ELAPOR1

Summary

ELAPOR1 (endosome-lysosome associated apoptosis and autophagy regulator 1, HGNC:29618) is a protein-coding gene on chromosome 1p13.3, encoding Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Q6UXG2). May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway.

Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 57535 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 186 total
• MANE Select transcript: NM_020775

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29618
Approved symbol	ELAPOR1
Name	endosome-lysosome associated apoptosis and autophagy regulator 1
Location	1p13.3
Locus type	gene with protein product
Status	Approved
Aliases	maba1, EIG121
Ensembl gene	ENSG00000116299
Ensembl biotype	protein_coding
OMIM	611298
Entrez	57535

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 12 protein_coding, 4 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000369936, ENST00000369938, ENST00000369939, ENST00000457623, ENST00000464345, ENST00000490758, ENST00000526264, ENST00000527501, ENST00000527996, ENST00000529753, ENST00000531664, ENST00000533147, ENST00000533374, ENST00000534476, ENST00000899218, ENST00000899219, ENST00000899220, ENST00000899221, ENST00000899222

RefSeq mRNA: 4 — MANE Select: NM_020775 NM_001267048, NM_001284352, NM_001284353, NM_020775

CCDS: CCDS58015, CCDS794

Canonical transcript exons

ENST00000369939 — 22 exons

Exon	Start	End
ENSE00001451285	109202944	109206781
ENSE00002163328	109114115	109114336
ENSE00003470599	109197979	109198075
ENSE00003484362	109172488	109172568
ENSE00003484805	109194421	109194594
ENSE00003488054	109191726	109191863
ENSE00003489143	109189592	109189682
ENSE00003491577	109185045	109185133
ENSE00003505690	109191366	109191471
ENSE00003558615	109198573	109198674
ENSE00003581990	109188177	109188354
ENSE00003585024	109173474	109173579
ENSE00003608796	109192611	109192874
ENSE00003621108	109200735	109200900
ENSE00003626838	109199854	109199980
ENSE00003630586	109200059	109200237
ENSE00003677105	109197474	109197654
ENSE00003687030	109173688	109173837
ENSE00003688933	109189066	109189194
ENSE00003790100	109161894	109162014
ENSE00003790131	109171866	109172013
ENSE00003791525	109164499	109164691

Expression profiles

Bgee: expression breadth ubiquitous, 209 present calls, max score 99.77.

FANTOM5 (CAGE): breadth broad, TPM avg 13.6545 / max 1392.7037, expressed in 669 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4388	12.2798	420
4384	0.4217	178
4390	0.4121	229
4387	0.3770	169
4386	0.1066	42
4385	0.0574	36

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	99.77	gold quality
body of pancreas	UBERON:0001150	98.09	gold quality
islet of Langerhans	UBERON:0000006	97.27	gold quality
trachea	UBERON:0003126	97.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.96	gold quality
pylorus	UBERON:0001166	96.76	gold quality
bronchial epithelial cell	CL:0002328	96.46	gold quality
pancreas	UBERON:0001264	96.46	gold quality
pituitary gland	UBERON:0000007	95.85	gold quality
rectum	UBERON:0001052	95.27	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.91	gold quality
right uterine tube	UBERON:0001302	94.70	gold quality
adenohypophysis	UBERON:0002196	94.67	gold quality
nasal cavity mucosa	UBERON:0001826	94.37	gold quality
mammary duct	UBERON:0001765	93.86	gold quality
epithelium of mammary gland	UBERON:0003244	93.21	gold quality
saliva-secreting gland	UBERON:0001044	92.97	gold quality
bronchus	UBERON:0002185	92.96	gold quality
colonic mucosa	UBERON:0000317	92.91	gold quality
epithelium of bronchus	UBERON:0002031	92.80	gold quality
duodenum	UBERON:0002114	92.58	gold quality
jejunal mucosa	UBERON:0000399	91.66	gold quality
prostate gland	UBERON:0002367	91.34	gold quality
minor salivary gland	UBERON:0001830	91.25	gold quality
endometrium	UBERON:0001295	90.67	gold quality
cardia of stomach	UBERON:0001162	90.59	gold quality
mucosa of transverse colon	UBERON:0004991	90.34	gold quality
corpus epididymis	UBERON:0004359	90.05	gold quality
ileal mucosa	UBERON:0000331	89.28	gold quality
ganglionic eminence	UBERON:0004023	89.18	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	279.14
E-MTAB-8060	yes	107.59
E-MTAB-5061	yes	30.75
E-GEOD-81547	yes	27.00
E-GEOD-125970	yes	14.08
E-HCAD-13	yes	7.38
E-GEOD-70580	no	940.90
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

108 targeting ELAPOR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-548AZ-5P	99.83	69.94	3230
HSA-MIR-548T-5P	99.83	69.91	3220
HSA-MIR-4307	99.82	70.45	3374

Literature-anchored findings (GeneRIF, showing 10)

• Down-regulation of KIAA1324 protein is associated with endometrial cancer (PMID:16322283)
• EIG121 may protect cells from cell death by upregulating the autophagy pathway. (PMID:21072319)
• High expression of ERalpha and the estrogen-induced gene EIG121 predicts shorter overall survival in patients with high-grade serous ovarian carcinoma. (PMID:21102415)
• A tumor suppressive role of KIAA1324 via inhibition of GRP78 oncoprotein activities in gastric cancer (PMID:26045166)
• The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here (PMID:27230222)
• it was found that EIG121 exerted dual functions in the regulation of autophagy and stemness not only in normal JEC cells but also JEC obtained CSCs. These findings could be useful for developing targeted therapies for endometrial carcinoma (PMID:28656197)
• Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas. (PMID:32377505)
• Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer. (PMID:33455017)
• Inceptor counteracts insulin signalling in beta-cells to control glycaemia. (PMID:33505018)
• ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. (PMID:34816763)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	elapor1	ENSDARG00000042899
mus_musculus	Elapor1	ENSMUSG00000040412
rattus_norvegicus	Elapor1	ENSRNOG00000020272

Paralogs (1): ELAPOR2 (ENSG00000164659)

Protein

Protein identifiers

Endosome/lysosome-associated apoptosis and autophagy regulator 1 — Q6UXG2 (reviewed: Q6UXG2)

Alternative names: Estrogen-induced gene 121 protein

All UniProt accessions (8): E9PB18, E9PIF6, E9PLQ2, E9PLY8, E9PMS2, E9PS21, Q6UXG2, H0YDD2

UniProt curated annotations — full annotation on UniProt →

Function. May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway. May play a role in apoptosis and cell proliferation through its interaction with HSPA5.

Subunit / interactions. Interacts with HSPA5; may regulate the function of HSPA5 in apoptosis and cell proliferation.

Subcellular location. Cell membrane. Late endosome membrane. Golgi apparatus. trans-Golgi network membrane. Lysosome membrane. Endoplasmic reticulum membrane.

Tissue specificity. Expressed in normal endometrium but overexpressed in endometroid tumors.

Induction. By estrogen replacement therapy.

Similarity. Belongs to the ELAPOR family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6UXG2-1	1	yes
Q6UXG2-2	2
Q6UXG2-3	3
Q6UXG2-4	4

RefSeq proteins (4): NP_001253977, NP_001271281, NP_001271282, NP_065826* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009011	Man6P_isomerase_rcpt-bd_dom_sf	Homologous_superfamily
IPR009030	Growth_fac_rcpt_cys_sf	Homologous_superfamily
IPR039181	Elapor1/2	Family
IPR044865	MRH_dom	Domain
IPR056606	Elapor1/2_C	Domain
IPR056607	Elapor1/2_MRH	Domain
IPR056608	Elapor1/2_GBD	Domain
IPR056609	Elapor1-like_3rd	Domain
IPR056610	Elapor1/2_TNFR-like	Domain

Pfam: PF23031, PF23032, PF23087, PF23089, PF23091

UniProt features (24 total): disulfide bond 7, sequence variant 4, splice variant 3, glycosylation site 3, topological domain 2, signal peptide 1, chain 1, sequence conflict 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6UXG2-F1	77.33	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (7): 308–330, 311–342, 658–704, 714–739, 808–844, 820–856, 278–295

Glycosylation sites (3): 153, 404, 672

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 210 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, BENPORATH_ES_WITH_H3K27ME3, GOBP_VACUOLE_ORGANIZATION, XU_GH1_AUTOCRINE_TARGETS_UP, GOCC_VACUOLAR_MEMBRANE, GOBP_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_UP, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, GOBP_REGULATION_OF_VACUOLE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION

GO Biological Process (5): autophagosome assembly (GO:0000045), cellular response to starvation (GO:0009267), positive regulation of vacuole organization (GO:0044090), positive regulation of autophagosome assembly (GO:2000786), autophagy (GO:0006914)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (12): lysosomal membrane (GO:0005765), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), late endosome membrane (GO:0031902), extracellular exosome (GO:0070062), lysosome (GO:0005764), endosome (GO:0005768), late endosome (GO:0005770), endoplasmic reticulum (GO:0005783), trans-Golgi network (GO:0005802), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
endomembrane system	3
cytoplasm	2
intracellular membrane-bounded organelle	2
Atg12 activating enzyme activity	1
protein-phosphatidylethanolamide deconjugating activity	1
Atg12 conjugating enzyme activity	1
Atg12 ligase activity	1
organelle assembly	1
Atg1/ULK1 kinase complex assembly	1
autophagosome organization	1
cellular response to nutrient levels	1
cellular response to stress	1
response to starvation	1
vacuole organization	1
positive regulation of organelle organization	1
regulation of vacuole organization	1
autophagosome assembly	1
positive regulation of macroautophagy	1
positive regulation of vacuole organization	1
positive regulation of organelle assembly	1
regulation of autophagosome assembly	1
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
nucleic acid binding	1
binding	1
lysosome	1
lytic vacuole membrane	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
late endosome	1
endosome membrane	1
extracellular vesicle	1
lytic vacuole	1
cytoplasmic vesicle	1
endosome	1
Golgi apparatus subcompartment	1

Protein interactions and networks

STRING

880 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ELAPOR1	HACE1	Q8IYU2	942
ELAPOR1	OR6S1	Q8NH40	399
ELAPOR1	S4R3Q2	S4R3Q2	396
ELAPOR1	C9orf152	Q5JTZ5	394
ELAPOR1	C11orf96	Q7Z7L8	391
ELAPOR1	TFF2	Q03403	376
ELAPOR1	BTBD7	Q9P203	325
ELAPOR1	RNF175	Q8N4F7	325
ELAPOR1	TMEM9B	Q9NQ34	323
ELAPOR1	SPNS3	Q6ZMD2	322
ELAPOR1	C17orf67	Q0P5P2	320
ELAPOR1	CMC2	Q9NRP2	319
ELAPOR1	ASRGL1	Q7L266	319
ELAPOR1	SPDEF	O95238	316
ELAPOR1	SEZ6	Q53EL9	315

IntAct

4 interactions, top by confidence:

A	B	Type	Score
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
ELAPOR1	KLHL41	psi-mi:“MI:0914”(association)	0.350

BioGRID (16): KIAA1324 (Affinity Capture-MS), KIAA1324 (Proximity Label-MS), CIB1 (Two-hybrid), KIAA1324 (Affinity Capture-MS), KIAA1324 (Two-hybrid), KIAA1324 (Two-hybrid), KIAA1324 (Affinity Capture-MS), KIAA1324 (Affinity Capture-RNA), TMEM131 (Affinity Capture-MS), OSBPL3 (Affinity Capture-MS), TAF1A (Affinity Capture-MS), IQCB1 (Affinity Capture-MS), TAF6L (Affinity Capture-MS), DCUN1D5 (Affinity Capture-MS), KLHL41 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D5PUP4, A2AFS3, M0R7X9, O70472, O75882, O95803, P01134, P26012, P52799, P52848, P69849, Q02353, Q05204, Q0VCJ8, Q12841, Q13635, Q15155, Q3UHN9, Q3ZBS2, Q58D84, Q5EA46, Q5JPE7, Q5R9Y1, Q5U4X8, Q5VV63, Q5ZJB7, Q5ZMH6, Q61115, Q62356, Q62632, Q6A051, Q6GQK9, Q6GQT9, Q6P988, Q6UXG2, Q7Z5A7, Q86TD4, Q90693, Q91WE9, Q96CW9

Diamond homologs: A2AFS3, A7E2Z9, A8MWY0, Q3UZV7, Q6DDW2, Q6UXG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

186 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	148
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3654 predictions. Top by Δscore:

Variant	Effect	Δscore
1:109162010:GTGCT:G	donor_gain	1.0000
1:109162012:GCT:G	donor_gain	1.0000
1:109162015:G:GG	donor_gain	1.0000
1:109164690:TC:T	donor_gain	1.0000
1:109164692:G:GG	donor_gain	1.0000
1:109171860:TCACA:T	acceptor_loss	1.0000
1:109171861:CACAG:C	acceptor_loss	1.0000
1:109171863:CA:C	acceptor_loss	1.0000
1:109171864:A:AG	acceptor_gain	1.0000
1:109171865:G:GG	acceptor_gain	1.0000
1:109172003:T:G	donor_gain	1.0000
1:109172003:T:TG	donor_gain	1.0000
1:109172009:TTTTC:T	donor_gain	1.0000
1:109172011:TTCGT:T	donor_loss	1.0000
1:109172012:TC:T	donor_gain	1.0000
1:109172012:TCG:T	donor_loss	1.0000
1:109172013:CGTA:C	donor_loss	1.0000
1:109172014:G:GG	donor_gain	1.0000
1:109172014:GTAA:G	donor_loss	1.0000
1:109172569:G:GG	donor_gain	1.0000
1:109173686:AGG:A	acceptor_gain	1.0000
1:109173687:GGG:G	acceptor_gain	1.0000
1:109189055:T:TA	acceptor_gain	1.0000
1:109189065:GACT:G	acceptor_gain	1.0000
1:109189590:A:AG	acceptor_gain	1.0000
1:109189590:AGGCT:A	acceptor_gain	1.0000
1:109189591:G:GG	acceptor_gain	1.0000
1:109189591:GGCT:G	acceptor_gain	1.0000
1:109189591:GGCTG:G	acceptor_gain	1.0000
1:109189676:GATT:G	donor_gain	1.0000

AlphaMissense

6646 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:109171873:T:A	W159R	1.000
1:109171873:T:C	W159R	1.000
1:109171875:G:C	W159C	1.000
1:109171875:G:T	W159C	1.000
1:109161944:G:C	W68C	0.999
1:109161944:G:T	W68C	0.999
1:109164507:T:A	C95S	0.999
1:109164508:G:A	C95Y	0.999
1:109164508:G:C	C95S	0.999
1:109164509:C:G	C95W	0.999
1:109164546:T:A	C108S	0.999
1:109164547:G:C	C108S	0.999
1:109164603:T:A	W127R	0.999
1:109164603:T:C	W127R	0.999
1:109164605:G:C	W127C	0.999
1:109164605:G:T	W127C	0.999
1:109171928:T:C	L177P	0.999
1:109172503:T:A	C211S	0.999
1:109172503:T:C	C211R	0.999
1:109172504:G:C	C211S	0.999
1:109173507:T:A	W244R	0.999
1:109173507:T:C	W244R	0.999
1:109173708:T:A	C275S	0.999
1:109173708:T:C	C275R	0.999
1:109173709:G:C	C275S	0.999
1:109173710:C:G	C275W	0.999
1:109189594:T:A	W451R	0.999
1:109189594:T:C	W451R	0.999
1:109191831:T:A	W551R	0.999
1:109191831:T:C	W551R	0.999

dbSNP variants (sampled 300 via entrez): RS1000014361 (1:109167000 GTTATT>G), RS1000055141 (1:109189987 A>C,G), RS1000184264 (1:109121982 T>C), RS1000220981 (1:109160483 A>G), RS1000263806 (1:109125177 C>T), RS1000295161 (1:109124894 C>T), RS1000299933 (1:109172759 T>C), RS1000386080 (1:109176626 T>A,G), RS1000415063 (1:109130982 T>C,G), RS1000417297 (1:109176941 G>T), RS1000427816 (1:109134615 G>C,T), RS1000436891 (1:109172374 T>C), RS1000515977 (1:109137585 T>C), RS1000518349 (1:109146464 C>T), RS1000533197 (1:109202066 C>T)

Disease associations

OMIM: gene MIM:611298 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002941_5	Airway imaging phenotypes	2.000000e-06
GCST010243_253	Apolipoprotein B levels	2.000000e-09
GCST90007009_9	Gut microbiota relative abundance (Faecalibacterium)	8.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007627	airway imaging measurement
EFO:0004615	apolipoprotein B measurement
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression	3
Aflatoxin B1	decreases methylation, increases expression	3
Particulate Matter	increases abundance, increases expression, affects expression, decreases expression	3
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	increases abundance, increases expression	2
Cisplatin	affects cotreatment, increases expression	2
Estradiol	affects cotreatment, increases expression, decreases expression	2
Valproic Acid	increases expression, affects expression	2
aristolochic acid I	increases expression	1
methyleugenol	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
entinostat	increases expression	1
jinfukang	affects cotreatment, increases expression	1
NSC 689534	affects binding, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	decreases expression	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Calcitriol	increases expression	1
Copper	affects binding, increases expression	1
Coumestrol	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment	1
N-Nitrosopyrrolidine	increases expression	1
Nickel	decreases expression	1
Smoke	increases abundance, increases expression	1
Testosterone	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.