EGR3-AS1

Summary

EGR3-AS1 (EGR3 and PEBP4 antisense RNA 1, HGNC:58186) is a long non-coding RNA gene on chromosome 8p21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58186
Approved symbol	EGR3-AS1
Name	EGR3 and PEBP4 antisense RNA 1
Location	8p21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253125
Ensembl biotype	lncRNA
Entrez	139281659
RNAcentral	URS00008BF90F — lncRNA, 1630 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 lncRNA, 1 retained_intron

ENST00000519624, ENST00000521141, ENST00000523627

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000519624 — 2 exons

Exon	Start	End
ENSE00002111567	22745570	22745737
ENSE00002115352	22744618	22744741

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 87.01.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.01	gold quality
cerebellar vermis	UBERON:0004720	85.76	gold quality
quadriceps femoris	UBERON:0001377	79.09	gold quality
colonic epithelium	UBERON:0000397	78.62	gold quality
bone marrow cell	CL:0002092	78.06	gold quality
skin of abdomen	UBERON:0001416	74.41	gold quality
skeletal muscle tissue	UBERON:0001134	73.38	gold quality
zone of skin	UBERON:0000014	72.68	gold quality
skin of leg	UBERON:0001511	71.34	gold quality
bone marrow	UBERON:0002371	71.01	gold quality
urinary bladder	UBERON:0001255	64.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.38	gold quality
tonsil	UBERON:0002372	62.66	gold quality
thymus	UBERON:0002370	60.88	silver quality
sural nerve	UBERON:0015488	60.56	gold quality
liver	UBERON:0002107	60.18	gold quality
muscle of leg	UBERON:0001383	60.14	gold quality
right lobe of liver	UBERON:0001114	58.49	gold quality
monocyte	CL:0000576	58.43	gold quality
apex of heart	UBERON:0002098	57.82	gold quality
superior frontal gyrus	UBERON:0002661	57.78	gold quality
small intestine	UBERON:0002108	57.66	gold quality
gastrocnemius	UBERON:0001388	57.08	gold quality
pancreas	UBERON:0001264	56.35	gold quality
prefrontal cortex	UBERON:0000451	55.54	gold quality
primary visual cortex	UBERON:0002436	54.95	gold quality
lymph node	UBERON:0000029	54.86	gold quality
heart left ventricle	UBERON:0002084	54.37	gold quality
vagina	UBERON:0000996	53.93	gold quality
calcaneal tendon	UBERON:0003701	53.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.