EGILA

Summary

EGILA (EGFR interacting lncRNA, HGNC:54482) is a long non-coding RNA gene on chromosome 14q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54482
Approved symbol	EGILA
Name	EGFR interacting lncRNA
Location	14q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-EGFR
Ensembl gene	ENSG00000258451
Ensembl biotype	lncRNA
Entrez	116435281
RNAcentral	URS0000D57AC6 — lncRNA, 736 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000554286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000554286 — 4 exons

Exon	Start	End
ENSE00002457875	20693480	20693749
ENSE00002461432	20699322	20699498
ENSE00002486764	20706747	20707120
ENSE00002527451	20699036	20699129

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 82.61.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3232 / max 81.1982, expressed in 56 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142051	0.1538	33
142050	0.0757	30
142048	0.0736	31
142052	0.0132	7
142049	0.0069	4

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	82.61	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.56	gold quality
liver	UBERON:0002107	76.51	gold quality
ventricular zone	UBERON:0003053	61.46	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.80	gold quality
mucosa of stomach	UBERON:0001199	60.12	gold quality
sural nerve	UBERON:0015488	59.95	silver quality
body of stomach	UBERON:0001161	59.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	58.95	gold quality
stomach	UBERON:0000945	58.78	gold quality
mucosa of transverse colon	UBERON:0004991	57.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.23	gold quality
transverse colon	UBERON:0001157	56.81	gold quality
monocyte	CL:0000576	55.59	gold quality
duodenum	UBERON:0002114	55.20	gold quality
rectum	UBERON:0001052	54.92	gold quality
skeletal muscle tissue	UBERON:0001134	54.89	gold quality
small intestine	UBERON:0002108	54.50	gold quality
small intestine Peyer’s patch	UBERON:0003454	54.47	gold quality
adipose tissue	UBERON:0001013	54.45	gold quality
body of pancreas	UBERON:0001150	54.33	gold quality
blood	UBERON:0000178	54.31	gold quality
left ovary	UBERON:0002119	54.22	gold quality
ovary	UBERON:0000992	53.60	gold quality
fundus of stomach	UBERON:0001160	53.46	gold quality
pancreas	UBERON:0001264	53.38	gold quality
right ovary	UBERON:0002118	53.28	gold quality
intestine	UBERON:0000160	53.16	gold quality
thoracic mammary gland	UBERON:0005200	53.03	gold quality
minor salivary gland	UBERON:0001830	52.98	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	2387.17
E-ANND-3	yes	6.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding-EGFR stimulates T-regulatory cell differentiation, suppresses cytotoxic T lymphocyte activity and promotes hepatocellular carcinoma growth in an EGFR-dependent manner. (PMID:28541302)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.