DYNAP

Summary

DYNAP (dynactin associated protein, HGNC:26808) is a protein-coding gene on chromosome 18q21.2, encoding Dynactin-associated protein (Q8N1N2). Plays a role in the regulation of cell proliferation.

Involved in several processes, including activation of protein kinase B activity; cellular response to ergosterol; and positive regulation of cell population proliferation. Located in Golgi apparatus and plasma membrane.

Source: NCBI Gene 284254 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 36 total — 1 pathogenic
• MANE Select transcript: NM_173629

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26808
Approved symbol	DYNAP
Name	dynactin associated protein
Location	18q21.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ39106
Ensembl gene	ENSG00000178690
Ensembl biotype	protein_coding
OMIM	619421
Entrez	284254

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000321600, ENST00000585973, ENST00000648945

RefSeq mRNA: 2 — MANE Select: NM_173629 NM_001307955, NM_173629

CCDS: CCDS11957, CCDS77190

Canonical transcript exons

ENST00000648945 — 3 exons

Exon	Start	End
ENSE00001262658	54594939	54595103
ENSE00001262667	54597813	54599493
ENSE00003910603	54591245	54591339

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 91.53.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0427 / max 49.3064, expressed in 5 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170302	0.0427	5

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	91.53	gold quality
esophagus mucosa	UBERON:0002469	86.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.90	gold quality
esophagus	UBERON:0001043	64.12	gold quality
spleen	UBERON:0002106	59.22	gold quality
smooth muscle tissue	UBERON:0001135	53.43	gold quality
left uterine tube	UBERON:0001303	53.26	gold quality
tonsil	UBERON:0002372	50.96	gold quality
right lobe of liver	UBERON:0001114	48.78	silver quality
uterine cervix	UBERON:0000002	47.41	gold quality
right ovary	UBERON:0002118	47.14	gold quality
blood	UBERON:0000178	45.29	silver quality
ectocervix	UBERON:0012249	45.15	gold quality
sural nerve	UBERON:0015488	44.62	gold quality
ovary	UBERON:0000992	44.57	gold quality
liver	UBERON:0002107	44.26	silver quality
left ovary	UBERON:0002119	43.89	gold quality
endocervix	UBERON:0000458	43.86	gold quality
right coronary artery	UBERON:0001625	43.69	gold quality
monocyte	CL:0000576	43.29	gold quality
primary visual cortex	UBERON:0002436	43.18	gold quality
granulocyte	CL:0000094	43.02	silver quality
leukocyte	CL:0000738	42.66	gold quality
fallopian tube	UBERON:0003889	42.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	42.38	gold quality
bone marrow	UBERON:0002371	42.13	silver quality
minor salivary gland	UBERON:0001830	41.09	gold quality
descending thoracic aorta	UBERON:0002345	40.83	silver quality
saliva-secreting gland	UBERON:0001044	40.80	gold quality
bone marrow cell	CL:0002092	40.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

92 targeting DYNAP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-623	99.76	68.16	1170
HSA-MIR-3913-3P	99.74	66.53	938
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-377-5P	99.70	65.28	712
HSA-MIR-6086	99.70	65.38	699
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-3616-5P	99.55	67.02	989
HSA-MIR-573	99.55	67.44	955
HSA-MIR-451B	99.55	68.28	1380
HSA-MIR-12117	99.50	67.57	868

Literature-anchored findings (GeneRIF, showing 1)

• DynAP, which promotes activation of Akt, can be a new target for cancer therapy. (PMID:20978158)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Dynap	ENSRNOG00000063474

Protein

Protein identifiers

Dynactin-associated protein — Q8N1N2 (reviewed: Q8N1N2)

All UniProt accessions (3): A0A3B3IRJ4, Q8N1N2, K7EMN5

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at ‘Ser-473’.

Subunit / interactions. Interacts with DCTN1 and DCTN2.

Subcellular location. Golgi apparatus membrane. Cell membrane.

Tissue specificity. Expressed in fibroblast and numerous cancer cell lines (at protein level).

RefSeq proteins (2): NP_001294884, NP_775900* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR031379	CLLAC	Domain
IPR053297	Dynactin-associated	Family

Pfam: PF15675

UniProt features (7 total): topological domain 2, sequence variant 2, chain 1, transmembrane region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N1N2-F1	60.24	0.10

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 117

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 62 (showing top): GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, GOBP_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS, GOBP_RESPONSE_TO_STEROL, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_RESPONSE_TO_LIPID, GOBP_CELLULAR_RESPONSE_TO_STEROL, GOBP_CELLULAR_RESPONSE_TO_ALCOHOL, GOBP_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY, GOBP_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY, GOBP_RESPONSE_TO_ALCOHOL

GO Biological Process (4): positive regulation of cell population proliferation (GO:0008284), activation of protein kinase B activity (GO:0032148), regulation of apoptotic process (GO:0042981), cellular response to ergosterol (GO:1901625)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
activation of protein kinase activity	1
apoptotic process	1
regulation of programmed cell death	1
cellular response to sterol	1
cellular response to alcohol	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

594 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DYNAP	CLIP1	P30622	592
DYNAP	PDXDC1	Q6P996	446
DYNAP	MTHFD2L	Q9H903	397
DYNAP	TEX28	O15482	349
DYNAP	PRCC	Q92733	348
DYNAP	FHIP2A	Q5W0V3	306
DYNAP	NT5DC1	Q5TFE4	297
DYNAP	ZMYM5	Q9UJ78	264
DYNAP	CEP85L	Q5SZL2	234
DYNAP	NT5DC2	Q9H857	224
DYNAP	SLC35F1	Q5T1Q4	219
DYNAP	TRUB1	Q8WWH5	214
DYNAP	MYCL	P12524	208
DYNAP	CLIP2	Q9UDT6	204
DYNAP	CT45A1	Q5HYN5	201

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0A7EPL0, A2RV66, A4QP16, A6QPF4, C4QM85, F4JYG0, O35892, P11836, P13386, P19437, P20490, P41739, P53762, P56645, P70326, P79778, Q01362, Q148B6, Q29131, Q3C1V0, Q3C2E2, Q3SA47, Q3UNB8, Q3V3Q4, Q3YBM2, Q5I2P1, Q5JT82, Q5R8D6, Q5R8E0, Q60HE7, Q68FU0, Q6A058, Q8BVM2, Q8N1N2, Q8NDZ0, Q8QGQ8, Q8WUU8, Q920C4, Q92540, Q96HJ5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	31
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1526620	GRCh37/hg19 18q21.2-22.1(chr18:50739715-63705988)	Pathogenic

SpliceAI

395 predictions. Top by Δscore:

Variant	Effect	Δscore
18:54591336:GCCG:G	donor_gain	1.0000
18:54591337:CCGGT:C	donor_loss	1.0000
18:54591339:GGT:G	donor_loss	1.0000
18:54591340:G:GG	donor_gain	1.0000
18:54591340:GTGA:G	donor_loss	1.0000
18:54591341:T:A	donor_loss	1.0000
18:54591342:GAGT:G	donor_loss	0.9900
18:54591335:AGCCG:A	donor_gain	0.9800
18:54591336:GCCGG:G	donor_gain	0.9800
18:54591337:CCG:C	donor_gain	0.9700
18:54591338:CG:C	donor_gain	0.9700
18:54591339:GG:G	donor_gain	0.9700
18:54597789:T:A	acceptor_gain	0.9500
18:54592092:G:GC	acceptor_gain	0.9200
18:54597807:GCTTA:G	acceptor_loss	0.9200
18:54597808:CTTAG:C	acceptor_loss	0.9200
18:54597809:TTA:T	acceptor_loss	0.9200
18:54597810:TAG:T	acceptor_loss	0.9200
18:54597811:AGGTA:A	acceptor_loss	0.9200
18:54597812:GGTAA:G	acceptor_loss	0.9200
18:54594938:GCCA:G	acceptor_gain	0.8800
18:54597806:T:G	acceptor_gain	0.8700
18:54591343:AGTGT:A	donor_loss	0.8400
18:54592151:G:C	acceptor_gain	0.8200
18:54597813:G:T	acceptor_loss	0.8200
18:54597805:AT:A	acceptor_gain	0.8000
18:54592060:T:TA	acceptor_gain	0.7600
18:54592125:GTAA:G	acceptor_gain	0.7600
18:54594937:A:AG	acceptor_gain	0.7500
18:54594938:G:GG	acceptor_gain	0.7500

AlphaMissense

1186 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:54597864:T:C	C118R	0.940
18:54597876:T:C	C122R	0.936
18:54597855:T:C	F115L	0.926
18:54597857:C:A	F115L	0.926
18:54597857:C:G	F115L	0.926
18:54597846:T:A	W112R	0.862
18:54597846:T:C	W112R	0.862
18:54597883:T:A	I124K	0.851
18:54597897:G:A	G129R	0.826
18:54597897:G:C	G129R	0.826
18:54597892:C:A	A127E	0.819
18:54597904:T:A	L131H	0.808
18:54597883:T:G	I124R	0.807
18:54597874:C:A	A121D	0.804
18:54597889:C:A	T126K	0.790
18:54597904:T:G	L131R	0.789
18:54597886:T:G	M125R	0.777
18:54597889:C:G	T126R	0.777
18:54597898:G:A	G129E	0.777
18:54597848:G:C	W112C	0.774
18:54597848:G:T	W112C	0.774
18:54597886:T:A	M125K	0.765
18:54597868:T:C	L119P	0.760
18:54597878:T:G	C122W	0.752
18:54597901:T:A	V130E	0.744
18:54597904:T:C	L131P	0.730
18:54597907:T:A	I132K	0.721
18:54597856:T:G	F115C	0.716
18:54597891:G:C	A127P	0.715
18:54597912:T:C	C134R	0.712

dbSNP variants (sampled 300 via entrez): RS1000056835 (18:54590393 C>G), RS1000101678 (18:54598930 A>G), RS1000277846 (18:54591842 A>G), RS1000355393 (18:54584920 A>G), RS1000355897 (18:54594522 A>G), RS1000386633 (18:54585171 G>C), RS1000389089 (18:54581029 A>G), RS1000414463 (18:54587360 T>C), RS1000416169 (18:54585545 C>T), RS1000486544 (18:54587161 C>T), RS1000518856 (18:54580412 G>A), RS1000601628 (18:54578989 C>G,T), RS1000663925 (18:54594167 T>A), RS1000689211 (18:54586305 G>A), RS1000951569 (18:54580666 T>C)

Disease associations

OMIM: gene MIM:619421 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004904_198	Body mass index	8.000000e-10
GCST005038_51	Allergic disease (asthma, hay fever or eczema)	6.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression, increases methylation	3
bisphenol F	affects cotreatment, decreases methylation	1
decabromobiphenyl ether	affects expression	1
sodium arsenite	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Benzo(a)pyrene	decreases methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.