DYNLRB2-AS1

Summary

DYNLRB2-AS1 (DYNLRB2 antisense RNA 1, HGNC:55405) is a long non-coding RNA gene on chromosome 16q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55405
Approved symbol	DYNLRB2-AS1
Name	DYNLRB2 antisense RNA 1
Location	16q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259867
Ensembl biotype	lncRNA
Entrez	102724084
RNAcentral	URS000075AAA3 — lncRNA, 565 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000563267, ENST00000564411, ENST00000565050, ENST00000568275, ENST00000568552, ENST00000568776, ENST00000568819, ENST00000658726, ENST00000663853, ENST00000666474, ENST00000668341, ENST00000718369, ENST00000718370, ENST00000718371, ENST00000718372, ENST00000718373, ENST00000718374

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563267 — 3 exons

Exon	Start	End
ENSE00002581386	80540850	80540953
ENSE00002582192	80526839	80527018
ENSE00002598691	80528642	80528786

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 78.61.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0031 / max 4.6972, expressed in 1 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158241	0.0031	1

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.61	gold quality
skeletal muscle tissue	UBERON:0001134	76.22	gold quality
ganglionic eminence	UBERON:0004023	67.68	gold quality
testis	UBERON:0000473	65.39	gold quality
left testis	UBERON:0004533	65.08	gold quality
cerebellar cortex	UBERON:0002129	64.59	gold quality
cerebellum	UBERON:0002037	64.58	gold quality
right testis	UBERON:0004534	64.53	gold quality
cerebellar hemisphere	UBERON:0002245	64.37	gold quality
gall bladder	UBERON:0002110	64.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.38	gold quality
placenta	UBERON:0001987	62.63	gold quality
mucosa of transverse colon	UBERON:0004991	61.84	gold quality
ventricular zone	UBERON:0003053	59.78	silver quality
adrenal tissue	UBERON:0018303	59.55	gold quality
monocyte	CL:0000576	58.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.10	gold quality
primary visual cortex	UBERON:0002436	57.49	gold quality
right adrenal gland cortex	UBERON:0035827	57.09	gold quality
prefrontal cortex	UBERON:0000451	56.87	gold quality
lymph node	UBERON:0000029	56.37	gold quality
islet of Langerhans	UBERON:0000006	56.05	gold quality
right adrenal gland	UBERON:0001233	55.97	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.35	gold quality
rectum	UBERON:0001052	54.93	gold quality
stromal cell of endometrium	CL:0002255	54.23	silver quality
adipose tissue	UBERON:0001013	53.83	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.64	gold quality
muscle of leg	UBERON:0001383	53.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	52.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.02

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein. (PMID:38908233)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.