EGOT

Summary

EGOT (eosinophil granule ontogeny transcript, HGNC:37129) is a long non-coding RNA gene on chromosome 3p26.1.

Biomarker of congestive heart failure.

Source: NCBI Gene 100126791 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37129
Approved symbol	EGOT
Name	eosinophil granule ontogeny transcript
Location	3p26.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	EGO, NCRNA00190
Ensembl gene	ENSG00000235947
Ensembl biotype	lncRNA
OMIM	611662
Entrez	100126791
RNAcentral	URS0000757E01 — lncRNA, 1529 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000414938

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414938 — 2 exons

Exon	Start	End
ENSE00001635469	4749192	4750010
ENSE00001706854	4750946	4751590

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 70.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.9557 / max 84.1220, expressed in 179 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40834	0.9557	179

Top tissues by expression

210 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	70.67	silver quality
caput epididymis	UBERON:0004358	70.66	gold quality
metanephros cortex	UBERON:0010533	69.90	gold quality
islet of Langerhans	UBERON:0000006	69.82	gold quality
adult mammalian kidney	UBERON:0000082	69.37	gold quality
sural nerve	UBERON:0015488	67.36	silver quality
cortex of kidney	UBERON:0001225	66.56	gold quality
kidney	UBERON:0002113	65.91	gold quality
colonic epithelium	UBERON:0000397	64.32	silver quality
pancreas	UBERON:0001264	62.88	gold quality
adrenal tissue	UBERON:0018303	62.39	gold quality
metanephros	UBERON:0000081	61.18	gold quality
calcaneal tendon	UBERON:0003701	60.70	gold quality
body of pancreas	UBERON:0001150	59.68	gold quality
tonsil	UBERON:0002372	57.61	gold quality
cauda epididymis	UBERON:0004360	57.43	gold quality
gall bladder	UBERON:0002110	56.84	gold quality
right uterine tube	UBERON:0001302	56.04	gold quality
vagina	UBERON:0000996	55.14	gold quality
corpus epididymis	UBERON:0004359	54.87	gold quality
tendon	UBERON:0000043	54.45	gold quality
right adrenal gland cortex	UBERON:0035827	54.33	gold quality
left adrenal gland cortex	UBERON:0035825	54.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	53.48	gold quality
uterine cervix	UBERON:0000002	53.42	gold quality
esophagus mucosa	UBERON:0002469	53.31	gold quality
cerebellar vermis	UBERON:0004720	53.20	gold quality
adrenal cortex	UBERON:0001235	52.82	gold quality
pituitary gland	UBERON:0000007	52.11	gold quality
adrenal gland	UBERON:0002369	52.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• EGO is a novel ncRNA gene expressed during eosinophil development and is necessary for normal MBP and EDN transcript expression. (PMID:17351112)
• EGOT may play an important role in breast cancer progression and prognosis and may serve as a new potential prognostic target in breast cancer patients. (PMID:26159853)
• Our results suggest that EGOT is a lncRNA induced after infection that increases viral replication by antagonizing the antiviral response. (PMID:27283940)
• Upregulation of lncRNA EGOT by transfection of 786O and ACHN RCC cells with pcDNA3.1EGOT suppressed cell proliferation, migration and invasion, and induced RCC cell apoptosis. (PMID:28901455)
• EGOT functions as an oncogene in GC, and may be useful as a conceivable diagnostic and prognostic biomarker for GC tumorigenesis. (PMID:29209988)
• EGOT is involved in the progression of head and neck squamous cell carcinomas (HSNCC) and seems particularly associated with virus-related forms of HNSCC. (PMID:30786685)
• EGOT-enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human breast cancer. (PMID:30999914)
• LncRNA EGOT decreases breast cancer cell viability and migration via inactivation of the Hedgehog pathway. (PMID:32150666)
• Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma. (PMID:34258170)
• Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients. (PMID:38184893)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.