EDC4

Summary

EDC4 (enhancer of mRNA decapping 4, HGNC:17157) is a protein-coding gene on chromosome 16q22.1, encoding Enhancer of mRNA-decapping protein 4 (Q6P2E9). In the process of mRNA degradation, seems to play a role in mRNA decapping. It is a selective cancer dependency (DepMap: 29.8% of cell lines).

Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm.

Source: NCBI Gene 23644 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 188 total
• Cancer dependency (DepMap): dependent in 29.8% of screened cell lines
• MANE Select transcript: NM_014329

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17157
Approved symbol	EDC4
Name	enhancer of mRNA decapping 4
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	RCD-8, Ge-1, HEDLS
Ensembl gene	ENSG00000038358
Ensembl biotype	protein_coding
OMIM	606030
Entrez	23644

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 21 protein_coding, 9 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000358933, ENST00000536072, ENST00000572031, ENST00000572221, ENST00000572724, ENST00000573985, ENST00000573992, ENST00000574770, ENST00000575033, ENST00000575507, ENST00000575514, ENST00000576972, ENST00000577028, ENST00000577105, ENST00000851718, ENST00000851719, ENST00000851720, ENST00000851721, ENST00000851722, ENST00000851723, ENST00000851724, ENST00000851725, ENST00000851726, ENST00000851727, ENST00000851728, ENST00000936214, ENST00000936215, ENST00000936216, ENST00000969096, ENST00000969097, ENST00000969098

RefSeq mRNA: 2 — MANE Select: NM_014329 NM_001427345, NM_014329

CCDS: CCDS10849

Canonical transcript exons

ENST00000358933 — 29 exons

Exon	Start	End
ENSE00001550467	67883956	67884499
ENSE00002669059	67873052	67873343
ENSE00003468969	67878166	67878275
ENSE00003482797	67880063	67880216
ENSE00003486215	67882958	67883177
ENSE00003497927	67881076	67881180
ENSE00003509274	67881497	67881533
ENSE00003510241	67875945	67876101
ENSE00003520171	67879850	67879971
ENSE00003523061	67876488	67876599
ENSE00003527880	67879237	67879309
ENSE00003528403	67882679	67882865
ENSE00003563163	67881954	67882109
ENSE00003563494	67882212	67882327
ENSE00003569209	67877217	67877406
ENSE00003571531	67881265	67881417
ENSE00003589857	67878360	67878443
ENSE00003595191	67876873	67876972
ENSE00003595822	67878957	67879137
ENSE00003597572	67880557	67880990
ENSE00003629028	67877509	67877656
ENSE00003644293	67879412	67879503
ENSE00003651102	67882429	67882594
ENSE00003661882	67877741	67877845
ENSE00003668741	67879587	67879774
ENSE00003669157	67881668	67881845
ENSE00003678079	67878737	67878839
ENSE00003682325	67878536	67878631
ENSE00003690650	67883568	67883731

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 96.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.5764 / max 123.9643, expressed in 1810 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154689	17.6241	1807
154688	0.8663	588
154690	0.0861	27

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	96.65	gold quality
cerebellum	UBERON:0002037	96.54	gold quality
cerebellar cortex	UBERON:0002129	96.52	gold quality
cerebellar hemisphere	UBERON:0002245	96.50	gold quality
pituitary gland	UBERON:0000007	96.04	gold quality
mucosa of transverse colon	UBERON:0004991	95.55	gold quality
adenohypophysis	UBERON:0002196	95.49	gold quality
left testis	UBERON:0004533	95.49	gold quality
granulocyte	CL:0000094	95.47	gold quality
right testis	UBERON:0004534	95.44	gold quality
left ovary	UBERON:0002119	95.12	gold quality
right ovary	UBERON:0002118	94.86	gold quality
apex of heart	UBERON:0002098	94.85	gold quality
ovary	UBERON:0000992	94.81	gold quality
right lobe of thyroid gland	UBERON:0001119	94.79	gold quality
ganglionic eminence	UBERON:0004023	94.69	gold quality
small intestine Peyer’s patch	UBERON:0003454	94.57	gold quality
testis	UBERON:0000473	94.51	gold quality
transverse colon	UBERON:0001157	94.41	gold quality
spleen	UBERON:0002106	94.36	gold quality
metanephros cortex	UBERON:0010533	94.36	gold quality
ventricular zone	UBERON:0003053	94.27	gold quality
right uterine tube	UBERON:0001302	94.25	gold quality
left lobe of thyroid gland	UBERON:0001120	94.24	gold quality
small intestine	UBERON:0002108	94.23	gold quality
left uterine tube	UBERON:0001303	94.22	gold quality
prostate gland	UBERON:0002367	94.19	gold quality
stromal cell of endometrium	CL:0002255	94.17	gold quality
thyroid gland	UBERON:0002046	94.06	gold quality
body of stomach	UBERON:0001161	94.02	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-110499	no	456.05
E-GEOD-106540	no	455.28
E-GEOD-124858	no	81.99
E-ANND-3	no	1.88

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

24 targeting EDC4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-513C-5P	99.50	68.42	1730
HSA-MIR-514B-5P	99.50	68.19	1766
HSA-MIR-136-5P	99.50	67.26	1153
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-4725-5P	98.67	65.42	628
HSA-MIR-6509-3P	98.32	67.33	1343
HSA-MIR-4518	98.12	66.82	1030
HSA-MIR-12120	98.05	68.44	1768
HSA-MIR-1266-5P	97.71	66.92	1052
HSA-MIR-6859-3P	97.26	64.69	428
HSA-MIR-6773-5P	97.04	64.30	595
HSA-MIR-4436B-5P	96.71	68.37	1346
HSA-MIR-6724-5P	96.41	63.11	507
HSA-MIR-6777-3P	95.35	64.30	699

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 29.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 8)

• EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies (PMID:22982864)
• The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5’-to-3’ mRNA degradation by XRN1 in human cells. (PMID:24510189)
• LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L. (PMID:24755989)
• EDC4 is a processing body (P-body) component. (PMID:24858563)
• The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6. (PMID:25970328)
• EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. (PMID:29511213)
• A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. (PMID:32510323)
• Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage. (PMID:33054858)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	edc4	ENSDARG00000062266
mus_musculus	Edc4	ENSMUSG00000036270
rattus_norvegicus	Edc4	ENSRNOG00000024025
drosophila_melanogaster	Ge-1	FBGN0283682
caenorhabditis_elegans	edc-4	WBGENE00021551

Protein

Protein identifiers

Enhancer of mRNA-decapping protein 4 — Q6P2E9 (reviewed: Q6P2E9)

Alternative names: Autoantigen Ge-1, Autoantigen RCD-8, Human enhancer of decapping large subunit

All UniProt accessions (4): Q6P2E9, I3L0V0, I3L2F4, I3L3M2

UniProt curated annotations — full annotation on UniProt →

Function. In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).

Subunit / interactions. Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2. Interacts with RC3H1. Interacts with NBDY. Interacts with TEX19. Interacts with LSM14A. Interacts with DDX6. Interacts with HELZ. (Microbial infection) Interacts with rotavirus A non-structural protein 2; this interaction probably plays a role in the sequestration of EDC4 in viral factories. Interacts with rotavirus A non-structural protein 5; this interaction probably plays a role in its sequestration in viral factories.

Subcellular location. Cytoplasm. P-body. Nucleus.

Similarity. Belongs to the WD repeat EDC4 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6P2E9-1	1	yes
Q6P2E9-2	2

RefSeq proteins (2): NP_001414274, NP_055144* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR032401	EDC4_WD40	Domain
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR044938	EDC4_C_sf	Homologous_superfamily
IPR045152	EDC4-like	Family
IPR049404	EDC4_C	Domain

Pfam: PF16529, PF21289

UniProt features (53 total): modified residue 26, region of interest 8, repeat 7, compositionally biased region 4, sequence conflict 4, initiator methionine 1, chain 1, coiled-coil region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P2E9-F1	63.18	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (26): 2, 3, 6, 125, 560, 565, 583, 585, 676, 693, 708, 723, 725, 727, 729, 741, 821, 844, 871, 875 …

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-430039	mRNA decay by 5’ to 3’ exoribonuclease

MSigDB gene sets: 171 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_UP, YAATNRNNNYNATT_UNKNOWN, MYOGENIN_Q6, chr16q22, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GCANCTGNY_MYOD_Q6, CMYB_01, MODULE_45, REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE, MORF_HDAC1, MORF_UBE2N, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, AREB6_01, RACCACAR_AML_Q6, MORF_HDAC2

GO Biological Process (1): deadenylation-independent decapping of nuclear-transcribed mRNA (GO:0031087)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): P-body (GO:0000932), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), membrane (GO:0016020), cytoplasmic ribonucleoprotein granule (GO:0036464)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Deadenylation-dependent mRNA decay	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	2
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	1
mRNA methylguanosine-cap decapping	1
binding	1
cytoplasmic ribonucleoprotein granule	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
ribonucleoprotein granule	1

Protein interactions and networks

STRING

1856 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EDC4	DCP1A	Q9NPI6	999
EDC4	DCP2	Q8IU60	998
EDC4	EDC3	Q96F86	998
EDC4	DDX6	P26196	994
EDC4	XRN1	Q8IZH2	978
EDC4	LSM14A	Q8ND56	936
EDC4	LSM1	O15116	882
EDC4	UPF1	Q92900	877
EDC4	AGO2	Q9UKV8	786
EDC4	DCP1B	Q8IZD4	780
EDC4	PATL1	Q86TB9	728
EDC4	TNRC6A	Q8NDV7	725
EDC4	CNOT1	A5YKK6	723
EDC4	EIF4ENIF1	Q9NRA8	713
EDC4	LSM4	Q9Y4Z0	696

IntAct

219 interactions, top by confidence:

A	B	Type	Score
EDC3	DDX6	psi-mi:“MI:0914”(association)	0.960
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
DCP2	EDC4	psi-mi:“MI:0915”(physical association)	0.890
EDC4	DCP2	psi-mi:“MI:0914”(association)	0.890
EDC4	DCP2	psi-mi:“MI:0915”(physical association)	0.890
DCP1A	EDC4	psi-mi:“MI:0914”(association)	0.880
EDC4	DCP1A	psi-mi:“MI:0403”(colocalization)	0.880
DCP1A	EDC4	psi-mi:“MI:0403”(colocalization)	0.880
DCP1A	EDC4	psi-mi:“MI:0915”(physical association)	0.880
EDC4	DCP1A	psi-mi:“MI:0915”(physical association)	0.880
SGF29	NDC80	psi-mi:“MI:0914”(association)	0.840
ATXN2	PABPC1	psi-mi:“MI:0915”(physical association)	0.820
DDX6	EDC4	psi-mi:“MI:0914”(association)	0.820
PATL1	LSM1	psi-mi:“MI:0914”(association)	0.770
EDC4	XRN1	psi-mi:“MI:0915”(physical association)	0.750
XRN1	EDC4	psi-mi:“MI:0914”(association)	0.750
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
EDC3	EDC4	psi-mi:“MI:0914”(association)	0.640

BioGRID (327): EDC4 (Affinity Capture-RNA), EDC4 (Affinity Capture-RNA), EDC4 (Affinity Capture-RNA), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Affinity Capture-MS), EDC4 (Co-fractionation), EDC4 (Affinity Capture-MS), EDC4 (Proximity Label-MS)

ESM2 similar proteins: A0A140LI67, A0A1W2PR48, A0JP70, D3YYM4, F1LW30, O13034, O15040, O70173, Q15345, Q3SXM0, Q3UDP0, Q3UJB9, Q3ULW6, Q3V129, Q3ZAV8, Q58DC2, Q5F479, Q5JV73, Q5M9H0, Q5M9H1, Q5R6T6, Q5R9H2, Q68DX3, Q6IRN0, Q6NV72, Q6P2E9, Q6P4K6, Q6PCD5, Q6ZPG2, Q6ZW76, Q7TNH6, Q80TQ5, Q8BLD6, Q8C008, Q8C5V5, Q8CBW4, Q8CIK8, Q8IWE5, Q8JZL1, Q8K1C9

Diamond homologs: Q1LUT1, Q3UJB9, Q3ZAV8, Q6P2E9, Q7ZXT3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 193 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA decay by 5’ to 3’ exoribonuclease	7	40.4×	9e-08
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	5	24.0×	3e-04
SARS-CoV-1-host interactions	9	12.0×	2e-05
SARS-CoV-1 modulates host translation machinery	5	11.7×	5e-03
SARS-CoV-1 Infection	8	8.7×	6e-04
Translation initiation complex formation	6	8.7×	5e-03
SARS-CoV-2-host interactions	7	6.3×	7e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	8	5.9×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
P-body assembly	5	31.5×	4e-04
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6	16.8×	6e-04
mRNA transport	7	11.0×	8e-04
negative regulation of translation	7	8.2×	3e-03
translation	9	5.5×	4e-03
mRNA splicing, via spliceosome	10	5.5×	2e-03
mRNA processing	10	4.7×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

188 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	151
Likely benign	9
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4524 predictions. Top by Δscore:

Variant	Effect	Δscore
16:67873339:GGGCG:G	donor_gain	1.0000
16:67873340:GGCG:G	donor_gain	1.0000
16:67873340:GGCGG:G	donor_gain	1.0000
16:67873341:GCGG:G	donor_gain	1.0000
16:67875839:T:G	donor_gain	1.0000
16:67875940:CCCA:C	acceptor_loss	1.0000
16:67875942:CA:C	acceptor_loss	1.0000
16:67875943:A:AG	acceptor_gain	1.0000
16:67875943:A:AT	acceptor_loss	1.0000
16:67875943:AG:A	acceptor_gain	1.0000
16:67875944:G:GT	acceptor_gain	1.0000
16:67875944:GG:G	acceptor_gain	1.0000
16:67875944:GGC:G	acceptor_gain	1.0000
16:67875944:GGCC:G	acceptor_gain	1.0000
16:67875944:GGCCC:G	acceptor_gain	1.0000
16:67876097:GTCAT:G	donor_gain	1.0000
16:67876102:G:GG	donor_gain	1.0000
16:67876485:CAG:C	acceptor_loss	1.0000
16:67876486:A:AG	acceptor_gain	1.0000
16:67876486:AGCT:A	acceptor_gain	1.0000
16:67876487:G:GG	acceptor_gain	1.0000
16:67876487:G:GT	acceptor_loss	1.0000
16:67876487:GCT:G	acceptor_gain	1.0000
16:67876487:GCTG:G	acceptor_gain	1.0000
16:67876487:GCTGT:G	acceptor_gain	1.0000
16:67876862:T:A	acceptor_gain	1.0000
16:67876863:G:A	acceptor_gain	1.0000
16:67876868:CTCAG:C	acceptor_loss	1.0000
16:67876870:CA:C	acceptor_loss	1.0000
16:67876871:A:AC	acceptor_loss	1.0000

AlphaMissense

9136 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:67873308:T:C	L16P	1.000
16:67873320:T:C	L20P	1.000
16:67876903:T:A	W128R	1.000
16:67876903:T:C	W128R	1.000
16:67878206:T:C	L312P	1.000
16:67878209:C:A	A313D	1.000
16:67878239:T:C	F323S	1.000
16:67878412:T:C	F353L	1.000
16:67878413:T:C	F353S	1.000
16:67878414:C:A	F353L	1.000
16:67878414:C:G	F353L	1.000
16:67878419:A:T	D355V	1.000
16:67878546:T:A	W367R	1.000
16:67878546:T:C	W367R	1.000
16:67878552:T:C	F369L	1.000
16:67878554:C:A	F369L	1.000
16:67878554:C:G	F369L	1.000
16:67878556:T:C	L370P	1.000
16:67878594:T:A	W383R	1.000
16:67878594:T:C	W383R	1.000
16:67878609:T:A	W388R	1.000
16:67878609:T:C	W388R	1.000
16:67878611:G:C	W388C	1.000
16:67878611:G:T	W388C	1.000
16:67878814:T:C	L421P	1.000
16:67878961:T:C	L431P	1.000
16:67879291:T:C	L508P	1.000
16:67883170:T:C	F1281S	1.000
16:67883572:T:C	L1285P	1.000
16:67883671:T:C	L1318P	1.000

dbSNP variants (sampled 300 via entrez): RS1000217523 (16:67880426 G>A), RS1000491813 (16:67873193 G>A,C,T), RS1000842486 (16:67873411 A>G,T), RS1001072909 (16:67876814 G>A), RS1001232055 (16:67872067 G>T), RS1001308848 (16:67883857 C>T), RS1001516286 (16:67874270 C>A,G,T), RS1001946610 (16:67872663 T>A), RS1002011024 (16:67873800 C>T), RS1002301810 (16:67875653 A>G,T), RS1002344442 (16:67879424 T>C), RS1002605561 (16:67875657 C>G,T), RS1002632472 (16:67873644 A>T), RS1002924613 (16:67875874 G>A,T), RS1003296910 (16:67881065 T>C)

Disease associations

OMIM: gene MIM:606030 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000974_8	HDL cholesterol	8.000000e-06
GCST001436_3	Metabolic syndrome	2.000000e-10
GCST002539_84	Schizophrenia	2.000000e-08
GCST006803_42	Schizophrenia	4.000000e-08
GCST010002_113	Refractive error	2.000000e-14

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0000195	metabolic syndrome

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, decreases expression	3
Smoke	increases abundance, increases expression, decreases expression	2
FR900359	affects phosphorylation	1
bisphenol A	decreases expression	1
perfluorooctanoic acid	decreases expression	1
coumarin	increases phosphorylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Fulvestrant	increases methylation	1
Leflunomide	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Caffeine	decreases phosphorylation	1
Clozapine	increases expression	1
Diazinon	increases methylation	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Aflatoxin B1	increases methylation	1
Genistein	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.