EEIG2

Summary

EEIG2 (EEIG family member 2, HGNC:27637) is a protein-coding gene on chromosome 1p13.3, encoding EEIG family member 2 (Q5T8I3).

At a glance

• Clinical variants (ClinVar): 45 total
• GTEx eGene: eQTL in 24 tissues, sQTL in 1 (q < 0.05)
• Constraint (gnomAD): pLI 0.90 (loss-of-function intolerant), LOEUF 0.55 (moderately constrained)
• MANE Select transcript: NM_001010883

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27637
Approved symbol	EEIG2
Name	EEIG family member 2
Location	1p13.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp779B126, SYM-3B
Ensembl gene	ENSG00000162636
Ensembl biotype	protein_coding
Entrez	284611

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 10 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

MANE Select: ENST00000370035

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 2: 1, TSL 5: 1

ENST00000370035, ENST00000405454, ENST00000483371, ENST00000931504, ENST00000931505, ENST00000931506, ENST00000931507, ENST00000931508, ENST00000931509, ENST00001079057, ENST00001123604, ENST00001142187

RefSeq mRNA: 1 — MANE Select: NM_001010883 NM_001010883

CCDS: CCDS30786

Canonical transcript exons

ENST00000370035 — 11 exons

Exon	Start	End
ENSE00001067143	108616382	108616428
ENSE00001067148	108628395	108628584
ENSE00001067152	108624645	108624748
ENSE00001207456	108628167	108628262
ENSE00001364404	108612178	108612294
ENSE00001365876	108606223	108606252
ENSE00001366448	108600566	108600686
ENSE00001958971	108635108	108639322
ENSE00003551250	108628677	108628804
ENSE00003596479	108629588	108629657
ENSE00003850002	108560100	108560565

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 94.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.4709 / max 565.2428, expressed in 1634 samples.

Highest expression (Bgee): dorsal root ganglion, Brodmann (1909) area 46, epithelial cell of pancreas, mucosa of sigmoid colon, colonic mucosa.

Genetic regulation across tissues (GTEx eQTL / sQTL)

EEIG2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 24 tissues and its splicing (sQTL) in 1 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 25 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Brain Cerebellum	eqtl	7.9e-19	+1.01	1:108635180:G:A
Brain Cerebellar Hemisphere	eqtl	1.7e-13	+0.77	1:108635180:G:A
Ovary	eqtl	4.1e-12	+1.54	1:108527873:C:T
Artery Tibial	eqtl	1.3e-11	+0.21	1:108531271:T:C
Testis	eqtl	2.2e-11	+0.24	1:108530482:C:T
Lung	eqtl	1.1e-09	+0.41	1:108596623:T:A
Cells EBV-transformed lymphocytes	eqtl	8.5e-07	-0.42	1:108538346:T:G
Colon Transverse	eqtl	2.5e-05	+0.48	1:108635180:G:A
Nerve Tibial	eqtl	3.8e-05	+0.14	1:108532569:C:T
Brain Cortex	eqtl	6.8e-05	+0.29	1:108635180:G:A
Cells EBV-transformed lymphocytes	sqtl	7.7e-05	-1.83	1:108635180:G:A
Brain Frontal Cortex BA9	eqtl	1.1e-04	+0.29	1:108635180:G:A
Skin Sun Exposed Lower leg	eqtl	1.2e-03	+0.24	1:108571155:C:G
Spleen	eqtl	2.3e-03	+0.42	1:108596473:G:A
Colon Sigmoid	eqtl	3.4e-03	+0.44	1:108635180:G:A
Adipose Visceral Omentum	eqtl	9.0e-03	+0.23	1:108666389:A:G
Bladder	eqtl	1.6e-02	-0.64	1:108119597:C:T
Pituitary	eqtl	1.8e-02	+0.53	1:108635180:G:A
Skin Not Sun Exposed Suprapubic	eqtl	2.4e-02	+0.27	1:108635180:G:A
Thyroid	eqtl	3.5e-02	+0.24	1:108635180:G:A

FANTOM5 promoters

1 alternative TSS:

Promoter ID	TPM avg	Samples expressed
4348	12.4709	1634

Top tissues by expression

showing 100 of 254 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsal root ganglion	UBERON:0000044	94.54	gold quality
Brodmann (1909) area 46	UBERON:0006483	93.79	gold quality
epithelial cell of pancreas	CL:0000083	93.68	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.34	gold quality
colonic mucosa	UBERON:0000317	92.27	gold quality
cerebellar vermis	UBERON:0004720	91.74	gold quality
parotid gland	UBERON:0001831	91.27	gold quality
trigeminal ganglion	UBERON:0001675	91.04	gold quality
ileal mucosa	UBERON:0000331	91.01	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.90	silver quality
superficial temporal artery	UBERON:0001614	90.76	gold quality
seminal vesicle	UBERON:0000998	90.31	gold quality
substantia nigra pars compacta	UBERON:0001965	90.14	gold quality
palpebral conjunctiva	UBERON:0001812	89.71	gold quality
parietal pleura	UBERON:0002400	89.68	gold quality
synovial joint	UBERON:0002217	89.55	gold quality
substantia nigra pars reticulata	UBERON:0001966	89.47	gold quality
layer of synovial tissue	UBERON:0007616	89.18	gold quality
superior frontal gyrus	UBERON:0002661	88.95	gold quality
middle temporal gyrus	UBERON:0002771	88.35	gold quality
left ventricle myocardium	UBERON:0006566	88.34	silver quality
jejunal mucosa	UBERON:0000399	88.20	gold quality
postcentral gyrus	UBERON:0002581	88.10	gold quality
caput epididymis	UBERON:0004358	87.90	gold quality
cauda epididymis	UBERON:0004360	87.76	gold quality
lateral nuclear group of thalamus	UBERON:0002736	87.59	gold quality
entorhinal cortex	UBERON:0002728	87.53	gold quality
parietal lobe	UBERON:0001872	87.46	gold quality
Brodmann (1909) area 23	UBERON:0013554	87.24	gold quality
rectum	UBERON:0001052	86.63	gold quality
prefrontal cortex	UBERON:0000451	85.90	gold quality
gall bladder	UBERON:0002110	85.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.56	gold quality
monocyte	CL:0000576	85.07	gold quality
skin of hip	UBERON:0001554	85.01	gold quality
cortical plate	UBERON:0005343	85.01	gold quality
leukocyte	CL:0000738	84.87	gold quality
duodenum	UBERON:0002114	84.70	gold quality
urethra	UBERON:0000057	84.69	gold quality
pericardium	UBERON:0002407	84.67	gold quality
corpus epididymis	UBERON:0004359	84.62	gold quality
saphenous vein	UBERON:0007318	84.45	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	84.37	gold quality
frontal cortex	UBERON:0001870	84.35	gold quality
myocardium	UBERON:0002349	84.26	silver quality
calcaneal tendon	UBERON:0003701	84.21	gold quality
urinary bladder	UBERON:0001255	84.19	gold quality
colonic epithelium	UBERON:0000397	84.11	gold quality
bone marrow	UBERON:0002371	84.01	gold quality
germinal epithelium of ovary	UBERON:0001304	83.83	gold quality
neocortex	UBERON:0001950	83.63	gold quality
cerebral cortex	UBERON:0000956	83.42	gold quality
epithelium of mammary gland	UBERON:0003244	83.42	gold quality
thymus	UBERON:0002370	83.35	gold quality
mammary duct	UBERON:0001765	83.34	gold quality
superior vestibular nucleus	UBERON:0007227	83.25	gold quality
thoracic mammary gland	UBERON:0005200	83.17	gold quality
mammary gland	UBERON:0001911	82.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.58	gold quality
primary visual cortex	UBERON:0002436	82.42	gold quality
heart right ventricle	UBERON:0002080	82.41	gold quality
smooth muscle tissue	UBERON:0001135	82.34	gold quality
visceral pleura	UBERON:0002401	82.27	gold quality
vermiform appendix	UBERON:0001154	82.19	gold quality
lower lobe of lung	UBERON:0008949	82.19	gold quality
occipital lobe	UBERON:0002021	82.08	gold quality
caecum	UBERON:0001153	82.06	gold quality
cerebellum	UBERON:0002037	82.00	gold quality
nasal cavity mucosa	UBERON:0001826	81.96	gold quality
secondary oocyte	CL:0000655	81.76	gold quality
cerebellar cortex	UBERON:0002129	81.59	gold quality
cerebellar hemisphere	UBERON:0002245	81.43	gold quality
ventricular zone	UBERON:0003053	81.23	gold quality
anterior cingulate cortex	UBERON:0009835	81.19	gold quality
tonsil	UBERON:0002372	80.97	gold quality
tendon	UBERON:0000043	80.96	gold quality
temporal lobe	UBERON:0001871	80.91	gold quality
vena cava	UBERON:0004087	80.83	gold quality
jejunum	UBERON:0002115	80.65	gold quality
lymph node	UBERON:0000029	80.20	gold quality
large intestine	UBERON:0000059	80.20	gold quality
mucosa of stomach	UBERON:0001199	80.20	gold quality
oral cavity	UBERON:0000167	79.85	gold quality
colon	UBERON:0001155	79.79	gold quality
descending thoracic aorta	UBERON:0002345	79.77	gold quality
saliva-secreting gland	UBERON:0001044	79.71	gold quality
intestine	UBERON:0000160	79.63	gold quality
Ammon’s horn	UBERON:0001954	79.60	gold quality
adipose tissue	UBERON:0001013	79.59	gold quality
stromal cell of endometrium	CL:0002255	79.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.56	gold quality
dorsal plus ventral thalamus	UBERON:0001897	79.54	gold quality
bone marrow cell	CL:0002092	79.53	gold quality
brain	UBERON:0000955	79.37	gold quality
adipose tissue of abdominal region	UBERON:0007808	79.30	gold quality
peritoneum	UBERON:0002358	79.13	gold quality
omental fat pad	UBERON:0010414	79.13	gold quality
substantia nigra	UBERON:0002038	79.06	gold quality
ascending aorta	UBERON:0001496	78.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.65

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 79 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Caudate putamen	tissue	55.0
Locus coeruleus	tissue	24.9
Frontal cortex	tissue	21.4
Postcentral gyrus	tissue	21.0
Spinal cord	tissue	20.6
Bone marrow	tissue	20.0	low
Prefrontal cortex	tissue	18.3
Cerebral cortex	tissue	18.3	medium
Medulla oblongata	tissue	18.2
Hypothalamus	tissue	17.8
Substantia nigra	tissue	17.6
Periaqueductal gray	tissue	17.1
Motor cortex	tissue	17.0
Pons	tissue	16.9
Midbrain	tissue	16.9
Olfactory bulb	tissue	16.8
Corpus callosum	tissue	16.7
Hippocampus	tissue	16.2	medium
Retrosplenial and cingulate cortex	tissue	16.2
Hippocampal formation	tissue	16.0
Entorhinal cortex	tissue	16.0
Septum	tissue	15.6
Urinary bladder	tissue	15.3	medium
Insular cortex	tissue	15.1
Retrosplenial cortex	tissue	14.8
Occipital cortex	tissue	14.2
Amygdala	tissue	13.8
Rectum	tissue	13.7	high
Gallbladder	tissue	13.7	high
Somatosensory cortex	tissue	13.6
Temporal cortex	tissue	13.6
Thalamus	tissue	13.5
Salivary gland	tissue	12.9	medium
Cerebellum	tissue	12.8	medium
Ventral forebrain	tissue	12.8
Colon	tissue	12.5	high
Putamen	tissue	11.1
Small intestine	tissue	10.5	high
Duodenum	tissue	10.4	high
Nucleus accumbens	tissue	10.2
Breast	tissue	10.0	low
Appendix	tissue	9.9	medium
Basal ganglia	tissue	9.4	medium
Superior colliculi	tissue	9.2
Adipose tissue	tissue	8.6	not detected
Lymph node	tissue	8.4	low
Smooth muscle	tissue	8.2	not detected
Spleen	tissue	8.2	not detected
Thymus	tissue	8.1
Testis	tissue	8.0	high
Tonsil	tissue	7.7	low
Lung	tissue	7.4	low
Seminal vesicle	tissue	7.3	low
Stomach 1	tissue	7.1	high
Parathyroid gland	tissue	7.1	medium
Cervix	tissue	6.9	medium
Ovary	tissue	6.3	low
Heart muscle	tissue	6.2	medium
Endometrium 1	tissue	6.1	high
Choroid plexus	tissue	5.9

Brain sub-regions (HPA Brain Atlas): detected in 191; highest nTPM — Claustrum (27.5), Perirhinal gyrus (27.0), Olfactory area (26.7), Olfactory tubercle (25.6), Mammillary body (25.5).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting EEIG2 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 204 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-548N	99.98	71.94	4170
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-568	99.98	69.86	2084

Functional genomics

gnomAD constraint: pLI 0.901, LOEUF 0.554, missense Z 1.47 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000370035 — one region, missense o/e 0.80.

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	fam102bb	ENSDARG00000002333
danio_rerio	eeig2a	ENSDARG00000053104
mus_musculus	Eeig2	ENSMUSG00000040339
rattus_norvegicus	Eeig2	ENSRNOG00000027540

Paralogs (1): EEIG1 (ENSG00000167106)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Xenopus laevis	Q6GNM6	76.8%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
HENMT1	protein-coding	113802
NBPF6	protein-coding	653149
FNDC7	protein-coding	163479
PRPF38B	protein-coding	55119

Protein

Protein identifiers

EEIG family member 2 — Q5T8I3 (reviewed: Q5T8I3)

All UniProt accessions (1): Q5T8I3

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the EEIG family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5T8I3-1	1	yes
Q5T8I3-2	2

RefSeq proteins (1): NP_001010883* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019448	NT-C2	Domain
IPR039931	EEIG1/2-like	Family

Pfam: PF10358

UniProt features (9 total): modified residue 6, chain 1, domain 1, splice variant 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T8I3-F1	70.80	0.37

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): cytosol; nucleoli

Antibody reliability (HPA): IH uncertain · IF approved

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6)

Type	Positions
Phosphoserine	228, 276, 288, 320, 321, 350

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 129 (showing top): CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, INGRAM_SHH_TARGETS_DN, KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN, GABRIELY_MIR21_TARGETS, LEE_BMP2_TARGETS_UP, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP, BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP, GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_BALBC_MOUSE_DN, CBX5_TARGET_GENES, SUPT16H_TARGET_GENES, ZNF350_TARGET_GENES, ZNF362_TARGET_GENES, ZNF592_TARGET_GENES

Protein interactions and networks

STRING

showing 15 of 704 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EEIG2	TSKS	Q9UJT2	530
EEIG2	GAPT	Q8N292	514
EEIG2	MAP3K19	Q56UN5	496
EEIG2	ANKRD23	Q86SG2	478
EEIG2	FILIP1L	Q4L180	473
EEIG2	TP53TG5	Q9Y2B4	469
EEIG2	SLC4A9	Q96Q91	461
EEIG2	FAM117A	Q9C073	460
EEIG2	MYOZ3	Q8TDC0	455
EEIG2	SLC30A2	Q9BRI3	455
EEIG2	PKIA	P04541	454
EEIG2	ANKRD39	Q53RE8	452
EEIG2	TMEM37	Q8WXS4	448
EEIG2	SLC7A14	Q8TBB6	435
EEIG2	FNDC7	Q5VTL7	429

Disease & clinical

Genetic variants

Variant evidence for EEIG2: 45 ClinVar records (0 pathogenic / likely pathogenic).

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	0
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 32 predictions of 1,017):

Position(s)	Effect	Δscore	Sites
1:108560566–108560567	donor_loss	1.0000	4
1:108600684	donor_gain	1.0000
1:108612175	acceptor_gain	1.0000
1:108612176–108612177	acceptor_loss	1.0000	6
1:108612295–108612296	donor_loss	1.0000	5
1:108628586	donor_loss	1.0000	2
1:108628674	acceptor_gain	1.0000
1:108560566	donor_loss	0.9900
1:108600687–108600688	donor_loss	0.9900	6
1:108606253–108606254	donor_loss	0.9900	5

AlphaMissense

868 missense substitutions predicted likely pathogenic (of 2,356 scored), across 201 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D130	8	0.993	0.998
N131	8	0.986	0.999
F9	8	0.976	0.999
D146	8	0.976	0.995
F149	8	0.961	0.998
F62	8	0.936	0.991
F316	8	0.854	0.968
W56	7	0.996	1.000
F29	7	0.995	0.999
F99	7	0.993	0.999
R85	7	0.992	1.000
E87	7	0.977	0.996
R46	7	0.975	0.998
F7	7	0.972	0.993
R300	7	0.972	0.997
F330	7	0.967	0.989
K96	7	0.955	0.999
F107	7	0.953	0.987
C148	7	0.941	0.992
F40	7	0.901	0.979

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Liver Hepatocellular Carcinoma (TCGA)	unfavorable	0.000453
Head and Neck Squamous Cell Carcinoma (TCGA)	favorable	0.000964

Disease associations

OMIM: gene `` | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, affects expression, affects cotreatment	2
Smoke	decreases expression, increases abundance, increases expression	2
Valproic Acid	affects expression, increases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
methylmercuric chloride	increases expression	1
bisphenol A	decreases methylation	1
hydroxyhydroquinone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression, increases response to substance	1
jinfukang	decreases expression	1
gardiquimod	decreases expression, decreases reaction	1
NSC 689534	affects binding, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Ethanol	increases expression	1
Arsenic	increases abundance, affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Carbamazepine	affects expression	1
Copper	affects binding, decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.