EML2

Summary

EML2 (EMAP like 2, HGNC:18035) is a protein-coding gene on chromosome 19q13.32, encoding Echinoderm microtubule-associated protein-like 2 (O95834). Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Located in mitotic spindle.

Source: NCBI Gene 24139 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 142 total — 1 likely-pathogenic
• MANE Select transcript: NM_012155

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18035
Approved symbol	EML2
Name	EMAP like 2
Location	19q13.32
Locus type	gene with protein product
Status	Approved
Aliases	EMAP2, ELP70, EMAP-2
Ensembl gene	ENSG00000125746
Ensembl biotype	protein_coding
OMIM	617494
Entrez	24139

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 21 protein_coding, 9 retained_intron, 6 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000245925, ENST00000399594, ENST00000536630, ENST00000585386, ENST00000586195, ENST00000586405, ENST00000586770, ENST00000586902, ENST00000587152, ENST00000587484, ENST00000587804, ENST00000588000, ENST00000588172, ENST00000588272, ENST00000588308, ENST00000588420, ENST00000588496, ENST00000588610, ENST00000588889, ENST00000589876, ENST00000590018, ENST00000590043, ENST00000590575, ENST00000590580, ENST00000590819, ENST00000591721, ENST00000592433, ENST00000592482, ENST00000592853, ENST00000592901, ENST00000593255, ENST00000905378, ENST00000905379, ENST00000905380, ENST00000905381, ENST00000905382, ENST00000933602, ENST00000953959

RefSeq mRNA: 7 — MANE Select: NM_012155 NM_001193268, NM_001193269, NM_001352051, NM_001352052, NM_001352053, NM_001352054, NM_012155

CCDS: CCDS12670, CCDS54280, CCDS59399

Canonical transcript exons

ENST00000245925 — 19 exons

Exon	Start	End
ENSE00002805624	45639357	45639397
ENSE00003493481	45619060	45619191
ENSE00003503545	45616461	45616558
ENSE00003509958	45614605	45614700
ENSE00003540729	45634322	45634471
ENSE00003543039	45617630	45617697
ENSE00003552659	45615802	45615889
ENSE00003565001	45609400	45609788
ENSE00003591675	45629951	45630046
ENSE00003605268	45638845	45638873
ENSE00003610005	45624719	45624818
ENSE00003610706	45638505	45638634
ENSE00003615699	45621483	45621637
ENSE00003659917	45613541	45613671
ENSE00003690789	45616765	45616853
ENSE00003783963	45621207	45621332
ENSE00003785819	45633070	45633139
ENSE00003788228	45632861	45632971
ENSE00003791677	45626705	45626839

Expression profiles

Bgee: expression breadth ubiquitous, 279 present calls, max score 97.29.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.1359 / max 120.2300, expressed in 1805 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181541	10.8855	1770
181543	1.2491	556
181549	0.7803	111
181548	0.6518	277
181544	0.5723	290
181545	0.4472	110
181546	0.4136	145
181551	0.3592	100
181550	0.2659	91
181542	0.2219	68

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	97.29	gold quality
lower esophagus mucosa	UBERON:0035834	96.17	gold quality
right adrenal gland	UBERON:0001233	96.07	gold quality
mucosa of transverse colon	UBERON:0004991	96.07	gold quality
right adrenal gland cortex	UBERON:0035827	95.93	gold quality
spinal cord	UBERON:0002240	95.82	gold quality
right frontal lobe	UBERON:0002810	95.67	gold quality
skin of leg	UBERON:0001511	95.63	gold quality
granulocyte	CL:0000094	95.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.60	gold quality
left adrenal gland	UBERON:0001234	95.56	gold quality
skin of abdomen	UBERON:0001416	95.55	gold quality
cerebellar hemisphere	UBERON:0002245	95.39	gold quality
left adrenal gland cortex	UBERON:0035825	95.39	gold quality
cerebellar cortex	UBERON:0002129	95.29	gold quality
esophagus mucosa	UBERON:0002469	95.22	gold quality
hypothalamus	UBERON:0001898	94.66	gold quality
adrenal cortex	UBERON:0001235	94.43	gold quality
minor salivary gland	UBERON:0001830	94.36	gold quality
cingulate cortex	UBERON:0003027	94.20	gold quality
anterior cingulate cortex	UBERON:0009835	94.08	gold quality
cerebellum	UBERON:0002037	93.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.77	gold quality
putamen	UBERON:0001874	93.76	gold quality
body of pancreas	UBERON:0001150	93.73	gold quality
adrenal gland	UBERON:0002369	93.70	gold quality
amygdala	UBERON:0001876	93.68	gold quality
right lobe of thyroid gland	UBERON:0001119	93.32	gold quality
transverse colon	UBERON:0001157	93.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.76

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

15 targeting EML2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-1255A	99.74	68.09	744
HSA-MIR-1255B-5P	99.74	68.16	741
HSA-MIR-3182	99.40	68.15	2454
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312
HSA-MIR-4782-5P	98.35	69.33	1474
HSA-MIR-5706	98.35	69.33	1463
HSA-MIR-514A-5P	96.94	65.49	801
HSA-MIR-6839-5P	96.74	68.29	1088
HSA-MIR-378J	96.44	66.20	1020
HSA-MIR-6861-5P	96.23	67.19	800
HSA-MIR-7108-3P	94.37	64.79	183
HSA-MIR-187-3P	81.56	59.38	111

Literature-anchored findings (GeneRIF, showing 3)

• Both EMAP II and CXCR3 were essentially required for gp120-induced lung microvascular endothelial cell apoptosis. (PMID:24318111)
• We have determined crystal structures of the coiled-coils from EML2 and EML4, which describe the structural basis of both EML self-association and oncogenic EML4-ALK activation. (PMID:25740311)
• EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules. (PMID:35963242)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	eml2	ENSDARG00000008808
mus_musculus	Eml2	ENSMUSG00000040811
rattus_norvegicus	Eml2	ENSRNOG00000030127

Paralogs (9): EML1 (ENSG00000066629), EML4 (ENSG00000143924), EML3 (ENSG00000149499), CFAP251 (ENSG00000158023), WDR90 (ENSG00000161996), EML5 (ENSG00000165521), CFAP52 (ENSG00000166596), CFAP44 (ENSG00000206530), EML6 (ENSG00000214595)

Protein

Protein identifiers

Echinoderm microtubule-associated protein-like 2 — O95834 (reviewed: O95834)

All UniProt accessions (18): O95834, A0A0C4DGQ7, C9JRL6, K7EII6, K7EIK7, K7EIM1, K7EIZ0, K7EJV6, K7EKG3, K7EKU5, K7EL23, K7ELB2, K7ELI8, K7EQR0, K7ERR2, K7ERR9, K7ERY9, K7ESL7

UniProt curated annotations — full annotation on UniProt →

Function. Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Subunit / interactions. Homotrimer; self-association is mediated by the N-terminal coiled coil. Interacts with GRID2 and may also interact with GRID1. Interacts with EML3. Binds unpolymerized tubulins via its WD repeat region.

Subcellular location. Cytoplasm. Cytoskeleton. Spindle.

Tissue specificity. Ubiquitous.

Domain organisation. Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain.

Similarity. Belongs to the WD repeat EMAP family.

Isoforms (3)

UniProt ID	Names	Canonical?
O95834-1	1	yes
O95834-2	2
O95834-3	3

RefSeq proteins (7): NP_001180197, NP_001180198, NP_001338980, NP_001338981, NP_001338982, NP_001338983, NP_036287* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR005108	HELP	Conserved_site
IPR011047	Quinoprotein_ADH-like_sf	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR050630	WD_repeat_EMAP	Family
IPR055439	Beta-prop_EML_1st	Domain
IPR055442	Beta-prop_EML-like_2nd	Domain

Pfam: PF03451, PF23409, PF23414

UniProt features (27 total): repeat 12, sequence variant 5, sequence conflict 3, splice variant 2, coiled-coil region 2, chain 1, region of interest 1, helix 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4CGB	X-RAY DIFFRACTION	2.15

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95834-F1	95.78	0.94

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 181 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_UP, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, MULLIGHAN_NPM1_SIGNATURE_3_UP, GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION, CGGAARNGGCNG_UNKNOWN, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_MICROTUBULE_NUCLEATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GGGTGGRR_PAX4_03, PATIL_LIVER_CANCER, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, BROWNE_HCMV_INFECTION_48HR_DN

GO Biological Process (5): microtubule cytoskeleton organization (GO:0000226), visual perception (GO:0007601), sensory perception of sound (GO:0007605), regulation of microtubule nucleation (GO:0010968), negative regulation of microtubule polymerization (GO:0031115)

GO Molecular Function (3): microtubule binding (GO:0008017), tubulin binding (GO:0015631), protein binding (GO:0005515)

GO Cellular Component (7): spindle (GO:0005819), microtubule (GO:0005874), microtubule associated complex (GO:0005875), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), membrane (GO:0016020), mitotic spindle (GO:0072686)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
microtubule cytoskeleton	3
regulation of microtubule polymerization	2
intracellular membraneless organelle	2
cellular anatomical structure	2
cytoskeleton organization	1
microtubule-based process	1
sensory perception of light stimulus	1
sensory perception of mechanical stimulus	1
microtubule nucleation	1
negative regulation of microtubule polymerization or depolymerization	1
negative regulation of protein polymerization	1
microtubule polymerization	1
negative regulation of supramolecular fiber organization	1
tubulin binding	1
cytoskeletal protein binding	1
binding	1
polymeric cytoskeletal fiber	1
protein-containing complex	1
intracellular anatomical structure	1
spindle	1

Protein interactions and networks

STRING

1820 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EML2	KLF11	O14901	456
EML2	ARHGEF3	Q9NR81	393
EML2	SYTL1	Q8IYJ3	379
EML2	RHOD	O00212	370
EML2	GLDC	P23378	348
EML2	ZNF222	Q9UK12	348
EML2	CRMP1	Q14194	341
EML2	HOXB1	P14653	322
EML2	INPP1	P49441	311
EML2	GALNT9	Q9HCQ5	310
EML2	ZNF226	Q9NYT6	308
EML2	APLP1	P51693	305
EML2	RESF1	Q9HCM1	302
EML2	ACYP2	P14621	302
EML2	PCDH15	Q96QU1	297
EML2	HUS1B	Q8NHY5	297

IntAct

21 interactions, top by confidence:

A	B	Type	Score
REL	EML2	psi-mi:“MI:0915”(physical association)	0.560
EML2	EXD1	psi-mi:“MI:0915”(physical association)	0.560
EXD1	EML2	psi-mi:“MI:0915”(physical association)	0.560
TUBB2A	EML2	psi-mi:“MI:0914”(association)	0.530
TUBB2B	EML2	psi-mi:“MI:0914”(association)	0.530
TUBB3	EML1	psi-mi:“MI:0914”(association)	0.350
TUBB8	POTEF	psi-mi:“MI:0914”(association)	0.350
TUBB4B	POTEF	psi-mi:“MI:0914”(association)	0.350
TUBB3	TUBB8B	psi-mi:“MI:0914”(association)	0.350
STX17	A2ML1	psi-mi:“MI:0914”(association)	0.350
OR2A4	A2ML1	psi-mi:“MI:0914”(association)	0.350
GOT1	A2ML1	psi-mi:“MI:0914”(association)	0.350
TUBB2B	POTEF	psi-mi:“MI:0914”(association)	0.350
EML1	EML2	psi-mi:“MI:0914”(association)	0.350
NEK6	EML2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (49): EML2 (Two-hybrid), EXD1 (Two-hybrid), EML2 (Affinity Capture-MS), EML2 (Affinity Capture-MS), EML2 (Co-fractionation), EML2 (Co-fractionation), TTC38 (Co-fractionation), EML2 (Affinity Capture-MS), EML2 (Affinity Capture-MS), EML3 (Affinity Capture-Western), EML2 (Affinity Capture-MS), EML2 (Affinity Capture-MS), EML2 (Affinity Capture-MS), EML2 (Affinity Capture-MS), EML2 (Two-hybrid)

ESM2 similar proteins: A1L112, A4IHS2, A8NZM5, B2ZZS9, O00423, O80775, O95834, P93107, P97452, Q05BC3, Q0DYP5, Q13216, Q13610, Q13685, Q15269, Q1JQD2, Q2HJ56, Q32KQ2, Q32P44, Q3SZK1, Q4V8C3, Q562C2, Q58DT8, Q5BIM8, Q5F3K4, Q5R9T6, Q5RCG7, Q5RFQ3, Q5VU92, Q5XI13, Q5ZK69, Q6DRF9, Q6P6T4, Q6PFM9, Q7TNG5, Q7YR70, Q810D6, Q8BH57, Q8BHB4, Q8BU03

Diamond homologs: A5E2R6, A7RWD2, A8IZG4, A9VDW7, B0XAF3, B3MC74, B3NQR5, B3RNR8, B4GDM7, B4HRQ6, B4JW81, B4KTK4, B4LJT7, B4MY77, B4P7Q3, B4QFZ8, B5X212, B5X9P2, B6K1G6, B7QKS1, O76071, O80990, O95834, Q17GR9, Q28DW0, Q292E8, Q32PJ6, Q4PCB8, Q55DA2, Q5AG86, Q5M7T1, Q6BIR9, Q6P0D9, Q6P6T4, Q7K1Y4, Q7PS24, Q99KN2, Q9SRI1, Q9UT57, Q9VUI3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 15 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	6	296.6×	4e-13
Transport of connexons to the plasma membrane	6	296.6×	4e-13
Gap junction trafficking and regulation	6	259.6×	6e-13
Gap junction trafficking	6	259.6×	6e-13
Activation of AMPK downstream of NMDARs	6	207.6×	2e-12
RHO GTPases activate IQGAPs	6	188.8×	3e-12
Sealing of the nuclear envelope (NE) by ESCRT-III	6	188.8×	3e-12
HCMV Infection	6	178.0×	3e-12

GO biological processes:

GO term	Partners	Fold	FDR
microtubule cytoskeleton organization	7	56.6×	1e-09
mitotic cell cycle	6	53.5×	3e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

142 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	117
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
148766	GRCh38/hg38 19q13.32(chr19:45387389-46831000)x1	Likely pathogenic

SpliceAI

3262 predictions. Top by Δscore:

Variant	Effect	Δscore
19:45613539:A:AC	donor_gain	1.0000
19:45613540:C:CA	donor_gain	1.0000
19:45613540:CT:C	donor_gain	1.0000
19:45613540:CTCG:C	donor_gain	1.0000
19:45613669:TCC:T	acceptor_gain	1.0000
19:45613669:TCCC:T	acceptor_loss	1.0000
19:45613670:CC:C	acceptor_gain	1.0000
19:45613670:CCC:C	acceptor_gain	1.0000
19:45613670:CCCTG:C	acceptor_loss	1.0000
19:45613671:CC:C	acceptor_gain	1.0000
19:45613672:C:CC	acceptor_gain	1.0000
19:45613672:CT:C	acceptor_loss	1.0000
19:45613673:T:A	acceptor_loss	1.0000
19:45614634:G:C	donor_gain	1.0000
19:45615800:A:AC	donor_gain	1.0000
19:45615801:C:CC	donor_gain	1.0000
19:45615801:CAGT:C	donor_gain	1.0000
19:45615801:CAGTA:C	donor_gain	1.0000
19:45615885:TGGCC:T	acceptor_gain	1.0000
19:45615886:GGCC:G	acceptor_gain	1.0000
19:45615887:GCC:G	acceptor_gain	1.0000
19:45615888:CC:C	acceptor_gain	1.0000
19:45615888:CCC:C	acceptor_gain	1.0000
19:45615889:CC:C	acceptor_gain	1.0000
19:45615890:C:CC	acceptor_gain	1.0000
19:45615890:CTGCG:C	acceptor_loss	1.0000
19:45616457:TCACC:T	donor_loss	1.0000
19:45616459:A:AC	donor_gain	1.0000
19:45616460:C:CA	donor_loss	1.0000
19:45616460:C:CC	donor_gain	1.0000

AlphaMissense

4226 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:45615825:G:A	S525F	1.000
19:45624728:A:G	W278R	1.000
19:45624728:A:T	W278R	1.000
19:45632871:A:G	F167S	1.000
19:45632945:C:A	W142C	1.000
19:45632945:C:G	W142C	1.000
19:45632947:A:G	W142R	1.000
19:45632947:A:T	W142R	1.000
19:45633101:C:T	G123E	1.000
19:45633107:G:T	A121D	1.000
19:45609677:A:G	W646R	0.999
19:45609677:A:T	W646R	0.999
19:45609695:C:G	D640H	0.999
19:45613587:T:A	D593V	0.999
19:45613588:C:G	D593H	0.999
19:45613666:A:G	W567R	0.999
19:45613666:A:T	W567R	0.999
19:45615826:A:G	S525P	0.999
19:45615875:A:C	F508L	0.999
19:45615875:A:T	F508L	0.999
19:45615877:A:G	F508L	0.999
19:45615878:A:C	S507R	0.999
19:45615878:A:T	S507R	0.999
19:45615880:T:G	S507R	0.999
19:45621269:C:A	G354W	0.999
19:45624726:C:A	W278C	0.999
19:45624726:C:G	W278C	0.999
19:45624754:C:T	G269E	0.999
19:45624755:C:A	G269W	0.999
19:45624757:G:T	T268K	0.999

dbSNP variants (sampled 300 via entrez): RS1000027988 (19:45646795 TTG>T), RS1000190817 (19:45625385 C>G,T), RS1000320840 (19:45619343 C>A,T), RS1000433873 (19:45624754 C>G), RS1000447785 (19:45624994 G>A,C), RS1000623644 (19:45637393 G>T), RS1000652496 (19:45630831 T>C), RS1000690543 (19:45637001 C>T), RS1000748007 (19:45618360 C>G), RS1000888158 (19:45614444 C>G,T), RS1000933403 (19:45642574 G>C), RS1001065477 (19:45643202 A>G), RS1001139067 (19:45640129 T>A,C), RS1001211057 (19:45639879 A>G), RS1001274255 (19:45612205 C>T)

Disease associations

OMIM: gene MIM:617494 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001521_31	Subcutaneous adipose tissue	2.000000e-06
GCST001521_39	Subcutaneous adipose tissue	1.000000e-06
GCST006001_5	Hemoglobin A1c levels	5.000000e-09
GCST010118_75	Type 2 diabetes	1.000000e-32
GCST010136_35	Fruit consumption	1.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004541	HbA1c measurement
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	affects expression, decreases methylation, increases abundance, increases expression	3
sodium arsenite	increases abundance, increases expression	2
Lead	affects expression, decreases expression	2
Smoke	decreases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	increases expression	1
bisphenol A	decreases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, decreases expression	1
decabromobiphenyl ether	decreases expression	1
beta-lapachone	increases expression	1
arsenite	increases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
tetrabromobisphenol A	decreases expression	1
manganese chloride	increases expression	1
di-n-butylphosphoric acid	affects expression	1
monomethylarsonous acid	increases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
Irinotecan	affects cotreatment, increases response to substance	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1
Air Pollutants	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.