EIF3J-DT

Summary

EIF3J-DT (EIF3J divergent transcript, HGNC:48616) is a long non-coding RNA gene on chromosome 15q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48616
Approved symbol	EIF3J-DT
Name	EIF3J divergent transcript
Location	15q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000179523
Ensembl biotype	lncRNA
Entrez	645212
RNAcentral	URS000075DE67 — lncRNA, 1865 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000313807, ENST00000558323, ENST00000559356, ENST00000560049, ENST00000560750, ENST00000653319, ENST00000657789, ENST00000702400, ENST00000769958, ENST00000769959, ENST00000769960, ENST00000769961, ENST00000769962, ENST00000769963, ENST00000769964, ENST00000769965

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000313807 — 2 exons

Exon	Start	End
ENSE00004131545	44533493	44535474
ENSE00004131571	44536043	44536946

Expression profiles

Bgee: expression breadth ubiquitous, 217 present calls, max score 88.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.4648 / max 110.7990, expressed in 1746 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149648	4.1826	1628
149647	3.2822	1487

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	88.86	gold quality
epithelial cell of pancreas	CL:0000083	87.61	silver quality
adenohypophysis	UBERON:0002196	87.21	gold quality
pituitary gland	UBERON:0000007	87.04	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.78	gold quality
spinal cord	UBERON:0002240	86.30	gold quality
hypothalamus	UBERON:0001898	85.88	gold quality
ventricular zone	UBERON:0003053	85.30	gold quality
popliteal artery	UBERON:0002250	84.89	gold quality
tibial artery	UBERON:0007610	84.88	gold quality
descending thoracic aorta	UBERON:0002345	84.80	gold quality
anterior cingulate cortex	UBERON:0009835	84.67	gold quality
right frontal lobe	UBERON:0002810	84.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.46	gold quality
left lobe of thyroid gland	UBERON:0001120	84.42	gold quality
right lobe of thyroid gland	UBERON:0001119	84.38	gold quality
thyroid gland	UBERON:0002046	84.31	gold quality
endocervix	UBERON:0000458	84.26	gold quality
aorta	UBERON:0000947	84.19	gold quality
left ovary	UBERON:0002119	84.09	gold quality
pons	UBERON:0000988	84.02	gold quality
substantia nigra	UBERON:0002038	83.82	gold quality
corpus epididymis	UBERON:0004359	83.68	gold quality
tibial nerve	UBERON:0001323	83.63	gold quality
right uterine tube	UBERON:0001302	83.53	gold quality
midbrain	UBERON:0001891	83.51	gold quality
muscle of leg	UBERON:0001383	83.47	gold quality
amygdala	UBERON:0001876	83.47	gold quality
right lung	UBERON:0002167	83.38	gold quality
thoracic aorta	UBERON:0001515	83.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• EIF3J-AS1 promotes CTNND2 expression via sponging miR-122-5p. Hypoxia-induced EIF3J-AS1 facilitates hepatocellular carcinoma progression via regulating CTNND2. (PMID:31421822)
• H3K27 acetylation-induced lncRNA EIF3J-AS1 improved proliferation and impeded apoptosis of colorectal cancer through miR-3163/YAP1 axis. (PMID:31709617)
• LncRNA EIF3J-AS1 enhanced esophageal cancer invasion via regulating AKT1 expression through sponging miR-373-3p. (PMID:32811869)
• Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation. (PMID:33764843)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.