EML4-AS1

Summary

EML4-AS1 (EML4 antisense RNA 1, HGNC:40112) is a long non-coding RNA gene on chromosome 2p21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40112
Approved symbol	EML4-AS1
Name	EML4 antisense RNA 1
Location	2p21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224875
Ensembl biotype	lncRNA
Entrez	102723824
RNAcentral	URS000075ADB2 — lncRNA, 1460 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000422013, ENST00000458490, ENST00000753457, ENST00000753458, ENST00000753459, ENST00000753460, ENST00000753461, ENST00000753462, ENST00000753463

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422013 — 4 exons

Exon	Start	End
ENSE00001746149	42147651	42147840
ENSE00002435115	42149935	42150032
ENSE00004100644	42142429	42143344
ENSE00004100659	42169970	42170348

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 77.31.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	77.31	gold quality
quadriceps femoris	UBERON:0001377	77.04	gold quality
cerebellar vermis	UBERON:0004720	76.73	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.03	silver quality
lymph node	UBERON:0000029	72.21	gold quality
thymus	UBERON:0002370	70.38	silver quality
tonsil	UBERON:0002372	69.92	gold quality
colonic epithelium	UBERON:0000397	68.82	silver quality
bone marrow	UBERON:0002371	68.71	gold quality
spleen	UBERON:0002106	68.18	gold quality
vermiform appendix	UBERON:0001154	65.75	gold quality
granulocyte	CL:0000094	64.31	gold quality
leukocyte	CL:0000738	63.39	gold quality
monocyte	CL:0000576	63.20	gold quality
blood	UBERON:0000178	63.06	gold quality
adrenal tissue	UBERON:0018303	61.92	gold quality
liver	UBERON:0002107	61.83	gold quality
skeletal muscle tissue	UBERON:0001134	61.47	silver quality
right lung	UBERON:0002167	60.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.12	gold quality
duodenum	UBERON:0002114	59.54	gold quality
small intestine	UBERON:0002108	55.85	gold quality
small intestine Peyer’s patch	UBERON:0003454	55.37	gold quality
urinary bladder	UBERON:0001255	55.32	gold quality
lung	UBERON:0002048	55.20	gold quality
islet of Langerhans	UBERON:0000006	55.06	gold quality
sural nerve	UBERON:0015488	54.66	silver quality
prefrontal cortex	UBERON:0000451	54.04	gold quality
gall bladder	UBERON:0002110	53.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.74	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	1234.60
E-ANND-3	no	2.55

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.