EMC3

Summary

EMC3 (ER membrane protein complex subunit 3, HGNC:23999) is a protein-coding gene on chromosome 3p25.3, encoding ER membrane protein complex subunit 3 (Q9P0I2). Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. It is a selective cancer dependency (DepMap: 79.4% of cell lines).

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of EMC complex.

Source: NCBI Gene 55831 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 36 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 79.4% of screened cell lines
• MANE Select transcript: NM_001394674

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23999
Approved symbol	EMC3
Name	ER membrane protein complex subunit 3
Location	3p25.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000125037
Ensembl biotype	protein_coding
OMIM	620273
Entrez	55831

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 6 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000245046, ENST00000429759, ENST00000470827, ENST00000487465, ENST00000497557, ENST00000685575, ENST00000686016, ENST00000693754, ENST00000881006, ENST00000881007

RefSeq mRNA: 2 — MANE Select: NM_001394674 NM_001394674, NM_018447

CCDS: CCDS2594

Canonical transcript exons

ENST00000245046 — 8 exons

Exon	Start	End
ENSE00000852115	9969719	9969801
ENSE00001324597	9962682	9964197
ENSE00001901463	9986507	9986841
ENSE00003471802	9977389	9977446
ENSE00003535381	9973628	9973709
ENSE00003611574	9976957	9977050
ENSE00003620923	9970582	9970661
ENSE00003688294	9974384	9974488

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 98.40.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 58.8229 / max 423.8560, expressed in 1826 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41010	56.7426	1826
41013	1.7430	909
41011	0.1760	62
41014	0.1613	53

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
triceps brachii	UBERON:0001509	98.40	gold quality
gluteal muscle	UBERON:0002000	98.34	gold quality
monocyte	CL:0000576	98.21	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	98.21	gold quality
gastrocnemius	UBERON:0001388	98.16	gold quality
biceps brachii	UBERON:0001507	98.15	gold quality
mononuclear cell	CL:0000842	98.03	gold quality
muscle of leg	UBERON:0001383	97.90	gold quality
leukocyte	CL:0000738	97.85	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.82	gold quality
muscle organ	UBERON:0001630	97.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.59	gold quality
heart right ventricle	UBERON:0002080	97.21	gold quality
islet of Langerhans	UBERON:0000006	97.12	gold quality
stromal cell of endometrium	CL:0002255	97.02	gold quality
diaphragm	UBERON:0001103	97.00	gold quality
vastus lateralis	UBERON:0001379	96.89	gold quality
skeletal muscle tissue	UBERON:0001134	96.83	gold quality
quadriceps femoris	UBERON:0001377	96.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.68	gold quality
blood	UBERON:0000178	96.50	gold quality
rectum	UBERON:0001052	96.50	gold quality
deltoid	UBERON:0001476	96.45	gold quality
heart left ventricle	UBERON:0002084	96.23	gold quality
cardiac ventricle	UBERON:0002082	96.13	gold quality
adrenal tissue	UBERON:0018303	96.12	gold quality
trabecular bone tissue	UBERON:0002483	96.10	gold quality
left testis	UBERON:0004533	96.10	gold quality
right atrium auricular region	UBERON:0006631	95.97	gold quality
right testis	UBERON:0004534	95.88	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	11.61
E-MTAB-9221	yes	10.90
E-HCAD-9	yes	5.67
E-MTAB-7606	no	681.97
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

56 targeting EMC3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-378A-5P	99.65	66.33	1311
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-3679-3P	99.64	69.88	1599
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-516A-3P	99.46	67.96	1378
HSA-MIR-516B-3P	99.46	67.96	1378
HSA-MIR-7162-5P	99.46	68.08	1368
HSA-MIR-150-3P	99.43	70.51	920
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-2116-5P	99.32	69.34	1273

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 79.4% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	emc3	ENSDARG00000020607
mus_musculus	Emc3	ENSMUSG00000030286
rattus_norvegicus	Emc3	ENSRNOG00000009934
drosophila_melanogaster	EMC3	FBGN0032292
caenorhabditis_elegans		WBGENE00013378

Protein

Protein identifiers

ER membrane protein complex subunit 3 — Q9P0I2 (reviewed: Q9P0I2)

Alternative names: Transmembrane protein 111

All UniProt accessions (5): Q9P0I2, A0A8I5KPL4, A0A8I5KS41, A0A8I5KU67, S4R3U9

UniProt curated annotations — full annotation on UniProt →

Function. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

Subunit / interactions. Component of the ER membrane protein complex (EMC).

Subcellular location. Endoplasmic reticulum membrane.

Similarity. Belongs to the EMC3 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9P0I2-1	1	yes
Q9P0I2-2	2

RefSeq proteins (2): NP_001381603, NP_060917 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002809	EMC3/TMCO1	Family
IPR008568	EMC3	Family

Pfam: PF01956

UniProt features (43 total): helix 14, mutagenesis site 9, strand 6, sequence conflict 4, topological domain 4, transmembrane region 3, initiator methionine 1, chain 1, splice variant 1

Structure

Experimental structures (PDB)

10 structures.

PDB	Method	Resolution (Å)
8J0O	ELECTRON MICROSCOPY	3.32
7ADO	ELECTRON MICROSCOPY	3.39
6WW7	ELECTRON MICROSCOPY	3.4
8EOI	ELECTRON MICROSCOPY	3.4
8J0N	ELECTRON MICROSCOPY	3.47
7ADP	ELECTRON MICROSCOPY	3.6
8S9S	ELECTRON MICROSCOPY	3.6
9ZZ6	ELECTRON MICROSCOPY	4.16
6Z3W	ELECTRON MICROSCOPY	6.4
9C7V	ELECTRON MICROSCOPY	6.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P0I2-F1	78.38	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (9):

Position	Phenotype
31	no effect on emc assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by t
31	no effect on emc assembly and no effect on membrane insertion of hydrophobic transmembrane helices-containing proteins b
101	no effect on emc assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by t
106	no effect on emc assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by t
110	no effect on emc assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by t
111	no effect on emc assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by t
173	no effect on emc assembly and no effect on membrane insertion of hydrophobic transmembrane helices-containing proteins b
180	no effect on emc assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by t
180	no effect on emc assembly and no effect on membrane insertion of hydrophobic transmembrane helices-containing proteins b

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8980692	RHOA GTPase cycle

MSigDB gene sets: 174 (showing top): E2F_Q4, E2F4DP1_01, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, TGACCTY_ERR1_Q2, E2F1DP1_01, E2F1DP2_01, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, PETRETTO_BLOOD_PRESSURE_UP, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, RYTTCCTG_ETS2_B, GOBP_MEMBRANE_ORGANIZATION, GOBP_ENDOPLASMIC_RETICULUM_ORGANIZATION, GOBP_LOCALIZATION_WITHIN_MEMBRANE, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN

GO Biological Process (2): protein insertion into ER membrane by stop-transfer membrane-anchor sequence (GO:0045050), tail-anchored membrane protein insertion into ER membrane (GO:0071816)

GO Molecular Function (2): protein binding (GO:0005515), membrane insertase activity (GO:0032977)

GO Cellular Component (4): endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020), EMC complex (GO:0072546), endoplasmic reticulum (GO:0005783)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein insertion into ER membrane	2
binding	1
establishment of protein localization to membrane	1
protein carrier activity	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1
endoplasmic reticulum membrane	1
membrane protein complex	1
endoplasmic reticulum protein-containing complex	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

918 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EMC3	EMC6	Q9BV81	904
EMC3	EMC2	Q15006	895
EMC3	EMC1	Q8N766	892
EMC3	EMC4	Q5J8M3	891
EMC3	MMGT1	Q8N4V1	885
EMC3	EMC7	Q9NPA0	827
EMC3	GET1	O00258	795
EMC3	EMC8	O43402	794
EMC3	EMC9	Q9Y3B6	774
EMC3	DERL2	Q9GZP9	758
EMC3	OXA1L	Q15070	733
EMC3	EMC10	Q5UCC4	710
EMC3	TMCO1	Q9UM00	690
EMC3	UBAC2	Q8NBM4	685
EMC3	GET3	O43681	606

IntAct

109 interactions, top by confidence:

A	B	Type	Score
EMC2	EMC8	psi-mi:“MI:0914”(association)	0.940
EMC8	EMC2	psi-mi:“MI:0914”(association)	0.940
EMC3	EMC2	psi-mi:“MI:0915”(physical association)	0.860
EMC2	EMC10	psi-mi:“MI:0914”(association)	0.800
EMC7	EMC8	psi-mi:“MI:0914”(association)	0.790
EMC3	EMC8	psi-mi:“MI:0914”(association)	0.730
MMGT1	EMC8	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
EMC1	EMC8	psi-mi:“MI:0914”(association)	0.640
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
EMC4	EMC8	psi-mi:“MI:0914”(association)	0.640
SLC12A2	CLGN	psi-mi:“MI:0914”(association)	0.640
EMC10	EMC8	psi-mi:“MI:0915”(physical association)	0.620
MTAP	EMC3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (211): EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC9 (Affinity Capture-MS), UBQLN2 (Affinity Capture-MS), EMC8 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC1 (Affinity Capture-MS), EMC7 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC3 (Affinity Capture-MS)

ESM2 similar proteins: A8N0V8, B2RZ37, C0HLM6, D3Z7Q2, F1MDB2, O35092, O49636, O60830, O80840, O95563, P00130, P08200, P0CM24, P0CM25, P11024, P38718, P39515, P59670, Q00765, Q13423, Q29RM3, Q2HJE9, Q3ZCB8, Q5BIN4, Q5M7K0, Q5R4Z3, Q5R7C1, Q5RE33, Q5U2V8, Q5U4U5, Q60870, Q61941, Q68EQ9, Q6INE8, Q6PBX9, Q6ZL94, Q7SXW4, Q8L7H8, Q8LD38, Q8N5G0

Diamond homologs: A7A082, B3LQQ2, B5VLV9, P36039, Q3ZCB8, Q54YN3, Q5R7C1, Q5U2V8, Q7SXW4, Q99KI3, Q9P0I2, Q9P787

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
EMC3	“form complex”	“Endoplasmic reticulum membrane complex- EMC9 variant”	binding
EMC3	“form complex”	“Endoplasmic reticulum membrane complex, EMC8 variant”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 115 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Defective CFTR causes cystic fibrosis	5	15.5×	4e-03
Anchoring of the basal body to the plasma membrane	9	14.3×	5e-06

GO biological processes:

GO term	Partners	Fold	FDR
tail-anchored membrane protein insertion into ER membrane	9	86.9×	7e-14
ERAD pathway	9	16.8×	6e-07
cilium assembly	8	6.1×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	21
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1242 predictions. Top by Δscore:

Variant	Effect	Δscore
3:9964194:CTGT:C	acceptor_gain	1.0000
3:9964218:C:T	acceptor_gain	1.0000
3:9970576:TCTTA:T	donor_loss	1.0000
3:9970577:CTTAC:C	donor_loss	1.0000
3:9970578:TTACC:T	donor_loss	1.0000
3:9970579:TACCA:T	donor_loss	1.0000
3:9970580:A:T	donor_loss	1.0000
3:9970581:C:CA	donor_loss	1.0000
3:9970657:TCACC:T	acceptor_gain	1.0000
3:9970658:CACC:C	acceptor_gain	1.0000
3:9970658:CACCC:C	acceptor_gain	1.0000
3:9970659:ACC:A	acceptor_gain	1.0000
3:9970660:CC:C	acceptor_gain	1.0000
3:9970660:CCC:C	acceptor_gain	1.0000
3:9970661:CC:C	acceptor_gain	1.0000
3:9970662:C:CC	acceptor_gain	1.0000
3:9970671:C:CT	acceptor_gain	1.0000
3:9973705:CTTGG:C	acceptor_gain	1.0000
3:9974382:A:AC	donor_gain	1.0000
3:9974383:C:CC	donor_gain	1.0000
3:9977051:C:CC	acceptor_gain	1.0000
3:9977442:CTTGA:C	acceptor_gain	1.0000
3:9986503:TGA:T	donor_loss	1.0000
3:9986504:GACCT:G	donor_loss	1.0000
3:9986505:ACCTG:A	donor_loss	1.0000
3:9986506:C:CG	donor_loss	1.0000
3:9964195:TGT:T	acceptor_gain	0.9900
3:9964197:TCT:T	acceptor_loss	0.9900
3:9964198:C:CA	acceptor_loss	0.9900
3:9964198:C:CC	acceptor_gain	0.9900

AlphaMissense

1736 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:9964185:C:G	A224P	1.000
3:9970620:A:G	L179P	1.000
3:9970623:C:T	G178E	1.000
3:9970635:A:G	L174P	1.000
3:9970635:A:T	L174H	1.000
3:9970645:A:G	W171R	1.000
3:9970645:A:T	W171R	1.000
3:9973675:C:A	K149N	1.000
3:9973675:C:G	K149N	1.000
3:9973678:A:C	F148L	1.000
3:9973678:A:T	F148L	1.000
3:9973679:A:G	F148S	1.000
3:9973680:A:G	F148L	1.000
3:9973696:A:C	F142L	1.000
3:9973696:A:T	F142L	1.000
3:9973698:A:G	F142L	1.000
3:9974389:A:T	V136D	1.000
3:9974391:A:C	F135L	1.000
3:9974391:A:T	F135L	1.000
3:9974393:A:G	F135L	1.000
3:9974417:A:G	W127R	1.000
3:9974417:A:T	W127R	1.000
3:9974422:C:T	G125D	1.000
3:9977428:G:C	S58R	1.000
3:9977428:G:T	S58R	1.000
3:9977430:T:G	S58R	1.000
3:9970620:A:T	L179H	0.999
3:9970624:C:G	G178R	0.999
3:9970624:C:T	G178R	0.999
3:9970625:A:C	F177L	0.999

dbSNP variants (sampled 300 via entrez): RS1000041788 (3:9963006 C>A), RS1000078926 (3:9980878 G>C), RS1000202791 (3:9975504 G>C), RS1000235520 (3:9980449 T>C), RS1000289192 (3:10007052 T>C), RS1000305352 (3:9982364 C>T), RS1000374148 (3:9986414 C>A,T), RS1000466282 (3:9974321 T>C,G), RS1000573300 (3:9979101 C>T), RS1000626481 (3:9982185 C>A,G,T), RS1000678041 (3:10004105 G>T), RS1000765082 (3:9990789 A>G), RS1000783703 (3:10004676 T>A), RS1000970499 (3:9976511 C>T), RS1000971877 (3:9962624 G>A)

Disease associations

OMIM: gene MIM:620273 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067207 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.00	Kd	10.02	nM	CHEMBL5653589
8.00	ED50	10.02	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148318: Binding affinity to human EMC3 incubated for 45 mins by Kinobead based pull down assay	kd	0.0100	uM

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Nickel	decreases expression	2
Valproic Acid	increases expression	2
Cadmium Chloride	increases expression	2
dicrotophos	decreases expression	1
cobaltous chloride	increases expression	1
zinc chromate	increases expression, increases abundance	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
chromium hexavalent ion	increases abundance, increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
Vorinostat	decreases expression	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Drugs, Chinese Herbal	increases expression	1
Hydrogen Peroxide	increases expression, affects cotreatment	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Smoke	decreases expression	1
Theophylline	affects cotreatment, increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Urethane	increases expression	1
Cyclosporine	increases expression	1
Sodium Selenite	decreases expression	1
Copper Sulfate	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651360	Binding	Binding affinity to human EMC3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.