EMC2

Summary

EMC2 (ER membrane protein complex subunit 2, HGNC:28963) is a protein-coding gene on chromosome 8q23.1, encoding ER membrane protein complex subunit 2 (Q15006). Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. It is a selective cancer dependency (DepMap: 20.0% of cell lines).

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Is extrinsic component of endoplasmic reticulum membrane. Part of EMC complex.

Source: NCBI Gene 9694 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 47 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 20.0% of screened cell lines
• MANE Select transcript: NM_014673

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28963
Approved symbol	EMC2
Name	ER membrane protein complex subunit 2
Location	8q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000104412
Ensembl biotype	protein_coding
OMIM	607722
Entrez	9694

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 6 protein_coding, 2 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000220853, ENST00000517593, ENST00000517784, ENST00000519450, ENST00000519642, ENST00000520294, ENST00000524143, ENST00000890427, ENST00000890428, ENST00000890429

RefSeq mRNA: 4 — MANE Select: NM_014673 NM_001329493, NM_001329494, NM_001329495, NM_014673

CCDS: CCDS6309

Canonical transcript exons

ENST00000220853 — 11 exons

Exon	Start	End
ENSE00001130722	108443624	108443698
ENSE00002097848	108486512	108489196
ENSE00003489653	108450428	108450492
ENSE00003509694	108470062	108470121
ENSE00003523467	108455873	108455930
ENSE00003535617	108469826	108469911
ENSE00003574064	108449823	108449936
ENSE00003576346	108479006	108479110
ENSE00003579331	108475882	108475963
ENSE00003652475	108453062	108453147
ENSE00003664948	108476782	108476892

Expression profiles

Bgee: expression breadth ubiquitous, 299 present calls, max score 98.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 47.9333 / max 2279.5144, expressed in 1799 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
90251	47.0040	1797
90250	0.9293	520

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.97	gold quality
corpus callosum	UBERON:0002336	97.73	gold quality
spinal cord	UBERON:0002240	97.45	gold quality
sperm	CL:0000019	97.18	gold quality
descending thoracic aorta	UBERON:0002345	96.64	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.41	gold quality
right coronary artery	UBERON:0001625	96.32	gold quality
body of pancreas	UBERON:0001150	96.30	gold quality
right atrium auricular region	UBERON:0006631	96.30	gold quality
popliteal artery	UBERON:0002250	96.26	gold quality
tibial artery	UBERON:0007610	96.26	gold quality
islet of Langerhans	UBERON:0000006	96.15	gold quality
aorta	UBERON:0000947	96.10	gold quality
artery	UBERON:0001637	96.07	gold quality
rectum	UBERON:0001052	96.01	gold quality
cranial nerve II	UBERON:0000941	95.97	gold quality
mucosa of stomach	UBERON:0001199	95.97	gold quality
thoracic aorta	UBERON:0001515	95.97	gold quality
ascending aorta	UBERON:0001496	95.96	gold quality
lateral globus pallidus	UBERON:0002476	95.96	gold quality
left coronary artery	UBERON:0001626	95.95	gold quality
subthalamic nucleus	UBERON:0001906	95.93	gold quality
gall bladder	UBERON:0002110	95.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.82	gold quality
lower esophagus	UBERON:0013473	95.79	gold quality
colonic epithelium	UBERON:0000397	95.70	gold quality
right lung	UBERON:0002167	95.63	gold quality
putamen	UBERON:0001874	95.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting EMC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-4666A-5P	99.41	69.72	1887
HSA-MIR-20B-3P	99.29	67.05	784
HSA-MIR-1264	99.25	66.81	1317
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-143-5P	98.98	68.87	946
HSA-MIR-4709-3P	98.88	68.04	1594
HSA-MIR-513B-3P	98.76	68.12	1577
HSA-MIR-1183	98.75	67.10	1116
HSA-MIR-3689A-5P	98.35	70.12	1049
HSA-MIR-3689B-5P	98.35	70.12	1049
HSA-MIR-3689E	98.35	70.12	1049
HSA-MIR-3689F	98.35	70.08	1052
HSA-MIR-1972	97.67	67.38	1172
HSA-MIR-4286	97.20	64.37	1587
HSA-MIR-873-3P	96.84	66.09	786

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 20.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• We then examined the oncogenic effects of the RSPO2-EMC2 fusion gene and confirmed that it can drive oncogenesis, sustain tumor growth and promote metastasis. (PMID:30250044)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	emc2	ENSDARG00000003308
mus_musculus	Emc2	ENSMUSG00000022337
rattus_norvegicus	Emc2	ENSRNOG00000005123
drosophila_melanogaster	EMC2B	FBGN0038461
drosophila_melanogaster	EMC2A	FBGN0038462
caenorhabditis_elegans		WBGENE00021973

Protein

Protein identifiers

ER membrane protein complex subunit 2 — Q15006 (reviewed: Q15006)

Alternative names: Tetratricopeptide repeat protein 35

All UniProt accessions (3): Q15006, E5RGJ2, H0YAS9

UniProt curated annotations — full annotation on UniProt →

Function. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

Subunit / interactions. Component of the ER membrane protein complex (EMC). Interacts with WNK1 (via amphipathic alpha-helix region); promoting the ER membrane protein complex assembly by preventing EMC2 ubiquitination.

Subcellular location. Endoplasmic reticulum membrane.

Post-translational modifications. Ubiquitinated when soluble in the cytoplasm, leading to its degradation by the proteasome. Interaction with EMC2 prevents its ubiquitination and degradation.

Similarity. Belongs to the EMC2 family.

RefSeq proteins (4): NP_001316422, NP_001316423, NP_001316424, NP_055488* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR039856	EMC2-like	Family
IPR055217	TPR_EMC2	Domain

Pfam: PF22890

UniProt features (41 total): helix 18, mutagenesis site 13, repeat 3, strand 2, modified residue 2, initiator methionine 1, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

11 structures.

PDB	Method	Resolution (Å)
6Y4L	X-RAY DIFFRACTION	2.2
8J0O	ELECTRON MICROSCOPY	3.32
7ADO	ELECTRON MICROSCOPY	3.39
6WW7	ELECTRON MICROSCOPY	3.4
8EOI	ELECTRON MICROSCOPY	3.4
8J0N	ELECTRON MICROSCOPY	3.47
7ADP	ELECTRON MICROSCOPY	3.6
8S9S	ELECTRON MICROSCOPY	3.6
9ZZ6	ELECTRON MICROSCOPY	4.16
6Z3W	ELECTRON MICROSCOPY	6.4
9C7V	ELECTRON MICROSCOPY	6.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15006-F1	94.40	0.85

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 255

Mutagenesis-validated functional residues (13):

Position	Phenotype
122	no effect on transmembrane domain binding of tail-anchored proteins; when associated with k-61 and k-95.
156	loss of interaction with emc5.
160	loss of interaction with emc5.
171	decreased interaction with emc5 and emc8.
180	decreased interaction with emc3.
189–191	decreased transmembrane domain binding of tail-anchored proteins.
193–194	no effect on transmembrane domain binding of tail-anchored proteins.
200	decreased interaction with emc5 and emc8.
227	loss of interaction with emc5 and emc8.
259	decreased interaction with emc3.
28	loss of interaction with emc5.
61	no effect on transmembrane domain binding of tail-anchored proteins; when associated with k-95 and e-122.
95	no effect on transmembrane domain binding of tail-anchored proteins; when associated with k-61 and e-122.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 157 (showing top): STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, ONKEN_UVEAL_MELANOMA_UP, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, INGRAM_SHH_TARGETS_DN, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_MEMBRANE_ORGANIZATION, GOBP_ENDOPLASMIC_RETICULUM_ORGANIZATION, BURTON_ADIPOGENESIS_12, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GOBP_PROTEIN_INSERTION_INTO_MEMBRANE, BRACHAT_RESPONSE_TO_CAMPTOTHECIN_DN, GOCC_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE

GO Biological Process (2): protein insertion into ER membrane by stop-transfer membrane-anchor sequence (GO:0045050), tail-anchored membrane protein insertion into ER membrane (GO:0071816)

GO Molecular Function (2): protein binding (GO:0005515), membrane insertase activity (GO:0032977)

GO Cellular Component (6): cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), extrinsic component of endoplasmic reticulum membrane (GO:0042406), EMC complex (GO:0072546), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein insertion into ER membrane	2
cellular anatomical structure	2
endoplasmic reticulum membrane	2
binding	1
establishment of protein localization to membrane	1
protein carrier activity	1
intracellular anatomical structure	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
extrinsic component of organelle membrane	1
membrane protein complex	1
endoplasmic reticulum protein-containing complex	1

Protein interactions and networks

STRING

1430 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EMC2	EMC6	Q9BV81	932
EMC2	EMC1	Q8N766	926
EMC2	EMC4	Q5J8M3	920
EMC2	EMC3	Q9P0I2	895
EMC2	MMGT1	Q8N4V1	873
EMC2	EMC8	O43402	771
EMC2	DERL2	Q9GZP9	760
EMC2	EMC9	Q9Y3B6	742
EMC2	EMC10	Q5UCC4	710
EMC2	EMC7	Q9NPA0	710
EMC2	ATP5MC3	P48201	622
EMC2	RPL8	P25120	621
EMC2	ACSF2	Q96CM8	621
EMC2	UBAC2	Q8NBM4	618
EMC2	CISD1	Q9NZ45	546

IntAct

187 interactions, top by confidence:

A	B	Type	Score
EMC9	EMC2	psi-mi:“MI:0915”(physical association)	0.940
EMC2	EMC9	psi-mi:“MI:0915”(physical association)	0.940
EMC2	EMC8	psi-mi:“MI:0915”(physical association)	0.940
EMC2	EMC8	psi-mi:“MI:0914”(association)	0.940
EMC8	EMC2	psi-mi:“MI:0915”(physical association)	0.940
EMC8	EMC2	psi-mi:“MI:0914”(association)	0.940
EMC3	EMC2	psi-mi:“MI:0915”(physical association)	0.860
MMGT1	EMC2	psi-mi:“MI:0915”(physical association)	0.860
EMC2	EMC10	psi-mi:“MI:0914”(association)	0.800
EMC7	EMC8	psi-mi:“MI:0914”(association)	0.790
EMC3	EMC8	psi-mi:“MI:0914”(association)	0.730
MMGT1	EMC8	psi-mi:“MI:0914”(association)	0.730

BioGRID (596): EMC8 (Two-hybrid), IKZF3 (Two-hybrid), EMC9 (Two-hybrid), CCDC33 (Two-hybrid), EMC2 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC10 (Affinity Capture-MS), EMC6 (Affinity Capture-MS), MMGT1 (Affinity Capture-MS)

ESM2 similar proteins: A0MT11, A1Z3X3, A2VD00, A4GWN3, A4II09, A4QNE0, A4VCH4, B5KFI0, O35841, P23116, P49754, Q09161, Q0P5I8, Q14152, Q15006, Q15386, Q1JU68, Q3B8M3, Q5E993, Q5E9L7, Q5KU39, Q5R4J9, Q5R644, Q5R882, Q5RE70, Q5XI83, Q5ZJZ6, Q5ZKG8, Q5ZMW3, Q68E01, Q6GLK9, Q6N069, Q6NRL4, Q6PCR7, Q6TGY8, Q6WKZ8, Q7L5D6, Q7TPD0, Q80UM3, Q8BHL5

Diamond homologs: B0BNG0, O60110, Q15006, Q5E993, Q5M7J9, Q5R882, Q6INS3, Q6TGY8, Q8AVU9, Q9CRD2, Q86K48

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
EMC2	“form complex”	“Endoplasmic reticulum membrane complex- EMC9 variant”	binding
EMC2	“form complex”	“Endoplasmic reticulum membrane complex, EMC8 variant”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 157 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
PD-L1(CD274) glycosylation and translocation to plasma membrane	5	26.8×	2e-04
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	5	17.3×	1e-03
Maturation of spike protein	6	16.4×	2e-04
Maturation of DENV proteins	7	15.3×	1e-04
Defective CFTR causes cystic fibrosis	5	11.3×	7e-03

GO biological processes:

GO term	Partners	Fold	FDR
tail-anchored membrane protein insertion into ER membrane	9	64.3×	2e-12
ERAD pathway	11	15.2×	5e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2113 predictions. Top by Δscore:

Variant	Effect	Δscore
8:108449817:TTTCA:T	acceptor_loss	1.0000
8:108449818:TTCAG:T	acceptor_loss	1.0000
8:108449819:TCAGA:T	acceptor_loss	1.0000
8:108449820:CAG:C	acceptor_loss	1.0000
8:108449821:A:AG	acceptor_gain	1.0000
8:108449821:AG:A	acceptor_loss	1.0000
8:108449822:G:GT	acceptor_gain	1.0000
8:108449822:GA:G	acceptor_gain	1.0000
8:108449822:GAA:G	acceptor_gain	1.0000
8:108449822:GAAA:G	acceptor_gain	1.0000
8:108449822:GAAAT:G	acceptor_gain	1.0000
8:108449885:G:GT	donor_gain	1.0000
8:108449932:TGATA:T	donor_gain	1.0000
8:108449933:GATA:G	donor_gain	1.0000
8:108449933:GATAG:G	donor_gain	1.0000
8:108449934:ATA:A	donor_gain	1.0000
8:108449935:TA:T	donor_gain	1.0000
8:108449936:AGTAA:A	donor_loss	1.0000
8:108449937:G:GG	donor_gain	1.0000
8:108449937:G:T	donor_loss	1.0000
8:108450416:A:AG	acceptor_gain	1.0000
8:108450416:AT:A	acceptor_gain	1.0000
8:108450416:ATGT:A	acceptor_gain	1.0000
8:108450417:T:G	acceptor_gain	1.0000
8:108450426:A:AG	acceptor_gain	1.0000
8:108450426:AGTTT:A	acceptor_gain	1.0000
8:108450427:G:GA	acceptor_gain	1.0000
8:108450427:GT:G	acceptor_gain	1.0000
8:108450427:GTT:G	acceptor_gain	1.0000
8:108450427:GTTT:G	acceptor_gain	1.0000

AlphaMissense

1974 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:108449892:G:A	G37E	1.000
8:108450430:T:A	W53R	1.000
8:108450430:T:C	W53R	1.000
8:108450460:G:C	A63P	1.000
8:108453078:T:C	L79P	1.000
8:108453089:T:C	F83L	1.000
8:108453091:C:A	F83L	1.000
8:108453091:C:G	F83L	1.000
8:108453106:A:C	R88S	1.000
8:108453106:A:T	R88S	1.000
8:108453122:G:C	G94R	1.000
8:108453123:G:A	G94D	1.000
8:108453137:G:C	A99P	1.000
8:108469838:C:A	R126S	1.000
8:108469839:G:C	R126P	1.000
8:108469893:T:C	L144P	1.000
8:108469905:T:C	L148P	1.000
8:108470084:T:A	W158R	1.000
8:108470084:T:C	W158R	1.000
8:108470094:T:C	L161P	1.000
8:108475892:G:C	A174P	1.000
8:108475903:T:G	C177W	1.000
8:108475914:T:C	L181P	1.000
8:108475959:C:A	A196D	1.000
8:108476882:G:A	G231E	1.000
8:108449850:G:C	R23T	0.999
8:108449850:G:T	R23I	0.999
8:108449851:A:C	R23S	0.999
8:108449851:A:T	R23S	0.999
8:108449891:G:A	G37R	0.999

dbSNP variants (sampled 300 via entrez): RS1000123960 (8:108456043 TAAA>T,TAA,TAAAA), RS1000141446 (8:108477612 A>C,G), RS1000271665 (8:108472114 T>C), RS1000274174 (8:108471341 T>G), RS1000289146 (8:108449438 A>G), RS1000302681 (8:108472454 A>T), RS1000412524 (8:108464905 A>G,T), RS1000469442 (8:108460066 C>G), RS1000544160 (8:108460385 CT>C), RS1000583644 (8:108478805 C>G), RS1000684376 (8:108454182 T>G), RS1000709279 (8:108470976 T>C), RS1000805680 (8:108489334 C>T), RS1000836762 (8:108489035 A>G), RS1000873510 (8:108447929 T>A)

Disease associations

OMIM: gene MIM:607722 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST002545_2	Ossification of the posterior longitudinal ligament of the spine	2.000000e-13
GCST003983_17	Male-pattern baldness	4.000000e-13
GCST006661_172	Male-pattern baldness	2.000000e-11
GCST006661_282	Male-pattern baldness	5.000000e-27
GCST010703_334	Brain morphology (MOSTest)	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066426 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.48	Kd	331.1	nM	CHEMBL5653589
6.48	ED50	331.1	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148317: Binding affinity to human EMC2 incubated for 45 mins by Kinobead based pull down assay	kd	0.3311	uM

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
bisphenol S	decreases methylation	1
Vorinostat	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Ivermectin	decreases expression	1
Tamoxifen	affects expression	1
Valproic Acid	decreases methylation	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651359	Binding	Binding affinity to human EMC2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1R3	Abcam HeLa EMC2 KO	Cancer cell line	Female
CVCL_E1W0	HAP1 EMC2 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.