EML6

Summary

EML6 (EMAP like 6, HGNC:35412) is a protein-coding gene on chromosome 2p16.1, encoding Echinoderm microtubule-associated protein-like 6 (Q6ZMW3). Microtubule-associated protein that plays an important role in the regulation of oocyte meiotic progression by maintaining spindle integrity and facilitating proper chromosome alignment.

Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule.

Source: NCBI Gene 400954 — RefSeq curated summary.

At a glance

• GWAS associations: 27
• Clinical variants (ClinVar): 362 total — 1 likely-pathogenic
• Phenotypes (HPO): 1
• MANE Select transcript: NM_001039753

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35412
Approved symbol	EML6
Name	EMAP like 6
Location	2p16.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ42562
Ensembl gene	ENSG00000214595
Ensembl biotype	protein_coding
OMIM	621084
Entrez	400954

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 7 protein_coding_CDS_not_defined, 4 nonsense_mediated_decay, 2 protein_coding, 1 retained_intron

ENST00000356458, ENST00000466608, ENST00000472965, ENST00000481376, ENST00000488611, ENST00000490828, ENST00000491655, ENST00000493997, ENST00000673655, ENST00000673746, ENST00000673905, ENST00000673912, ENST00000673916, ENST00000674035

RefSeq mRNA: 1 — MANE Select: NM_001039753 NM_001039753

CCDS: CCDS46286

Canonical transcript exons

ENST00000356458 — 42 exons

Exon	Start	End
ENSE00001534017	54903371	54903502
ENSE00001534019	54903044	54903196
ENSE00001534021	54899641	54899782
ENSE00001534022	54895273	54895400
ENSE00001534024	54894915	54895026
ENSE00001534025	54892454	54892656
ENSE00001534026	54891054	54891154
ENSE00001534028	54879547	54879640
ENSE00001534033	54869181	54869367
ENSE00001534034	54866766	54866884
ENSE00001534044	54853643	54853855
ENSE00001534046	54849962	54850218
ENSE00001534048	54847486	54847623
ENSE00001534052	54844047	54844248
ENSE00001534055	54829342	54829477
ENSE00001534059	54827566	54827751
ENSE00001534062	54820394	54820462
ENSE00001534065	54816787	54816885
ENSE00001547832	54910954	54911042
ENSE00001551428	54916759	54916935
ENSE00001561833	54928313	54928514
ENSE00001944258	54724549	54725258
ENSE00003331670	54928625	54928751
ENSE00003367631	54967000	54967103
ENSE00003410438	54970071	54972025
ENSE00003475468	54968668	54968768
ENSE00003484249	54952594	54952692
ENSE00003534203	54957790	54957998
ENSE00003542451	54871500	54871605
ENSE00003543942	54963986	54964158
ENSE00003548067	54964571	54964733
ENSE00003548449	54953983	54954156
ENSE00003571582	54959104	54959261
ENSE00003586053	54968128	54968281
ENSE00003596186	54950650	54950779
ENSE00003599351	54962523	54962711
ENSE00003632084	54859534	54859701
ENSE00003663543	54863783	54863889
ENSE00003687853	54960220	54960334
ENSE00003688117	54813232	54813391
ENSE00003690143	54948882	54948960
ENSE00003929029	54723662	54723777

Expression profiles

Bgee: expression breadth ubiquitous, 217 present calls, max score 88.99.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8977 / max 28.7072, expressed in 333 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
20323	0.3218	171
20322	0.2934	172
20321	0.2798	137
20327	0.0028	2

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
middle temporal gyrus	UBERON:0002771	88.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.83	gold quality
Brodmann (1909) area 23	UBERON:0013554	87.76	gold quality
ganglionic eminence	UBERON:0004023	87.53	gold quality
cerebellar hemisphere	UBERON:0002245	86.93	gold quality
cerebellar cortex	UBERON:0002129	86.80	gold quality
primary visual cortex	UBERON:0002436	86.74	gold quality
cerebellum	UBERON:0002037	86.08	gold quality
right frontal lobe	UBERON:0002810	85.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.05	gold quality
occipital lobe	UBERON:0002021	83.51	gold quality
ileal mucosa	UBERON:0000331	83.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.78	gold quality
postcentral gyrus	UBERON:0002581	81.96	gold quality
pituitary gland	UBERON:0000007	81.83	gold quality
anterior cingulate cortex	UBERON:0009835	81.40	gold quality
superior frontal gyrus	UBERON:0002661	81.39	gold quality
frontal cortex	UBERON:0001870	81.03	gold quality
neocortex	UBERON:0001950	80.98	gold quality
cerebral cortex	UBERON:0000956	80.32	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.23	gold quality
parietal lobe	UBERON:0001872	80.22	gold quality
adenohypophysis	UBERON:0002196	80.22	gold quality
brain	UBERON:0000955	79.77	gold quality
bone marrow cell	CL:0002092	79.52	gold quality
left adrenal gland	UBERON:0001234	79.44	gold quality
right adrenal gland cortex	UBERON:0035827	79.41	gold quality
caudate nucleus	UBERON:0001873	79.37	gold quality
left testis	UBERON:0004533	79.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

124 targeting EML6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-124-3P	99.89	73.74	3043

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	EML6	ENSDARG00000102755
mus_musculus	Eml6	ENSMUSG00000044072
rattus_norvegicus	Eml6	ENSRNOG00000037462

Paralogs (9): EML1 (ENSG00000066629), EML2 (ENSG00000125746), EML4 (ENSG00000143924), EML3 (ENSG00000149499), CFAP251 (ENSG00000158023), WDR90 (ENSG00000161996), EML5 (ENSG00000165521), CFAP52 (ENSG00000166596), CFAP44 (ENSG00000206530)

Protein

Protein identifiers

Echinoderm microtubule-associated protein-like 6 — Q6ZMW3 (reviewed: Q6ZMW3)

Alternative names: Echinoderm microtubule-associated protein-like 5-like

All UniProt accessions (6): A0A669KAL3, A0A669KB40, A0A669KB65, A0A669KBD4, A0A669KBH1, Q6ZMW3

UniProt curated annotations — full annotation on UniProt →

Function. Microtubule-associated protein that plays an important role in the regulation of oocyte meiotic progression by maintaining spindle integrity and facilitating proper chromosome alignment.

Subcellular location. Cytoplasm. Cytoskeleton. Spindle.

Similarity. Belongs to the WD repeat EMAP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6ZMW3-1	1	yes
Q6ZMW3-2	2

RefSeq proteins (1): NP_001034842* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR005108	HELP	Conserved_site
IPR011047	Quinoprotein_ADH-like_sf	Homologous_superfamily
IPR011048	Haem_d1_sf	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR050630	WD_repeat_EMAP	Family
IPR055439	Beta-prop_EML_1st	Domain
IPR055442	Beta-prop_EML-like_2nd	Domain

Pfam: PF03451, PF23409, PF23414

UniProt features (37 total): repeat 30, region of interest 2, compositionally biased region 2, chain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZMW3-F1	87.42	0.62

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 111 (showing top): SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, BILD_E2F3_ONCOGENIC_SIGNATURE, GOMF_CYTOSKELETAL_PROTEIN_BINDING, DODD_NASOPHARYNGEAL_CARCINOMA_DN, GOCC_SUPRAMOLECULAR_COMPLEX, GOCC_POLYMERIC_CYTOSKELETAL_FIBER, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, E2F3_UP.V1_UP, GOCC_SUPRAMOLECULAR_POLYMER, CIITA_TARGET_GENES, DLX2_TARGET_GENES, E2F5_TARGET_GENES, FEV_TARGET_GENES, FOXD2_TARGET_GENES, GLI1_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (2): microtubule binding (GO:0008017), protein binding (GO:0005515)

GO Cellular Component (3): microtubule (GO:0005874), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
tubulin binding	1
binding	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
intracellular anatomical structure	1
cellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1661 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
EML6	CIMAP1D	Q3SX64	515
EML6	KIAA1755	Q5JYT7	446
EML6	EPB41L4A	Q9HCS5	386
EML6	HAUS1	Q96CS2	385
EML6	SLC6A7	Q99884	377
EML6	ITM2C	Q9NQX7	363
EML6	TMEM69	Q5SWH9	358
EML6	ANTXRL	A6NF34	353
EML6	OR2T4	Q8NH00	349
EML6	LMAN1L	Q9HAT1	346
EML6	TOGARAM2	Q6ZUX3	346
EML6	GPBP1L1	Q9HC44	339
EML6	PPP1R37	O75864	331
EML6	CCDC167	Q9P0B6	324
EML6	TSPYL6	Q8N831	323

IntAct

9 interactions, top by confidence:

A	B	Type	Score
TUBB2B	EML2	psi-mi:“MI:0914”(association)	0.530
TUBB3	EML1	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
TUBB8	POTEF	psi-mi:“MI:0914”(association)	0.350
TUBB3	TUBB8B	psi-mi:“MI:0914”(association)	0.350

BioGRID (19): EML6 (Affinity Capture-MS), EML6 (Affinity Capture-MS), EML6 (Affinity Capture-MS), EML6 (Affinity Capture-RNA), EML6 (Affinity Capture-MS), EML6 (Affinity Capture-MS), EML6 (Affinity Capture-MS), EML6 (Affinity Capture-MS), EML6 (Affinity Capture-MS), EML6 (Cross-Linking-MS (XL-MS)), EML6 (Affinity Capture-RNA), EML6 (Cross-Linking-MS (XL-MS)), EML6 (Cross-Linking-MS (XL-MS)), EML6 (Co-fractionation), EML6 (Co-fractionation)

ESM2 similar proteins: A3LX18, A5DGL8, A5DVY3, A8ILK1, E1BKF9, E3LB80, F1SS88, O00423, O14301, O75083, O88342, O93277, P0CS32, P0CS33, P23232, Q05BC3, Q05BV3, Q15269, Q26613, Q29HG9, Q2KJH4, Q4P6E2, Q54MT0, Q5AI86, Q5F201, Q5RFQ3, Q5RHH4, Q5RKI0, Q5SQM0, Q6BSL7, Q6CI08, Q6DIF4, Q6ED65, Q6FL15, Q6PAX7, Q6ZMW3, Q759L2, Q8BHB4, Q8BQM8, Q8BU03

Diamond homologs: A0AUS0, A0DB19, A0JMQ0, A1CJY4, A1D7I5, A2QEV8, A3LX18, A4H6F7, A4HUV2, A4RDD7, A5DGL8, A5DVY3, A6RUL1, A6ZMK5, A7EF03, A7RM20, A7TH19, A8QBF3, A8WVX8, A8XYW9, A9UZS7, B0BNA7, B0XFT7, B0XYC8, B3MVL6, B3N4C7, B4GIU9, B4GSH1, B4I195, B4JB43, B4KGX9, B4KQU8, B4LUA5, B4MYI5, B4N0L0, B4NW98, B4Q354, B5FZ19, B6K1G6, B8M0Q1

SIGNOR signaling

0 interactions.

Disease & clinical

Cancer significance

Clinical variants and AI predictions

ClinVar

362 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	327
Likely benign	8
Benign	5

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3236471	NM_001039753.4(EML6):c.2563G>A (p.Gly855Arg)	Likely pathogenic

SpliceAI

7401 predictions. Top by Δscore:

Variant	Effect	Δscore
2:54725257:AGG:A	donor_loss	1.0000
2:54725258:GGTA:G	donor_loss	1.0000
2:54725260:T:G	donor_loss	1.0000
2:54813230:A:AG	acceptor_gain	1.0000
2:54813231:G:GG	acceptor_gain	1.0000
2:54813231:GC:G	acceptor_gain	1.0000
2:54813231:GCCTT:G	acceptor_gain	1.0000
2:54813388:ACAG:A	donor_loss	1.0000
2:54813389:CAGG:C	donor_loss	1.0000
2:54813390:AGG:A	donor_loss	1.0000
2:54813391:GG:G	donor_loss	1.0000
2:54813393:T:G	donor_loss	1.0000
2:54816785:A:AG	acceptor_gain	1.0000
2:54816786:G:GG	acceptor_gain	1.0000
2:54816786:GC:G	acceptor_gain	1.0000
2:54816883:AGGGT:A	donor_loss	1.0000
2:54816884:GG:G	donor_gain	1.0000
2:54816884:GGGT:G	donor_loss	1.0000
2:54816885:GG:G	donor_gain	1.0000
2:54816886:G:GA	donor_loss	1.0000
2:54816887:T:A	donor_loss	1.0000
2:54845422:T:G	donor_gain	1.0000
2:54847595:G:GT	donor_gain	1.0000
2:54849957:TACA:T	acceptor_loss	1.0000
2:54849958:ACAG:A	acceptor_loss	1.0000
2:54849960:A:AG	acceptor_gain	1.0000
2:54849960:A:C	acceptor_loss	1.0000
2:54849961:G:GG	acceptor_gain	1.0000
2:54849961:GA:G	acceptor_gain	1.0000
2:54849961:GAGAT:G	acceptor_gain	1.0000

AlphaMissense

12913 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:54725113:G:T	G18W	1.000
2:54725114:G:A	G18E	1.000
2:54725134:C:A	R25S	1.000
2:54725142:C:A	N27K	1.000
2:54725142:C:G	N27K	1.000
2:54725171:T:A	V37D	1.000
2:54725191:G:T	G44W	1.000
2:54725257:A:C	S66R	1.000
2:54813232:C:A	S66R	1.000
2:54813232:C:G	S66R	1.000
2:54813261:T:A	V76D	1.000
2:54813264:C:A	A77E	1.000
2:54813269:G:C	G79R	1.000
2:54813270:G:A	G79D	1.000
2:54813302:T:A	W90R	1.000
2:54813302:T:C	W90R	1.000
2:54813357:G:A	G108E	1.000
2:54816796:T:C	S123P	1.000
2:54816797:C:T	S123F	1.000
2:54816802:G:A	G125R	1.000
2:54816802:G:C	G125R	1.000
2:54816802:G:T	G125W	1.000
2:54816803:G:A	G125E	1.000
2:54816832:T:A	W135R	1.000
2:54816832:T:C	W135R	1.000
2:54816872:G:A	G148D	1.000
2:54820439:A:C	S168R	1.000
2:54820441:C:A	S168R	1.000
2:54820441:C:G	S168R	1.000
2:54820445:G:A	G170R	1.000

dbSNP variants (sampled 300 via entrez): RS1000006016 (2:54800605 A>G), RS1000011384 (2:54841743 C>G,T), RS1000013851 (2:54832334 C>T), RS1000016846 (2:54773322 A>C), RS1000064081 (2:54945936 G>A,C,T), RS1000066743 (2:54850186 G>A), RS1000071381 (2:54864163 A>G), RS1000082336 (2:54912431 G>C,T), RS1000087097 (2:54832532 G>A,C), RS1000094944 (2:54824270 C>T), RS1000104163 (2:54803997 G>A), RS1000121787 (2:54941451 C>G), RS1000126887 (2:54859747 G>A,C,T), RS1000133278 (2:54915681 A>G), RS1000141786 (2:54733365 A>G)

Disease associations

OMIM: gene MIM:621084 | disease phenotypes: MIM:148300

GenCC curated gene-disease

Mondo (1): keratoconus (MONDO:0015486)

Orphanet (2): OBSOLETE: Keratoconus (Orphanet:156071), NON RARE IN EUROPE: Isolated keratoconus (Orphanet:2335)

HPO phenotypes

1 total (1 of 1 shown, HPO-id order):

HPO	Term
HP:0000563	Keratoconus

GWAS associations

27 associations (top):

Study	Trait	p-value
GCST002685_16	Refractive astigmatism	2.000000e-06
GCST003943_5	Hepcidin levels	1.000000e-08
GCST003943_7	Hepcidin levels	3.000000e-06
GCST003945_3	Hepcidin/transferrin saturation ratio	3.000000e-06
GCST003945_8	Hepcidin/transferrin saturation ratio	2.000000e-07
GCST004599_274	Mean platelet volume	2.000000e-11
GCST004610_42	White blood cell count	3.000000e-09
GCST004613_90	Sum neutrophil eosinophil counts	7.000000e-10
GCST004614_126	Granulocyte count	5.000000e-10
GCST004620_130	Sum basophil neutrophil counts	1.000000e-10
GCST004626_14	Myeloid white cell count	3.000000e-10
GCST004629_22	Neutrophil count	1.000000e-10
GCST005721_1	Food allergy (parent-of-origin effect)	1.000000e-06
GCST005978_1	Diastolic blood pressure	5.000000e-12
GCST006010_4	Mean arterial pressure	8.000000e-12
GCST006031_4	Potassium levels	6.000000e-09
GCST006460_4	Bronchopulmonary dysplasia in preterm infants	5.000000e-06
GCST007703_96	Systolic blood pressure	2.000000e-07
GCST007704_98	Diastolic blood pressure	2.000000e-14
GCST007706_10	Mean arterial pressure	1.000000e-11
GCST007707_99	Hypertension	5.000000e-06
GCST010002_365	Refractive error	3.000000e-34
GCST012226_160	Waist circumference adjusted for body mass index	2.000000e-08
GCST012226_161	Waist circumference adjusted for body mass index	4.000000e-09
GCST012489_108	Heel bone mineral density x serum urate levels interaction	2.000000e-08
GCST90002387_256	Immature fraction of reticulocytes	1.000000e-09
GCST90002395_323	Mean platelet volume	8.000000e-23

EFO canonical traits (14, from GWAS)

EFO ID	Trait name
EFO:0007902	hepcidin:transferrin saturation ratio
EFO:0004833	neutrophil count
EFO:0004842	eosinophil count
EFO:0007987	granulocyte count
EFO:0005090	basophil count
EFO:0005939	parental genotype effect measurement
EFO:0007016	food allergy measurement
EFO:0006336	diastolic blood pressure
EFO:0006340	mean arterial pressure
EFO:0009283	potassium measurement
EFO:0006335	systolic blood pressure
EFO:0007789	BMI-adjusted waist circumference
EFO:0004531	urate measurement
EFO:0009270	heel bone mineral density

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007640	Keratoconus	C11.204.627

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation, affects cotreatment, increases expression, affects expression	9
trichostatin A	decreases expression, increases expression, affects expression	2
Nickel	decreases expression	2
bisphenol F	affects cotreatment, decreases methylation	1
methyleugenol	decreases expression	1
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Ethinyl Estradiol	affects expression	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	increases expression	1
Lead	affects expression	1
Methyl Methanesulfonate	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Vincristine	decreases expression	1
Cyclosporine	decreases expression	1
Okadaic Acid	increases expression	1
Genistein	affects expression	1

Clinical trials (associated diseases)

279 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT01485211	PHASE4	COMPLETED	Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin
NCT02119039	PHASE4	COMPLETED	Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus
NCT03245853	PHASE4	COMPLETED	Epi-On Corneal Crosslinking for Keratoconus
NCT03429569	PHASE4	UNKNOWN	Cross-Linking ACcéléré Iontophorèse Confocal kératocONE
NCT04427956	PHASE4	COMPLETED	Corneal Crosslinking Treatment Study
NCT07474870	PHASE4	NOT_YET_RECRUITING	Outcomes of CTAK Surgery
NCT00371202	PHASE3	UNKNOWN	Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus
NCT00647699	PHASE3	COMPLETED	Corneal Collagen Cross-linking for Progressive Keratoconus
NCT00815256	PHASE3	UNKNOWN	Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate Keratoconus
NCT00887900	PHASE3	COMPLETED	Deep Anterior Lamellar Keratoplasty (DALK)
NCT01112072	PHASE3	UNKNOWN	Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia
NCT01152541	PHASE3	UNKNOWN	Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin
NCT01190306	PHASE3	TERMINATED	Safety Study of the VEGA UV-A System to Treat Keratoconus
NCT01344187	PHASE3	COMPLETED	Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
NCT01459679	PHASE3	TERMINATED	Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
NCT01464268	PHASE3	UNKNOWN	Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
NCT01604135	PHASE3	ACTIVE_NOT_RECRUITING	Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
NCT01643226	PHASE3	COMPLETED	Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
NCT01672814	PHASE3	COMPLETED	Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus
NCT01682993	PHASE3	TERMINATED	Corneal Cross Linking and Topography Guided Excimer Laser Treatment
NCT01972854	PHASE3	TERMINATED	Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus
NCT02613780	PHASE3	UNKNOWN	Refractive Treatment of Early Keratoconus
NCT02638376	PHASE3	UNKNOWN	Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus
NCT03080077	PHASE3	UNKNOWN	Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
NCT03187912	PHASE3	COMPLETED	Accelerated Corneal Cross-linking With Different Riboflavin Solutions
NCT03442751	PHASE3	COMPLETED	Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
NCT03858036	PHASE3	UNKNOWN	Corneal Collagen Cross-Linking (CXL) Performed With Epi-ON Versus Epi-OFF in Eyes With Keratoconus and Other Corneal Ectatic Disorders
NCT04897503	PHASE3	UNKNOWN	Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose
NCT04905108	PHASE3	UNKNOWN	Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia
NCT05027295	PHASE3	UNKNOWN	Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light
NCT06100939	PHASE3	ACTIVE_NOT_RECRUITING	Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
NCT06100952	PHASE3	ACTIVE_NOT_RECRUITING	Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age with Keratoconus
NCT06450470	PHASE3	RECRUITING	Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus
NCT06601101	PHASE3	RECRUITING	Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus
NCT07124910	PHASE3	RECRUITING	Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
NCT07135167	PHASE3	RECRUITING	Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
NCT00409955	PHASE2	COMPLETED	Lamellar Transplant With Lyophilized Corneas
NCT00925327	PHASE2	UNKNOWN	Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking for Compassionate Treatment in Pediatric Patients With Progressive Keratoconus
NCT01143389	PHASE2	COMPLETED	Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
NCT01181219	PHASE2	COMPLETED	Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus