DUSP15

Summary

DUSP15 (dual specificity phosphatase 15, HGNC:16236) is a protein-coding gene on chromosome 20q11.21, encoding Dual specificity protein phosphatase 15 (Q9H1R2). May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6.

The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 128853 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 64 total
• Druggable target: yes
• MANE Select transcript: NM_080611

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16236
Approved symbol	DUSP15
Name	dual specificity phosphatase 15
Location	20q11.21
Locus type	gene with protein product
Status	Approved
Aliases	bA243J16.6, VHY, FLJ20645, bA243J16.5
Ensembl gene	ENSG00000149599
Ensembl biotype	protein_coding
OMIM	616776
Entrez	128853

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000278979, ENST00000339738, ENST00000375966, ENST00000398083, ENST00000398084, ENST00000428829, ENST00000447647, ENST00000459848, ENST00000486996, ENST00000493115, ENST00000916132

RefSeq mRNA: 5 — MANE Select: NM_080611 NM_001012644, NM_001320478, NM_001320479, NM_080611, NM_177991

CCDS: CCDS13193, CCDS42862, CCDS82606, CCDS82607

Canonical transcript exons

ENST00000339738 — 7 exons

Exon	Start	End
ENSE00001850086	31870317	31870527
ENSE00003532553	31867071	31867153
ENSE00003609302	31869564	31869597
ENSE00003633907	31863907	31863981
ENSE00003644385	31862571	31862742
ENSE00003693737	31864953	31865002
ENSE00003916510	31861077	31861675

Expression profiles

Bgee: expression breadth ubiquitous, 194 present calls, max score 98.89.

FANTOM5 (CAGE): breadth broad, TPM avg 3.6690 / max 327.4877, expressed in 645 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
186878	1.7335	385
186880	0.5364	326
186879	0.5128	261
186877	0.4633	92
186881	0.2759	15
186876	0.0761	32
186883	0.0612	9
186882	0.0098	3

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	98.89	gold quality
right testis	UBERON:0004534	98.76	gold quality
testis	UBERON:0000473	96.14	gold quality
tibial nerve	UBERON:0001323	91.14	gold quality
adult mammalian kidney	UBERON:0000082	88.26	gold quality
sperm	CL:0000019	88.24	gold quality
metanephros cortex	UBERON:0010533	87.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.16	gold quality
kidney epithelium	UBERON:0004819	86.94	gold quality
cortex of kidney	UBERON:0001225	85.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.30	gold quality
descending thoracic aorta	UBERON:0002345	84.44	gold quality
spinal cord	UBERON:0002240	84.28	gold quality
right coronary artery	UBERON:0001625	83.14	gold quality
vena cava	UBERON:0004087	82.71	silver quality
kidney	UBERON:0002113	82.55	gold quality
putamen	UBERON:0001874	82.21	gold quality
nucleus accumbens	UBERON:0001882	81.65	gold quality
ascending aorta	UBERON:0001496	81.11	gold quality
thoracic aorta	UBERON:0001515	81.11	gold quality
apex of heart	UBERON:0002098	80.86	gold quality
trigeminal ganglion	UBERON:0001675	80.82	gold quality
sural nerve	UBERON:0015488	80.61	gold quality
substantia nigra	UBERON:0002038	80.58	gold quality
aorta	UBERON:0000947	80.31	gold quality
hypothalamus	UBERON:0001898	80.12	gold quality
midbrain	UBERON:0001891	79.89	gold quality
caudate nucleus	UBERON:0001873	79.85	gold quality
popliteal artery	UBERON:0002250	79.79	gold quality
tibial artery	UBERON:0007610	79.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.70

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting DUSP15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-103A-1-5P	99.39	67.78	1545
HSA-MIR-103A-2-5P	99.39	67.72	1577
HSA-MIR-328-5P	99.08	64.65	1000
HSA-MIR-6885-5P	98.71	64.33	902
HSA-MIR-6818-3P	98.56	68.23	1307
HSA-MIR-6827-5P	98.46	64.88	1256
HSA-MIR-505-5P	97.01	65.54	778

Literature-anchored findings (GeneRIF, showing 6)

• VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases (PMID:15138252)
• crystal structure of catalytic domain (PMID:16170801)
• Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates. (PMID:22792334)
• The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population. (PMID:27223645)
• Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein. (PMID:33417224)
• Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder. (PMID:34257739)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Dusp15	ENSMUSG00000042662
rattus_norvegicus	Dusp15	ENSRNOG00000008534

Paralogs (31): DUSP13B (ENSG00000079393), DUSP12 (ENSG00000081721), SSH1 (ENSG00000084112), DUSP3 (ENSG00000108861), PTPMT1 (ENSG00000110536), DUSP16 (ENSG00000111266), EPM2A (ENSG00000112425), DUSP22 (ENSG00000112679), DUSP1 (ENSG00000120129), DUSP4 (ENSG00000120875), STYXL1 (ENSG00000127952), DUSP9 (ENSG00000130829), DUSP26 (ENSG00000133878), DUSP5 (ENSG00000138166), DUSP6 (ENSG00000139318), SSH2 (ENSG00000141298), DUSP10 (ENSG00000143507), DUSP2 (ENSG00000158050), KASH5 (ENSG00000161609), DUSP19 (ENSG00000162999), DUSP7 (ENSG00000164086), DUSP18 (ENSG00000167065), SSH3 (ENSG00000172830), DUSP8 (ENSG00000184545), DUSP28 (ENSG00000188542), DUSP29 (ENSG00000188716), DUSP21 (ENSG00000189037), STYX (ENSG00000198252), STYXL2 (ENSG00000198842), DUSP14 (ENSG00000276023), DUSP13A (ENSG00000293543)

Protein

Protein identifiers

Dual specificity protein phosphatase 15 — Q9H1R2 (reviewed: Q9H1R2)

Alternative names: VH1-related member Y, Vaccinia virus VH1-related dual-specific protein phosphatase Y

All UniProt accessions (3): Q9H1R2, H0Y5A2, Q5QP64

UniProt curated annotations — full annotation on UniProt →

Function. May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6. May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation. Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination.

Subcellular location. Cytoplasm Cell membrane.

Tissue specificity. Highly expressed in testis. Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions.

Similarity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9H1R2-1	1	yes
Q9H1R2-2	2
Q9H1R2-3	3, A
Q9H1R2-4	4

RefSeq proteins (5): NP_001012662, NP_001307407, NP_001307408, NP_542178, NP_817130 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000340	Dual-sp_phosphatase_cat-dom	Domain
IPR000387	Tyr_Pase_dom	Domain
IPR008984	SMAD_FHA_dom_sf	Homologous_superfamily
IPR016130	Tyr_Pase_AS	Active_site
IPR020422	TYR_PHOSPHATASE_DUAL_dom	Domain
IPR029021	Prot-tyrosine_phosphatase-like	Homologous_superfamily

Pfam: PF00782

Catalyzed reactions (Rhea), 3 shown:

• O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (RHEA:10684)
• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (25 total): helix 8, strand 5, splice variant 4, chain 1, domain 1, region of interest 1, initiator methionine 1, lipid moiety-binding region 1, compositionally biased region 1, active site 1, mutagenesis site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1YZ4	X-RAY DIFFRACTION	2.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H1R2-F1	67.61	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 85 (phosphocysteine intermediate)

Post-translational modifications (1): 2

Mutagenesis-validated functional residues (1):

Position	Phenotype
85	loss of phosphatase activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 75 (showing top): BENPORATH_ES_WITH_H3K27ME3, GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE, GOBP_NEUROGENESIS, SP1_Q2_01, GTGCCTT_MIR506, GOBP_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_DEPHOSPHORYLATION, GOBP_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION, CCCAGAG_MIR326, GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE, GOBP_GLIAL_CELL_DIFFERENTIATION, chr20q11, GOBP_OLIGODENDROCYTE_DIFFERENTIATION, TGCCTTA_MIR124A

GO Biological Process (6): negative regulation of transcription by RNA polymerase II (GO:0000122), signal transduction (GO:0007165), dephosphorylation (GO:0016311), regulation of oligodendrocyte differentiation (GO:0048713), positive regulation of ERK1 and ERK2 cascade (GO:0070374), protein dephosphorylation (GO:0006470)

GO Molecular Function (7): protein serine/threonine phosphatase activity (GO:0004722), protein tyrosine phosphatase activity (GO:0004725), protein tyrosine/serine/threonine phosphatase activity (GO:0008138), phosphatase activity (GO:0016791), phosphoprotein phosphatase activity (GO:0004721), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (4): cytosol (GO:0005829), plasma membrane (GO:0005886), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
phosphoprotein phosphatase activity	3
cellular anatomical structure	3
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
phosphate-containing compound metabolic process	1
regulation of glial cell differentiation	1
oligodendrocyte differentiation	1
positive regulation of MAPK cascade	1
ERK1 and ERK2 cascade	1
regulation of ERK1 and ERK2 cascade	1
dephosphorylation	1
protein modification process	1
phosphoric ester hydrolase activity	1
phosphatase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
cytoplasm	1
membrane	1
cell periphery	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1186 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DUSP15	DUSP23	Q9BVJ7	728
DUSP15	MYRF	Q9Y2G1	534
DUSP15	ZNF215	Q9UL58	449
DUSP15	UBE2QL1	A1L167	428
DUSP15	PDCD11	Q14690	410
DUSP15	DUSP22	Q9NRW4	405
DUSP15	SAXO4	Q7Z5V6	403
DUSP15	ALDH5A1	P51649	400
DUSP15	LRATD1	Q96KN4	387
DUSP15	COX4I2	Q96KJ9	386
DUSP15	PTPN1	P18031	382
DUSP15	PPM1J	Q5JR12	370
DUSP15	COX4I1	P13073	365
DUSP15	FAM222A	Q5U5X8	360
DUSP15	RNF113A	O15541	358
DUSP15	PTPN9	P43378	358

IntAct

17 interactions, top by confidence:

A	B	Type	Score
PLCG1	DUSP15	psi-mi:“MI:0407”(direct interaction)	0.540
DUSP15	PLCG1	psi-mi:“MI:0915”(physical association)	0.540
DUSP15	ABL1	psi-mi:“MI:0915”(physical association)	0.400
CRK	DUSP15	psi-mi:“MI:0915”(physical association)	0.400
SRC	DUSP15	psi-mi:“MI:0915”(physical association)	0.400
FYN	DUSP15	psi-mi:“MI:0915”(physical association)	0.400
DUSP15	GRB2	psi-mi:“MI:0915”(physical association)	0.400
DUSP15	NCK1	psi-mi:“MI:0915”(physical association)	0.400
PIK3R1	DUSP15	psi-mi:“MI:0915”(physical association)	0.400
DUSP15	IGF1R	psi-mi:“MI:0915”(physical association)	0.370
DUSP15	PTK7	psi-mi:“MI:0915”(physical association)	0.370
CUL4B	GGTLC3	psi-mi:“MI:0914”(association)	0.350
MYC		psi-mi:“MI:0914”(association)	0.350
DUSP15	GALT	psi-mi:“MI:0914”(association)	0.350
DUSP15	PCK1	psi-mi:“MI:0914”(association)	0.350

BioGRID (35): DUSP15 (Two-hybrid), DUSP15 (Two-hybrid), PSMD3 (Affinity Capture-MS), PSMC5 (Affinity Capture-MS), PSMD2 (Affinity Capture-MS), PSMD1 (Affinity Capture-MS), PSMD6 (Affinity Capture-MS), PSMD13 (Affinity Capture-MS), HLCS (Affinity Capture-MS), PSMC3 (Affinity Capture-MS), PTPN5 (Affinity Capture-MS), PSMD7 (Affinity Capture-MS), DUSP15 (Affinity Capture-MS), ANKRD28 (Affinity Capture-MS), ANKRD52 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WVF3, A0A087WXS9, A0A087X179, A0A087X1G2, A6NDS4, A6NER0, A6QPT6, B9A6J9, M3WHG5, O14771, O15482, O15553, O19110, O76081, P0C7X1, P0C7X3, P0C7X4, P35125, P48778, P48967, P79209, Q13670, Q15697, Q2TBC4, Q3T191, Q3UZD7, Q4R2Z8, Q5DRQ5, Q5SSQ6, Q5XFX8, Q69ZB3, Q6DHY5, Q6IPX1, Q6ZMN8, Q8BLR5, Q8BWA8, Q8IYF1, Q8IZP1, Q8JZW5, Q8N7G0

Diamond homologs: A4IHU7, F1QWM2, O09112, O13632, O55737, O95147, P0C591, P0C592, P0C593, P0C594, P0C595, P0C596, P0C597, P0C598, P0C599, P0C5A0, P0C5A1, P0C5A2, P28562, P28563, P51452, Q05922, Q13115, Q13202, Q148W8, Q16828, Q16829, Q17QJ3, Q17QM8, Q1LWL2, Q29RA3, Q2KJ36, Q39491, Q4KL92, Q4RQD3, Q4V7N3, Q54T76, Q54Y32, Q556Y8, Q55BI8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 15 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Downstream signal transduction	6	175.7×	1e-10
FCGR3A-mediated phagocytosis	6	86.4×	5e-09
VEGFA-VEGFR2 Pathway	5	53.6×	1e-06

GO biological processes:

GO term	Partners	Fold	FDR
ephrin receptor signaling pathway	5	114.6×	2e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1271 predictions. Top by Δscore:

Variant	Effect	Δscore
20:31863901:A:C	donor_gain	1.0000
20:31863901:ACTC:A	donor_loss	1.0000
20:31863902:CTCA:C	donor_loss	1.0000
20:31863903:T:TA	donor_loss	1.0000
20:31863904:CA:C	donor_loss	1.0000
20:31863905:A:AC	donor_gain	1.0000
20:31863905:A:C	donor_loss	1.0000
20:31863906:C:CC	donor_gain	1.0000
20:31863982:C:CC	acceptor_gain	1.0000
20:31867066:AGTAC:A	donor_loss	1.0000
20:31867067:GTA:G	donor_loss	1.0000
20:31867068:TACC:T	donor_loss	1.0000
20:31867069:A:AT	donor_loss	1.0000
20:31867070:C:A	donor_loss	1.0000
20:31867151:CAT:C	acceptor_gain	1.0000
20:31867154:C:CC	acceptor_gain	1.0000
20:31867154:CTGA:C	acceptor_loss	1.0000
20:31869594:GTACC:G	acceptor_loss	1.0000
20:31869595:TACC:T	acceptor_loss	1.0000
20:31869596:ACC:A	acceptor_loss	1.0000
20:31869597:CCT:C	acceptor_loss	1.0000
20:31869598:CTA:C	acceptor_loss	1.0000
20:31869599:T:A	acceptor_loss	1.0000
20:31861671:CGAAG:C	acceptor_gain	0.9900
20:31861672:GAAG:G	acceptor_gain	0.9900
20:31861674:AG:A	acceptor_gain	0.9900
20:31861676:C:CC	acceptor_gain	0.9900
20:31861676:CTG:C	acceptor_loss	0.9900
20:31861681:G:C	acceptor_gain	0.9900
20:31861681:G:GC	acceptor_gain	0.9900

AlphaMissense

1511 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:31862613:A:C	F128L	1.000
20:31862613:A:T	F128L	1.000
20:31862614:A:G	F128S	1.000
20:31862615:A:G	F128L	1.000
20:31863918:G:C	C81W	1.000
20:31863951:G:C	F70L	1.000
20:31863951:G:T	F70L	1.000
20:31863953:A:G	F70L	1.000
20:31862614:A:C	F128C	0.999
20:31862615:A:C	F128V	0.999
20:31862626:G:T	P124H	0.999
20:31862627:G:A	P124S	0.999
20:31862632:G:T	A122D	0.999
20:31862640:C:A	R119S	0.999
20:31862640:C:G	R119S	0.999
20:31862641:C:A	R119M	0.999
20:31862641:C:G	R119T	0.999
20:31862704:G:T	A98E	0.999
20:31862721:G:C	S92R	0.999
20:31862721:G:T	S92R	0.999
20:31862723:T:G	S92R	0.999
20:31862726:G:T	R91S	0.999
20:31862734:C:A	G88V	0.999
20:31862734:C:T	G88D	0.999
20:31862735:C:A	G88C	0.999
20:31862735:C:G	G88R	0.999
20:31863908:A:G	C85R	0.999
20:31863909:G:C	H84Q	0.999
20:31863909:G:T	H84Q	0.999
20:31863916:A:G	L82P	0.999

dbSNP variants (sampled 300 via entrez): RS1000036719 (20:31849056 C>T), RS1000192116 (20:31855069 A>C,G), RS1000249644 (20:31852053 G>T), RS1000340713 (20:31861845 T>C), RS1000645861 (20:31851562 G>A), RS1000663562 (20:31859712 C>A), RS1000674527 (20:31860653 G>T), RS1000724816 (20:31860351 C>T), RS1000881409 (20:31866628 C>T), RS1000974509 (20:31853619 C>A,G,T), RS1000990778 (20:31853622 G>A), RS1001245497 (20:31856265 G>A,T), RS1001249881 (20:31867013 A>T), RS1001403150 (20:31863079 G>A,C,T), RS1001507771 (20:31869435 T>A)

Disease associations

OMIM: gene MIM:616776 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010703_295	Brain morphology (MOSTest)	1.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2396507 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.54	IC50	2900	nM	CHEMBL2396718
5.34	IC50	4600	nM	CHEMBL2396719

PubChem BioAssay actives

2 with measured affinity, of 2 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
3-[2-(3-chlorophenyl)ethynyl]-6-hydroxy-2-[4-[2-oxo-2-(propylamino)ethoxy]phenyl]-1-benzofuran-5-carboxylic acid	755761: Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis	ic50	2.9000	uM
3-[2-(3-chlorophenyl)ethynyl]-2-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]-6-hydroxy-1-benzofuran-5-carboxylic acid	755761: Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis	ic50	4.6000	uM

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
dicrotophos	decreases expression	1
methyleugenol	increases expression	1
aflatoxin B2	decreases methylation	1
resorcinol	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
CGP 52608	increases reaction, affects binding	1
clothianidin	increases expression	1
nutlin 3	affects cotreatment, increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Bortezomib	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Leflunomide	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Camptothecin	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
N-Nitrosopyrrolidine	increases expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Tetrachlorodibenzodioxin	decreases expression	1
Urethane	increases expression	1
Particulate Matter	increases abundance, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2401183	Binding	Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis	A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.