DYNLT3

Summary

DYNLT3 (dynein light chain Tctex-type 3, HGNC:11694) is a protein-coding gene on chromosome Xp11.4, encoding Dynein light chain Tctex-type 3 (P51808). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.

This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.

Source: NCBI Gene 6990 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 40 total — 1 pathogenic
• MANE Select transcript: NM_006520

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11694
Approved symbol	DYNLT3
Name	dynein light chain Tctex-type 3
Location	Xp11.4
Locus type	gene with protein product
Status	Approved
Aliases	TCTEX1L
Ensembl gene	ENSG00000165169
Ensembl biotype	protein_coding
OMIM	300302
Entrez	6990

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000378578, ENST00000378581, ENST00000432389, ENST00000859528, ENST00000859529

RefSeq mRNA: 1 — MANE Select: NM_006520 NM_006520

CCDS: CCDS14243

Canonical transcript exons

ENST00000378578 — 5 exons

Exon	Start	End
ENSE00001090921	37841028	37841105
ENSE00001090923	37846317	37846358
ENSE00001312293	37838836	37840651
ENSE00001324086	37841782	37841905
ENSE00001478005	37847481	37847571

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.4054 / max 588.4982, expressed in 1758 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
198885	17.2340	1731
198886	10.6730	1701
198887	0.3777	183
198888	0.1206	37

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gingiva	UBERON:0001828	99.14	gold quality
gingival epithelium	UBERON:0001949	99.14	gold quality
esophagus squamous epithelium	UBERON:0006920	99.10	gold quality
tongue squamous epithelium	UBERON:0006919	99.05	gold quality
pons	UBERON:0000988	98.97	gold quality
squamous epithelium	UBERON:0006914	98.60	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	98.59	gold quality
substantia nigra pars compacta	UBERON:0001965	98.53	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.51	gold quality
lateral nuclear group of thalamus	UBERON:0002736	98.38	gold quality
cranial nerve II	UBERON:0000941	98.32	gold quality
oral cavity	UBERON:0000167	98.29	gold quality
renal glomerulus	UBERON:0000074	98.27	gold quality
dorsal root ganglion	UBERON:0000044	98.22	gold quality
metanephric glomerulus	UBERON:0004736	98.20	gold quality
epithelium of esophagus	UBERON:0001976	98.13	gold quality
superior vestibular nucleus	UBERON:0007227	97.91	gold quality
nephron tubule	UBERON:0001231	97.88	gold quality
postcentral gyrus	UBERON:0002581	97.86	gold quality
substantia nigra pars reticulata	UBERON:0001966	97.85	gold quality
cartilage tissue	UBERON:0002418	97.84	gold quality
hair follicle	UBERON:0002073	97.78	gold quality
superior frontal gyrus	UBERON:0002661	97.64	gold quality
trigeminal ganglion	UBERON:0001675	97.59	gold quality
parietal lobe	UBERON:0001872	97.59	gold quality
kidney epithelium	UBERON:0004819	97.48	gold quality
entorhinal cortex	UBERON:0002728	97.39	gold quality
pharyngeal mucosa	UBERON:0000355	97.26	gold quality
middle temporal gyrus	UBERON:0002771	97.19	gold quality
medulla oblongata	UBERON:0001896	97.09	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	37.68
E-MTAB-6701	yes	18.39
E-MTAB-9388	yes	10.22
E-MTAB-6142	no	164.05
E-HCAD-13	no	3.51
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

159 targeting DYNLT3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-548AB	99.95	71.31	3488

Literature-anchored findings (GeneRIF, showing 4)

• The N-terminal half of pUL35, in particular residues 30-43, was identified as a common region for the binding of DYNLT1 and DYNLT3. (PMID:20668116)
• These data show that both DYNLT1 and DYNLT3 interact with L2 of human papillomavirus 16 during virus infection. (PMID:21166973)
• Age-associated genes in human mammary gland drive human breast cancer progression. (PMID:32539762)
• The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition. (PMID:37260179)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dynlt3	ENSDARG00000046132
mus_musculus	Dynlt3	ENSMUSG00000031176
rattus_norvegicus	Dynlt3	ENSRNOG00000003611

Paralogs (5): DYNLT1 (ENSG00000146425), DYNLT5 (ENSG00000152760), DYNLT2 (ENSG00000184786), DYNLT4 (ENSG00000188396), DYNLT2B (ENSG00000213123)

Protein

Protein identifiers

Dynein light chain Tctex-type 3 — P51808 (reviewed: P51808)

Alternative names: Protein 91/23, T-complex-associated testis-expressed 1-like

All UniProt accessions (3): A6NGJ0, P51808, F2Z328

UniProt curated annotations — full annotation on UniProt →

Function. Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.

Subunit / interactions. Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.

Subcellular location. Nucleus. Cytoplasm. Cytoskeleton. Chromosome. Centromere. Kinetochore.

Similarity. Belongs to the dynein light chain Tctex-type family.

RefSeq proteins (1): NP_006511* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005334	Tctex-1-like	Family
IPR038586	Tctex-1-like_sf	Homologous_superfamily

Pfam: PF03645

UniProt features (2 total): chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P51808-F1	90.46	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 286 (showing top): GOBP_CHROMOSOME_ORGANIZATION, GOBP_REGULATION_OF_CELL_CYCLE_CHECKPOINT, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, ZHAN_LATE_DIFFERENTIATION_GENES_UP, GOBP_REGULATION_OF_NUCLEAR_DIVISION, GOZGIT_ESR1_TARGETS_DN, GOBP_CELL_CYCLE_PHASE_TRANSITION, GOBP_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, GOBP_CHROMOSOME_SEPARATION, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1

GO Biological Process (4): microtubule-based movement (GO:0007018), regulation of mitotic cell cycle (GO:0007346), positive regulation of mitotic cell cycle (GO:0045931), cell division (GO:0051301)

GO Molecular Function (3): identical protein binding (GO:0042802), dynein intermediate chain binding (GO:0045505), protein binding (GO:0005515)

GO Cellular Component (10): kinetochore (GO:0000776), nucleus (GO:0005634), cytoplasm (GO:0005737), cytoplasmic dynein complex (GO:0005868), mitotic spindle astral microtubule (GO:0061673), chromosome, centromeric region (GO:0000775), chromosome (GO:0005694), cytoskeleton (GO:0005856), microtubule (GO:0005874), dynein complex (GO:0030286)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	3
mitotic cell cycle	2
protein binding	2
microtubule-based process	1
regulation of cell cycle	1
regulation of mitotic cell cycle	1
positive regulation of cell cycle	1
cellular process	1
binding	1
condensed chromosome, centromeric region	1
supramolecular complex	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
dynein complex	1
astral microtubule	1
mitotic spindle	1
chromosomal region	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
microtubule associated complex	1
catalytic complex	1

Protein interactions and networks

STRING

1200 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
DYNLT3	BUB3	O43684	880
DYNLT3	DYNLL2	Q96FJ2	825
DYNLT3	DYNLL1	P63167	791
DYNLT3	DYNLRB2	Q8TF09	786
DYNLT3	DYNLRB1	Q9NP97	743
DYNLT3	DYNLT2B	Q8WW35	709
DYNLT3	DYNC1LI2	O43237	683
DYNLT3	DYNC2LI1	Q8TCX1	667
DYNLT3	DYNC2I2	Q96EX3	636
DYNLT3	DYNC2I1	Q8WVS4	635
DYNLT3	DYNC1H1	Q14204	633
DYNLT3	DYNC1LI1	Q9Y6G9	626
DYNLT3	DYNC1I1	O14576	590
DYNLT3	DRC5	Q5JU00	543
DYNLT3	DYNC1I2	Q13409	518

IntAct

56 interactions, top by confidence:

A	B	Type	Score
DYNC1I2	DYNLT3	psi-mi:“MI:0915”(physical association)	0.750
DYNLT3	DYNLT3	psi-mi:“MI:0915”(physical association)	0.740
DYNLT3	DYNLT1	psi-mi:“MI:0915”(physical association)	0.730
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
DYNC1I2	DYNC1LI2	psi-mi:“MI:0914”(association)	0.680
DYNLT1	DYNC1LI2	psi-mi:“MI:0914”(association)	0.640
DYNLT3	NIF3L1	psi-mi:“MI:0915”(physical association)	0.560
NIF3L1	DYNLT3	psi-mi:“MI:0915”(physical association)	0.560
DYNLT3	DYNC1I2	psi-mi:“MI:0915”(physical association)	0.560
DYNLT3	PMS1	psi-mi:“MI:0915”(physical association)	0.560
DYNLT3	CCL28	psi-mi:“MI:0915”(physical association)	0.560
DYNLT3	C2orf15	psi-mi:“MI:0915”(physical association)	0.560
DYNLT3	ZC3H14	psi-mi:“MI:0915”(physical association)	0.560
DYNC1LI1	DYNC1LI2	psi-mi:“MI:0914”(association)	0.530
PAFAH1B1	DYNLT3	psi-mi:“MI:0914”(association)	0.510
DYNLT2B	TIPRL	psi-mi:“MI:0914”(association)	0.510
BMP2K	DYNLT3	psi-mi:“MI:0915”(physical association)	0.490
BUB3	DYNLT3	psi-mi:“MI:0407”(direct interaction)	0.440
HTRA1	DYNLT3	psi-mi:“MI:0915”(physical association)	0.370
DYNLT3	TESC	psi-mi:“MI:0915”(physical association)	0.370
Dynlrb1	DYNC1LI2	psi-mi:“MI:0914”(association)	0.350
DYNC1H1		psi-mi:“MI:0914”(association)	0.350
MAPRE1	SCAMP1	psi-mi:“MI:0914”(association)	0.350

BioGRID (57): DYNLT3 (Two-hybrid), NIF3L1 (Two-hybrid), DYNLT3 (Affinity Capture-MS), DYNLT3 (Two-hybrid), TESC (Two-hybrid), DYNLT3 (Two-hybrid), DYNLT3 (Affinity Capture-MS), DYNLT3 (Affinity Capture-MS), PAFAH1B1 (Affinity Capture-MS), DYNLT3 (Affinity Capture-MS), TCTEX1D2 (Affinity Capture-MS), DYNLT3 (Affinity Capture-MS), DYNLT3 (Proximity Label-MS), DYNLT3 (Proximity Label-MS), DYNLT3 (Proximity Label-MS)

ESM2 similar proteins: A6SM77, A7F3L0, B4MYA1, F1QMY1, O02173, O04420, O61820, O74366, O95433, P11645, P32502, P34605, P34686, P36149, P38886, P51808, P56387, P87123, Q08CN0, Q13257, Q1HPS4, Q23400, Q28IG8, Q2F5R8, Q32P71, Q54EY2, Q54LT2, Q54PG1, Q5NVF5, Q5ZKP4, Q66IC8, Q6DG85, Q6XXL8, Q7QGK4, Q84WI4, Q86K94, Q8BK64, Q8H0S3, Q8N9S3, Q8SPS9

Diamond homologs: F1QMY1, P51807, P51808, P56387, P63171, P63172, Q54PG1, Q5NVF5, Q6XXL8, Q8SPS9, Q94524, Q9Z336, Q8WW35, Q9CQ66, A2VDD2, P11985, Q3B8D7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 26 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Aggrephagy	6	99.3×	1e-10
COPI-independent Golgi-to-ER retrograde traffic	7	96.9×	3e-12
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	6	77.4×	5e-10
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	9	69.9×	6e-14
EML4 and NUDC in mitotic spindle formation	9	55.7×	2e-13
Loss of Nlp from mitotic centrosomes	5	52.9×	1e-07
Loss of proteins required for interphase microtubule organization from the centrosome	5	52.9×	1e-07
Resolution of Sister Chromatid Cohesion	9	51.9×	3e-13

GO biological processes:

GO term	Partners	Fold	FDR
microtubule-based movement	5	67.2×	8e-07
cell division	5	10.5×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	10
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2685701	GRCh37/hg19 Xp22.11-11.3(chrX:24633854-44236178)x1	Pathogenic

SpliceAI

580 predictions. Top by Δscore:

Variant	Effect	Δscore
X:37840648:GTTCC:G	acceptor_loss	1.0000
X:37840650:TC:T	acceptor_gain	1.0000
X:37840651:CC:C	acceptor_gain	1.0000
X:37840652:C:CC	acceptor_gain	1.0000
X:37840652:C:G	acceptor_loss	1.0000
X:37841022:TCTTA:T	donor_loss	1.0000
X:37841023:CTTA:C	donor_loss	1.0000
X:37841024:TTAC:T	donor_loss	1.0000
X:37841025:TA:T	donor_loss	1.0000
X:37841026:A:AG	donor_loss	1.0000
X:37841027:C:A	donor_loss	1.0000
X:37841104:CA:C	acceptor_gain	1.0000
X:37841106:C:CC	acceptor_gain	1.0000
X:37841135:T:C	acceptor_gain	1.0000
X:37841776:ACTT:A	donor_loss	1.0000
X:37841778:TTA:T	donor_loss	1.0000
X:37841779:TAC:T	donor_loss	1.0000
X:37841780:A:AC	donor_gain	1.0000
X:37841780:AC:A	donor_gain	1.0000
X:37841781:C:CA	donor_gain	1.0000
X:37841781:CC:C	donor_gain	1.0000
X:37841781:CCA:C	donor_gain	1.0000
X:37841781:CCAA:C	donor_gain	1.0000
X:37841781:CCAAT:C	donor_gain	1.0000
X:37841901:ACACA:A	acceptor_gain	1.0000
X:37841902:CACA:C	acceptor_gain	1.0000
X:37841902:CACAC:C	acceptor_gain	1.0000
X:37841904:CA:C	acceptor_gain	1.0000
X:37841906:C:CC	acceptor_gain	1.0000
X:37846313:TCACC:T	donor_loss	1.0000

AlphaMissense

774 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:37841046:A:G	W86R	0.999
X:37841046:A:T	W86R	0.999
X:37841789:T:A	K63N	0.999
X:37841789:T:G	K63N	0.999
X:37840596:A:C	F110L	0.998
X:37840596:A:T	F110L	0.998
X:37840598:A:G	F110L	0.998
X:37841031:C:G	D91H	0.998
X:37841044:C:A	W86C	0.998
X:37841044:C:G	W86C	0.998
X:37841814:A:G	L55P	0.998
X:37840600:A:T	V109D	0.997
X:37840611:A:C	C105W	0.997
X:37841030:T:A	D91V	0.997
X:37841060:G:T	A81D	0.997
X:37841098:A:C	C68W	0.997
X:37841100:A:G	C68R	0.997
X:37841790:T:A	K63I	0.997
X:37841791:T:C	K63E	0.997
X:37841838:A:T	I47K	0.997
X:37840594:G:T	A111D	0.996
X:37840606:A:T	V107D	0.996
X:37841029:A:C	D91E	0.996
X:37841029:A:T	D91E	0.996
X:37841045:C:G	W86S	0.996
X:37841061:C:G	A81P	0.996
X:37846324:A:T	V22D	0.996
X:37841030:T:G	D91A	0.995
X:37841031:C:A	D91Y	0.995
X:37841099:C:T	C68Y	0.995

dbSNP variants (sampled 300 via entrez): RS1000210049 (X:37842677 C>A,T), RS1000220055 (X:37845070 T>A,C), RS1000655595 (X:37845433 T>G), RS1002294228 (X:37847223 C>G,T), RS1002528651 (X:37845625 T>C), RS1002674938 (X:37842336 C>A,T), RS1002705960 (X:37842792 A>G), RS1002768931 (X:37845292 C>T), RS1003530498 (X:37847566 C>T), RS1003563687 (X:37849515 T>C), RS1003682089 (X:37840437 A>C), RS1003773040 (X:37847278 C>A), RS1004002896 (X:37838363 G>A), RS1004213960 (X:37846688 C>T), RS1004243644 (X:37848965 A>G)

Disease associations

OMIM: gene MIM:300302 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression	2
Resveratrol	decreases expression, affects cotreatment, increases expression	2
Estradiol	increases expression, increases reaction	2
Phenylmercuric Acetate	increases expression, affects cotreatment	2
dicrotophos	decreases expression	1
alpha phellandrene	increases expression	1
triphenyl phosphate	affects expression	1
kojic acid	decreases expression	1
trichostatin A	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
potassium chromate(VI)	decreases expression	1
4-hydroxy-2-nonenal	affects binding	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Antimycin A	decreases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation, increases methylation	1
Carbamazepine	affects expression	1
Cisplatin	increases expression	1
Coumestrol	affects cotreatment, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diethylhexyl Phthalate	increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Quercetin	increases expression	1
Rotenone	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1QI	Abcam HeLa DYNLT3 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.