EGFLAM

Summary

EGFLAM (EGF like, fibronectin type III and laminin G domains, HGNC:26810) is a protein-coding gene on chromosome 5p13.2-p13.1, encoding Pikachurin (Q63HQ2). Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception.

Predicted to enable calcium ion binding activity and glycosaminoglycan binding activity. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Part of cell surface.

Source: NCBI Gene 133584 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 199 total
• MANE Select transcript: NM_152403

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26810
Approved symbol	EGFLAM
Name	EGF like, fibronectin type III and laminin G domains
Location	5p13.2-p13.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ39155, AGRINL, AGRNL, PIKA
Ensembl gene	ENSG00000164318
Ensembl biotype	protein_coding
OMIM	617683
Entrez	133584

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 8 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000322350, ENST00000336740, ENST00000354891, ENST00000397202, ENST00000397210, ENST00000504709, ENST00000506135, ENST00000508131, ENST00000508868, ENST00000513131, ENST00000514476

RefSeq mRNA: 4 — MANE Select: NM_152403 NM_001205301, NM_152403, NM_182798, NM_182801

CCDS: CCDS3924, CCDS3925, CCDS47199, CCDS56363

Canonical transcript exons

ENST00000322350 — 22 exons

Exon	Start	End
ENSE00001243246	38462908	38463011
ENSE00001243406	38438275	38438455
ENSE00001243414	38435137	38435253
ENSE00001243423	38431177	38431288
ENSE00001243501	38458311	38458394
ENSE00001345105	38463832	38465480
ENSE00001621585	38406126	38406241
ENSE00001668826	38406828	38407146
ENSE00001731042	38409004	38409104
ENSE00001736163	38407805	38407905
ENSE00001754862	38370296	38370462
ENSE00001756078	38418066	38418255
ENSE00003474728	38337520	38337629
ENSE00003475956	38352196	38352331
ENSE00003498625	38424967	38425092
ENSE00003524469	38338698	38338781
ENSE00003530437	38412504	38412648
ENSE00003559075	38350501	38350618
ENSE00003594467	38448301	38448379
ENSE00003622013	38427009	38427252
ENSE00003666933	38451315	38451458
ENSE00003847947	38258559	38258851

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 94.09.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1662 / max 96.3490, expressed in 693 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56190	1.4146	471
56187	0.8983	230
56189	0.6195	290
56186	0.1844	88
203529	0.0263	11
56188	0.0124	3
203530	0.0108	4

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	94.09	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.07	gold quality
muscle of leg	UBERON:0001383	93.68	gold quality
tibialis anterior	UBERON:0001385	93.49	gold quality
deltoid	UBERON:0001476	91.21	gold quality
vastus lateralis	UBERON:0001379	90.80	gold quality
omental fat pad	UBERON:0010414	90.79	gold quality
quadriceps femoris	UBERON:0001377	90.71	gold quality
tibial nerve	UBERON:0001323	90.69	gold quality
peritoneum	UBERON:0002358	90.65	gold quality
adipose tissue of abdominal region	UBERON:0007808	90.32	gold quality
apex of heart	UBERON:0002098	90.30	gold quality
skeletal muscle tissue	UBERON:0001134	90.13	gold quality
biceps brachii	UBERON:0001507	89.72	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	89.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.98	gold quality
right ovary	UBERON:0002118	88.66	gold quality
left ovary	UBERON:0002119	88.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	88.20	gold quality
popliteal artery	UBERON:0002250	88.05	gold quality
tibial artery	UBERON:0007610	88.05	gold quality
adipose tissue	UBERON:0001013	86.99	gold quality
muscle tissue	UBERON:0002385	86.79	gold quality
heart left ventricle	UBERON:0002084	86.67	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.30	gold quality
cardiac ventricle	UBERON:0002082	86.08	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	85.24	silver quality
descending thoracic aorta	UBERON:0002345	85.05	gold quality
aorta	UBERON:0000947	84.93	gold quality
placenta	UBERON:0001987	84.70	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-11268	yes	1960.23
E-ANND-3	yes	11.36
E-GEOD-36552	no	58.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

74 targeting EGFLAM, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-516A-3P	99.46	67.96	1378
HSA-MIR-516B-3P	99.46	67.96	1378
HSA-MIR-7162-5P	99.46	68.08	1368

Literature-anchored findings (GeneRIF, showing 5)

• Strong candidate gene for macular dystrophy, MCDR3 (human 5p15.33-p13.1). Conclusion is based on a massive expression data set for mouse (103 strains) and joint analysis of RetNet database. (PMID:19727342)
• rs1465567 of EGFLAM and rs113710653 of SPATC1L may be susceptibility loci for true aortic aneurysm and rs143881017 of RNASE13 may be such a locus for dissecting aortic aneurysm in Japanese individuals. (PMID:28339009)
• this is the first report to describe that EGFLAM promoted the proliferation, migration and invasion of GBM cells via the activation of PI3K/AKT pathway, and predicted poor prognosis in GBM patients. (PMID:30829611)
• Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179. (PMID:37490546)
• EGFLAM exhibits oncogenic activity and shows promise as a prognostic biomarker and therapeutic target in glioblastoma. (PMID:38996666)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	EGFLAM	ENSDARG00000099008
mus_musculus	Egflam	ENSMUSG00000042961
rattus_norvegicus	Egflam	ENSRNOG00000012058

Paralogs (27): USH2A (ENSG00000042781), LAMC3 (ENSG00000050555), LAMA3 (ENSG00000053747), LAMC2 (ENSG00000058085), NTN1 (ENSG00000065320), NTN4 (ENSG00000074527), ATRN (ENSG00000088812), LAMB4 (ENSG00000091128), LAMB1 (ENSG00000091136), LAMA1 (ENSG00000101680), MEGF8 (ENSG00000105429), MEGF9 (ENSG00000106780), ATRNL1 (ENSG00000107518), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMC1 (ENSG00000135862), NTN5 (ENSG00000142233), HSPG2 (ENSG00000142798), TMEFF2 (ENSG00000144339), NTN3 (ENSG00000162068), NTNG1 (ENSG00000162631), LAMB2 (ENSG00000172037), AGRN (ENSG00000188157), NTNG2 (ENSG00000196358), LAMA2 (ENSG00000196569), LAMB3 (ENSG00000196878), TMEFF1 (ENSG00000241697)

Protein

Protein identifiers

Pikachurin — Q63HQ2 (reviewed: Q63HQ2)

Alternative names: Agrin-like protein, EGF-like, fibronectin type-III and laminin G-like domain-containing protein

All UniProt accessions (3): D6RG24, D6RJD2, Q63HQ2

UniProt curated annotations — full annotation on UniProt →

Function. Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness.

Subunit / interactions. Interacts with DAG1 alpha-dystroglycan. Interacts with GPR158 and GPR179; transsynaptic interaction is required for synaptic organization of photoreceptor cells.

Subcellular location. Secreted. Extracellular space. Extracellular matrix. Synaptic cleft. Presynaptic active zone.

Post-translational modifications. O-glycosylated; contains chondroitin sulfate and heparan sulfate.

Isoforms (5)

UniProt ID	Names	Canonical?
Q63HQ2-1	1	yes
Q63HQ2-2	2
Q63HQ2-3	3
Q63HQ2-4	4
Q63HQ2-5	5

RefSeq proteins (4): NP_001192230, NP_689616, NP_877950, NP_877953 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000742	EGF	Domain
IPR001791	Laminin_G	Domain
IPR001881	EGF-like_Ca-bd_dom	Domain
IPR003961	FN3_dom	Domain
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036116	FN3_sf	Homologous_superfamily
IPR050372	Neurexin-related_CASP	Family
IPR056943	EGF_Pikachurin	Domain

Pfam: PF00008, PF00041, PF00054, PF02210, PF25016

UniProt features (74 total): strand 29, disulfide bond 11, domain 8, sequence variant 6, splice variant 5, sequence conflict 5, turn 4, helix 3, signal peptide 1, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7ZC9	X-RAY DIFFRACTION	2.1
7ZCB	X-RAY DIFFRACTION	2.5
8D1B	ELECTRON MICROSCOPY	3.57

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q63HQ2-F1	80.81	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (11): 347–358, 352–369, 371–380, 534–564, 569–580, 574–590, 592–601, 788–799, 793–808, 810–819, 987–1014

Glycosylation sites (1): 47

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 119 (showing top): RNGTGGGC_UNKNOWN, AGGAAGC_MIR5163P, BENPORATH_ES_WITH_H3K27ME3, GGTGTGT_MIR329, WWTAAGGC_UNKNOWN, GOBP_SYNAPSE_ASSEMBLY, RORA1_01, TTTGTAG_MIR520D, CACCAGC_MIR138, AAAYRNCTG_UNKNOWN, GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION, GOBP_CELL_JUNCTION_ORGANIZATION, SOX9_B1, GATA1_04, GATA1_03

GO Biological Process (3): synapse assembly (GO:0007416), positive regulation of cell-substrate adhesion (GO:0010811), extracellular matrix organization (GO:0030198)

GO Molecular Function (3): calcium ion binding (GO:0005509), glycosaminoglycan binding (GO:0005539), protein binding (GO:0005515)

GO Cellular Component (10): basement membrane (GO:0005604), interstitial matrix (GO:0005614), synaptic cleft (GO:0043083), presynaptic active zone (GO:0048786), photoreceptor ribbon synapse (GO:0098684), extracellular region (GO:0005576), cell surface (GO:0009986), extracellular matrix (GO:0031012), cell projection (GO:0042995), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
extracellular matrix	2
nervous system development	1
cell junction assembly	1
synapse organization	1
regulation of cell-substrate adhesion	1
cell-substrate adhesion	1
positive regulation of cell adhesion	1
extracellular structure organization	1
external encapsulating structure organization	1
metal ion binding	1
carbohydrate derivative binding	1
binding	1
extracellular region	1
presynapse	1
ribbon synapse	1
external encapsulating structure	1
cell junction	1

Protein interactions and networks

STRING

2000 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EGFLAM	DAG1	Q14118	994
EGFLAM	DMD	P11532	690
EGFLAM	POMT2	Q9UKY4	649
EGFLAM	POMT1	Q9Y6A1	644
EGFLAM	GPR179	Q6PRD1	628
EGFLAM	CTBP2	P56545	617
EGFLAM	CABP4	P57796	594
EGFLAM	POMGNT1	Q8WZA1	594
EGFLAM	FKTN	O75072	592
EGFLAM	TLR3	O15455	569
EGFLAM	FKRP	Q9H9S5	547
EGFLAM	NRXN2	Q9P2S2	541
EGFLAM	B4GAT1	O43505	537
EGFLAM	NRXN1	Q9ULB1	530
EGFLAM	LRIT3	Q3SXY7	517

IntAct

10 interactions, top by confidence:

A	B	Type	Score
PDPK1	AGRN	psi-mi:“MI:0914”(association)	0.530
FGF1	SDC4	psi-mi:“MI:0914”(association)	0.530
GPR179	EGFLAM	psi-mi:“MI:0915”(physical association)	0.460
GPR179	EGFLAM	psi-mi:“MI:0403”(colocalization)	0.460
CUL2	ANXA2P2	psi-mi:“MI:0914”(association)	0.350
Gpr158	AGRN	psi-mi:“MI:0914”(association)	0.350
EGFLAM	CLSTN1	psi-mi:“MI:0914”(association)	0.350
BTRC	BHLHE40	psi-mi:“MI:0914”(association)	0.350

BioGRID (17): EGFLAM (Affinity Capture-RNA), EGFLAM (Affinity Capture-MS), EGFLAM (Affinity Capture-MS), EGFLAM (Affinity Capture-MS), EGFLAM (Affinity Capture-MS), EGFLAM (Affinity Capture-MS), FBXW11 (Affinity Capture-MS), EGFLAM (Affinity Capture-MS), DAG1 (Affinity Capture-MS), HSPA5 (Affinity Capture-MS), BTRC (Affinity Capture-MS), UBR1 (Affinity Capture-MS), CLSTN1 (Affinity Capture-MS), MAN2C1 (Affinity Capture-MS), EGFLAM (Affinity Capture-MS)

ESM2 similar proteins: A1XQX0, A1XQX2, A1XQX8, A1XQY1, A3KN33, B4F785, B8UU78, D0PRN3, E9Q7X7, P12080, P29319, P29320, P54764, Q02763, Q02858, Q03137, Q06807, Q07310, Q07496, Q0V8S9, Q0V8T0, Q0V8T3, Q0V8T4, Q0V8T5, Q0V8T6, Q0V8T7, Q0V8T8, Q0V8T9, Q19617, Q28146, Q3KN41, Q4VBE4, Q5RD64, Q63372, Q63374, Q63HQ2, Q6P9K9, Q8QFX6, Q8WYK1, Q91694

Diamond homologs: A2ASQ1, A2ASS6, A3KN33, A8DYP0, B4F785, O00468, O35474, O43854, O55005, O88516, O89026, O94779, P00740, P25304, P29294, P35590, Q05793, Q06561, Q16787, Q4LDE5, Q4VBE4, Q5R7K9, Q5RBN1, Q63HQ2, Q7TPD3, Q8N9C0, Q8TER0, Q8WZ42, Q95ND7, Q96MS0, Q9HCK4, Q9NYJ7, Q9NYQ8, Q9Y2H6, Q9Y6N7, Q9Z2I4, A2CG49, G5EBF1, O01761, O60229

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

199 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	164
Likely benign	9
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4402 predictions. Top by Δscore:

Variant	Effect	Δscore
5:38258850:AGGTA:A	donor_loss	1.0000
5:38258851:GGTAA:G	donor_loss	1.0000
5:38337511:T:TA	acceptor_gain	1.0000
5:38337512:G:A	acceptor_gain	1.0000
5:38337630:G:GG	donor_gain	1.0000
5:38338782:G:GA	donor_loss	1.0000
5:38338783:T:TC	donor_loss	1.0000
5:38338784:GA:G	donor_loss	1.0000
5:38370285:A:AG	acceptor_gain	1.0000
5:38370286:A:G	acceptor_gain	1.0000
5:38370289:A:AG	acceptor_gain	1.0000
5:38370290:A:AG	acceptor_gain	1.0000
5:38370292:A:AG	acceptor_gain	1.0000
5:38370292:AAAG:A	acceptor_gain	1.0000
5:38370293:A:G	acceptor_gain	1.0000
5:38370294:A:AG	acceptor_gain	1.0000
5:38370295:G:GG	acceptor_gain	1.0000
5:38370295:GGCC:G	acceptor_gain	1.0000
5:38370295:GGCCA:G	acceptor_gain	1.0000
5:38370463:G:GG	donor_gain	1.0000
5:38406121:T:TA	acceptor_gain	1.0000
5:38406124:A:AG	acceptor_gain	1.0000
5:38406125:G:GG	acceptor_gain	1.0000
5:38406237:AGGAG:A	donor_loss	1.0000
5:38406238:GGAG:G	donor_gain	1.0000
5:38406238:GGAGG:G	donor_loss	1.0000
5:38406239:G:GT	donor_gain	1.0000
5:38406240:AGGT:A	donor_loss	1.0000
5:38406241:GGT:G	donor_loss	1.0000
5:38406243:T:G	donor_loss	1.0000

AlphaMissense

6630 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:38352270:T:A	W162R	0.994
5:38352270:T:C	W162R	0.994
5:38458382:T:A	V928D	0.993
5:38431215:T:C	L698P	0.992
5:38427183:T:C	L662P	0.991
5:38431227:G:C	R702P	0.991
5:38458372:T:A	W925R	0.991
5:38458372:T:C	W925R	0.991
5:38407901:T:C	F415S	0.990
5:38425050:T:C	C590R	0.990
5:38448349:T:C	L846P	0.990
5:38370391:T:C	F214S	0.989
5:38425056:T:C	C592R	0.989
5:38427216:T:C	F673S	0.989
5:38427219:G:C	R674P	0.989
5:38451382:T:A	W879R	0.989
5:38451382:T:C	W879R	0.989
5:38458388:C:A	A930D	0.989
5:38425052:C:G	C590W	0.988
5:38425083:T:A	C601S	0.988
5:38425084:G:C	C601S	0.988
5:38427185:T:C	S663P	0.988
5:38458374:G:C	W925C	0.988
5:38458374:G:T	W925C	0.988
5:38462985:T:C	L958P	0.988
5:38337585:T:A	W55R	0.987
5:38337585:T:C	W55R	0.987
5:38425084:G:A	C601Y	0.987
5:38438419:T:C	C810R	0.987
5:38407895:T:C	L413P	0.986

dbSNP variants (sampled 300 via entrez): RS1000031020 (5:38354703 C>T), RS1000040573 (5:38369994 G>C), RS1000058290 (5:38296743 G>A), RS1000076544 (5:38415839 G>A), RS1000078375 (5:38342926 C>G), RS1000108875 (5:38462762 T>C,G), RS1000112961 (5:38418466 G>A), RS1000137512 (5:38399432 T>C), RS1000167522 (5:38289604 T>G), RS1000174045 (5:38352812 G>C,T), RS1000178226 (5:38294562 T>C), RS1000203315 (5:38373217 T>G), RS1000210679 (5:38334995 C>T), RS1000211303 (5:38337874 A>C), RS1000267842 (5:38399952 C>A,T)

Disease associations

OMIM: gene MIM:617683 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST001591_1	Response to citalopram treatment	3.000000e-06
GCST003801_5	Response to selective serotonin reuptake inhibitors in depression	4.000000e-07
GCST005174_17	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes	6.000000e-06
GCST005212_31	Asthma	3.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005658	response to selective serotonin reuptake inhibitor
EFO:0004723	coronary artery calcification

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	4
Benzo(a)pyrene	affects methylation, increases expression	3
bisphenol A	decreases methylation, affects cotreatment, increases expression	2
Vorinostat	affects cotreatment, increases expression	2
Dexamethasone	increases expression, affects cotreatment	2
bisphenol F	affects cotreatment, increases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
trichostatin A	increases expression	1
arsenite	increases methylation	1
mono-(2-ethylhexyl)phthalate	increases abundance, increases methylation	1
tebuconazole	decreases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects methylation	1
Cytarabine	decreases expression	1
Diethylhexyl Phthalate	increases abundance, increases methylation	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Lead	affects expression	1
Pesticides	decreases methylation	1
Rotenone	decreases expression	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	decreases methylation	1
Aflatoxin B1	affects methylation	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A1F1	SEES3-1V human EGFLAM, clone1	Embryonic stem cell	Male
CVCL_A1F2	SEES3-1V human EGFLAM, clone2	Embryonic stem cell	Male
CVCL_A1F3	SEES3-1V human EGFLAM, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.