DUSP18

Summary

DUSP18 (dual specificity phosphatase 18, HGNC:18484) is a protein-coding gene on chromosome 22q12.2, encoding Dual specificity protein phosphatase 18 (Q8NEJ0). Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).

Source: NCBI Gene 150290 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 41 total
• MANE Select transcript: NM_152511

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18484
Approved symbol	DUSP18
Name	dual specificity phosphatase 18
Location	22q12.2
Locus type	gene with protein product
Status	Approved
Aliases	DUSP20
Ensembl gene	ENSG00000167065
Ensembl biotype	protein_coding
OMIM	611446
Entrez	150290

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 19 protein_coding, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000334679, ENST00000342474, ENST00000377087, ENST00000403268, ENST00000404885, ENST00000407308, ENST00000412865, ENST00000430175, ENST00000442752, ENST00000461301, ENST00000866296, ENST00000866297, ENST00000866298, ENST00000866299, ENST00000866300, ENST00000866301, ENST00000866302, ENST00000912603, ENST00000912604, ENST00000965881, ENST00000965882, ENST00000965883, ENST00000965884

RefSeq mRNA: 4 — MANE Select: NM_152511 NM_001304794, NM_001304795, NM_001304796, NM_152511

CCDS: CCDS13883, CCDS77667

Canonical transcript exons

ENST00000334679 — 2 exons

Exon	Start	End
ENSE00001332764	30661445	30664080
ENSE00001940744	30667462	30667875

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 96.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.4586 / max 90.8435, expressed in 1699 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193658	7.2236	1693
193657	0.2350	106

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.48	gold quality
bronchial epithelial cell	CL:0002328	94.36	gold quality
bronchus	UBERON:0002185	93.30	gold quality
oocyte	CL:0000023	90.13	gold quality
ileal mucosa	UBERON:0000331	89.77	gold quality
oviduct epithelium	UBERON:0004804	89.05	gold quality
left testis	UBERON:0004533	87.42	gold quality
right testis	UBERON:0004534	87.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.00	gold quality
testis	UBERON:0000473	85.81	gold quality
mucosa of paranasal sinus	UBERON:0005030	84.68	gold quality
cortical plate	UBERON:0005343	83.26	gold quality
sperm	CL:0000019	82.99	silver quality
right uterine tube	UBERON:0001302	82.85	gold quality
blood	UBERON:0000178	82.68	gold quality
pancreatic ductal cell	CL:0002079	82.37	silver quality
cardiac muscle of right atrium	UBERON:0003379	81.99	gold quality
tibialis anterior	UBERON:0001385	81.66	silver quality
monocyte	CL:0000576	81.41	gold quality
leukocyte	CL:0000738	81.27	gold quality
left ventricle myocardium	UBERON:0006566	81.10	gold quality
fallopian tube	UBERON:0003889	79.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.53	gold quality
kidney epithelium	UBERON:0004819	78.58	gold quality
buccal mucosa cell	CL:0002336	78.28	gold quality
granulocyte	CL:0000094	78.19	gold quality
esophagus squamous epithelium	UBERON:0006920	78.06	gold quality
rectum	UBERON:0001052	77.90	gold quality
upper arm skin	UBERON:0004263	77.68	gold quality
ganglionic eminence	UBERON:0004023	77.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.40

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

77 targeting DUSP18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-8062	99.88	68.43	995
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306

Literature-anchored findings (GeneRIF, showing 5)

• molecular cloning, base sequence and amino acid sequence (PMID:12591617)
• The crystal structure of human DSP18 (official symbol DUSP18) has been determined at 2.0 A resolution. (PMID:16699184)
• DUSP18 appears to serve an important role by regulation of SAPK/JNK pathway (PMID:16720344)
• JNK and DUSP18 reciprocally modulate the SUMOylation, which plays a regulatory role in the aggregation of ataxin-1. (PMID:29852174)
• Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion. (PMID:35841693)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Dusp18	ENSMUSG00000047205
rattus_norvegicus	Dusp18	ENSRNOG00000024945

Paralogs (31): DUSP13B (ENSG00000079393), DUSP12 (ENSG00000081721), SSH1 (ENSG00000084112), DUSP3 (ENSG00000108861), PTPMT1 (ENSG00000110536), DUSP16 (ENSG00000111266), EPM2A (ENSG00000112425), DUSP22 (ENSG00000112679), DUSP1 (ENSG00000120129), DUSP4 (ENSG00000120875), STYXL1 (ENSG00000127952), DUSP9 (ENSG00000130829), DUSP26 (ENSG00000133878), DUSP5 (ENSG00000138166), DUSP6 (ENSG00000139318), SSH2 (ENSG00000141298), DUSP10 (ENSG00000143507), DUSP15 (ENSG00000149599), DUSP2 (ENSG00000158050), KASH5 (ENSG00000161609), DUSP19 (ENSG00000162999), DUSP7 (ENSG00000164086), SSH3 (ENSG00000172830), DUSP8 (ENSG00000184545), DUSP28 (ENSG00000188542), DUSP29 (ENSG00000188716), DUSP21 (ENSG00000189037), STYX (ENSG00000198252), STYXL2 (ENSG00000198842), DUSP14 (ENSG00000276023), DUSP13A (ENSG00000293543)

Protein

Protein identifiers

Dual specificity protein phosphatase 18 — Q8NEJ0 (reviewed: Q8NEJ0)

Alternative names: Low molecular weight dual specificity phosphatase 20

All UniProt accessions (5): C9JEE9, F2Z2P2, F8VX42, H7C401, Q8NEJ0

UniProt curated annotations — full annotation on UniProt →

Function. Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus where it dephosphorylates SRC, resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption.

Subunit / interactions. Interacts with KISS1R and SRC; the interaction depends on activation of KISS1/KISS1R signaling pathway and is required for SRC dephosphorylation and inactivation. Interaction with KISS1R and SRC is relevant for down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption.

Subcellular location. Cytoplasm. Nucleus. Mitochondrion inner membrane.

Tissue specificity. Widely expressed with highest levels in liver, brain, ovary and testis.

Activity regulation. Activated by manganese ions, inhibited by iodoacetic acid.

Similarity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

RefSeq proteins (4): NP_001291723, NP_001291724, NP_001291725, NP_689724* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000340	Dual-sp_phosphatase_cat-dom	Domain
IPR000387	Tyr_Pase_dom	Domain
IPR016130	Tyr_Pase_AS	Active_site
IPR020420	Atypical_DUSP_subfamB	Family
IPR020422	TYR_PHOSPHATASE_DUAL_dom	Domain
IPR029021	Prot-tyrosine_phosphatase-like	Homologous_superfamily

Pfam: PF00782

Catalyzed reactions (Rhea), 3 shown:

• O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (RHEA:10684)
• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (23 total): helix 8, strand 6, mutagenesis site 5, chain 1, domain 1, active site 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2ESB	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NEJ0-F1	92.97	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 104 (phosphocysteine intermediate)

Mutagenesis-validated functional residues (5):

Position	Phenotype
73	abolishes most of in vitro phosphatase activity.
102	no effect on in vitro phosphatase activity.
104	abolishes most of phosphatase activity. decreases interaction with src. decreases src phosphorylation.
110	abolishes most of in vitro phosphatase activity.
111	abolishes most of in vitro phosphatase activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 117 (showing top): GOBP_NEGATIVE_REGULATION_OF_TISSUE_REMODELING, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_REGULATION_OF_BONE_REMODELING, GOCC_MITOCHONDRIAL_ENVELOPE, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, GOBP_DEPHOSPHORYLATION, GOBP_PROTEIN_DEPHOSPHORYLATION, GOBP_BONE_RESORPTION, GOBP_REGULATION_OF_TISSUE_REMODELING, GRADE_COLON_AND_RECTAL_CANCER_UP, GOCC_ORGANELLE_INNER_MEMBRANE, GOBP_HOMEOSTATIC_PROCESS, GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS, GOMF_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY, GOMF_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY

GO Biological Process (4): dephosphorylation (GO:0016311), peptidyl-tyrosine dephosphorylation (GO:0035335), peptidyl-threonine dephosphorylation (GO:0035970), protein dephosphorylation (GO:0006470)

GO Molecular Function (8): protein serine/threonine phosphatase activity (GO:0004722), protein tyrosine phosphatase activity (GO:0004725), protein tyrosine/serine/threonine phosphatase activity (GO:0008138), phosphatase activity (GO:0016791), MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017), phosphoprotein phosphatase activity (GO:0004721), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (6): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), mitochondrial inner membrane (GO:0005743), mitochondrion (GO:0005739), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
phosphoprotein phosphatase activity	3
cellular anatomical structure	3
protein dephosphorylation	2
intracellular membrane-bounded organelle	2
phosphate-containing compound metabolic process	1
dephosphorylation	1
protein modification process	1
phosphoric ester hydrolase activity	1
protein tyrosine/serine/threonine phosphatase activity	1
MAP kinase phosphatase activity	1
phosphatase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
nuclear lumen	1
intracellular anatomical structure	1
organelle inner membrane	1
mitochondrial membrane	1
cytoplasm	1

Protein interactions and networks

STRING

718 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DUSP18	MAPK8	P45983	478
DUSP18	HDHD5	Q9BXW7	456
DUSP18	PTPN21	Q16825	432
DUSP18	DUSP11	O75319	424
DUSP18	MAPK14	Q16539	421
DUSP18	MAPK3	P27361	421
DUSP18	KCNT2	Q6UVM3	395
DUSP18	PPM1M	Q96MI6	385
DUSP18	PLPP6	Q8IY26	368
DUSP18	NMRK2	Q9NPI5	359
DUSP18	H0YHX9	H0YHX9	356
DUSP18	KCNE5	Q9UJ90	352
DUSP18	DAP	P51397	349
DUSP18	PUDP	Q08623	341
DUSP18	MTMR9	Q96QG7	338

IntAct

22 interactions, top by confidence:

A	B	Type	Score
DUSP18	JPH3	psi-mi:“MI:0915”(physical association)	0.560
INSR	DUSP18	psi-mi:“MI:0915”(physical association)	0.510
DUSP18	INSR	psi-mi:“MI:0915”(physical association)	0.510
DUSP18	PTPN6	psi-mi:“MI:0915”(physical association)	0.400
DUSP18	MAPK8IP2	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	ERBB4	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	ERBB2	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	ERBB3	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	TEK	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	ROR1	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	ROR2	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	IGF1R	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	PTK7	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	EPHA3	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	EPHA7	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	EPHA2	psi-mi:“MI:0915”(physical association)	0.370
DUSP18	EPHB6	psi-mi:“MI:0915”(physical association)	0.370
KLHL22	TRAV18	psi-mi:“MI:0914”(association)	0.350
DUSP18	SNX4	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (25): DUSP18 (Two-hybrid), DUSP18 (Affinity Capture-Western), DUSP18 (Affinity Capture-Western), DUSP18 (Two-hybrid), DUSP18 (Two-hybrid), PTPN6 (Affinity Capture-MS), DCP1A (Proximity Label-MS), SNX4 (Proximity Label-MS), GORASP2 (Proximity Label-MS), HELZ (Proximity Label-MS), DUSP18 (Two-hybrid), DUSP18 (Two-hybrid), DUSP18 (Two-hybrid), DUSP18 (Two-hybrid), DUSP18 (Two-hybrid)

ESM2 similar proteins: A0A3L7I2I8, B2RZ50, E9Q4Z2, G4LTX4, O08586, O42099, O54857, O60733, O82656, O88712, O94806, P29074, P60483, P60484, P97570, P97819, Q02384, Q07832, Q07890, Q16667, Q1PET6, Q4R678, Q5BIP9, Q5F361, Q5F480, Q5IH13, Q5IH14, Q5RF15, Q5VNW5, Q641K1, Q66H63, Q6AXW7, Q6NRC7, Q6NU47, Q6NU98, Q810P3, Q8BM85, Q8K1Y2, Q8NEJ0, Q8TEA7

Diamond homologs: A4IHU7, F1QWM2, O09112, O13632, O55737, O95147, P0C591, P0C592, P0C593, P0C594, P0C595, P0C596, P0C597, P0C598, P0C599, P0C5A0, P0C5A1, P0C5A2, P28562, P28563, P51452, Q05922, Q13115, Q13202, Q148W8, Q16828, Q16829, Q17QJ3, Q17QM8, Q1LWL2, Q29RA3, Q2KJ36, Q39491, Q4KL92, Q4RQD3, Q4V7N3, Q54T76, Q54Y32, Q556Y8, Q55BI8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 19 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
cell surface receptor protein tyrosine kinase signaling pathway	7	67.6×	2e-09
positive regulation of MAPK cascade	6	26.9×	5e-06
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	6	26.1×	5e-06
negative regulation of apoptotic process	5	9.7×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

41 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

975 predictions. Top by Δscore:

Variant	Effect	Δscore
22:30663462:T:TA	donor_gain	0.9900
22:30664081:C:CC	acceptor_gain	0.9900
22:30664947:C:A	donor_gain	0.9900
22:30667467:T:A	donor_gain	0.9800
22:30654646:T:C	acceptor_gain	0.9700
22:30664076:GAAAA:G	acceptor_gain	0.9700
22:30664078:AAA:A	acceptor_gain	0.9700
22:30664079:AA:A	acceptor_gain	0.9700
22:30665117:CAAAG:C	acceptor_gain	0.9700
22:30652298:C:CC	acceptor_gain	0.9600
22:30664078:AAAC:A	acceptor_loss	0.9600
22:30664079:AACT:A	acceptor_loss	0.9600
22:30664081:C:T	acceptor_loss	0.9600
22:30663403:CCT:C	donor_gain	0.9500
22:30663835:C:CT	donor_gain	0.9500
22:30663836:T:TT	donor_gain	0.9500
22:30664080:ACTGC:A	acceptor_gain	0.9500
22:30664946:T:TA	donor_gain	0.9500
22:30654304:T:C	donor_gain	0.9400
22:30664949:CTTCA:C	donor_loss	0.9400
22:30664950:TTCA:T	donor_loss	0.9400
22:30664951:TCACC:T	donor_loss	0.9400
22:30664952:CA:C	donor_loss	0.9400
22:30664953:A:AC	donor_loss	0.9400
22:30664954:C:CT	donor_loss	0.9400
22:30667461:CCTCT:C	donor_gain	0.9400
22:30652294:GGGG:G	acceptor_gain	0.9300
22:30654303:A:AC	donor_gain	0.9300
22:30663834:A:AC	donor_gain	0.9300
22:30664081:CTGC:C	acceptor_gain	0.9300

AlphaMissense

1244 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:30663563:A:C	F147L	0.996
22:30663563:A:T	F147L	0.996
22:30663565:A:G	F147L	0.996
22:30663677:G:C	S109R	0.995
22:30663677:G:T	S109R	0.995
22:30663678:C:A	S109I	0.995
22:30663679:T:G	S109R	0.995
22:30663616:C:G	A130P	0.994
22:30663552:A:G	L151P	0.991
22:30663576:G:T	P143H	0.991
22:30663577:G:A	P143S	0.991
22:30663914:G:C	S30R	0.991
22:30663914:G:T	S30R	0.991
22:30663916:T:G	S30R	0.991
22:30663684:C:T	G107D	0.990
22:30663552:A:T	L151H	0.989
22:30663785:G:C	D73E	0.988
22:30663785:G:T	D73E	0.988
22:30663564:A:G	F147S	0.987
22:30663592:G:C	R138G	0.987
22:30663615:G:T	A130D	0.987
22:30663659:G:C	C115W	0.987
22:30663661:A:G	C115R	0.987
22:30663787:C:G	D73H	0.987
22:30663692:A:C	C104W	0.986
22:30663694:A:G	C104R	0.986
22:30663676:G:T	R110S	0.985
22:30663684:C:A	G107V	0.985
22:30663654:G:T	A117D	0.984
22:30663669:G:T	A112D	0.984

dbSNP variants (sampled 300 via entrez): RS1000095639 (22:30652366 T>C), RS1000148986 (22:30660115 T>C), RS1000354461 (22:30666697 A>G), RS1000356204 (22:30661694 G>A), RS1000447800 (22:30652679 G>A), RS1000818153 (22:30666451 G>A), RS1000961869 (22:30660476 G>GA), RS1001011504 (22:30654304 T>C), RS1001046748 (22:30654140 C>A,T), RS1001117826 (22:30666915 A>C), RS1001330204 (22:30660753 A>G,T), RS1001407874 (22:30661176 G>A), RS1001432506 (22:30659327 G>C), RS1001473367 (22:30659155 T>A,C), RS1001499209 (22:30654040 C>A,G,T)

Disease associations

OMIM: gene MIM:611446 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
Smoke	decreases expression, increases abundance, increases expression	2
urushiol	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzene	increases expression	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.