ELFN1

Summary

ELFN1 (extracellular leucine rich repeat and fibronectin type III domain containing 1, HGNC:33154) is a protein-coding gene on chromosome 7p22.3, encoding Protein ELFN1 (P0C7U0). Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment.

Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in synapse organization. Predicted to act upstream of or within several processes, including chemical synaptic transmission; synapse assembly; and visual perception. Predicted to be located in dendrite and excitatory synapse. Predicted to be active in several cellular components, including axon terminus; glutamatergic synapse; and postsynaptic density membrane.

Source: NCBI Gene 392617 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 214 total — 5 pathogenic
• Phenotypes (HPO): 120
• MANE Select transcript: NM_001128636

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33154
Approved symbol	ELFN1
Name	extracellular leucine rich repeat and fibronectin type III domain containing 1
Location	7p22.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000225968
Ensembl biotype	protein_coding
OMIM	614964
Entrez	392617

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 20 protein_coding, 1 retained_intron

ENST00000424383, ENST00000561626, ENST00000688716, ENST00000691883, ENST00000853552, ENST00000853553, ENST00000853554, ENST00000853555, ENST00000853556, ENST00000853557, ENST00000853558, ENST00000853559, ENST00000853560, ENST00000853561, ENST00000853562, ENST00000853563, ENST00000853564, ENST00000853565, ENST00000853566, ENST00000936129, ENST00000936130

RefSeq mRNA: 3 — MANE Select: NM_001128636 NM_001128636, NM_001394187, NM_001394188

CCDS: CCDS59046

Canonical transcript exons

ENST00000424383 — 4 exons

Exon	Start	End
ENSE00001629647	1709091	1709252
ENSE00003934387	1744304	1747946
ENSE00003935877	1688058	1688150
ENSE00003938134	1670277	1670354

Expression profiles

Bgee: expression breadth ubiquitous, 190 present calls, max score 91.84.

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	91.84	gold quality
kidney epithelium	UBERON:0004819	84.82	silver quality
germinal epithelium of ovary	UBERON:0001304	84.30	gold quality
heart right ventricle	UBERON:0002080	82.79	gold quality
middle temporal gyrus	UBERON:0002771	80.17	silver quality
Brodmann (1909) area 46	UBERON:0006483	80.11	silver quality
pigmented layer of retina	UBERON:0001782	79.23	gold quality
parietal pleura	UBERON:0002400	78.80	gold quality
right lobe of liver	UBERON:0001114	78.59	gold quality
liver	UBERON:0002107	78.37	gold quality
Brodmann (1909) area 23	UBERON:0013554	77.72	silver quality
visceral pleura	UBERON:0002401	76.63	silver quality
apex of heart	UBERON:0002098	75.98	gold quality
endothelial cell	CL:0000115	75.82	silver quality
upper arm skin	UBERON:0004263	75.46	gold quality
sperm	CL:0000019	74.55	gold quality
thymus	UBERON:0002370	74.12	silver quality
stromal cell of endometrium	CL:0002255	74.09	gold quality
lateral globus pallidus	UBERON:0002476	74.05	silver quality
substantia nigra pars compacta	UBERON:0001965	73.98	silver quality
tibia	UBERON:0000979	73.89	gold quality
entorhinal cortex	UBERON:0002728	73.50	silver quality
substantia nigra pars reticulata	UBERON:0001966	73.47	gold quality
ventral tegmental area	UBERON:0002691	73.47	gold quality
secondary oocyte	CL:0000655	73.41	silver quality
cardiac ventricle	UBERON:0002082	72.93	gold quality
superior frontal gyrus	UBERON:0002661	72.70	gold quality
heart left ventricle	UBERON:0002084	72.64	gold quality
primary visual cortex	UBERON:0002436	72.59	gold quality
occipital lobe	UBERON:0002021	72.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

62 targeting ELFN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-548AW	99.99	72.57	3559
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-6124	99.87	69.78	3551

Literature-anchored findings (GeneRIF, showing 4)

• Damaging missense mutations of ELFN1, that are clustered in the carboxy-terminal region required for mGluR7 recruitment, are found in patients with epilepsy and attention deficit hyperactivity disorder. (PMID:25047565)
• the binding specificity of ELFN1 and found it to be recruited selectively to all group III mGluRs (mGluR4, mGluR6, mGluR7, and mGluR8), but not other mGluR species. (PMID:29686062)
• Biallelic mutations in ELFN1 gene associated with developmental and epileptic encephalopathy and joint laxity. (PMID:34509675)
• ELFN1 is a new extracellular matrix (ECM)-associated protein. (PMID:38986898)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	elfn1b	ENSDARG00000074372
mus_musculus	Elfn1	ENSMUSG00000048988
rattus_norvegicus	Elfn1	ENSRNOG00000022767
drosophila_melanogaster	Con	FBGN0005775
drosophila_melanogaster	kek3	FBGN0028370
caenorhabditis_elegans	lron-9	WBGENE00011971
caenorhabditis_elegans		WBGENE00020649

Paralogs (22): CHADL (ENSG00000100399), LGI1 (ENSG00000108231), LGR6 (ENSG00000133067), CHAD (ENSG00000136457), LRIG3 (ENSG00000139263), LGR5 (ENSG00000139292), LRIG1 (ENSG00000144749), LRRTM2 (ENSG00000146006), LRIT1 (ENSG00000148602), LGI2 (ENSG00000153012), LGI4 (ENSG00000153902), LRRC52 (ENSG00000162763), ELFN2 (ENSG00000166897), LGI3 (ENSG00000168481), LRG1 (ENSG00000171236), CPN2 (ENSG00000178772), LRIT3 (ENSG00000183423), LRRC26 (ENSG00000184709), LRIG2 (ENSG00000198799), LGR4 (ENSG00000205213), LRRC24 (ENSG00000254402), TRIL (ENSG00000255690)

Protein

Protein identifiers

Protein ELFN1 — P0C7U0 (reviewed: P0C7U0)

Alternative names: Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1, Protein phosphatase 1 regulatory subunit 28

All UniProt accessions (1): P0C7U0

UniProt curated annotations — full annotation on UniProt →

Function. Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses. Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Subunit / interactions. Interacts with PPP1CA.

Subcellular location. Membrane. Cell projection. Dendrite. Axon.

Disease relevance. Dursun-Ozgul neurodevelopmental syndrome (DONDS) [MIM:621344] An autosomal recessive neurodevelopmental disorder characterized by developmental delay, intellectual disability, behavioral abnormalities, epilepsy, and movement disorders. The disease is caused by variants affecting the gene represented in this entry.

RefSeq proteins (3): NP_001122108, NP_001381116, NP_001381117 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000483	Cys-rich_flank_reg_C	Domain
IPR001611	Leu-rich_rpt	Repeat
IPR003591	Leu-rich_rpt_typical-subtyp	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR050541	LRR_TM_domain-containing	Family
IPR055106	ELFN_Fn3	Domain

Pfam: PF13855, PF22986

UniProt features (32 total): repeat 6, glycosylation site 6, compositionally biased region 5, region of interest 4, domain 2, topological domain 2, modified residue 2, sequence variant 2, signal peptide 1, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7U0-F1	62.62	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 461, 645

Glycosylation sites (6): 59, 85, 90, 122, 210, 376

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 85 (showing top): GOBP_SYNAPSE_ASSEMBLY, PEREZ_TP63_TARGETS, chr7p22, GOBP_CELL_CELL_SIGNALING, GOBP_CELL_CELL_ADHESION, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS, GOBP_SYNAPTIC_SIGNALING, GOBP_SENSORY_PERCEPTION, GOBP_CELL_JUNCTION_ASSEMBLY, GOCC_NEURON_PROJECTION, GOCC_EXCITATORY_SYNAPSE, GOCC_NEURON_PROJECTION_TERMINUS, GOCC_POSTSYNAPSE, GOCC_SYNAPSE

GO Biological Process (7): chemical synaptic transmission (GO:0007268), synapse assembly (GO:0007416), visual perception (GO:0007601), establishment of protein localization (GO:0045184), synapse organization (GO:0050808), synaptic membrane adhesion (GO:0099560), synaptic signaling (GO:0099536)

GO Molecular Function (3): protein phosphatase inhibitor activity (GO:0004864), signaling receptor activity (GO:0038023), protein binding (GO:0005515)

GO Cellular Component (10): plasma membrane (GO:0005886), dendrite (GO:0030425), axon terminus (GO:0043679), excitatory synapse (GO:0060076), postsynaptic density membrane (GO:0098839), glutamatergic synapse (GO:0098978), membrane (GO:0016020), cell projection (GO:0042995), neuron projection terminus (GO:0044306), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
synapse	3
cellular anatomical structure	3
synapse organization	2
neuron projection	2
anterograde trans-synaptic signaling	1
nervous system development	1
cell junction assembly	1
sensory perception of light stimulus	1
establishment of localization	1
cell junction organization	1
cell-cell adhesion	1
cell-cell signaling	1
phosphoprotein phosphatase activity	1
phosphatase inhibitor activity	1
protein phosphatase regulator activity	1
molecular transducer activity	1
binding	1
membrane	1
cell periphery	1
dendritic tree	1
neuron projection terminus	1
presynapse	1
distal axon	1
postsynaptic density	1
postsynaptic membrane	1
postsynaptic specialization membrane	1
cell junction	1

Protein interactions and networks

STRING

1348 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ELFN1	CACNA1F	O60840	663
ELFN1	GRM6	O15303	653
ELFN1	GRM7	Q14831	617
ELFN1	TRPM1	Q7Z4N2	559
ELFN1	IGSF9B	Q9UPX0	528
ELFN1	EGFLAM	Q63HQ2	515
ELFN1	GRM8	O00222	456
ELFN1	KCNC3	Q14003	434
ELFN1	DLX1	P56177	421
ELFN1	DPYS	Q14117	418
ELFN1	GRIN2B	Q13224	418
ELFN1	GAD1	Q99259	409
ELFN1	KCNC1	P48547	408
ELFN1	FNDC1	Q4ZHG4	399
ELFN1	DLX5	P56178	396

IntAct

8 interactions, top by confidence:

A	B	Type	Score
ELFN1	PPP1CA	psi-mi:“MI:0407”(direct interaction)	0.440
MYC		psi-mi:“MI:0914”(association)	0.350
ELFN2	TBC1D4	psi-mi:“MI:0914”(association)	0.350
CLGN	TMEM131L	psi-mi:“MI:0914”(association)	0.350
DLK1	PLPP3	psi-mi:“MI:0914”(association)	0.350
SCN2B	RIMOC1	psi-mi:“MI:0914”(association)	0.350
SIGLECL1	IPO5	psi-mi:“MI:0914”(association)	0.350

BioGRID (17): ELFN1 (Affinity Capture-MS), ELFN1 (Affinity Capture-MS), ELFN1 (Affinity Capture-RNA), ELFN1 (Affinity Capture-MS), ELFN1 (Proximity Label-MS), ELFN1 (Cross-Linking-MS (XL-MS)), ELFN1 (Co-fractionation), ETFA (Co-fractionation), ETFB (Co-fractionation), OXSM (Co-fractionation), TPM4 (Co-fractionation), ELFN1 (Affinity Capture-MS), ELFN1 (Co-fractionation), ELFN1 (Co-fractionation), ELFN1 (Affinity Capture-RNA)

ESM2 similar proteins: A1XQX3, A1XQY0, A1XQY3, A2ALI5, A6QLD2, B5X216, D0PRN4, E9PUN2, O35181, O75151, O94933, O94991, P0C7U0, P15379, P23470, P49415, P56975, P58401, P80560, Q05909, Q3SXY7, Q3UH99, Q3V1G4, Q4W8E7, Q58EG3, Q5EGE1, Q5R3F8, Q5R5B8, Q63376, Q63475, Q68BL8, Q68FM6, Q6QD51, Q6ZSJ9, Q76KF0, Q80Z10, Q810B7, Q810B9, Q8AXP2, Q8C8T7

Diamond homologs: P0C7U0, Q5R3F8, Q68FM6, Q8C8T7, Q8BGX3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

214 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	5
Likely pathogenic	0
Uncertain significance	167
Likely benign	18
Benign	13

Top pathogenic / likely-pathogenic (5)

Variant ID	HGVS	Classification
4083482	NM_001128636.4(ELFN1):c.149C>A (p.Pro50His)	Pathogenic
4083483	ELFN1, 92-KB DEL	Pathogenic
4083484	NM_001128636.4(ELFN1):c.1767del (p.Val591fs)	Pathogenic
4083485	NM_001128636.4(ELFN1):c.475_477del (p.Val159del)	Pathogenic
4083486	NM_001128636.4(ELFN1):c.128_137del (p.Ile43fs)	Pathogenic

SpliceAI

726 predictions. Top by Δscore:

Variant	Effect	Δscore
7:1709253:G:GG	donor_gain	1.0000
7:1709229:T:TA	donor_gain	0.9900
7:1692950:C:T	donor_gain	0.9800
7:1744302:AGCAG:A	acceptor_gain	0.9800
7:1744303:GCA:G	acceptor_gain	0.9800
7:1744303:GCAGG:G	acceptor_gain	0.9800
7:1744302:A:AG	acceptor_gain	0.9700
7:1744303:G:GA	acceptor_gain	0.9700
7:1744303:GC:G	acceptor_gain	0.9700
7:1709230:C:CA	donor_gain	0.9500
7:1744300:GCA:G	acceptor_loss	0.9500
7:1744303:G:C	acceptor_loss	0.9500
7:1709259:C:T	donor_gain	0.9400
7:1709190:G:GT	donor_gain	0.9200
7:1744139:G:GT	donor_gain	0.9200
7:1692928:G:T	donor_gain	0.9100
7:1709191:G:T	donor_gain	0.9100
7:1688146:TACAG:T	donor_loss	0.8900
7:1688147:ACAG:A	donor_loss	0.8900
7:1688149:AGG:A	donor_loss	0.8900
7:1688150:GG:G	donor_loss	0.8900
7:1688151:G:GA	donor_loss	0.8900
7:1688152:T:G	donor_loss	0.8900
7:1689749:TGGC:T	donor_gain	0.8800
7:1689750:GGCG:G	donor_gain	0.8800
7:1709249:ACAAG:A	donor_loss	0.8800
7:1709250:CAAG:C	donor_loss	0.8800
7:1709251:AAG:A	donor_loss	0.8800
7:1709252:AGTAA:A	donor_loss	0.8800
7:1709253:GTAAG:G	donor_loss	0.8800

AlphaMissense

5329 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:1744790:T:C	L65P	1.000
7:1744805:A:T	N70I	1.000
7:1744806:C:A	N70K	1.000
7:1744806:C:G	N70K	1.000
7:1744862:T:C	L89P	1.000
7:1744868:T:C	L91P	1.000
7:1744877:A:T	N94I	1.000
7:1744878:C:A	N94K	1.000
7:1744878:C:G	N94K	1.000
7:1744950:C:A	N118K	1.000
7:1744950:C:G	N118K	1.000
7:1745022:C:A	N142K	1.000
7:1745022:C:G	N142K	1.000
7:1745084:T:C	L163P	1.000
7:1745093:A:T	N166I	1.000
7:1745094:C:A	N166K	1.000
7:1745094:C:G	N166K	1.000
7:1744714:T:A	W40R	0.999
7:1744714:T:C	W40R	0.999
7:1744718:T:C	L41P	0.999
7:1744726:T:C	C44R	0.999
7:1744727:G:A	C44Y	0.999
7:1744728:C:G	C44W	0.999
7:1744796:T:A	L67H	0.999
7:1744796:T:C	L67P	0.999
7:1744804:A:G	N70D	0.999
7:1744811:T:C	I72T	0.999
7:1744853:T:A	L86H	0.999
7:1744853:T:C	L86P	0.999
7:1744862:T:A	L89H	0.999

dbSNP variants (sampled 300 via entrez): RS1000010891 (7:1693398 G>A,T), RS1000021918 (7:1667649 C>T), RS1000024525 (7:1700322 G>A), RS1000045716 (7:1744603 G>A), RS1000075173 (7:1691645 C>A,T), RS1000090724 (7:1744631 G>A), RS1000175904 (7:1732726 A>C), RS1000237401 (7:1732498 A>G), RS1000265957 (7:1695979 G>A), RS1000269596 (7:1741166 G>A,C), RS1000272977 (7:1676824 C>T), RS1000274282 (7:1680834 T>C), RS1000276417 (7:1727818 G>A), RS1000289620 (7:1732199 C>A,G,T), RS1000350433 (7:1705075 C>T)

Disease associations

OMIM: gene MIM:614964 | disease phenotypes: MIM:621344

GenCC curated gene-disease

Mondo (1): Dursun-Ozgul neurodevelopmental syndrome (MONDO:0979898)

Orphanet (0):

HPO phenotypes

120 total (30 of 120 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000154	Wide mouth
HP:0000179	Thick lower lip vermilion
HP:0000219	Thin upper lip vermilion
HP:0000232	Everted lower lip vermilion
HP:0000252	Microcephaly
HP:0000276	Long face
HP:0000278	Retrognathia
HP:0000280	Coarse facial features
HP:0000286	Epicanthus
HP:0000297	Facial hypotonia
HP:0000307	Pointed chin
HP:0000316	Hypertelorism
HP:0000319	Smooth philtrum
HP:0000322	Short philtrum
HP:0000325	Triangular face
HP:0000341	Narrow forehead
HP:0000343	Long philtrum
HP:0000365	Hearing impairment
HP:0000400	Macrotia
HP:0000426	Prominent nasal bridge
HP:0000486	Strabismus
HP:0000490	Deeply set eye
HP:0000520	Proptosis
HP:0000582	Upslanted palpebral fissure
HP:0000639	Nystagmus
HP:0000664	Synophrys
HP:0000729	Autistic behavior
HP:0000733	Motor stereotypy
HP:0000742	Self-mutilation

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST006479_87	Diverticular disease	1.000000e-06
GCST006940_34	Neurociticism	8.000000e-09
GCST006943_43	Feeling miserable	6.000000e-12
GCST007094_162	Diastolic blood pressure	9.000000e-06
GCST007099_232	Systolic blood pressure	1.000000e-08
GCST007603_39	Smoking initiation	3.000000e-10
GCST008114_6	Type 2 diabetes	3.000000e-06
GCST008832_2	Gastroesophageal reflux disease	3.000000e-09
GCST011703_79	Smoking initiation	3.000000e-12

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease
EFO:0007660	neuroticism measurement
EFO:0009598	feeling miserable measurement
EFO:0006336	diastolic blood pressure
EFO:0006335	systolic blood pressure
EFO:0005670	smoking initiation

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, affects methylation	3
Valproic Acid	increases expression, increases methylation, affects expression	3
(+)-JQ1 compound	decreases expression	2
FR900359	affects phosphorylation	1
2-methyl-4-isothiazolin-3-one	increases expression	1
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	increases abundance, affects methylation	1
tobacco tar	decreases reaction, increases expression	1
benzo(e)pyrene	increases methylation	1
diallyl disulfide	decreases reaction, increases expression	1
allyl sulfide	increases expression, decreases reaction	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
abrine	increases expression	1
Cannabinoids	affects methylation, increases abundance	1
Dexamethasone	decreases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Methapyrilene	increases methylation	1
Methotrexate	decreases expression	1
Niclosamide	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Triclosan	decreases expression	1
1-Methyl-4-phenylpyridinium	decreases expression	1
Aflatoxin B1	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SL87	HAP1 ELFN1 (-) 1	Cancer cell line	Male
CVCL_SL88	HAP1 ELFN1 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.