EIPR1

Summary

EIPR1 (EARP complex and GARP complex interacting protein 1, HGNC:12383) is a protein-coding gene on chromosome 2p25.3, encoding EARP and GARP complex-interacting protein 1 (Q53HC9). Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network.

This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11.

Source: NCBI Gene 7260 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 73 total — 1 pathogenic
• MANE Select transcript: NM_003310

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12383
Approved symbol	EIPR1
Name	EARP complex and GARP complex interacting protein 1
Location	2p25.3
Locus type	gene with protein product
Status	Approved
Aliases	EIPR-1
Ensembl gene	ENSG00000032389
Ensembl biotype	protein_coding
OMIM	608998
Entrez	7260

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 8 protein_coding, 3 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000382125, ENST00000398659, ENST00000406835, ENST00000435721, ENST00000441271, ENST00000443925, ENST00000444776, ENST00000455162, ENST00000462515, ENST00000463662, ENST00000470625, ENST00000478754, ENST00000482570, ENST00000496433, ENST00000864323, ENST00000864324, ENST00000955638

RefSeq mRNA: 3 — MANE Select: NM_003310 NM_001330530, NM_001330531, NM_003310

CCDS: CCDS1651, CCDS82416

Canonical transcript exons

ENST00000382125 — 9 exons

Exon	Start	End
ENSE00001737497	3377648	3377818
ENSE00003485237	3214149	3214248
ENSE00003577527	3196881	3197017
ENSE00003579689	3354550	3354633
ENSE00003610735	3338017	3338149
ENSE00003616665	3193999	3194166
ENSE00003690705	3257299	3257455
ENSE00003788368	3192414	3192581
ENSE00003900920	3188970	3189508

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 92.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.3503 / max 100.3328, expressed in 1798 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
26707	13.3503	1798

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	92.28	gold quality
adenohypophysis	UBERON:0002196	91.08	gold quality
nucleus accumbens	UBERON:0001882	90.88	gold quality
anterior cingulate cortex	UBERON:0009835	90.67	gold quality
pituitary gland	UBERON:0000007	90.66	gold quality
cingulate cortex	UBERON:0003027	90.59	gold quality
right frontal lobe	UBERON:0002810	90.57	gold quality
putamen	UBERON:0001874	90.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.28	gold quality
caudate nucleus	UBERON:0001873	90.25	gold quality
oocyte	CL:0000023	90.13	gold quality
frontal cortex	UBERON:0001870	89.90	gold quality
neocortex	UBERON:0001950	89.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.83	gold quality
cortical plate	UBERON:0005343	89.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.28	gold quality
amygdala	UBERON:0001876	89.14	gold quality
cerebellar vermis	UBERON:0004720	89.01	gold quality
middle temporal gyrus	UBERON:0002771	88.99	gold quality
forebrain	UBERON:0001890	88.68	gold quality
telencephalon	UBERON:0001893	88.65	gold quality
lower esophagus mucosa	UBERON:0035834	88.58	gold quality
cerebral cortex	UBERON:0000956	88.53	gold quality
hypothalamus	UBERON:0001898	88.13	gold quality
brain	UBERON:0000955	88.00	gold quality
ganglionic eminence	UBERON:0004023	87.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.43	gold quality
granulocyte	CL:0000094	87.14	gold quality
cerebellar cortex	UBERON:0002129	87.01	gold quality
cerebellar hemisphere	UBERON:0002245	87.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.53

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting EIPR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-548V	99.29	69.47	1157
HSA-MIR-4727-5P	99.23	67.55	1154
HSA-MIR-558	97.50	67.16	977
HSA-MIR-6802-3P	97.29	65.42	613
HSA-MIR-1306-5P	97.11	64.04	755
HSA-MIR-3649	96.85	64.10	340

Literature-anchored findings (GeneRIF, showing 3)

• TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. (PMID:23933319)
• Fluorescence recovery after photobleaching shows that TSSC1 is required for efficient recruitment of GARP to the TGN. These studies thus demonstrate that TSSC1 plays a critical role in endosomal retrieval pathways as a regulator of both GARP and EARP function. (PMID:27440922)
• Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function. (PMID:33963283)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	eipr1	ENSDARG00000043417
mus_musculus	Eipr1	ENSMUSG00000036613
rattus_norvegicus	Eipr1	ENSRNOG00000009285
drosophila_melanogaster	CG10646	FBGN0036292
caenorhabditis_elegans	eipr-1	WBGENE00013599

Protein

Protein identifiers

EARP and GARP complex-interacting protein 1 — Q53HC9 (reviewed: Q53HC9)

Alternative names: Endosome-associated recycling protein-interacting protein, Golgi-associated retrograde protein-interacting protein, Tumor-suppressing STF cDNA 1 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

All UniProt accessions (8): A8MUM1, C9J0U9, C9JVR6, D3YTH5, F8WB12, F8WDS8, F8WDX0, Q53HC9

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.

Subunit / interactions. Interacts with two multisubunit tethering complexes: EARP composed of VPS50, VPS51, VPS52 and VPS53 subunits and GARP complex composed of VPS51, VPS52, VPS53 and VPS54 subunits. Interacts with SNAP29.

Subcellular location. Golgi apparatus. trans-Golgi network.

Similarity. Belongs to the WD repeat EIPR1 family.

RefSeq proteins (3): NP_001317459, NP_001317460, NP_003301* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR040323	EIPR1	Family
IPR059104	Beta-prop_EIPR1-like	Domain

Pfam: PF00400, PF23609

UniProt features (14 total): repeat 7, modified residue 2, sequence conflict 2, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q53HC9-F1	89.26	0.79

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 320

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 153 (showing top): chr2p25, TGCGCANK_UNKNOWN, GOBP_INSULIN_SECRETION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_CELL_CELL_SIGNALING, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT, GOBP_REGULATION_OF_PROTEIN_SECRETION, GOCC_TRANS_GOLGI_NETWORK, GOBP_REGULATION_OF_CELLULAR_LOCALIZATION, GOBP_SECRETION, GOBP_SIGNAL_RELEASE

GO Biological Process (7): protein ubiquitination (GO:0016567), endocytic recycling (GO:0032456), regulation of insulin secretion (GO:0050796), positive regulation of retrograde transport, endosome to Golgi (GO:1905281), positive regulation of endocytic recycling (GO:2001137), regulation of transport (GO:0051049), regulation of cellular localization (GO:0060341)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): trans-Golgi network (GO:0005802), GARP complex (GO:0000938), Golgi apparatus (GO:0005794), EARP complex (GO:1990745)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of intracellular transport	2
regulation of localization	2
protein modification by small protein conjugation	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
insulin secretion	1
regulation of protein secretion	1
regulation of peptide hormone secretion	1
retrograde transport, endosome to Golgi	1
regulation of retrograde transport, endosome to Golgi	1
endocytic recycling	1
regulation of endocytic recycling	1
transport	1
regulation of cellular process	1
cellular localization	1
binding	1
Golgi apparatus subcompartment	1
Golgi apparatus	1
cytoplasmic vesicle	1
vesicle tethering complex	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
protein-containing complex	1
recycling endosome	1

Protein interactions and networks

STRING

650 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EIPR1	CCDC186	Q7Z3E2	717
EIPR1	VPS50	Q96JG6	645
EIPR1	TRAPPC12	Q8WVT3	612
EIPR1	VPS51	Q9UID3	590
EIPR1	VPS54	Q9P1Q0	588
EIPR1	RNF144A	P50876	582
EIPR1	VPS53	Q5VIR6	559
EIPR1	DCDC2C	A8MYV0	513
EIPR1	VPS52	Q8N1B4	501
EIPR1	RUNDC1	Q96C34	496
EIPR1	DTWD2	Q8NBA8	480
EIPR1	CPD	O75976	475
EIPR1	BRIX1	Q8TDN6	475
EIPR1	DTNBP1	Q96EV8	472
EIPR1	CLPB	Q9H078	470

IntAct

93 interactions, top by confidence:

A	B	Type	Score
ODAD1	HGS	psi-mi:“MI:0914”(association)	0.850
EXOC1	EXOC5	psi-mi:“MI:0914”(association)	0.730
VPS50	EIPR1	psi-mi:“MI:0914”(association)	0.730
CCT2	TXNDC9	psi-mi:“MI:0914”(association)	0.730
CCT3	TXNDC9	psi-mi:“MI:0914”(association)	0.640
NOTO	EIPR1	psi-mi:“MI:0915”(physical association)	0.560
EIPR1	LDHC	psi-mi:“MI:0914”(association)	0.530
KXD1	HIP1	psi-mi:“MI:0914”(association)	0.530
DHH	HSPA5	psi-mi:“MI:0914”(association)	0.530
CCT7	PEX7	psi-mi:“MI:0914”(association)	0.530
KXD1	TRAK2	psi-mi:“MI:0914”(association)	0.530
EIPR1	TCP1	psi-mi:“MI:0914”(association)	0.530
EXOC4	EXOC5	psi-mi:“MI:0914”(association)	0.510
MLF1	EIPR1	psi-mi:“MI:0915”(physical association)	0.400
MLF2	EIPR1	psi-mi:“MI:0915”(physical association)	0.400
HSP90AB1	EIPR1	psi-mi:“MI:0915”(physical association)	0.400
NUDC	EIPR1	psi-mi:“MI:0915”(physical association)	0.400
EIPR1	NUDCD3	psi-mi:“MI:0915”(physical association)	0.400
EIPR1	PSMD2	psi-mi:“MI:0915”(physical association)	0.400
EIPR1		psi-mi:“MI:0915”(physical association)	0.400
EIPR1	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
EIPR1	STUB1	psi-mi:“MI:0915”(physical association)	0.400
EIPR1	PFDN5	psi-mi:“MI:0915”(physical association)	0.400
EIPR1	AARSD1	psi-mi:“MI:0915”(physical association)	0.400
EIPR1	PPP5C	psi-mi:“MI:0915”(physical association)	0.400
Snap29	PTTG1IP	psi-mi:“MI:0914”(association)	0.350
VPS50	PHF20L1	psi-mi:“MI:0914”(association)	0.350

BioGRID (159): TSSC1 (Affinity Capture-MS), TSSC1 (Affinity Capture-MS), TSSC1 (Affinity Capture-MS), CCT7 (Affinity Capture-MS), VPS53 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6A (Affinity Capture-MS), YEATS2 (Affinity Capture-MS), TCP1 (Affinity Capture-MS), VPS51 (Affinity Capture-MS), VPS54 (Affinity Capture-MS), RPL23 (Affinity Capture-MS), LRIF1 (Affinity Capture-MS), VPS52 (Affinity Capture-MS)

ESM2 similar proteins: A4QNE6, B0BNA7, B5FZ19, O43172, O74184, Q13347, Q29RH4, Q29RZ9, Q38884, Q3KPT3, Q3MHE2, Q3UGF1, Q4R571, Q53HC9, Q561Y0, Q5E959, Q5E966, Q5M7F6, Q5M8I4, Q5MNZ6, Q5NVD0, Q5PPK9, Q5R7W0, Q5XIG8, Q5XJP1, Q5ZL16, Q5ZL33, Q640T2, Q66J51, Q68F45, Q6DUZ9, Q6H8D5, Q6H8D6, Q7ZUW6, Q8BGF3, Q8K0G5, Q8NEZ3, Q8VE80, Q91VM3, Q96J01

Diamond homologs: A1CF18, A1CUD6, A1DP19, A2QP30, A4R3M4, A7ECP3, A7EKM8, A8NEG8, A8XZJ9, B0XM00, B2AEZ5, B2B766, B2VWG7, B6GZD3, B6HP56, B6QC06, B6QC56, B8M0Q1, B8N9H4, B8PD53, B9WD30, C0NRC6, C0S902, C1GB49, C4JPW9, C4JZS6, C4Q0P6, C4YPI7, C5FWH1, C5GVJ9, C5JD40, C5MJE8, C5PFX0, C6HTE8, C7Z6H2, D1ZEB4, D1ZEM6, D4AZ50, D4DG66, D5GBI7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 103 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Prefoldin mediated transfer of substrate to CCT/TriC	5	29.0×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
protein folding	8	8.7×	8e-04
protein transport	11	5.1×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	57
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4279236	GRCh37/hg19 2p25.3(chr2:887655-3350776)x1	Pathogenic

SpliceAI

4671 predictions. Top by Δscore:

Variant	Effect	Δscore
2:3189504:TGCTC:T	acceptor_gain	1.0000
2:3189506:CTC:C	acceptor_gain	1.0000
2:3189508:CCT:C	acceptor_loss	1.0000
2:3189509:C:CA	acceptor_loss	1.0000
2:3189510:T:A	acceptor_loss	1.0000
2:3192412:A:AC	donor_gain	1.0000
2:3192413:C:CC	donor_gain	1.0000
2:3192413:CTT:C	donor_gain	1.0000
2:3192413:CTTCT:C	donor_gain	1.0000
2:3192415:T:TA	donor_gain	1.0000
2:3192435:T:TA	donor_gain	1.0000
2:3193961:AATCC:A	donor_gain	1.0000
2:3193972:C:A	donor_gain	1.0000
2:3193993:CCCTA:C	donor_loss	1.0000
2:3193994:CCTAC:C	donor_loss	1.0000
2:3193995:CTA:C	donor_loss	1.0000
2:3193996:TAC:T	donor_loss	1.0000
2:3193997:A:AC	donor_gain	1.0000
2:3193997:A:T	donor_loss	1.0000
2:3193998:C:CC	donor_gain	1.0000
2:3194162:TCTGG:T	acceptor_loss	1.0000
2:3194163:CTGG:C	acceptor_gain	1.0000
2:3194163:CTGGC:C	acceptor_loss	1.0000
2:3194164:TGG:T	acceptor_gain	1.0000
2:3194166:GCTG:G	acceptor_loss	1.0000
2:3194167:C:CC	acceptor_gain	1.0000
2:3194167:CT:C	acceptor_loss	1.0000
2:3194168:T:G	acceptor_loss	1.0000
2:3194186:A:T	acceptor_gain	1.0000
2:3197040:C:CT	acceptor_gain	1.0000

AlphaMissense

2583 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:3189352:C:A	K382N	1.000
2:3189352:C:G	K382N	1.000
2:3189397:G:C	S367R	1.000
2:3189397:G:T	S367R	1.000
2:3189399:T:G	S367R	1.000
2:3189407:G:T	A364D	1.000
2:3189417:A:G	W361R	1.000
2:3189417:A:T	W361R	1.000
2:3189433:C:A	W355C	1.000
2:3189433:C:G	W355C	1.000
2:3189435:A:G	W355R	1.000
2:3189435:A:T	W355R	1.000
2:3189449:A:T	V350D	1.000
2:3189451:G:C	S349R	1.000
2:3189451:G:T	S349R	1.000
2:3189453:T:G	S349R	1.000
2:3192522:T:A	D294V	1.000
2:3192523:C:G	D294H	1.000
2:3192524:A:C	S293R	1.000
2:3192524:A:T	S293R	1.000
2:3192526:T:G	S293R	1.000
2:3192527:G:C	S292R	1.000
2:3192527:G:T	S292R	1.000
2:3192528:C:A	S292I	1.000
2:3192529:T:G	S292R	1.000
2:3192543:A:G	L287P	1.000
2:3194000:A:G	W274R	1.000
2:3194000:A:T	W274R	1.000
2:3194003:G:C	H273D	1.000
2:3194054:A:G	W256R	1.000

dbSNP variants (sampled 300 via entrez): RS1000008140 (2:3287836 T>C), RS1000040378 (2:3331165 G>A,C), RS1000043431 (2:3251656 G>C), RS1000067738 (2:3363551 C>A,T), RS1000085371 (2:3322839 G>A), RS1000096348 (2:3306790 C>T), RS1000097549 (2:3325497 C>T), RS1000098279 (2:3363375 A>C,G), RS1000100495 (2:3209653 G>A), RS1000118292 (2:3288012 C>T), RS1000128929 (2:3267505 A>G), RS1000130178 (2:3283292 C>A), RS1000180034 (2:3310014 G>A), RS1000199259 (2:3225768 T>G), RS1000206642 (2:3366698 G>A)

Disease associations

OMIM: gene MIM:608998 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST002726_73	Glucose homeostasis traits	1.000000e-06
GCST003075_105	Cognitive decline rate in late mild cognitive impairment	7.000000e-09
GCST003075_84	Cognitive decline rate in late mild cognitive impairment	5.000000e-10
GCST003097_36	Pediatric autoimmune diseases	2.000000e-07
GCST003458_1	World class endurance athleticism	2.000000e-06
GCST003809_5	Response to selective serotonin reuptake inhibitors and depression	2.000000e-06
GCST007622_1	Impulsivity	1.000000e-07
GCST007628_2	Impulsivity (motor)	9.000000e-07
GCST007629_2	Impulsivity (non-planning)	4.000000e-07
GCST010002_383	Refractive error	5.000000e-10
GCST010345_1	TPE interval (response to exercise)	2.000000e-08
GCST010727_3	Deep white matter hyperintensities	3.000000e-06
GCST012305_6	Major depressive disorder x sex interaction	4.000000e-06

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0004471	insulin sensitivity measurement
EFO:0007710	cognitive decline measurement
EFO:0007818	athletic endurance measurement
EFO:0005658	response to selective serotonin reuptake inhibitor
EFO:0006946	behavioural disinhibition measurement
EFO:0004644	TPE interval measurement
EFO:0007768	response to exercise
EFO:0005665	white matter hyperintensity measurement
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	6
bisphenol A	decreases expression, decreases methylation	2
Air Pollutants	increases abundance, increases oxidation, decreases expression, affects cotreatment	2
Arsenic	increases abundance, affects methylation, decreases expression	2
Aflatoxin B1	affects methylation, decreases methylation, affects expression	2
FR900359	decreases phosphorylation	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases abundance, decreases expression	1
tetrabromobisphenol A	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1
methacrylaldehyde	increases abundance, affects cotreatment, increases oxidation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
hexabrominated diphenyl ether 153	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Caffeine	decreases phosphorylation	1
Cisplatin	decreases expression	1
Fluorouracil	decreases expression, affects reaction	1
Gallic Acid	decreases expression	1
Ivermectin	decreases expression	1
Methapyrilene	increases methylation	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Thiram	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1QY	Abcam HeLa EIPR1 KO	Cancer cell line	Female
CVCL_TU97	HAP1 TSSC1 (-) 1	Cancer cell line	Male
CVCL_TU98	HAP1 TSSC1 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.