ELFN1-AS1

Summary

ELFN1-AS1 (ELFN1 antisense RNA 1, HGNC:39071) is a long non-coding RNA gene on chromosome 7p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39071
Approved symbol	ELFN1-AS1
Name	ELFN1 antisense RNA 1
Location	7p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MYCLo-2
Ensembl gene	ENSG00000236081
Ensembl biotype	lncRNA
Entrez	101927125
RNAcentral	URS000075CB12 — lncRNA, 1008 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000415399, ENST00000453348, ENST00000844177

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415399 — 2 exons

Exon	Start	End
ENSE00001706292	1742209	1742291
ENSE00001778593	1738983	1739535

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 82.64.

FANTOM5 (CAGE): breadth broad, TPM avg 3.0918 / max 236.5221, expressed in 321 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82437	2.9844	319
82436	0.1074	60

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	82.64	silver quality
cardiac muscle of right atrium	UBERON:0003379	78.43	gold quality
left ventricle myocardium	UBERON:0006566	78.19	gold quality
ileal mucosa	UBERON:0000331	77.35	silver quality
myocardium	UBERON:0002349	72.35	gold quality
bone marrow cell	CL:0002092	71.52	gold quality
kidney epithelium	UBERON:0004819	70.93	gold quality
upper arm skin	UBERON:0004263	68.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.72	gold quality
epithelial cell of pancreas	CL:0000083	68.48	gold quality
pancreatic ductal cell	CL:0002079	68.37	silver quality
secondary oocyte	CL:0000655	68.10	gold quality
nasal cavity epithelium	UBERON:0005384	67.68	gold quality
deltoid	UBERON:0001476	66.61	gold quality
muscle tissue	UBERON:0002385	65.68	gold quality
skeletal muscle tissue	UBERON:0001134	63.22	gold quality
ganglionic eminence	UBERON:0004023	63.20	gold quality
gingival epithelium	UBERON:0001949	63.06	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	62.68	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	61.07	gold quality
quadriceps femoris	UBERON:0001377	60.64	gold quality
gingiva	UBERON:0001828	60.40	gold quality
biceps brachii	UBERON:0001507	60.31	gold quality
jejunal mucosa	UBERON:0000399	60.28	gold quality
rectum	UBERON:0001052	59.61	gold quality
epithelium of nasopharynx	UBERON:0001951	59.44	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.22	gold quality
trabecular bone tissue	UBERON:0002483	59.16	gold quality
germinal epithelium of ovary	UBERON:0001304	58.52	gold quality
vastus lateralis	UBERON:0001379	58.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• ELFN1-AS1 accelerates the proliferation and migration of colorectal cancer via regulation of miR-4644/TRIM44 axis. (PMID:31929141)
• LncRNA ELFN1-AS1 promotes esophageal cancer progression by up-regulating GFPT1 via sponging miR-183-3p. (PMID:32229685)
• A long non-coding RNA, ELFN1-AS1, sponges miR-1250 to upregulate MTA1 to promote cell proliferation, migration and invasion, and induce apoptosis in colorectal cancer. (PMID:34337713)
• lncRNA ELFN1-AS1 predicts poor prognosis and promotes tumor progression of non-small cell lung cancer by sponging miR-497. (PMID:35431233)
• MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1. (PMID:35857351)
• lncRNA ELFN1-AS1 promotes proliferation, migration and invasion and suppresses apoptosis in colorectal cancer cells by enhancing G6PD activity. (PMID:36786074)
• lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression. (PMID:36876422)
• m6A-related lncRNAs as potential biomarkers and the lncRNA ELFN1-AS1/miR-182-5p/BCL-2 regulatory axis in diffuse large B-cell lymphoma. (PMID:38037859)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.