E2F3-IT1

Summary

E2F3-IT1 (E2F3 intronic transcript 1, HGNC:41329) is a long non-coding RNA gene on chromosome 6p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41329
Approved symbol	E2F3-IT1
Name	E2F3 intronic transcript 1
Location	6p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RBAT1
Ensembl gene	ENSG00000224707
Ensembl biotype	lncRNA
Entrez	100874268
RNAcentral	URS00004DC2BD — lncRNA, 400 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000433182

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433182 — 2 exons

Exon	Start	End
ENSE00001646313	20439957	20440178
ENSE00001694745	20437821	20437998

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 92.11.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.11	gold quality
sural nerve	UBERON:0015488	74.06	gold quality
bone marrow cell	CL:0002092	73.29	gold quality
colonic epithelium	UBERON:0000397	70.35	gold quality
corpus callosum	UBERON:0002336	68.33	gold quality
bone marrow	UBERON:0002371	68.25	gold quality
skeletal muscle tissue	UBERON:0001134	67.90	silver quality
adrenal tissue	UBERON:0018303	64.95	gold quality
liver	UBERON:0002107	64.36	gold quality
blood	UBERON:0000178	63.15	gold quality
tonsil	UBERON:0002372	60.41	silver quality
calcaneal tendon	UBERON:0003701	60.11	gold quality
monocyte	CL:0000576	59.73	gold quality
urinary bladder	UBERON:0001255	59.03	silver quality
islet of Langerhans	UBERON:0000006	56.70	gold quality
prefrontal cortex	UBERON:0000451	54.84	gold quality
kidney	UBERON:0002113	54.32	gold quality
primary visual cortex	UBERON:0002436	54.27	gold quality
adrenal gland	UBERON:0002369	53.90	gold quality
gastrocnemius	UBERON:0001388	51.91	gold quality
uterine cervix	UBERON:0000002	51.69	silver quality
stomach	UBERON:0000945	51.09	gold quality
smooth muscle tissue	UBERON:0001135	50.83	gold quality
right lobe of liver	UBERON:0001114	50.48	gold quality
lung	UBERON:0002048	50.21	gold quality
multicellular organism	UBERON:0000468	48.78	gold quality
heart	UBERON:0000948	48.60	gold quality
tibial artery	UBERON:0007610	48.16	gold quality
heart left ventricle	UBERON:0002084	48.00	gold quality
left adrenal gland cortex	UBERON:0035825	47.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Integrative lncRNA-mRNA co-expression network analysis identifies novel lncRNA E2F3-IT1 for rheumatoid arthritis. (PMID:33634971)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.