EGFR-AS1

Summary

EGFR-AS1 (EGFR antisense RNA 1, HGNC:40207) is a long non-coding RNA gene on chromosome 7p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40207
Approved symbol	EGFR-AS1
Name	EGFR antisense RNA 1
Location	7p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224057
Ensembl biotype	lncRNA
Entrez	100507500
RNAcentral	URS000075EB15 — lncRNA, 2821 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000442411, ENST00000836806

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442411 — 2 exons

Exon	Start	End
ENSE00004256629	55188857	55188986
ENSE00004256631	55179750	55182477

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 79.41.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1984 / max 110.4463, expressed in 34 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84144	0.1631	28
84145	0.0353	17

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.41	gold quality
bone marrow	UBERON:0002371	74.79	silver quality
thymus	UBERON:0002370	74.26	silver quality
placenta	UBERON:0001987	73.94	gold quality
duodenum	UBERON:0002114	70.92	gold quality
skeletal muscle tissue	UBERON:0001134	64.52	silver quality
quadriceps femoris	UBERON:0001377	64.14	gold quality
cerebellar vermis	UBERON:0004720	63.05	gold quality
tonsil	UBERON:0002372	62.80	silver quality
sural nerve	UBERON:0015488	60.43	silver quality
small intestine	UBERON:0002108	59.26	gold quality
liver	UBERON:0002107	58.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.61	gold quality
lower esophagus mucosa	UBERON:0035834	57.08	gold quality
skin of leg	UBERON:0001511	56.64	gold quality
zone of skin	UBERON:0000014	56.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.21	gold quality
skin of abdomen	UBERON:0001416	56.16	gold quality
stromal cell of endometrium	CL:0002255	55.78	gold quality
blood	UBERON:0000178	54.03	gold quality
vagina	UBERON:0000996	53.69	gold quality
right lobe of liver	UBERON:0001114	53.60	gold quality
uterine cervix	UBERON:0000002	53.48	gold quality
tibial nerve	UBERON:0001323	52.65	gold quality
calcaneal tendon	UBERON:0003701	51.93	silver quality
spinal cord	UBERON:0002240	50.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	50.64	gold quality
ectocervix	UBERON:0012249	50.23	gold quality
esophagus mucosa	UBERON:0002469	49.75	gold quality
intestine	UBERON:0000160	49.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• Knockdown of EGFR-AS1 inhibited the proliferation of GC cells via suppressing EGFR-dependent PI3K/AKT pathway in vitro and in vivo. (PMID:30138934)
• The expression of lncRNA EGFR-AS1 is decreased in preeclampsia patients, promoting disease progression by inhibiting EGFR-JAK/STAT signaling pathway. (PMID:30338781)
• Data found that EGFRAS1 was abnormally upregulated in nonsmall cell lung cancer (NSCLC) tissues and in plasma samples from patients with cisplatin-based chemotherapy resistance. Further results confirmed that EGFRAS1 mediated cell proliferation and chemoresistance through directly binding to microRNA223. Therefore, EGFRAS1 overexpression-induced chemoresistance can contribute to poor prognosis in NSCLC. (PMID:30431074)
• EGFR-AS1 was significantly upregulated in renal cell carcinoma tissues, and enhances the malignant phenotype of renal cell carcinoma cells by enhancing HuR-mediated mRNA stability of EGFR. (PMID:30770799)
• These findings elucidated that EGFR-AS1 accelerated cell proliferation, migration, invasion and prevented apoptosis in glioma cells by regulating miR-133b/RACK1, providing new insights for the diagnosis and molecular therapy of Glioblastoma multiforme. (PMID:31545240)
• LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration. (PMID:31702393)
• Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation. (PMID:33211633)
• EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR. (PMID:33426060)
• Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D. (PMID:33888812)
• lncRNA EGFR-AS1 facilitates leiomyosarcoma progression and immune escape via the EGFR-MYC-PD-L1 axis. (PMID:35485964)
• TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression. (PMID:36941595)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.