ELF3-AS1

Summary

ELF3-AS1 (ELF3 antisense RNA 1, HGNC:40211) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40211
Approved symbol	ELF3-AS1
Name	ELF3 antisense RNA 1
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000415582, SCAT7
Ensembl gene	ENSG00000234678
Ensembl biotype	lncRNA
Entrez	102723465
RNAcentral	URS0000BC45EE — lncRNA, 831 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000415582, ENST00000419190, ENST00000719677, ENST00000719678

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415582 — 2 exons

Exon	Start	End
ENSE00001758543	202000101	202000327
ENSE00001795816	202001011	202001283

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 80.55.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4364 / max 33.0274, expressed in 222 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
16696	0.1813	86
16698	0.1303	58
16697	0.1248	51

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	80.55	gold quality
monocyte	CL:0000576	78.41	gold quality
granulocyte	CL:0000094	78.38	gold quality
lower esophagus mucosa	UBERON:0035834	78.10	gold quality
leukocyte	CL:0000738	77.93	gold quality
apex of heart	UBERON:0002098	77.39	gold quality
bone marrow cell	CL:0002092	77.22	gold quality
right lobe of thyroid gland	UBERON:0001119	76.97	gold quality
colonic epithelium	UBERON:0000397	76.33	gold quality
bone marrow	UBERON:0002371	76.30	gold quality
left lobe of thyroid gland	UBERON:0001120	76.10	gold quality
esophagus mucosa	UBERON:0002469	76.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.71	gold quality
thyroid gland	UBERON:0002046	75.62	gold quality
transverse colon	UBERON:0001157	75.57	gold quality
cerebellar hemisphere	UBERON:0002245	75.13	gold quality
body of pancreas	UBERON:0001150	75.12	gold quality
minor salivary gland	UBERON:0001830	75.11	gold quality
small intestine	UBERON:0002108	75.08	gold quality
cerebellar cortex	UBERON:0002129	75.02	gold quality
cerebellum	UBERON:0002037	74.94	gold quality
skin of leg	UBERON:0001511	74.83	gold quality
skin of abdomen	UBERON:0001416	74.82	gold quality
zone of skin	UBERON:0000014	74.79	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.40	gold quality
saliva-secreting gland	UBERON:0001044	74.34	gold quality
mucosa of stomach	UBERON:0001199	74.27	gold quality
duodenum	UBERON:0002114	74.07	gold quality
pancreas	UBERON:0001264	73.89	gold quality
spleen	UBERON:0002106	73.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• This study has unraveled a novel mechanism of ELF3-AS1-mediated oncogenesis in bladder cancer by reinforcement of ELF3-AS1/KLF8 signaling with potential implications for therapeutic intervention. (PMID:30528231)
• LncRNA ELF3-AS1 Promotes Non-Small Cell Lung Cancer Cell Invasion and Migration by Downregulating miR-212. (PMID:32598181)
• Diagnostic and Prognostic Potentials of Long Noncoding RNA ELF3-AS1 in Glioma Patients. (PMID:33014189)
• LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma. (PMID:34336727)
• ELF3-AS1 contributes to gastric cancer progression by binding to hnRNPK and induces thrombocytosis in peripheral blood. (PMID:34418240)
• LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex. (PMID:36457025)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.