGC:G	donor_gain	1.0000
1:161751778:C:CG	donor_gain	1.0000
1:161751782:G:GG	donor_gain	1.0000
1:161751856:A:AG	acceptor_gain	1.0000
1:161751857:T:G	acceptor_gain	1.0000
1:161751859:A:AG	acceptor_gain	1.0000
1:161751860:TTACA:T	acceptor_loss	1.0000
1:161751861:TACA:T	acceptor_loss	1.0000
1:161751862:A:AG	acceptor_gain	1.0000
1:161751862:ACAG:A	acceptor_gain	1.0000
1:161751864:A:AG	acceptor_gain	1.0000
1:161751864:AG:A	acceptor_gain	1.0000
1:161751864:AGGAT:A	acceptor_gain	1.0000
1:161751865:G:A	acceptor_loss	1.0000
1:161751865:G:GA	acceptor_gain	1.0000
1:161751865:GG:G	acceptor_gain	1.0000
1:161751865:GGA:G	acceptor_gain	1.0000
1:161751865:GGAT:G	acceptor_gain	1.0000
1:161751865:GGATG:G	acceptor_gain	1.0000
1:161751980:TCCAG:T	donor_gain	1.0000
1:161751981:CCAG:C	donor_gain	1.0000
1:161751982:CAG:C	donor_gain	1.0000
1:161751983:AG:A	donor_gain	1.0000
1:161751983:AGGT:A	donor_loss	1.0000
1:161751984:GG:G	donor_gain	1.0000
1:161751984:GGTA:G	donor_loss	1.0000
1:161751985:G:GG	donor_gain	1.0000
1:161752366:A:AG	acceptor_gain	1.0000
1:161752367:G:GG	acceptor_gain	1.0000

AlphaMissense

2227 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:161753223:T:A	W275R	0.998
1:161753223:T:C	W275R	0.998
1:161756792:T:C	C290R	0.997
1:161753225:G:C	W275C	0.995
1:161753225:G:T	W275C	0.995
1:161756822:T:C	F300L	0.995
1:161756824:C:A	F300L	0.995
1:161756824:C:G	F300L	0.995
1:161752451:T:C	C221R	0.994
1:161756828:T:A	W302R	0.993
1:161756828:T:C	W302R	0.993
1:161752451:T:A	C221S	0.992
1:161752452:G:C	C221S	0.992
1:161756792:T:A	C290S	0.992
1:161756793:G:C	C290S	0.992
1:161752460:T:C	C224R	0.991
1:161756801:T:A	C293S	0.991
1:161756802:G:C	C293S	0.991
1:161752460:T:A	C224S	0.990
1:161752461:G:C	C224S	0.990
1:161756794:C:G	C290W	0.990
1:161756801:T:C	C293R	0.990
1:161756816:G:C	G298R	0.990
1:161756874:T:C	F317S	0.990
1:161751681:A:C	S120R	0.989
1:161751683:T:A	S120R	0.989
1:161751683:T:G	S120R	0.989
1:161751879:T:C	F158L	0.989
1:161751881:T:A	F158L	0.989
1:161751881:T:G	F158L	0.989

dbSNP variants (sampled 300 via entrez): RS1000018263 (1:161749677 CG>C), RS1000187820 (1:161748865 G>C,T), RS1001347210 (1:161749550 C>A), RS1001502933 (1:161755627 C>T), RS1001743802 (1:161751177 G>A,C), RS1001798775 (1:161757680 CATT>C), RS1001828511 (1:161754353 A>T), RS1002091331 (1:161750924 C>T), RS1003506027 (1:161752780 G>A), RS1003855000 (1:161749362 T>A,G), RS1003858698 (1:161749626 G>C,T), RS1003986575 (1:161752957 T>C), RS1004028595 (1:161757630 G>A), RS1005449746 (1:161753712 A>C,T), RS1005586759 (1:161750733 C>G,T)

Disease associations

OMIM: gene MIM:604835 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST005987_23	Albumin-globulin ratio	6.000000e-15
GCST005990_39	Non-albumin protein levels	4.000000e-21
GCST006000_1	Immunoglobulin measurement (zinc sulfate turbidity test)	3.000000e-13
GCST90011900_53	Serum alkaline phosphatase levels	3.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005128	albumin:globulin ratio measurement
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs881152	Efficacy	3	salbutamol	Asthma

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs881152	DUSP1	3	0.75	1	salbutamol

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases reaction, increases expression, decreases activity, decreases expression	3
Air Pollutants	increases abundance, increases expression, decreases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Valproic Acid	affects expression, decreases methylation	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
bisphenol A	affects expression	1
cobaltous chloride	increases expression	1
manganese chloride	decreases expression, increases abundance	1
cylindrospermopsin	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
abrine	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Antimony Potassium Tartrate	increases expression, decreases reaction	1
Cadmium	increases abundance, increases expression	1
Catechin	decreases expression, affects cotreatment	1
Ivermectin	decreases expression	1
Manganese	decreases expression, increases abundance	1
Methyl Methanesulfonate	increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tretinoin	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B6SE	HEK293 GFP-DUSP12	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.