DUSP8

Summary

DUSP8 (dual specificity phosphatase 8, HGNC:3074) is a protein-coding gene on chromosome 11p15.5, encoding Dual specificity protein phosphatase 8 (Q13202). Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Source: NCBI Gene 1850 — RefSeq curated summary.

At a glance

• Gene–disease (curated): hereditary gingival fibromatosis (Limited, GenCC)
• GWAS associations: 3
• Clinical variants (ClinVar): 107 total
• MANE Select transcript: NM_004420

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:3074
Approved symbol	DUSP8
Name	dual specificity phosphatase 8
Location	11p15.5
Locus type	gene with protein product
Status	Approved
Aliases	HVH-5, HB5, FLJ42958
Ensembl gene	ENSG00000184545
Ensembl biotype	protein_coding
OMIM	602038
Entrez	1850

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000331588, ENST00000397374, ENST00000528778, ENST00000892337, ENST00000951652, ENST00000951653, ENST00000951654

RefSeq mRNA: 1 — MANE Select: NM_004420 NM_004420

CCDS: CCDS7724

Canonical transcript exons

ENST00000397374 — 7 exons

Exon	Start	End
ENSE00001301940	1554051	1557574
ENSE00001326809	1563851	1563989
ENSE00001528450	1565596	1565934
ENSE00001528452	1571901	1572271
ENSE00003551156	1557794	1557917
ENSE00003612447	1558112	1558271
ENSE00003653718	1558889	1559055

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 94.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9790 / max 291.5094, expressed in 1407 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117981	8.0610	1317
117980	1.7226	729
117979	0.2677	124
117978	0.2582	114
117976	0.2036	123
117973	0.1782	86
117975	0.1284	74
117977	0.1146	56
117974	0.0447	15

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of stomach	UBERON:0001199	94.35	gold quality
superior frontal gyrus	UBERON:0002661	94.35	gold quality
primary visual cortex	UBERON:0002436	94.09	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.74	gold quality
cerebellum	UBERON:0002037	93.08	gold quality
cerebellar cortex	UBERON:0002129	93.01	gold quality
cerebellar hemisphere	UBERON:0002245	92.98	gold quality
right frontal lobe	UBERON:0002810	92.47	gold quality
frontal cortex	UBERON:0001870	92.31	gold quality
prefrontal cortex	UBERON:0000451	92.19	gold quality
nucleus accumbens	UBERON:0001882	91.82	gold quality
putamen	UBERON:0001874	91.80	gold quality
anterior cingulate cortex	UBERON:0009835	91.64	gold quality
cerebral cortex	UBERON:0000956	91.59	gold quality
temporal lobe	UBERON:0001871	91.58	gold quality
cortical plate	UBERON:0005343	91.58	gold quality
amygdala	UBERON:0001876	91.49	gold quality
Ammon’s horn	UBERON:0001954	91.07	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.97	gold quality
caudate nucleus	UBERON:0001873	90.71	gold quality
brain	UBERON:0000955	90.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.06	gold quality
adenohypophysis	UBERON:0002196	89.71	gold quality
popliteal artery	UBERON:0002250	89.22	gold quality
tibial artery	UBERON:0007610	89.18	gold quality
pituitary gland	UBERON:0000007	88.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.56	gold quality
apex of heart	UBERON:0002098	87.50	gold quality
hypothalamus	UBERON:0001898	87.14	gold quality
ganglionic eminence	UBERON:0004023	86.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYCN

miRNA regulators (miRDB)

175 targeting DUSP8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-106A-5P	99.90	73.94	2683

Literature-anchored findings (GeneRIF, showing 7)

• DUSP8 is genetically linked to alcohol dependence and was found on chromosome 11p15.5 (PMID:13129832)
• Because this variant of hVH-5 lacked intronic sequences in its genomic structure, we suggest it might be a processed pseudogene of hVH-5. (PMID:15899389)
• The phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation. (PMID:22100391)
• Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans. (PMID:33131190)
• Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways. (PMID:35428675)
• DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. (PMID:37909329)
• miR-147b mediated suppression of DUSP8 promotes lung cancer progression. (PMID:38396293)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dusp8a	ENSDARG00000009299
mus_musculus	Dusp8	ENSMUSG00000037887
rattus_norvegicus	Dusp8	ENSRNOG00000029394

Paralogs (31): DUSP13B (ENSG00000079393), DUSP12 (ENSG00000081721), SSH1 (ENSG00000084112), DUSP3 (ENSG00000108861), PTPMT1 (ENSG00000110536), DUSP16 (ENSG00000111266), EPM2A (ENSG00000112425), DUSP22 (ENSG00000112679), DUSP1 (ENSG00000120129), DUSP4 (ENSG00000120875), STYXL1 (ENSG00000127952), DUSP9 (ENSG00000130829), DUSP26 (ENSG00000133878), DUSP5 (ENSG00000138166), DUSP6 (ENSG00000139318), SSH2 (ENSG00000141298), DUSP10 (ENSG00000143507), DUSP15 (ENSG00000149599), DUSP2 (ENSG00000158050), KASH5 (ENSG00000161609), DUSP19 (ENSG00000162999), DUSP7 (ENSG00000164086), DUSP18 (ENSG00000167065), SSH3 (ENSG00000172830), DUSP28 (ENSG00000188542), DUSP29 (ENSG00000188716), DUSP21 (ENSG00000189037), STYX (ENSG00000198252), STYXL2 (ENSG00000198842), DUSP14 (ENSG00000276023), DUSP13A (ENSG00000293543)

Protein

Protein identifiers

Dual specificity protein phosphatase 8 — Q13202 (reviewed: Q13202)

Alternative names: Dual specificity protein phosphatase hVH-5

All UniProt accessions (1): Q13202

UniProt curated annotations — full annotation on UniProt →

Function. Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.

Subunit / interactions. Monomer.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Abundant in brain, heart and skeletal muscle.

Similarity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

RefSeq proteins (1): NP_004411* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000340	Dual-sp_phosphatase_cat-dom	Domain
IPR000387	Tyr_Pase_dom	Domain
IPR001763	Rhodanese-like_dom	Domain
IPR008343	MKP	Family
IPR016130	Tyr_Pase_AS	Active_site
IPR020422	TYR_PHOSPHATASE_DUAL_dom	Domain
IPR029021	Prot-tyrosine_phosphatase-like	Homologous_superfamily
IPR036873	Rhodanese-like_dom_sf	Homologous_superfamily
IPR048035	DUSP8_DSP	Domain

Pfam: PF00581, PF00782

Catalyzed reactions (Rhea), 3 shown:

• O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (RHEA:10684)
• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (25 total): strand 8, helix 8, compositionally biased region 3, domain 2, chain 1, region of interest 1, active site 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4JMK	X-RAY DIFFRACTION	1.9

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13202-F1	63.99	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 246 (phosphocysteine intermediate)

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-112409	RAF-independent MAPK1/3 activation
R-HSA-5675221	Negative regulation of MAPK pathway
R-HSA-9652817	Signaling by MAPK mutants

MSigDB gene sets: 203 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, AAGCAAT_MIR137, BENPORATH_ES_WITH_H3K27ME3, BROWNE_HCMV_INFECTION_8HR_UP, TGCACTT_MIR519C_MIR519B_MIR519A, ENK_UV_RESPONSE_KERATINOCYTE_UP, KEGG_MAPK_SIGNALING_PATHWAY, GOZGIT_ESR1_TARGETS_DN, MAZ_Q6, TATTATA_MIR374, NAGASHIMA_NRG1_SIGNALING_UP, GGGTGGRR_PAX4_03, GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION

GO Biological Process (4): signal transduction (GO:0007165), dephosphorylation (GO:0016311), negative regulation of MAPK cascade (GO:0043409), protein dephosphorylation (GO:0006470)

GO Molecular Function (9): protein serine/threonine phosphatase activity (GO:0004722), protein tyrosine/threonine phosphatase activity (GO:0008330), phosphatase activity (GO:0016791), MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017), MAP kinase tyrosine phosphatase activity (GO:0033550), phosphoprotein phosphatase activity (GO:0004721), protein tyrosine phosphatase activity (GO:0004725), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
MAPK1/MAPK3 signaling	1
RAF/MAP kinase cascade	1
Oncogenic MAPK signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
phosphoprotein phosphatase activity	3
MAP kinase phosphatase activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
phosphate-containing compound metabolic process	1
MAPK cascade	1
regulation of MAPK cascade	1
negative regulation of intracellular signal transduction	1
dephosphorylation	1
protein modification process	1
phosphoric ester hydrolase activity	1
protein tyrosine/serine/threonine phosphatase activity	1
protein tyrosine phosphatase activity	1
phosphatase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1664 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DUSP8	IGHV4-38-2	P0DP08	580
DUSP8	DUSP10	Q9Y6W6	550
DUSP8	DUSP7	Q16829	532
DUSP8	DUSP9	Q99956	522
DUSP8	HNRNPC	P07910	516
DUSP8	CDR2	Q01850	505
DUSP8	DUSP6	Q16828	471
DUSP8	MAPK12	P53778	468
DUSP8	MAPK13	O15264	462
DUSP8	ECHS1	P30084	455
DUSP8	MAPK11	Q15759	442
DUSP8	JUN	P05412	438
DUSP8	LRRC56	Q8IYG6	436
DUSP8	TNF	P01375	428
DUSP8	DUSP22	Q9NRW4	428

IntAct

8 interactions, top by confidence:

A	B	Type	Score
MAPK9	WDR62	psi-mi:“MI:0914”(association)	0.800
MAPK8	WDR62	psi-mi:“MI:0914”(association)	0.730
DUSP8	MAPK8	psi-mi:“MI:0914”(association)	0.660
MAPK8	DUSP8	psi-mi:“MI:0915”(physical association)	0.660
CDC25A	DUSP8	psi-mi:“MI:0915”(physical association)	0.370
MAPK8	WDR62	psi-mi:“MI:0914”(association)	0.350
MAPK9	FTH1	psi-mi:“MI:0914”(association)	0.350

BioGRID (50): DUSP8 (Affinity Capture-MS), MAPK8 (Affinity Capture-MS), MAPK9 (Affinity Capture-MS), DUSP8 (Affinity Capture-MS), DUSP8 (Affinity Capture-MS), DUSP16 (Affinity Capture-MS), MAPK9 (Affinity Capture-MS), ANKMY2 (Affinity Capture-MS), SUGT1 (Affinity Capture-MS), MAPK8 (Affinity Capture-MS), FKBP5 (Affinity Capture-MS), FBXO11 (Affinity Capture-MS), GRB2 (Affinity Capture-MS), MAPK3 (Affinity Capture-MS), NDUFAF4 (Affinity Capture-MS)

ESM2 similar proteins: A1XQX1, A4FUY1, A6NFA1, A6NLU5, B1ATG9, C0HL12, D0PRN2, E1BBQ2, E9PUN2, O09112, O14514, O54693, O54951, O60347, O70141, P01346, P07456, P09535, P0DI97, P10764, P16611, P58400, P58401, P97260, Q0IJ12, Q13202, Q14CZ8, Q20FD0, Q28142, Q28143, Q3TZ87, Q3UHD1, Q63373, Q63376, Q640R3, Q6A039, Q6PDS0, Q6ZRP7, Q80UW0, Q86YJ5

Diamond homologs: A4IHU7, F1QWM2, O09112, O13632, O55737, O95147, P0C591, P0C592, P0C593, P0C594, P0C595, P0C596, P0C597, P0C598, P0C599, P0C5A0, P0C5A1, P0C5A2, P28562, P28563, P51452, Q05922, Q13115, Q13202, Q148W8, Q16828, Q16829, Q17QJ3, Q17QM8, Q1LWL2, Q29RA3, Q2KJ36, Q39491, Q4KL92, Q4RQD3, Q4V7N3, Q54T76, Q54Y32, Q556Y8, Q55BI8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
DUSP8	down-regulates	MAPK14	dephosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

107 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	105
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1003 predictions. Top by Δscore:

Variant	Effect	Δscore
11:1557574:CCTG:C	acceptor_loss	1.0000
11:1557575:CTGCG:C	acceptor_loss	1.0000
11:1557788:TGGTA:T	donor_loss	1.0000
11:1557789:GGTAC:G	donor_loss	1.0000
11:1557790:GTACC:G	donor_loss	1.0000
11:1557791:TACC:T	donor_loss	1.0000
11:1557792:A:T	donor_loss	1.0000
11:1557793:CCTGT:C	donor_loss	1.0000
11:1558108:TCA:T	donor_loss	1.0000
11:1558109:CACCG:C	donor_loss	1.0000
11:1558110:A:AC	donor_gain	1.0000
11:1558110:AC:A	donor_gain	1.0000
11:1558111:C:CC	donor_gain	1.0000
11:1558111:CC:C	donor_gain	1.0000
11:1558111:CCG:C	donor_gain	1.0000
11:1558111:CCGA:C	donor_gain	1.0000
11:1558267:AGATC:A	acceptor_gain	1.0000
11:1558268:GATC:G	acceptor_gain	1.0000
11:1558269:ATC:A	acceptor_gain	1.0000
11:1558270:TC:T	acceptor_gain	1.0000
11:1558271:CC:C	acceptor_gain	1.0000
11:1558272:C:CC	acceptor_gain	1.0000
11:1558272:C:T	acceptor_gain	1.0000
11:1558272:CTGGA:C	acceptor_loss	1.0000
11:1558282:G:T	acceptor_gain	1.0000
11:1558888:C:G	donor_loss	1.0000
11:1559051:GCCCC:G	acceptor_gain	1.0000
11:1559052:CCCC:C	acceptor_gain	1.0000
11:1559052:CCCCC:C	acceptor_gain	1.0000
11:1559053:CCC:C	acceptor_gain	1.0000

AlphaMissense

4013 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:1557518:A:G	L293P	1.000
11:1557524:C:T	G291D	1.000
11:1557525:C:G	G291R	1.000
11:1557529:G:C	F289L	1.000
11:1557529:G:T	F289L	1.000
11:1557530:A:C	F289C	1.000
11:1557530:A:G	F289S	1.000
11:1557531:A:G	F289L	1.000
11:1557532:G:C	N288K	1.000
11:1557532:G:T	N288K	1.000
11:1557536:A:G	F287S	1.000
11:1557538:G:C	N286K	1.000
11:1557538:G:T	N286K	1.000
11:1557542:G:C	P285R	1.000
11:1557542:G:T	P285H	1.000
11:1557543:G:A	P285S	1.000
11:1557543:G:T	P285T	1.000
11:1557548:A:T	I283N	1.000
11:1557558:G:C	R280G	1.000
11:1557558:G:T	R280S	1.000
11:1557565:C:A	K277N	1.000
11:1557565:C:G	K277N	1.000
11:1557567:T:C	K277E	1.000
11:1557569:A:T	V276E	1.000
11:1557572:A:G	F275S	1.000
11:1557798:A:C	Y273D	1.000
11:1557798:A:G	Y273H	1.000
11:1557800:G:T	A272D	1.000
11:1557833:A:T	I261N	1.000
11:1557837:A:C	Y260D	1.000

dbSNP variants (sampled 300 via entrez): RS1000029971 (11:1572792 C>A,G,T), RS1000102260 (11:1565528 C>T), RS1000229116 (11:1562597 G>A), RS1000429271 (11:1562807 C>T), RS1000548052 (11:1557114 G>C), RS1000568116 (11:1563699 C>T), RS1000568637 (11:1562128 A>G), RS1000592485 (11:1568467 T>C), RS1000660864 (11:1567402 C>A,T), RS1000747360 (11:1554150 G>C), RS1000900210 (11:1571945 G>A), RS1000936550 (11:1568714 T>C), RS1001346950 (11:1554456 A>G), RS1001388779 (11:1571461 G>A,C), RS1001507457 (11:1566677 C>A,T)

Disease associations

OMIM: gene MIM:602038 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
hereditary gingival fibromatosis	Limited	Autosomal dominant

Mondo (1): hereditary gingival fibromatosis (MONDO:0016070)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005439_7	Response to alcohol consumption (flushing response)	4.000000e-06
GCST006479_10	Diverticular disease	7.000000e-06
GCST010703_211	Brain morphology (MOSTest)	2.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Phenylmercuric Acetate	increases expression, affects cotreatment	2
Valproic Acid	increases expression, increases methylation	2
Asbestos, Crocidolite	affects expression, increases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
aristolochic acid I	increases expression	1
dicrotophos	increases expression	1
methylmercuric chloride	increases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
deoxynivalenol	increases expression	1
beta-lapachone	increases expression	1
sulforaphane	decreases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
S-(1,2-dichlorovinyl)cysteine	increases expression, affects cotreatment, affects response to substance	1
mercuric bromide	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
15-acetyldeoxynivalenol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
3,4,5,4’-tetramethoxystilbene	affects expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	decreases expression, affects cotreatment	1
NSC 689534	affects binding, increases expression	1
(+)-JQ1 compound	decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Febuxostat	increases expression	1
Resveratrol	increases expression	1
Arsenic Trioxide	increases expression	1
Leflunomide	increases expression	1
Acetaldehyde	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_F1RI	HyCyte MCF-7 KO-hDUSP8	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.